Infectious disease

Researchers at Aarhus University Hospital are tracking adults with recurrent Clostridioides difficile infection who receive fecal microbiota transplantation, a treatment that moves stool from a screened donor into the patient's gut. Donor material is delivered by colonoscopy, a t…

Researchers are testing whether a combination of cipargamin and KLU156 (ganaplacide plus lumefantrine) can cure uncomplicated Plasmodium falciparum malaria in children aged 2 to under 12. The trial compares this oral regimen with standard Coartem treatment. The main goal is to se…

Researchers test whether adding daily inhaled caspofungin to standard antifungal therapy helps adults with Pneumocystis pneumonia recover faster. The trial enrolls 100 adults receiving oxygen or breathing support and standard antifungal drugs. Participants receive either the inha…

This trial tests different doses of tafenoquine, a single-dose drug, to see if it can effectively cure Plasmodium vivax malaria by targeting dormant liver stages. The study involves 820 people in Southeast Asia with confirmed vivax malaria. Researchers aim to find a dose that pre…

Researchers are testing whether ear drops made from Prunus salicina (a type of plum) extract can treat otomycosis, a fungal infection of the ear canal. The trial compares two versions of the plum extract drops, one with chitosan nanoparticles, against standard clotrimazole antifu…

Researchers are testing a new combination therapy for chronic hepatitis B that pairs immune checkpoint inhibitors (sintilimab or envafolimab) with interferon and a standard antiviral drug (entecavir, tenofovir, or tenofovir alafenamide). The goal is to see if this approach can he…

Researchers compare three antiparasitic drugs, albendazole, tribendimidine, and praziquantel, for treating clonorchiasis, a liver fluke infection people get from eating raw or undercooked freshwater fish. The trial enrolls 318 adults in Guangxi, China, who have confirmed Clonorch…

This phase 3 trial compares two ways to prevent relapses of Plasmodium vivax malaria in Indian adults and children. Participants receive either a single dose of tafenoquine or a 14-day course of primaquine, both alongside chloroquine, the standard treatment for the initial infect…

Researchers are testing a combination of an anti-PD-1/anti-PD-L1 antibody, pegylated interferon alfa, and nucleos(t)ide analogues in adults with chronic hepatitis B. The goal is to see whether this mix can help more people lose hepatitis B surface antigen, which doctors call a fu…

This phase 3 study tests an investigational meningococcal conjugate vaccine in healthy infants and toddlers aged 2 to 23 months in China. The vaccine targets four serogroups of meningococcal bacteria (A, C, W, Y) that can cause meningitis and bloodstream infections. Researchers c…

Researchers are testing a single injection vaccine designed to protect adults 60 and older from two respiratory viruses: RSV and HMPV. The trial plans to enroll about 8,000 participants who will randomly receive either the vaccine or a placebo. Scientists will track who develops …

This study tests an experimental flu vaccine called BPL-1357, given as a shot or nasal spray, to see if it is safe and can protect against multiple flu types. About 129 healthy adults aged 18-55 will receive the vaccine or a placebo, then be exposed to a flu virus in a controlled…

This early-stage trial is testing a new COVID-19 booster vaccine called OCU500, which is given as a nasal spray or inhaled mist instead of a shot. The study involves 80 healthy adults aged 18-64 who have already been vaccinated against COVID-19. Researchers are checking if the va…

This phase 3 trial is investigating whether giving a repeat dose of the RSVpreF vaccine to immunocompromised adults is safe and triggers a strong immune response. Participants, aged 18 and older, will receive one shot and be monitored for about a year. The study aims to find the …

This trial is testing an experimental vaccine designed to protect against two respiratory viruses at once: RSV and HMPV. The study involves about 2,400 adults aged 60 and older, who will receive one of several dose levels of the vaccine, a placebo, or a control vaccine. Researche…

This trial tests a new pneumococcal vaccine, called PG4, in adults aged 18 to 49. Researchers compare three batches of PG4 to each other and to the current vaccine, Prevnar 20, to see if they produce similar immune responses and are equally safe. Participants receive one injectio…

