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Could probiotics stop preterm birth? new trial investigates

NCT ID NCT05966649

Recruiting now Prevention Sponsor: Ziekenhuis Oost-Limburg Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a daily oral synbiotic (a mix of probiotics and prebiotics) can help women with a history of preterm birth carry their baby longer. About 400 pregnant women will take either the supplement or a placebo from early pregnancy. The goal is to see if the supplement improves vaginal health and reduces the chance of delivering too early.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Oral synbiotic (8 probiotic Lactobacillus strains, inulin, FOS, D-mannose)
What this could lead to
If it works, this could offer a simple, safe way to reduce the risk of preterm birth in women who have had one before.
What could go wrong
This is a mid-sized trial, and the effect may be small or not work for everyone. The supplement is generally safe, but results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infectious disease Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MICROBIAL COLONIZATION MICROBIOME DYSBIOSIS PRETERM BIRTH PRETERM SPONTANEOUS LABOR WITH PRETERM DELIVERY SYNBIOTICS VAGINAL MICROBIOME

Contacts and locations

Locations

  • AZ Groeninge

    RECRUITING

    Kortrijk, 8500, Belgium

  • AZ Maria Middelares

    RECRUITING

    Ghent, West-Vlaanderen, 9000, Belgium

  • AZ Sint-Jan

    RECRUITING

    Bruges, West-Vlaanderen, 8300, Belgium

  • AZ Sint-Lucas

    RECRUITING

    Bruges, West-Vlaanderen, 8310, Belgium

  • CHR Citadelle

    RECRUITING

    Liège, Liège, 4000, Belgium

  • UZ Gent

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Universitaire Ziekenhuis Antwerpen

    RECRUITING

    Edegem, Antwerpen, 2650, Belgium

  • Universitaire Ziekenhuizen Leuven

    RECRUITING

    Leuven, Limburg, 3000, Belgium

  • Ziekenhuis Oost-Limburg

    RECRUITING

    Genk, Limburg, 3600, Belgium

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