Ohio State University

This study aims to find the best way for paramedics to help critically ill children breathe during emergencies like cardiac arrest or severe injury. It will compare three different airway management strategies used by Emergency Medical Services (EMS) on 3,000 children. The main g…

This study aims to find out if taking a pill (metformin) is just as good as using insulin shots for managing diabetes that develops during pregnancy (gestational diabetes). Researchers will follow over 1,500 pregnant people and their babies for two years to see which treatment le…

This study is testing whether suvorexant, a medication currently used for insomnia, can help people with moderate to severe alcohol use disorder drink less. 250 participants will take either the drug or a placebo pill nightly for 8 weeks while tracking their drinking, cravings, a…

This 12-week pilot study is exploring whether two different ketosis-based approaches can help improve symptoms of Polycystic Ovary Syndrome (PCOS). Researchers at Ohio State University are enrolling 40 women with PCOS to compare a strict ketogenic diet against a standard diet plu…

This study is testing if a common cholesterol-lowering drug (atorvastatin) can reduce the long-term risk of heart disease in people who developed high blood pressure during pregnancy. After they stop breastfeeding, 76 participants will take either the drug or a placebo pill for t…

This study is testing a new, specially designed catheter and wire during a procedure to stop chronic bleeding around the brain. Researchers want to see if these new devices work better or faster than the tools surgeons normally choose. About 100 adults with a specific type of bra…

This study tests whether a new hearing monitoring system used during cochlear implant surgery can help preserve patients' remaining natural hearing. Researchers will compare surgery with the monitoring system to standard surgery to see which better protects hearing. The goal is t…

This study is testing whether a mobile phone app, combined with educational booklets, can help adults with sickle cell disease better manage their condition. The goal is to see if using these tools leads to fewer trips to the emergency room and hospital. Researchers will compare …

This study aims to create and test a tool that predicts which military service members with suicidal thoughts will benefit from standard mental health care, and which might need a different, specialized therapy first. It involves 1,200 participants who will receive their usual ca…

This study is testing whether a new combination of three antibiotics works better than the current standard antibiotics to help prolong pregnancy and improve outcomes for both mother and baby when water breaks too early (before 34 weeks). The research involves 56 hospitalized pre…

This study is testing whether a ketone ester supplement can improve heart function and exercise capacity in people with type 2 diabetes. Researchers will compare the supplement to a placebo in 30 participants using heart scans and exercise tests. The goal is to see if this nutrit…

This study is testing whether following a strict high-fat, low-carb ketogenic diet for one year can slow the progression of polycystic kidney disease (PKD) in patients at high risk for rapid decline. It involves 20 patients from Ohio State University who will have their kidney si…

This study is testing a new, comprehensive support program for pregnant people who have conditions like high blood pressure, diabetes, depression, or anxiety. The goal is to see if this program helps improve their overall health, reduces depression and anxiety, and lowers the ris…

This study is testing whether adding small bone graft spacers between the joints of the neck during a common spinal fusion surgery helps bones heal together better and reduces the risk of nerve problems. Researchers will follow 45 adults with severe neck arthritis who need this s…

This study is testing a special sleeve worn on the forearm that helps people with paralysis in all four limbs (tetraplegia) regain control of their hand grasp. The sleeve detects tiny muscle signals when a person tries to move their hand, then uses gentle electrical stimulation t…

This study is testing whether combining healthy food support and fitness guidance with new diabetes medications helps women stick with their treatment and improves heart health. Researchers will follow 200 post-menopausal women with type 2 diabetes and heart health risks for 24 w…

This study is observing patients who need a dental bone graft before getting an implant. Sometimes, after placing the graft, the gum tissue cannot fully cover the area. The study will compare healing in patients where a special collagen patch is placed over the exposed graft vers…

This study is testing if a special type of MRI scan can help doctors choose the best chemotherapy for pancreatic cancer. The scan measures blood flow in the tumor, which may show early on if the chemo is working. If successful, this approach could help shrink tumors enough so tha…

