Ohio State University

This study tests whether a continuous glucose monitor (CGM) paired with a coaching app helps pregnant women with type 2 diabetes achieve better blood sugar control compared to standard care. Participants use a Dexcom G7 CGM sensor and receive guidance through a mobile app and car…

This study compares two treatments for gestational diabetes: oral metformin pills and injectable insulin. Researchers want to see if metformin is as good as insulin at preventing problems for mothers and babies, like high birth weight or low blood sugar. About 1,500 pregnant wome…

This trial tests whether force feedback instruments—tools that let surgeons feel the forces they apply during robotic surgery—improve recovery after lung removal. About 270 adults having robotic-assisted lung surgery will be randomly assigned to surgery with or without force feed…

This trial tests a short virtual therapy called IMPROVE, designed to help people on medication for opioid use disorder who also drink heavily. Participants attend three one-hour online sessions and use a mobile app to learn skills for managing emotional distress that can trigger …

This study tests whether a program called BETTER can help pregnant women have healthier births. The program includes a one-on-one coaching session and regular text messages to help women connect with resources for housing, food, and transportation. Researchers will compare outcom…

This study looks at whether a well-formulated ketogenic diet can delay the progression of polycystic kidney disease in 20 adults who are at high risk for kidney failure. Participants will follow the diet for one year and have regular blood tests, urine tests, and MRI scans to tra…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests whether a telehealth program that coaches parents to use adaptive standers can improve physical activity, sleep, and endurance in children ages 1-6 with severe motor delays (like cerebral palsy). Twenty children and their parents will take part in 8 weeks of stan…

This study looks at two ways of managing blood sugar during labor in pregnant women with type 1 diabetes. One group will follow a strict target (70-110 mg/dL), while the other will have a more relaxed target (70-140 mg/dL). The goal is to see if the relaxed approach is safe for n…

This study tests whether eating a special oil (high in linoleic acid) every day can help older adults with muscle loss (sarcopenia) build stronger muscles and improve mobility. Researchers will give 66 participants either the oil or a placebo for a period, then measure changes in…

This study is testing whether adding registered dietitian counseling or occupational therapy home safety tips to regular home-delivered meals can reduce fall risk in older adults. Researchers will compare four groups: meals alone, meals plus dietitian, meals plus occupational the…

This study tests whether a mobile health app and educational booklets can help adults with sickle cell disease reduce emergency room visits and hospital stays. Researchers will compare the app-plus-booklet approach to booklets alone in 287 participants. The goal is to see if givi…

This study looks at whether a 24-week program of healthy eating and exercise helps post-menopausal women with type 2 diabetes and heart-kidney problems stick to their new GLP-1 medication. Researchers will track how many women stop taking the drug and measure changes in heart dis…

This study looks at whether placing a special collagen material over an exposed barrier membrane helps gum wounds heal better after guided bone regeneration (GBR) for dental implants. About 30 people who already need GBR will be observed; if the membrane is exposed, the surgeon m…

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy better than the current standard antibiotics in pregnant people hospitalized after their water breaks early (before 34 weeks). About 56 participants wil…

This study tests a new microcatheter device (Aristotle 14 guidewire and Plato 17 microcatheter) for treating chronic subdural hematoma, a type of brain bleed. About 100 adults will be randomly assigned to receive the new device or the surgeon's usual choice. Researchers will comp…

This study tests a new rehabilitation program for people with recent spinal cord injuries (within 1-5 months). Participants walk on a downhill treadmill while receiving electrical stimulation to their leg and trunk muscles. The goal is to improve walking and movement. Researchers…

This study tests whether suvorexant, a sleep medication, can help people with alcohol use disorder drink less and handle stress better. About 250 adults who want to cut back on alcohol will take either the drug or a placebo nightly for 8 weeks. Researchers will track drinking hab…

This study tests a 10-week swim and water safety program called AquOTic for children with autism ages 5 to 9. The program uses one-on-one coaching in small groups to teach swimming and safety skills. Researchers want to see if the program works and which teaching method is best—u…

This study tests whether taking atorvastatin (a statin) for 3 months after childbirth can reduce the long-term risk of heart disease in women who had high blood pressure disorders during pregnancy. 76 postpartum women will receive either atorvastatin or a placebo, and their cardi…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will take part in weekly physical activity, health education, and work with a coach and trainer. The goal is to see if the program improves heart health and reduces st…