This study tests an experimental RNA-based vaccine called BNT168 in adults both with and without HIV. The goal is to see if the vaccine is safe, triggers an immune response, and can help control the amount of virus in the body. Participants receive either the vaccine or a placebo…

This Phase 3 trial tests a new yellow fever vaccine (vYF) in about 2,440 healthy children aged 9 months to 5 years. Researchers will compare vYF to two licensed vaccines (Stamaril and YF-VAX) to see if it triggers a strong immune response and is safe. Some children will also rece…

Lassa fever is a severe viral illness common in West Africa, and no effective treatment exists. Researchers are testing a new vaccine candidate called MOPEVAC-Las in 72 healthy adults aged 18 to 55. The trial compares three different doses of the vaccine to a placebo, given as tw…

This study tests whether a vaccine can prevent C. difficile infection in adults 65 and older. About 32,000 participants will receive either the vaccine or a placebo shot. The study will track infections and side effects over up to three and a half years.

Researchers are testing an mRNA-based seasonal influenza vaccine in adults aged 18 to 64. The trial compares the immune response and side effects of the mRNA vaccine against standard flu vaccines. About 3,000 participants receive one injection in the upper arm and are followed fo…

This early-stage trial is testing whether experimental HIV vaccines can safely teach the immune system to recognize and fight the virus. Healthy adults without HIV will receive a protein nanoparticle vaccine, followed by a booster—either another protein nanoparticle or an mRNA va…

This study tests a new nasal spray vaccine (BLB-201) to prevent RSV, a common virus that can cause serious breathing problems in young children. About 137 infants and children aged 8 to 59 months will receive either the vaccine or a placebo. The goal is to check if the vaccine is…

Researchers are testing an RSV vaccine in healthy adults aged 60 and older to see how safe it is and how well it triggers an immune response. The trial enrolls about 600 people in China and the United States. In China, participants receive either the vaccine or a placebo; in the …

This study aims to develop a vaccine to prevent malaria during pregnancy. Researchers will test potential vaccines in the lab using blood samples from pregnant women aged 15-25 in Mali. The goal is to see if these vaccines can block the malaria parasite from attaching to the plac…

This study tests the Shingrix vaccine in people with HIV and healthy volunteers to see how well it boosts immunity against shingles. Participants receive two shots two months apart and are followed for a year. The goal is to understand if the vaccine works safely in those with di…

This study tests whether a pneumococcal vaccine (Pneumosil) can produce a strong immune response in children aged 6-59 months who are hospitalised with severe acute malnutrition. Half the children will receive the pneumococcal vaccine, and the other half will receive a typhoid va…

This trial tests a new oral cholera vaccine called PanChol in healthy adults aged 18 to 55 in Zambia. The vaccine is designed to be safer and more effective than current options. Researchers will monitor participants for side effects and measure their immune response after vaccin…

This study tests two experimental vaccines against Epstein-Barr virus (EBV), which causes mono and is linked to cancers. Researchers will give 750 healthy adults aged 18-29 three shots over several months to check for side effects and immune response. The goal is to find a safe v…

This study looks at how well the shingles vaccine Shingrix works in people who have had a stem cell transplant. About 55 adults who received the vaccine at least a year after their transplant will have their immune responses measured. Researchers want to see if the timing of the …

Researchers are testing a recombinant RSV vaccine made in CHO cells to see if it prevents lower respiratory tract disease in adults aged 60 and older. The trial plans to enroll 25,000 participants, including about 30% aged 70 and above, who receive either the vaccine or a placebo…

This study tests an experimental vaccine called V132 in healthy adults aged 50 and older. The goal is to see how safe it is and how well it triggers an immune response compared to existing pneumococcal vaccines. Participants will receive one of several formulations of V132 or a c…

This early-stage trial is testing a new vaccine called V118C to prevent pneumococcal disease, which can cause serious lung and other infections. About 210 toddlers and infants will receive either V118C or an existing vaccine to compare safety and immune response. The study is cur…

This study tests an experimental vaccine from GSK that targets two respiratory viruses: RSV and hMPV. About 1,800 adults aged 18-80 will receive different doses to check safety and immune response. The goal is to see if a single shot can protect against both viruses, which can ca…

This trial tests a new recombinant polio vaccine (rPV) against the current standard IPOL vaccine in healthy adults aged 18 to 60. The goal is to see if the new vaccine is safe and triggers a strong immune response. It is a small, early-stage study to gather initial data.

