PRETERM BIRTH

This study tests whether adding a cervical stitch (cerclage) to standard vaginal progesterone therapy works better than progesterone alone to prevent preterm birth in women with a short cervix. About 328 pregnant women with a single baby and a cervix shorter than 25 mm will be ra…

This study looks at whether giving pregnant people at risk of preterm birth a single, lower dose of steroids works as well as the usual two-dose treatment. The goal is to reduce serious health problems in premature babies, like breathing issues or brain bleeding. About 3,250 part…

This study tests whether taking synbiotics (a mix of probiotics and prebiotics) early in pregnancy can help women who have had a preterm birth before. The goal is to see if these supplements can stabilize the vaginal microbiome and reduce the chance of delivering too early. About…

This study is testing whether treating pregnant women who have bacteria in their urine but no symptoms can reduce the risk of preterm birth, stillbirth, or having a baby that is too small. About 1,134 pregnant women in seven low- and middle-income countries will be randomly assig…

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can help pregnant people with preterm premature rupture of membranes (PPROM) before 34 weeks stay pregnant longer and have healthier outcomes compared to the current standard…

This study looks at the best way to provide balanced energy and protein supplements to pregnant women in Addis Ababa, Ethiopia. Researchers will compare giving supplements to everyone versus targeting only those at high risk. The goal is to prevent serious problems like low birth…

This study tests whether giving caffeine early to premature babies (born before 32 weeks) can prevent acute kidney injury. About 236 newborns will be randomly assigned to receive either caffeine or standard supportive care within hours of birth. The goal is to see if caffeine red…

This study tests whether sulfasalazine, a drug used for arthritis, can prevent preterm birth in women who have had one before. The drug aims to lower a stress hormone linked to early labor. About 50 pregnant women will take either sulfasalazine or a placebo, and researchers will …

This study looks at when during a pregnancy ultrasound it is best to measure the cervix (the lower part of the womb) to better predict preterm birth. About 550 pregnant women will be randomly assigned to have the measurement at the start or end of their routine anatomy scan. The …

This study looks at why young adults born very preterm (before 32 weeks) often don't get fitter from aerobic exercise. Researchers think early birth may damage mitochondria, the energy powerhouses in cells. They will compare mitochondrial DNA and fitness changes in 60 inactive ad…

This study looks at whether placing a moderate or late preterm baby directly on the mother's skin right after vaginal birth can reduce stress and improve development. Researchers will compare babies who get immediate skin-to-skin contact with those who are separated briefly. The …

This study looks at whether a special imaging technique (electrical impedance tomography) and lung ultrasound can help doctors predict which premature babies will develop a serious lung condition called bronchopulmonary dysplasia (BPD). The study will include 104 preterm infants …

This study looks at how showing AI predictions in different ways affects doctors' judgment when assessing preterm birth risk. 125 doctors will review cases with ultrasound images and make decisions before and after seeing AI results. The goal is to see which AI format helps docto…

This study looks at how stress and childhood trauma might increase the risk of preterm birth by affecting tiny energy-producing parts of cells called mitochondria. Researchers will follow 200 pregnant women, mostly Black and Hispanic, to understand these connections and why prete…

This study is following 2,800 pregnant women and their children in Weifang, China, to see how things like diet, environment, and lifestyle during pregnancy affect health for both mother and child. Researchers will track pregnancy complications, birth outcomes, and child developme…

This UK study follows 90 families of very premature babies (born before 30 weeks) for one year after leaving the hospital. It measures the baby's health, plus the financial, emotional, and social impact on parents and siblings. The goal is to understand the full burden of prematu…

This study looks at whether giving weekly money to low-income mothers of preterm babies helps them visit the neonatal intensive care unit (NICU) more often. The goal is to see if this support increases breastfeeding and skin-to-skin care, which are good for the baby's health. Abo…

This study aims to understand how exposure to high temperatures during pregnancy affects the health of mothers and their babies. Researchers will follow 6,000 pregnant women in rural Pakistan, where extreme heat is common, by monitoring their environment and health throughout pre…