Scientists inject aggressive individuals with endotoxin to uncover Inflammation's role in anger
NCT ID NCT06665074
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study investigates whether inflammation worsens anger and aggression in people with Intermittent Explosive Disorder (IED). Researchers will give 112 participants (half with IED, half healthy controls) a low dose of endotoxin or a placebo on separate days. They will measure anger, aggressive behavior, brain activity, and inflammatory markers to see if those with IED react more strongly to inflammation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Endotoxin (a substance that triggers temporary inflammation)
- What this could lead to
- If it works, this could help explain why some people become more aggressive when their body is inflamed, pointing toward new ways to treat impulsive aggression.
- What could go wrong
- This is an early-phase study with only 112 participants, so results may not apply to everyone. The endotoxin causes temporary flu-like symptoms, and the study is designed to understand mechanisms, not to test a treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Ohio State University Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
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