This study tests a small, portable device called P4 that sits inside an MRI scanner to improve the accuracy of scans for pancreatic cancer. Researchers want to see if it can reduce errors when measuring blood flow in tumors, which helps doctors know if treatment is working. The t…

This study aims to create a better way to diagnose pneumonia in older adults (65+) who come to the emergency department with suspected pneumonia. Researchers will observe 250 participants and test whether new biomarkers can improve diagnostic accuracy. The goal is to help doctors…

This study looks at whether doing a diabetes test right after giving birth (instead of waiting 4-12 weeks) helps more women get screened for type 2 diabetes after having gestational diabetes. It also asks women about their views on heart-health programs after pregnancy. About 104…

This study tests whether a nightly drop of low-dose atropine in both eyes can delay the start of nearsightedness in children aged 6–11 who are not yet nearsighted. Over 600 kids will be randomly assigned to get either the atropine drops or placebo drops for two years. The main go…

This study tests whether taking 162 mg of aspirin daily is better than the standard 81 mg dose for preventing high blood pressure disorders (like preeclampsia) in pregnant women at risk. Over 10,000 participants will be assigned to one of the two doses early in pregnancy. The goa…

This study tests whether rinsing the bladder with Irrisept (a chlorhexidine solution) before removing a urinary catheter can prevent infections better than rinsing with salt water. Researchers will compare infection rates and antibiotic use in 300 adults. The goal is to find a no…

This study tests two counseling programs—one focused on motivation and coping skills, the other on strengths and advocacy—to prevent opioid misuse in 300 homeless youth aged 14-24. Participants are randomly assigned to one of the programs or standard services, and tracked for two…

This study tests whether adding a crisis response plan (CRP) to prolonged exposure (PE) therapy helps reduce suicidal thoughts and behaviors in people with PTSD. Researchers will compare PE plus CRP to PE with standard care in 100 adults. The goal is to find a better way to suppo…

This study tests whether a spinal cord stimulator can reduce pain and improve nerve function in people with diabetic peripheral neuropathy. Sixty adults with pain that hasn't responded to standard treatments will be randomly assigned to receive the implant or standard care. Resea…

This study is testing whether glasses prescriptions made by a computer analyzing detailed eye images can give better vision for children with Down syndrome than standard prescriptions from a routine eye exam. The study will enroll 24 children aged 5 to 12 with Down syndrome. Each…

This study tests whether a 6-month course of pancrelipase (CREON) can improve digestive symptoms in people who have exocrine pancreatic insufficiency (EPI) after an acute pancreatitis attack. About 30 adults with confirmed EPI and moderate-to-severe symptoms will take the enzyme …

This study tests whether daily training with colored lights can reduce light sensitivity in people who have had a traumatic brain injury. Twenty participants will use a device at home for 20 minutes a day, first with a blue light and then with a red light, or vice versa. Research…

This study tests whether a 3D-printed replica of a person's own nose can help them position their head better when using steroid nasal rinses. 200 adults with chronic sinusitis will use a daily steroid rinse for 8 weeks, with some getting the 3D model to guide their head position…

This 12-week study at Ohio State University tests whether a keto diet or a mixed diet with ketone supplements can help women with PCOS have regular periods and improve hormone balance. About 40 women aged 18-40 will be randomly assigned to one of two groups. The goal is to see if…

This study tests whether a low glycemic diet and lower-body electrical stimulation can prevent blood pressure from dropping too low after meals in people with chronic spinal cord injury. Thirteen participants will try both a low and high glycemic diet, with and without electrical…

This study tests if rotating the breathing tube 180 degrees before placing it can lower the chance of a sore throat after surgery. About 357 adults having general anesthesia will take part. The goal is to see if this simple change helps patients feel better after their procedure.

Suicide is the leading cause of death among youth experiencing homelessness, and most don't get help. This study will test whether 10 sessions of Cognitive Therapy for Suicide Prevention (CTSP), delivered by outreach workers, can reduce suicidal thoughts, substance use, and depre…

This study looks at whether a ketone ester supplement can improve heart function and exercise ability in people with type 2 diabetes. About 30 adults will take either the supplement or a placebo and undergo heart scans and fitness tests. The goal is to see if this simple drink ca…

This study looks at how comfortable daily disposable contact lenses are for people with astigmatism when worn for long hours. Researchers will ask 40 current soft toric lens wearers to rate their comfort. The goal is to see if these lenses work well for long days.