This Phase 3 trial tests updated versions of the BNT162b2 COVID-19 vaccine in adults and children aged 5 and older. Participants include those aged 5 to 64 with medical conditions that raise their risk of severe COVID-19, as well as everyone aged 65 and older. The study compares …

This study tests a vaccine given to pregnant women to see if it can protect their babies from group B streptococcus (GBS) infection, a serious illness in newborns. Healthy pregnant women aged 49 or younger, between 24 and 36 weeks of pregnancy, can join. Participants receive one …

This study tests an experimental vaccine called RSVpreF in adults to see if it is safe and triggers a strong immune response against respiratory syncytial virus (RSV). Around 540 adults in India will receive either the vaccine or a placebo. Researchers will monitor for side effec…

This study compares a high-dose flu vaccine to the standard dose in 312 children aged 3-17 who have received a kidney, heart, or liver transplant within the past two years. The goal is to see if the high-dose vaccine triggers a stronger immune response and is just as safe. Partic…

This study tests a new whole-cell pneumococcal vaccine (wSp) in healthy children aged around 7 to 9 months who already received standard pneumonia vaccines. The goal is to see if wSp reduces pneumococcal bacteria in the nose and boosts immune protection. Researchers will compare …

This early-stage trial tests a new vaccine (rVSVΔG-MARV-GP) to see if it is safe and triggers an immune response against Marburg virus, a rare but severe disease. About 112 healthy adults aged 18-50 will receive either the vaccine or a placebo. The study focuses on side effects a…

This first-in-human trial tests an experimental vaccine called LTB-NG6, designed to protect against gonorrhea. The study will enroll healthy adults aged 18-50 to evaluate the vaccine's safety and its ability to trigger an immune response. Participants will receive either the vacc…

This early-phase trial tests a new drug called TNP-2092, given as an injection into the knee joint, for people with infections after knee replacement surgery. The study includes 33 participants and compares the new drug to standard antibiotics. The main goal is to check safety an…

This study looks at whether giving a longer course (10 days instead of 5) or adding another antiviral (remdesivir) to the standard Paxlovid treatment helps immunocompromised people clear COVID-19 faster. About 256 adults with mild or no symptoms will be randomly assigned to diffe…

This Phase 3 trial tests a new drug called fosmanogepix against standard treatments for life-threatening Candida bloodstream or organ infections. About 450 adults will be randomly assigned to receive either fosmanogepix (first by IV, then as a pill) or the usual IV caspofungin fo…

This study tests a program called ARC that helps HIV clinics improve their work environment and reduce discrimination. Researchers will compare viral suppression and care retention in clinics using ARC versus standard care. The goal is to see if better clinic culture leads to bet…

Researchers are following 1,500 people with HIV who start long-acting injections of cabotegravir and rilpivirine. The study collects clinical and lab data over time to see how well the regimen controls the virus and what factors affect tolerability, side effects, and quality of l…

This phase 2 trial tests whether adding an experimental vaccine (PRGN-2009) to standard chemotherapy can improve outcomes for people with newly diagnosed HPV-related throat cancer, potentially allowing them to skip radiation. About 70 adults will receive either chemo alone or che…

This study offers continued access to HIV medications for children and adolescents who completed a previous Gilead HIV treatment study. About 350 participants will receive their study drug or switch to a standard HIV medication, and researchers will monitor for side effects. The …

This study tests two smoking cessation methods—varenicline pills and nicotine patches with gum—in 660 people with HIV in South Africa. Participants will receive one of these treatments for 12 weeks, along with counseling. The goal is to see which approach works best to help them …