This study is testing a 24-week community program called Black Impact, designed to improve heart health and reduce stress in Black men. Participants will receive weekly physical activity, health education, and support from coaches. The goal is to see if this program can be a scal…

This study is testing a reading program called STAR, where parents read with their 4-5 year old children who have language delays. Researchers want to see if the program improves the children's early reading skills and if sending encouraging texts or offering small rewards helps …

This study is testing a small, portable device called the P4 to improve the accuracy of MRI scans used to monitor pancreatic cancer. The goal is to reduce errors between different MRI machines and over time, so doctors can better see if a patient's treatment is working by measuri…

This study aims to create a better, more accurate way to diagnose pneumonia in older adults who come to the emergency department. Researchers will observe 250 patients aged 65+ with suspected pneumonia to see if new blood markers can help doctors tell if it's bacterial, viral, or…

This study is testing whether a small, wearable glucose monitor is a more convenient and acceptable way to screen for diabetes risk in women who had diabetes during pregnancy. Researchers will ask 20 new mothers to wear the monitor for a period after giving birth and complete sur…

This study has two main parts. First, it tests whether checking for diabetes right after giving birth (before leaving the hospital) is better than the standard check done weeks later for women who had diabetes during pregnancy. Second, it asks women about their experiences gettin…

This large study aims to find out if a higher daily dose of aspirin (162 mg) works better than the standard lower dose (81 mg) at preventing serious high blood pressure conditions during pregnancy. It will enroll over 10,000 pregnant individuals who are at risk for these complica…

This study is testing whether adding a brief online therapy for fear of the unknown makes standard firearm safety counseling more effective for military members. It aims to see if reducing this specific anxiety helps people feel safer storing their firearms locked and unloaded, w…

This study is testing whether rinsing the bladder with an antiseptic solution (Irrisept) right before removing a urinary catheter can prevent common infections. Researchers will compare the antiseptic rinse to a simple saltwater rinse in 300 adults having their catheters removed.…

This study aims to prevent opioid and other substance use disorders in homeless youth, a group at very high risk. Researchers are testing different combinations of counseling and practical support services to see which work best. They will follow 300 young people aged 14-24 for t…

This study is testing whether giving an antibiotic pill right before a bladder bulking procedure can prevent urinary tract infections after surgery. Researchers will compare women who receive the antibiotic to those who receive a placebo (sugar pill). The study also aims to learn…

This study is testing a 10-week swim and water safety program called AquOTic for children with autism. The program aims to teach essential skills to help prevent drowning, a leading cause of death for autistic children. Researchers will enroll 108 kids to see if the program works…

This study is testing whether combining two talk therapies—one for PTSD and one for suicide prevention—works better than standard care to reduce suicidal thoughts and behaviors. The research involves 190 military personnel and veterans who have both PTSD symptoms and recent suici…

This study is comparing two different weekly programs to see which better helps adults in farming communities who feel lonely or disconnected. 65 participants will be randomly assigned to receive either a special therapy focused on social isolation or general health education ses…

This study aims to understand how comfortable daily disposable contact lenses feel for people with astigmatism during long days of wear. Researchers will recruit 40 current contact lens wearers to test the lenses and report their comfort levels. The main goal is to measure how ma…

This study is testing a new rehabilitation program to help people recover walking ability after a recent spinal cord injury. Researchers will first test participants' blood and spinal fluid to find the best time to start a 12-week program of walking downhill on a treadmill while …

This study is testing if using lower air pressure inside the abdomen during laparoscopic colon surgery helps patients' bowels 'wake up' faster after the operation. Researchers will compare different pressure levels and devices in 125 adults having this type of surgery. The main g…

This study is testing whether a 6-month course of pancreatic enzyme supplements (CREON) can improve digestive symptoms in adults who develop pancreatic insufficiency after an episode of acute pancreatitis. Researchers will enroll 60 participants who have specific digestive sympto…

This study is testing whether a short form of online talk therapy can help reduce suicidal thoughts and prevent suicide attempts in adults with physical, vision, or hearing disabilities. Researchers will work with 60 participants who have recently had suicidal thoughts or a suici…

