New antibiotic cocktail aims to delay preterm birth after water breaks

NCT ID NCT06396078

Recruiting now Disease control Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy better than the current standard antibiotics in pregnant people hospitalized after their water breaks early (before 34 weeks). About 56 participants will be randomly assigned to one of the two antibiotic regimens. The goal is to see if the new combination delays delivery and reduces serious health problems for the newborn.

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Conditions

The condition(s) this trial relates to.

chorioamnionitis Premature Birth preterm premature rupture of the membranes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREGNANCY, HIGH RISK PRETERM BIRTH PRETERM PREMATURE RUPTURE OF MEMBRANE

Contacts and locations

Locations

The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine
RECRUITING

Columbus, Ohio, 43210, United States
University of Texas Medical Branch
RECRUITING

Galveston, Texas, 775555, United States

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