This multicenter trial compares two ways to manage the abdomen after surgery for fecal or diffuse peritonitis, a severe infection of the abdominal lining. One approach uses a vacuum-assisted dressing that applies suction to the open abdomen. The other closes the abdomen and reope…

This study tests a new drug, brincidofovir, against the current treatment cidofovir for adenovirus infection in children and adults who have had a stem cell transplant. About 180 participants will receive one of the two drugs intravenously until the virus is cleared or up to 12 w…

This trial tests whether children and teens with uncomplicated bloodstream infections can safely switch from intravenous (IV) antibiotics to oral antibiotics earlier than usual. Half the participants will switch to oral antibiotics as soon as they are stable, within 4 days of sta…

This study tests two blood products used to control bleeding during liver transplant surgery. It compares a newer product, Intercept Fibrinogen Complex, to standard cryoprecipitate. The goal is to see if the newer product works as well or better at stopping bleeding. The study wi…

This phase 3 trial tests tabelecleucel, a cell therapy made from donor immune cells, in 115 organ or stem cell transplant patients who developed a rare cancer (EBV+ PTLD) after standard treatment failed. The goal is to see if it can shrink tumors and improve outcomes. Participant…

This study tests new combinations of drugs for adults with lung tuberculosis (TB). The goal is to see if these new regimens work faster and are safer than the current standard treatment. About 315 participants will receive either an experimental drug combo or the usual care for 8…

This study tests two doses of an experimental drug, zampilimab, against a placebo in 240 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal is to see if the drug can improve lung function over 24 weeks, with an …

This phase 2 trial tests an oral drug called PIPE-791 in 324 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Participants take either a low or high dose of PIPE-791 or a placebo daily for several months. The main goal is t…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This phase 2 trial tests an oral drug called ibezapolstat in 20 people who have had three or more C. diff infections in the past year. The goal is to see if the drug can cure the current infection and reduce the chance of it coming back. Participants will take the drug twice a da…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This phase 2 trial is testing a five-drug combination for a rare, aggressive type of T-cell leukemia called ETP-ALL. The study aims to see if this mix can help more patients achieve remission after their first treatment. About 27 newly diagnosed adults will receive the drugs, and…

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease after a half-matched bone marrow transplant in people living with HIV who also have a blood cancer. The trial involves 265 participants…

This early study tests a new drug called BAY 3389934 in 36 hospital ICU patients with sepsis-induced coagulopathy, a condition where the body forms dangerous blood clots. The main goal is to check safety and find the right dose. Researchers will monitor side effects and blood clo…

Researchers are testing whether Jin-shui Huan-xian Granules, a traditional Chinese herbal formula, can slow the loss of lung function in people with idiopathic pulmonary fibrosis (IPF). The trial enrolls 384 adults aged 40 to 85 with IPF who also have specific patterns of fatigue…

This study tests a treatment called photodynamic therapy (PDT) for women with low-grade cervical precancer caused by HPV types 16 or 18. A photosensitizing cream is applied to the cervix, then activated with light to destroy abnormal cells. The trial will compare 225 women who re…

This pilot study will test whether the antibiotic cefotetan works as well as standard treatments for E. coli infections in the blood or urinary tract. About 84 hospitalized adults will be randomly assigned to receive cefotetan or usual care. The goal is to see if cefotetan can su…

This Phase 2 trial tests an experimental inhaled medication called LTI-03 in about 120 people with idiopathic pulmonary fibrosis (IPF), a progressive lung disease that causes scarring and breathing difficulty. Participants will inhale LTI-03 or a placebo twice daily for 24 weeks.…

This study tests whether using a device that heats skin lesions to 50°C for 30 seconds can effectively treat cutaneous leishmaniasis in primary health centers in Ethiopia. 103 patients aged 12 to 60 with up to four lesions will receive thermotherapy and be monitored for 90 days. …

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

This phase 2 trial tests the drug daratumumab in 28 adults with three rare and aggressive blood cancers: primary effusion lymphoma, plasmablastic lymphoma, and multicentric Castleman disease. Participants must have failed standard therapy or be unable to receive it. Daratumumab i…

