Impulse control disorder

This study tests whether a computerized training program designed to improve response inhibition — the ability to stop an automatic action — can reduce symptoms in people with obsessive-compulsive disorder, trichotillomania (hair-pulling), or skin-picking disorder. Participants a…

This study tests whether high-intensity brain stimulation (HI-tACS) can help people with gambling disorder. Researchers will give 60 adults either real or fake stimulation to see if it reduces gambling urges and improves thinking. Participants are followed for three months to che…

This study compares virtual reality exposure therapy (VRET) to standard imaginal exposure therapy for people with gambling disorder. Both treatments are combined with cognitive-behavioral therapy (CBT) over 12 sessions. The goal is to see if VRET is as good as or better than imag…

This study tests whether a proactive phone call can help people who gamble heavily to cut back. About 195 high-risk gamblers from Norway's horse racing betting service will be randomly chosen to receive a call offering tips like lowering their loss limit, or to receive no call. R…

This study tests whether adding small rewards (contingency management) to standard counseling helps people with gambling disorder stay in treatment and stop gambling. It uses video calls to reach people living in rural or remote areas. About 54 adults with gambling disorder will …

This study compares a new pacing method (left bundle branch pacing) with a standard pacemaker-defibrillator in 30 people who have hypertrophic cardiomyopathy and a specific heart block after myectomy surgery. The goal is to see if the new method better prevents heart failure wors…

This study compares deep brain stimulation (DBS) plus medication against medication alone for Parkinson's patients who also have impulse control disorders, like gambling or compulsive behaviors. About 60 participants aged 70 or younger will be randomly assigned to one of the two …

This phase 2 study tests a new radioactive imaging agent, 18F-mFBG, to measure nerve damage in the hearts of 20 people with stable heart failure and implantable defibrillators (ICDs). The goal is to see if the agent can reveal differences in nerve function between those who have …

This study compares a new diagnostic test using mannitol infusion to the standard hypertonic saline test for diagnosing the cause of polyuria-polydipsia syndrome (excessive urination and thirst). Researchers will enroll 144 adults to see if the mannitol test is as accurate and mo…

This study tests a digital escape room game designed to teach high school students about the risks of gambling. Researchers will compare gambling habits and attitudes between students who play the game and those who don't. The goal is to see if this fun, interactive approach can …

This study tests a vibrating bracelet called Keen2 that buzzes when it detects hair-pulling motions, paired with a smartphone app that teaches behavior-changing techniques. Researchers will compare it to a non-vibrating reminder bracelet in 90 adults with trichotillomania (hair-p…

This study tests whether a smartphone app called Change4Better (C4B) can help reduce problem gambling compared to standard treatment alone. About 128 adults who gamble and want help will use the app for 6 months. Researchers will track changes in gambling symptoms and how often p…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce impulse control disorders in people with Parkinson's disease who are on dopamine therapy. Twenty participants will receive both real and sham stimulation in random order, then complete task…

This early-phase study tests whether a noninvasive brain stimulation technique called rTMS can help people with impulse control disorders, specifically excessive eating. Researchers will enroll 30 adults aged 21 to 60 with a BMI over 30 to receive personalized, accelerated rTMS s…

This study tests whether a daily medication called valbenazine can reduce hair-pulling in adults with trichotillomania. About 20 people will receive either the drug or a placebo for 12 weeks, then everyone gets the drug for another 12 weeks. The goal is to see if the drug safely …

This small study tests a bracelet called Keen2 that detects hair-pulling episodes in adults with trichotillomania. For 8 weeks, participants wear the device and log what they were doing or feeling when pulling occurred. The bracelet then sends personalized alerts to help them use…

This study investigates whether inflammation worsens anger and aggression in people with Intermittent Explosive Disorder (IED). Researchers will give 112 participants (half with IED, half healthy controls) a low dose of endotoxin or a placebo on separate days. They will measure a…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study looks at how a heart rhythm treatment called catheter ablation affects the quality of life of people with ventricular tachycardia who have an implantable defibrillator. Researchers will ask 70 participants to fill out questionnaires about their health and well-being at…

This study looks at whether working unusual hours or having idle time at work makes people more likely to gamble in risky ways. Researchers will interview 25 adults who currently have or have had gambling problems and who have worked in the past year. The goal is to understand ho…

This study aims to measure how often a heart valve leak (tricuspid regurgitation) develops or worsens after getting a pacemaker or defibrillator with a lead that crosses the valve. About 200 adults who need their first device will have heart ultrasounds before and after the proce…

This study looks at how deep brain stimulation (DBS) for Parkinson's disease affects speech. Researchers will record voices of 60 participants before and after surgery to measure changes in clarity, emotion, and word choice. The goal is to better understand the benefits and risks…

This study follows over 2,700 people seeking help for behavioral addictions (like gambling or gaming) at a French hospital. Researchers will track their progress over time to learn what factors influence recovery and how well patients stick with treatment. No new treatments are t…