Ohio State University

This study aims to reduce suicidal thoughts and behaviors in 100 adults with PTSD by combining two proven treatments: prolonged exposure therapy and a crisis response plan. Participants will receive either the combined therapy or prolonged exposure with standard care. The goal is…

This study tests whether a 24-week food and fitness program helps 200 post-menopausal women with type 2 diabetes and heart-kidney problems stick to their new GLP-1 medication. The program includes exercise sessions, nutrition counseling, and home food deliveries. Researchers will…

This study tests whether a mobile app that provides easy-to-understand sickle cell disease guidelines can help adults reduce emergency room visits, hospital stays, and infusion center visits. About 287 adults with sickle cell disease will use the app along with a booklet, and the…

This study tests whether suvorexant, a drug used for insomnia, can help people with alcohol use disorder drink less and handle stress better. About 250 adults will take either the drug or a placebo nightly for 8 weeks. Researchers will track drinking habits, cravings, and stress …

This study looks at whether a well-formulated ketogenic diet can slow the progression of polycystic kidney disease in 20 adults who are at high risk for kidney failure. Participants will follow the diet for one year and have regular MRIs, blood tests, and urine tests to track kid…

This study tests whether taking atorvastatin (a cholesterol-lowering drug) for 3 months after pregnancy can reduce the long-term risk of heart disease in women who had high blood pressure conditions like preeclampsia. 76 women will receive either the drug or a placebo, starting a…

This study compares two treatments for gestational diabetes (high blood sugar during pregnancy): metformin pills and insulin shots. About 1,572 pregnant women who need medication will be randomly assigned to one of the two options. The goal is to see if metformin works as well as…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will do weekly physical activity and health education, and work with a coach and community health worker. The goal is to see if the program improves heart health and r…

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can help pregnant people with preterm premature rupture of membranes (PPROM) before 34 weeks stay pregnant longer and have healthier outcomes compared to the current standard…

This study tests whether a special MRI technique called DCE-MRI can help doctors choose the best chemotherapy for people with borderline resectable pancreatic cancer. The goal is to shrink the tumor enough so it can be removed by surgery. About 50 adults will receive chemotherapy…

This study looks at two ways of managing blood sugar during labor in pregnant women with type 1 diabetes. One method is strict (keeping blood sugar between 70-110 mg/dL) and the other is more relaxed (70-140 mg/dL). The goal is to see if the relaxed approach is just as safe for t…

This study tests a new program called MOMI PODS that provides extra medical and emotional support to new mothers after childbirth. The goal is to improve heart health, reduce depression and anxiety, and lower the risk of serious health problems. About 384 mother-baby pairs will t…

This study looks at whether adding occupational therapy and dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with dietitian support, meals with …

This study is checking if taking vitamin C daily can strengthen the gut lining and lower body-wide inflammation in adults with obesity. A weaker gut barrier ('leaky gut') might let harmful substances into the blood, raising risks for other health problems. Researchers will compar…

This study looks at better ways to diagnose pneumonia in older adults (65+) who come to the emergency room. Researchers will test 250 patients and use new biomarkers to tell if pneumonia is bacterial, viral, or both. The goal is to create a clearer, more accurate diagnostic path …

This study is testing a small, portable device called the P4 that sits inside an MRI scanner to improve the accuracy of scans for pancreatic cancer. The goal is to see if the device can help doctors better measure how well cancer treatment is working by tracking blood flow change…

This large study tests whether a 162 mg daily aspirin dose works better than the standard 81 mg dose to prevent dangerous high blood pressure disorders (like preeclampsia) in pregnant people at risk. Over 10,000 participants will be followed to see which dose reduces complication…

This study tests whether nightly atropine eye drops can delay the start of nearsightedness in children aged 6 to 11 who are at risk. About 664 children will receive either the active drops or a placebo for two years. Researchers will measure how many children become nearsighted a…

This study tests if Irrisept, an antiseptic rinse, can prevent urinary tract infections (UTIs) when a urinary catheter is removed. About 300 adults will get either Irrisept or a saltwater rinse before catheter removal. The goal is to see if Irrisept reduces infections and the nee…

This study looks at whether taking antibiotics before a procedure called urethral bulking (using Bulkamid gel) for stress urinary incontinence can lower the chance of getting a urinary tract infection (UTI) right after. About 138 adults will be randomly assigned to get either ant…

This study tests whether offering counseling, advocacy, and basic support can prevent opioid misuse and mental health problems in homeless youth aged 14 to 24. About 300 participants will be randomly assigned to different combinations of services at a drop-in center. Researchers …

This study tests a simple change in how a breathing tube is placed during surgery. By rotating the tube 180 degrees before insertion, doctors hope to lower the chance of a sore throat afterward. About 357 adults having surgery with a breathing tube will take part. The goal is to …

This study looks at whether using lower pressure gas during laparoscopic large bowel surgery can prevent temporary bowel paralysis (postoperative ileus) and help patients recover and leave the hospital sooner. About 125 adults having laparoscopic right colon or sigmoid colon surg…