This phase 2 trial tests whether the drug nivolumab can slow or stop the growth of Epstein-Barr virus (EBV)-positive lymphoproliferative disorders and non-Hodgkin lymphomas. About 40 people aged 12 and older whose cancers have not responded to standard therapy will receive nivolu…

This study looks at a newly recognized disease called KSHV Inflammatory Cytokine Syndrome (KICS), caused by a virus that can also lead to certain cancers. Researchers aim to learn more about the disease and test experimental treatments, including antiviral and chemotherapy drugs,…

This study tests an experimental drug called PrP-siRNA in 30 adults with symptomatic prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce the harmful prion protein in the brain. The main goal is to check safety and find the …

This study tests a drug called abemaciclib, already used for breast cancer, in people with Kaposi sarcoma (KS), both with and without HIV. The goal is to find a safe dose and see if it can shrink KS tumors. About 111 adults will take the drug daily in 28-day cycles until their ca…

This study tests two drugs, PDS01ADC and M7824, that work with the immune system to fight Kaposi sarcoma (KS), a cancer often linked to HIV or organ transplants. The trial enrolls 80 adults with advanced KS that has not responded well to prior therapy. Participants receive PDS01A…

Very premature infants with late-onset sepsis often develop dangerously low blood pressure that does not respond to fluids. Doctors commonly use either dopamine or norepinephrine, but they lack clear evidence on which drug works better. This international study compares the two d…

This study tests a new treatment called FB301, a capsule containing beneficial bacteria, for women with an imbalance of vaginal bacteria who have had a failed frozen embryo transfer (IVF). Thirty women aged 18-40 will receive FB301 or a placebo during a mock IVF cycle, with some …

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

Researchers are testing an experimental drug called ORJ-001 in adults with idiopathic pulmonary fibrosis, a condition that scars the lungs and makes breathing hard. The trial has two parts: first, they check whether the drug is safe and well tolerated; second, they measure whethe…

This study tests a new treatment for progressive multifocal leukoencephalopathy (PML), a rare brain infection with no approved therapy. Researchers will give 23 patients donor immune cells that target the virus causing PML. The goal is to see if the treatment is safe, improves ne…

This study tests whether adding the drug lenacapavir to standard HIV treatment can reduce the hidden HIV reservoirs that remain in the body. About 50 adults with well-controlled HIV will either continue their usual therapy or receive lenacapavir injections plus pills. Researchers…

This study tests a combination of two antibiotics, aztreonam and avibactam, in newborns and infants up to 9 months old who have serious infections caused by gram-negative bacteria. The trial has two parts: one to see how a single dose moves through the body, and another to test m…

This study tests an experimental drug called LXE408 in 130 adults with chronic Chagas disease who do not have severe organ damage. The goal is to see if LXE408 can clear or reduce the parasite level in the blood over 6 months, compared to placebo and standard treatment. Participa…

This study tests a new drug called GenSci142, given as a vaginal capsule, for treating bacterial vaginosis (BV). About 30 women with BV will receive either GenSci142 or a standard antibiotic cream to compare safety and how well each works. The goal is to see if the new capsule is…

This study tests new drug combinations to treat pulmonary tuberculosis (TB) faster than the standard 24-week regimen. About 2500 adults with TB will receive one of several experimental combinations, including two new drugs (BTZ-043 and GSK3036656), for 8 to 16 weeks. Researchers …

This early-stage trial tests adding lenalidomide to standard chemotherapy (EPOCH) for adult T-cell leukemia-lymphoma, a rare and aggressive blood cancer linked to HTLV-1 infection. The main goal is to find the safest dose of lenalidomide when used with chemo. Up to 30 adults with…

This study tests an inhaled version of the drug nintedanib (called AP02) in people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. About 160 adults aged 40 and older who are not currently on IPF treatment will take either a low o…

This study tests an oral medication called ibuzatrelvir in adults and teens with COVID-19 who are not hospitalized but have a high risk of becoming severely ill. Participants will receive either the drug or a placebo for 5 days, and researchers will track whether it reduces emerg…