This study is testing a new online exercise program made specifically for people with chronic brain injury. Researchers want to see if it helps them be more active and feel more confident about exercising. Sixty adults with chronic brain injury will take part; half will use the n…

This study is testing whether people with recurrent acute or chronic pancreatitis can safely drink a soy tomato juice beverage every day. Researchers will check for side effects, measure inflammation in the blood, and ask participants how they feel. The goal is to see if the drin…

This study looks at how people with presbyopia (age-related blurry near vision) feel about wearing multifocal contact lenses compared to regular contact lenses plus reading glasses. About 30 adults aged 40 and older will try both options and report which they prefer. The goal is …

This study looks at whether dry needling can ease knee pain and improve leg strength and function in people with patellofemoral pain syndrome (pain around the kneecap). Researchers will give dry needling treatments to 120 adults aged 18 to 40 and measure changes in pain and movem…

This study tests whether adding a brief crisis coping strategy (Crisis Response Planning) to a standard talk therapy (Cognitive Processing Therapy) can lower suicidal thoughts and behaviors in veterans with PTSD. About 190 active-duty service members and veterans with PTSD and re…

This study tests whether adding a one-hour cognitive behavioral session focused on handling uncertainty to standard lethal means counseling helps active-duty service members store firearms more securely. One hundred participants who own unlocked, loaded guns will attend two sessi…

This study is testing a type of talk therapy, called Brief Cognitive Behavioral Therapy for Suicide Prevention, delivered via video call. The goal is to see if it can reduce suicidal thoughts and attempts in adults with physical disabilities affecting vision, hearing, or mobility…

This study tests whether listening to 15 minutes of frequency-filtered classical music before each cognitive processing therapy session can improve PTSD symptom relief. 100 adults with PTSD or subthreshold PTSD will be randomly assigned to hear either filtered or unfiltered music…

This study tests a treatment that uses precise radiation beams to target nerves in the back, aiming to reduce muscle tightness (spasticity) caused by stroke, spinal cord injury, or cerebral palsy. About 22 people will be randomly assigned to receive either the real treatment or a…

This study looks at whether using lower pressure gas during laparoscopic large bowel surgery can protect the gut and help patients recover faster. About 125 adults having certain types of colon surgery will be randomly assigned to different pressure levels. The goal is to see if …

This study tests whether taking vitamin C daily can improve gut health and reduce inflammation in adults with obesity. Over two 2-week periods, 34 participants will take either vitamin C or a placebo, and researchers will measure gut permeability using sugar drinks and blood, uri…

This study tests whether a 6-session therapy program (CBT-PSI) can reduce loneliness and improve mental health in adults living in agricultural areas. 65 participants will be assigned to either the therapy or a health education group. The goal is to see if changing thoughts and b…

This study looks at whether taking antibiotics before a procedure to treat stress urinary incontinence (leaking urine with cough or sneeze) can lower the chance of getting a urinary tract infection (UTI) afterward. About 138 women will receive either antibiotics or a placebo befo…

This study tests a 15-week shared reading program called Sit Together and Read (STAR) for children ages 4 to 5 with developmental language disorder. Caregivers are guided to read with their child using specific techniques to build print and letter knowledge. The study also looks …

This study looks at whether a ketogenic diet or ketone supplements can reduce the mental and physical downsides of sleep loss. Sixty healthy adults ages 18–40 will cut their sleep by half for four nights while following either a ketogenic or Mediterranean diet, and taking either …

About 30 million US adults suffer from nasal sinus disease, often causing nasal obstruction and loss of smell. This study from Ohio State University will test a nasal plug (similar to a swimmer's nose clip) as a tool to better evaluate these symptoms. Researchers hope to develop …

This study looks at how memory, attention, and other thinking skills change in people who have surgery to remove a meningioma (a type of brain tumor) from the front or side of the brain. Researchers will test cognitive function before surgery and one year later in about 50 adults…

This study looks at how a person's age and metabolic health change the way their body processes a ketone supplement drink. Researchers will give 400 healthy adults aged 20-70 a single dose of the drink and track ketone levels in their blood and urine. The goal is to understand wh…