This study looks at how comfortable and clear a weekly replacement contact lens feels for adults with astigmatism who have never worn contacts before. Sixty participants will wear the lenses for about 3 weeks and answer surveys about their experience. The goal is to see if these …

This study looks at whether dry needling can help people with long-term knee pain feel better and move easier. Dry needling uses thin needles placed into tight muscles to help them relax and reduce pain. The study will include 120 adults aged 18 to 40 who have had knee pain for a…

This study tests whether a 45-day balance training program can help healthy older adults better sense body tilts and movements, and improve their balance. Participants will sit on a moving platform and practice identifying directions of motion while getting feedback. The goal is …

This study is testing a new online exercise program made specifically for people with chronic brain injury. Researchers want to see if using this platform helps survivors become more active and feel more confident about exercising. Sixty adults with chronic brain injury will take…

This study tests whether adding a short therapy focused on handling uncertainty to standard firearm safety counseling helps active-duty military members store their guns more safely. About 100 participants will attend two counseling sessions and complete daily surveys for 28 days…

This study tests whether adding Cognitive Therapy for Suicide Prevention (CTSP) to standard services can reduce suicidal thoughts in homeless youth aged 15-24 who use alcohol or drugs. About 300 participants will be split into two groups: one gets CTSP plus usual care, the other …

This study tests a 10-week swimming and water safety program called AquOTic for children with autism ages 5 to 9. The program uses one-on-one coaching in small groups to teach swim skills and water confidence. Researchers want to see if it works and compare two ways of delivering…

This study is testing whether people with recurrent acute or chronic pancreatitis can safely drink a soy tomato juice every day. Researchers will check for side effects, measure inflammation in the blood, and ask participants how they feel. Everyone in the trial gets the same dri…

This study looks at how comfortable daily disposable contact lenses are for people with astigmatism who wear them for long hours. Researchers want to see if these lenses keep eyes feeling good all day. About 40 current contact lens wearers will take part.

This pilot study tests a wearable sleeve that uses muscle signals and gentle electrical pulses to help people with chronic tetraplegia (from spinal cord injury) grasp objects. Twelve adults will use the sleeve during 12 weeks of hand therapy. The goal is to see if the device is s…

This study tests whether taking a daily oil rich in linoleic acid can improve muscle strength, size, and endurance in older adults with sarcopenia (age-related muscle loss). Participants will consume 12 grams of safflower oil daily for several weeks. The goal is to see if this si…

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 who have movement problems from conditions like cerebral palsy. The children will attend pool sessions twice a week for ten weeks, focusing on swim safety, arm function, and daily self-care. Res…

This study tests whether adding a brief crisis coping strategy (Crisis Response Planning) to a standard PTSD talk therapy (Cognitive Processing Therapy) can reduce suicidal thoughts and behaviors in veterans and active-duty service members. About 190 participants with PTSD and re…

This study tests whether a telehealth program that coaches parents to use adaptive standers can improve physical activity, sleep, and endurance in children ages 1-6 with severe motor delays (like cerebral palsy). Children will stand in a special stander for 30 minutes, three time…

This 12-week study at Ohio State University will test if a ketogenic diet or a mixed diet with ketone supplements can help women with PCOS have more regular periods and improve hormone balance. About 40 women aged 18-40 with PCOS will be randomly assigned to one of two groups. Th…

This study tests whether a ketone ester supplement can improve exercise ability and heart function in people with type 2 diabetes. About 30 adults will take either the supplement or a placebo and undergo heart MRI scans and quality-of-life surveys. The goal is to see if this simp…

This study tests whether a type of talk therapy, delivered over video calls, can reduce suicidal thoughts and attempts in adults with physical disabilities (like vision, hearing, or mobility problems). Researchers will enroll 60 people who have had recent suicidal thoughts or a r…

This study tests whether a low-sugar diet and mild electrical pulses to the legs can prevent blood pressure from dropping too low after eating in people with chronic spinal cord injury. Researchers will measure blood pressure changes in the lab and at home over several days. The …

This study tests a radiation treatment that targets specific nerves in the back to reduce muscle tightness (spasticity) caused by stroke, spinal cord injury, or cerebral palsy. About 22 people will be randomly assigned to receive either the real treatment or a fake (sham) procedu…

This study tests whether a 6-week group program can reduce loneliness and improve mental health in adults living in agricultural areas. Researchers will enroll 65 people who feel lonely or disconnected. Participants will attend weekly sessions and report changes in loneliness, an…

This study tests whether taking pancrelipase (CREON) for 6 months can improve symptoms of exocrine pancreatic insufficiency (EPI) after a bout of acute pancreatitis. About 60 adults with low fecal elastase and bothersome symptoms will receive the enzyme treatment. Researchers wil…

This study tests whether listening to 15 minutes of frequency-filtered classical music before daily therapy sessions helps reduce PTSD symptoms more than regular music. About 100 adults with PTSD will receive 10 sessions of cognitive processing therapy while their stress levels a…