This study tests a 10-session counseling program called STEP-AD for Black women living with HIV who have a history of trauma. The goal is to help them stick to their HIV medication and achieve viral suppression. Researchers will enroll 250 participants and compare the program to …

This Phase 2 trial tests whether switching to a combination of two injectable drugs, GS-3242 and lenacapavir, works as well as staying on the daily pill Biktarvy for people with HIV who already have the virus under control. About 175 participants will be randomly assigned to eith…

This study tests a program to expand medication-assisted treatment for opioid addiction in Kazakhstan, Kyrgyzstan, and Tajikistan. Researchers will train local health officials and track how many people start and stay on treatment. The goal is to reduce HIV spread among people wh…

This study tests whether giving a second dose of an RSV vaccine to pregnant women who already received it in a prior pregnancy is safe and boosts immunity. About 550 women aged 18-49, between 24-36 weeks pregnant, will receive either the vaccine or a placebo. Researchers will tra…

This phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 …

This phase 3 trial tests a new antiviral pill, ibuzatrelvir, alone or with an IV drug (remdesivir) in 300 adults with weak immune systems who have mild-to-moderate COVID-19. The goal is to see if the combination prevents hospitalizations or worsening symptoms better than remdesiv…

This study tests whether giving two powerful HIV-fighting antibodies along with standard HIV medication (ART) to people diagnosed very early with HIV can help them control the virus without daily pills later. 48 adults with acute HIV infection will receive either the antibodies o…

This study compares a light-activated gel treatment (ALA-PDT) to standard surgery (LEEP) for women with high-grade cervical precancer (HSIL/CIN2). About 560 women will receive either the gel plus red light therapy or surgery. The goal is to see if the gel treatment works as well …

This medical access program provides valemetostat tosylate, an oral drug already approved in Japan, to adults with peripheral T-cell lymphoma that has come back or stopped responding to at least two prior treatments. Participants take a 200 mg pill once daily in 28-day cycles for…

Murine and scrub typhus are bacterial infections spread by fleas and mites. Doctors often treat them with doxycycline or azithromycin, but they do not know which drug clears the bacteria faster or how the drugs move through the body. This trial enrolls 72 adults with typhus in La…

Researchers are running a first-in-human trial of RBD2080, an experimental drug given by injection, in 24 healthy adults aged 18 to 50. The goal is to check safety, tolerability, and how the body processes the drug, both after single and multiple doses. Participants receive eithe…

This study tests whether the antiviral drug molnupiravir can prevent severe illness from COVID-19 in adults at high risk. About 3,000 non-hospitalized participants will take either molnupiravir or a placebo for 5 days. The main goal is to see if the drug reduces hospitalizations,…

This study tests whether a once-weekly combination of two experimental drugs (islatravir and ulonivirine) works as well as the standard daily three-drug pill Biktarvy for people newly diagnosed with HIV-1. About 570 adults who have never taken HIV medication will be randomly assi…

This Phase 2 trial tests an experimental drug called AHB-137 in 84 adults with chronic hepatitis B who are already on antiviral therapy. The goal is to see if AHB-137 can clear the hepatitis B surface antigen and keep the virus under control, potentially leading to a functional c…

This study compares two antibiotic approaches for a serious heart valve infection caused by staph bacteria. One group gets a standard treatment that includes the drug rifampin, while the other group gets a treatment without it. The goal is to see if skipping rifampin is just as e…

This study tests whether an injectable combination of two experimental drugs, GS-3242 and lenacapavir, can control HIV-1 as well as the daily pill Biktarvy. About 700 people with HIV who have never taken antiviral treatment will receive either the injectable regimen or the standa…

This phase 3 trial tests whether the oral drug rentosertib (INS018_055) can slow lung function decline in adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease. About 320 participants will receive either rentosertib or a placebo daily for 52 weeks. The main …

This pilot trial explores whether a non-invasive cardiac output monitor (NICOM) can help guide fluid resuscitation in emergency department patients with sepsis and low blood pressure. Participants receive standard care, and some also undergo a one-time NICOM assessment that inclu…

