Could probiotics stop preterm birth? new trial investigates
NCT ID NCT05966649
First seen Feb 28, 2026 · Last updated Jun 20, 2026 · Updated 11 times
Summary
This study tests whether a daily oral synbiotic (a mix of probiotics and prebiotics) can help women with a history of preterm birth carry their baby longer. About 400 pregnant women will take either the supplement or a placebo from early pregnancy. The goal is to see if the supplement improves vaginal health and reduces the chance of delivering too early.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AZ Groeninge
RECRUITINGKortrijk, 8500, Belgium
Contact
Contact Phone: •••-•••-••••
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AZ Maria Middelares
RECRUITINGGhent, West-Vlaanderen, 9000, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
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AZ Sint-Jan
RECRUITINGBruges, West-Vlaanderen, 8300, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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AZ Sint-Lucas
RECRUITINGBruges, West-Vlaanderen, 8310, Belgium
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHR Citadelle
RECRUITINGLiège, Liège, 4000, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UZ Gent
RECRUITINGGhent, Oost-Vlaanderen, 9000, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Universitaire Ziekenhuis Antwerpen
RECRUITINGEdegem, Antwerpen, 2650, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitaire Ziekenhuizen Leuven
RECRUITINGLeuven, Limburg, 3000, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Ziekenhuis Oost-Limburg
RECRUITINGGenk, Limburg, 3600, Belgium
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Oral synbiotic (8 probiotic Lactobacillus strains, inulin, FOS, D-mannose)
What this could lead to
If it works, this could offer a simple, safe way to reduce the risk of preterm birth in women who have had one before.
What could go wrong
This is a mid-sized trial, and the effect may be small or not work for everyone. The supplement is generally safe, but results are not guaranteed.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.