This study follows 400 parents in rural Ohio who are part of the Ohio START program, which connects them to substance use treatment and peer mentors. Researchers want to see if having treatment services close to home and strong social support helps parents recover and improves th…

This study will video-record occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to understand exactly what therapists do to help patients improve arm and hand movement. The goal is to create a toolkit that makes rehabilitation …

This study tests whether eating walnuts daily for a week can improve thinking and memory in adults who feel their memory is slipping. Participants will eat either walnuts or a white chocolate bar each day, then switch after a break. Researchers will measure brain function and gut…

This study watches how gum grafts heal in 15 people after routine surgery for receding gums. Researchers use painless scans and blood flow tests to track swelling and new blood vessel growth. Saliva samples are also checked for healing markers. The goal is to learn what normal he…

This study compares a standard and a new system for collecting bone marrow from the hip. Six adults aged 18–50 having minimally invasive hip repair will provide samples from both hips. The goal is to see which method collects more stem cells, cytokines, and growth factors. No new…

This study looks at videos and sounds from babies to find early clues about conditions like cerebral palsy and autism. About 46 infants who were in the NICU will have their movements and cries recorded at home. Researchers hope to identify patterns that could lead to earlier dete…

This study investigates whether inflammation worsens anger and aggression in people with Intermittent Explosive Disorder (IED). Researchers will give 112 participants (half with IED, half healthy controls) a low dose of endotoxin or a placebo on separate days. They will measure a…

This observational study aims to understand differences between people with and without low back or neck pain by comparing their health history and movement. Over 10,000 participants will wear motion sensors and complete questionnaires in a single session, with follow-ups over 5 …

This study looks at two thinking and memory tests—the Coding Test and the SAGE test—to see if they can help doctors better understand and track Huntington's disease. Researchers will compare these tests with standard ones used in clinics. The goal is to find easier or better ways…

This study tests whether a special MRI technique called DCE-MRI can guide chemotherapy for people with borderline resectable pancreatic cancer. The goal is to see if this imaging method can better track tumor blood flow and help doctors decide if the treatment is working, so they…

This study collects skin samples and medical information from people with hidradenitis suppurativa and other skin conditions. The goal is to create a biobank that scientists can use in future studies to better understand inflammatory skin disorders. Participants are seen at Ohio …

This study aims to create a treatment prognosis calculator for military personnel with suicidal thoughts. Researchers will test whether a specialized therapy called Brief Cognitive Behavioral Therapy (BCBT) works better than standard care for those predicted not to respond to usu…

This study looks at whether guiding caregivers to use educational media or storybooks with their children can improve early reading skills. About 450 children aged 3.5 to 4.75 years will take part. Caregivers will be trained to use either a Super Why! media program or storybooks …

This study aims to understand which emotion regulation strategies work best for military personnel experiencing suicidal thoughts. Researchers will track 334 service members in real time using smartphone surveys to see how strategies like distraction, social support, or thinking …

This study looks at whether a continuous glucose monitor (CGM) — a small sensor worn under the skin — is an acceptable and useful tool for checking diabetes risk in women who recently had gestational diabetes. Twenty women will wear the CGM for 10 days at 6-8 weeks after giving b…

This study looks at how well the bones in the neck fuse together after a type of back surgery called posterior cervical fusion, where small spacers are placed between the joints. About 45 adults with neck problems from aging will be followed for up to 2 years after their surgery.…

This study is for pregnant people at risk for preeclampsia who are taking aspirin as part of their care. Researchers want to see how aspirin changes tiny particles from the placenta in the blood. They hope to create a blood test that can better monitor placental health and predic…

This study is working to create better methods for evaluating how children with and without stroke or cerebral palsy use their arms and hands. Researchers will observe 80 children, including those with perinatal stroke and typically developing infants, using video and play-based …

This study looks at how teaching children to recognize and play with sounds in words (phonological awareness) can boost their reading and spelling skills. Researchers will compare two teaching approaches in 720 prekindergarten and kindergarten children who are behind in sound awa…

This study tests whether a simple balance training program can help healthy older adults better sense motion and maintain stability. Thirty participants will practice detecting tilts and translations while receiving feedback, then be tested on balance tasks. The goal is to see if…

This study tests whether a special monitoring tool called electrocochleography can help surgeons preserve a patient's remaining natural hearing while placing a cochlear implant. About 40 adults with severe hearing loss in both ears will be randomly assigned to receive the monitor…