This study is testing the drug letermovir to prevent cytomegalovirus (CMV) infection in children and teens who have had a kidney transplant and weigh less than 40 kg. About 40 participants will receive the drug to see how it moves through their bodies and if it is safe. The goal …

This Phase 3 trial tests whether giving immune globulin (IGI) regularly can prevent serious infections in adults with multiple myeloma who are receiving a bispecific antibody therapy. About 183 participants will be randomly assigned to get IGI right away for 12 months or only aft…

This study tests whether the drug emetine can help people hospitalized with dengue fever. About 600 adults aged 18 to 65 will take either a low or high dose of emetine or a placebo pill for 7 days. Researchers will track if the drug reduces deaths or stops the disease from becomi…

This phase 1 trial is testing whether combining two drugs, azacitidine and abatacept, can shrink tumors in adults with T-cell lymphoma that has relapsed or not responded to prior treatment. Up to 20 participants will receive the drugs in 28-day cycles for up to 13 cycles. The stu…

This phase 3 trial is testing whether the oral antiviral secutrelvir can prevent severe COVID-19 in people who are at high risk for complications. Participants with mild symptoms and confirmed SARS-CoV-2 infection will receive either secutrelvir or a placebo. The study will measu…

Researchers in Armenia, Georgia, and Tanzania are comparing two ways to deliver hepatitis C care to people who inject drugs. One model confirms infection with an RNA test before starting sofosbuvir/velpatasvir, a daily pill that cures most hepatitis C. The other starts the same p…

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolv…

This program provides emergency access to REGN-EB3, a combination of three antibodies, for people with confirmed Ebola virus disease. It is available to both adults and children in Ebola-affected regions, including pregnant women. The goal is to offer a potential treatment option…

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study tests a program called Light Inside, designed to reduce stigma for women living with HIV who use drugs. The program involves five small-group sessions that teach coping skills and communication strategies to help participants stay engaged in HIV care and adhere to thei…

This study tests a new treatment called SNIPR001, which uses specially designed viruses to kill a type of antibiotic-resistant E. coli bacteria. The trial includes 24 adults with blood cancer who are scheduled for a stem cell transplant and already carry these resistant bacteria.…

This phase 3 trial compares a new drug, brelovitug, to an existing treatment (bulevirtide) for chronic hepatitis delta, a serious liver infection. About 172 adults with the infection will receive either drug to see which better controls the virus and normalizes liver enzymes. The…

This study is testing the safety and how the body handles Vaborem, a combination of two antibiotics (meropenem and vaborbactam), in children from birth to under 18 years old who have serious Gram-negative bacterial infections. All 44 participants will receive the drug intravenous…

Researchers test whether guiding fluid and blood pressure treatment with a non-invasive heart monitor called NICaS improves survival in sepsis patients compared to standard guidelines. The trial enrolls 430 adults with sepsis or septic shock. Patients receive either NICaS-guided …

This trial investigates whether therapeutic plasma exchange — a procedure that filters the blood to remove harmful substances — can reduce deaths in critically ill children with severe sepsis or septic shock. Participants are randomly assigned to receive either standard sepsis ca…

This study is testing whether a drug called Cytogam (CMVIG) can prevent cytomegalovirus (CMV) infection in kidney transplant patients who are switching to a new immunosuppressant. The researchers will measure antibody levels in 30 adult patients over 8 weeks to see how the drug w…

This study tests a vaccine called CMV-MVA Triplex in 80 children who have had a stem cell transplant and are at risk for CMV infection. The goal is to find the best dose and see if it safely prevents CMV reactivation. Participants receive the vaccine and are monitored for side ef…

This large study in Fiji tests whether a new combination of drugs (moxidectin plus two others) can safely treat three common parasitic infections: lymphatic filariasis, scabies, and strongyloidiasis. About 5,100 people will receive either the new combo or the standard treatment o…

This study tests whether transferring gut microbes from a mother to her baby after a cesarean section can restore the infant's gut microbiome to resemble that of a vaginally born baby. Researchers will give some infants a fecal transplant (containing bacteria or viruses) and comp…