This study compares two common solutions for presbyopia (age-related blurry near vision). Researchers want to see if people prefer wearing multifocal contact lenses or single vision lenses with reading glasses. They'll ask 30 participants aged 40+ about their comfort and daily ex…

This study is testing whether a technique called dry needling can help people with chronic knee pain. Dry needling involves inserting thin needles into tight muscles to help them relax, aiming to reduce pain and improve strength and movement. The study will compare real dry needl…

This study is testing a new online exercise platform designed specifically for people living with chronic brain injury. Researchers are working with 60 participants to see if this special streaming service helps them become more physically active and feel more confident about exe…

This study is testing whether listening to specially filtered classical music for 15 minutes before daily therapy sessions helps people with PTSD feel better. Researchers will compare this music-enhanced therapy to standard therapy alone in 100 adults. They will track symptoms, s…

This study is testing a new, non-surgical procedure that uses precise beams of radiation to target specific nerves in the spine. The goal is to see if this can safely and effectively reduce severe, treatment-resistant muscle stiffness (spasticity) caused by conditions like stroke…

This study is testing how well weekly replacement contact lenses work for people with astigmatism who have never worn contacts before. Sixty participants will wear the lenses for about three weeks and report on their vision and comfort. Researchers want to understand the wear exp…

This study is testing whether a daily soy tomato juice drink is safe and tolerable for people with recurrent or chronic pancreatitis. All 35 participants will drink the juice for four weeks while researchers check for side effects and measure inflammation levels. The goal is to s…

This study is testing a 10-week warm water therapy program for children with movement challenges like cerebral palsy. Kids aged 3-9 will attend pool sessions twice a week to work on swimming safety, arm movement, and daily self-care skills like dressing. Researchers want to see i…

This study aims to understand if two existing cognitive tests—the Coding Test and the Self-Administered Gerocognitive Examination (SAGE)—are useful for people with Huntington's disease. Researchers will enroll 76 participants with Huntington's disease for a single visit to comple…

This study aims to create better tools for measuring how babies use their arms and hands. Researchers will analyze videos of children, including some who had a stroke around birth and some who are developing typically, to understand movement patterns. The goal is to develop a new…

This study aims to collect and store blood, skin, and swab samples from patients with and without certain skin conditions. The goal is to create a resource for future research to better understand how diseases like hidradenitis suppurativa work. It involves 175 participants who a…

This study aims to understand if a temporary, mild inflammatory response in the body can directly increase feelings of anger and aggressive behavior. Researchers will compare 45 adults with a history of frequent, problematic impulsive aggression (Intermittent Explosive Disorder) …

This study is testing whether training older adults to better sense body movements can improve their balance. Researchers will have 30 healthy adults aged 65-89 practice detecting tilts and side-to-side motions while receiving feedback. The goal is to understand if this type of t…

This study is testing whether taking vitamin C daily can improve gut health and reduce body-wide inflammation in adults with obesity. Researchers want to see if vitamin C can help strengthen the gut lining, which may be linked to health risks. Participants will take vitamin C or …

This study aims to find new markers in the blood that can show how the placenta is working and how it responds to low-dose aspirin in pregnant people at risk for preeclampsia. Researchers will collect blood samples from up to 1,000 participants during pregnancy to analyze tiny pa…

This study aims to find the best teaching method and timing to help young children who struggle with reading. Researchers will compare two different ways of teaching sound awareness skills to 720 pre-kindergarten and kindergarten students. The goal is to see which approach better…

This study is testing whether using educational TV shows and videos can be an easier and more effective way for parents to help their young children develop early reading skills, compared to traditional storybook reading. Researchers are working with 450 low-income families with …

This study aims to better understand how occupational therapists help adults recover arm and hand function after a stroke or spinal cord injury. Researchers will video record real outpatient therapy sessions to identify what makes treatments effective. The goal is to create a pra…

This study aims to understand which coping strategies help military personnel reduce suicidal thoughts in real-world situations. Researchers will track 334 active military members with recent suicidal thoughts using smartphone surveys throughout their day. The goal is to identify…