This study looks at how people with presbyopia (age-related blurry near vision) feel about wearing multifocal contact lenses compared to wearing regular contact lenses plus reading glasses. About 30 adults aged 40 and older will try both options and say which they prefer. The goa…

This study looks at two thinking and memory tests—the Coding Test and the SAGE—to see if they can help screen and track Huntington's disease. Researchers will compare these tests with standard ones in 76 adults aged 30-65 who have a genetic diagnosis of Huntington's. The goal is …

This study looks at whether using educational media together with a caregiver can improve early reading skills in children ages 3 to 5. About 450 children and their caregivers will be assigned to a media-based activity, a storybook reading activity, or no activity. The goal is to…

This study aims to create and improve methods for measuring arm and hand movements in infants, including those with perinatal stroke or cerebral palsy. Researchers will analyze video recordings and developmental tests from 80 children, both with and without motor challenges. No t…

This study looks at how well the bones in the neck fuse together after a type of spine surgery called posterior cervical fusion, where small spacers are placed between the joints. Researchers will follow 45 adults for up to 2 years after surgery, using X-rays and CT scans to chec…

This study aims to better understand low back and neck pain by comparing the health history and movement abilities of people with and without these conditions. Researchers will use wearable motion sensors and questionnaires to identify patterns that could predict injury risk or h…

This study looks at a shared reading program called Sit Together and Read (STAR) for children ages 4 to 5 who have developmental language disorder. Caregivers will be assigned to one of three STAR groups or a control group to see if small rewards or encouraging texts help them st…

This study looks at whether a special monitoring system used during cochlear implant surgery can help save a person's remaining natural hearing. About 40 adults with severe hearing loss in both ears will take part. Researchers will measure hearing changes over two years to see if…

This study looks at how different types of dietary fats affect thinking and memory in adults who have mild memory complaints. Over 88 participants will eat a special snack each day for one week. Researchers will measure brain function and gut health to see if certain fats can hel…

This study collects skin samples from 175 people with hidradenitis suppurativa, a painful inflammatory skin disease. The samples are stored in a biorepository for future research. The goal is to help scientists better understand and potentially find new treatments for this and ot…

This study tests whether screening for diabetes right after giving birth (before leaving the hospital) is better than the usual 4-12 week wait. It also asks 104 women who had gestational diabetes about their views on heart health programs and what makes it easier or harder to joi…

This study watches and listens to babies to find early clues for conditions like cerebral palsy and autism. Parents of 46 infants who were in the NICU will upload short videos at home. Researchers will analyze the babies' movements and sounds to see if they can spot problems earl…

This study looks at 720 children in pre-kindergarten and kindergarten to find the best way to teach them how to recognize and work with sounds in words. The goal is to improve their reading and spelling later on. The children will get one of two types of sound training, and resea…

This study aims to create a treatment prognosis calculator for 1,200 active-duty military members with suicidal thoughts. The goal is to predict who will improve with standard care and who needs a specialized therapy called Brief Cognitive Behavioral Therapy (BCBT). Participants …

This study looks at pregnant people who are at risk for preeclampsia and are taking aspirin as part of their care. Researchers will collect blood samples up to four times during pregnancy to study tiny particles from the placenta. The goal is to find a set of proteins that can sh…

This study watches and analyzes video recordings of real occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to identify the key techniques therapists use to improve arm and hand function. The goal is to create a toolkit that he…

This study watches how gum grafts heal in 15 people getting treatment for receding gums. Researchers use a scanner to measure swelling, a device to check blood flow, and saliva tests to look at healing markers. Participants also answer questions about pain. The goal is to learn w…

This study looks at whether people with a history of impulsive aggression react more strongly to inflammation than others. Participants will receive a low dose of endotoxin (which causes temporary inflammation) or a placebo on separate days. Researchers will measure anger, aggres…

This study looks at how U.S. military members use emotion regulation strategies to reduce suicidal thoughts. Researchers will track participants' strategies and moods in real time using smartphone surveys. The goal is to understand which strategies work best and for whom, to impr…

This study looks at whether a continuous glucose monitor (CGM) — a small sensor worn under the skin — can help screen women for diabetes risk after having gestational diabetes. About 20 women will wear the CGM for a short time after giving birth and answer surveys about their exp…

This study looks at two different systems for collecting bone marrow from the hip. Six people having hip surgery will give bone marrow samples using both a standard system and a new one. The samples will be compared in the lab to see which method collects more stem cells and heal…

This study looks at a new, tiny wire and catheter system for treating a type of brain bleed called chronic subdural hematoma. Researchers want to see if this new tool works faster and safer than the standard tools doctors usually choose. About 100 adults with this condition will …

This study is testing a new rehabilitation program for people with spinal cord injury (SCI) that combines walking downhill on a treadmill with mild electrical stimulation to activate weak muscles. Researchers will also check blood and spinal fluid for biomarkers to decide whether…

This study looks at a collagen patch (Mucograft) used to cover exposed barrier membranes after guided bone regeneration (GBR) for dental implants. About 30 adults who need GBR will be observed. The study compares healing and success when the patch is used versus when it is not, b…