This study tests two remote programs—peer support groups and strengths-based case management—for adults aged 50+ living with HIV in rural Southern U.S. counties. The goal is to see if these programs help with viral suppression, medication adherence, quality of life, and depressio…

This study tests an experimental drug called dovramilast in 45 adults with moderate to severe leprosy type 2 reaction, a painful skin condition. Participants receive either dovramilast (100 mg or 150 mg) or standard treatments like prednisolone or thalidomide. The goal is to see …

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 will receive letermovir and be monitored for 14 weeks. The goal is to see if the drug …

This trial investigates whether keeping magnesium levels in the upper normal range can lower the amount and duration of norepinephrine, a drug that raises blood pressure, in adults with septic shock. Participants are randomly assigned to receive individualized magnesium infusions…

This study is testing whether giving fewer non-essential fluids to adults with septic shock can improve outcomes. The trial will enroll 1,850 patients in intensive care, comparing a restrictive fluid strategy to usual care. The main goal is to see if this approach reduces deaths …

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This study is testing an antibiotic called Sulbactam-Durlobactam in hospitalized children from birth to under 18 years old who have or may have an Acinetobacter infection. The goal is to find the right dose and check that it is safe. About 48 children will receive the drug throug…

This study tests whether IgPro20 (HIZENTRA), a concentrated antibody solution given under the skin, can prevent infections in people with multiple myeloma who have low antibody levels due to bispecific antibody therapy. About 100 participants will either receive IgPro20 plus stan…

This study tests a drug called foscenvivint in people with liver cirrhosis caused by HIV and hepatitis C co-infection who also have hemophilia. Participants receive the drug once a week for 24 weeks. Researchers will check if the drug improves liver function and is safe to use.

This early-stage trial is testing a new treatment called DISP-10 for people with advanced gastrointestinal cancers, including colorectal and stomach cancers. The treatment combines a virus (DV-10) with specially engineered immune cells (CAR T cells) to attack cancer. The study ai…

This study will test whether giving an extra antibiotic during a heart valve replacement procedure (TAVI) can lower the chance of bloodstream infection or death within 6 months. About 2,000 patients in Denmark will take part. Half will get the standard antibiotic, and half will g…

This Phase 2 trial tests whether a new drug called EL219 (Turletricin) is safe and effective for early treatment of invasive mould infections in people with weakened immune systems, such as those who have had a bone marrow transplant. About 60 participants will receive either EL2…

This phase 2 trial tests whether propranolol, a drug usually used for high blood pressure, can treat Kaposi sarcoma. About 25 children and adults will take propranolol pills for up to 24 weeks. Researchers will measure how many participants see their tumors shrink or disappear, a…

This study tests whether teriflunomide, a drug already used for multiple sclerosis, can help people with a rare spinal cord disease called HAM/TSP caused by the HTLV-1 virus. About 24 adults will take the drug daily for 9 months to see if it reduces harmful immune activity and im…

This small Phase 2 trial tests whether alendronate, a drug used for bone health, can reduce the hidden HIV reservoir in people already on antiretroviral therapy. About 30 participants will receive either alendronate or a placebo, and researchers will measure changes in HIV DNA an…

This study tests whether a gel called Multi-Gyn ActiGel Plus can effectively treat bacterial vaginosis, a common vaginal infection. About 200 women will use the gel or a placebo twice daily for one week. Researchers will check if the infection is gone three weeks after starting t…

Leptospirosis is a bacterial infection spread through water contaminated by animal urine, and it can lead to serious kidney damage. Researchers at Chulalongkorn University are testing a five-step hospital care bundle for adults admitted with suspected leptospirosis. The bundle gu…

This study tests a gel device called Multi-Gyn FemiTotal in 80 women with bacterial vaginosis or vaginal yeast infections. Participants use the gel for 7 days, and if symptoms clear, they are followed for 4 months to see if the infection returns. The goal is to see if the gel can…

This study looks at the long-term safety of an inhaled drug (AP01) for people with progressive lung scarring (pulmonary fibrosis). It is for those who already completed an earlier Avalyn Pharma study. About 340 participants will receive the drug and be monitored for side effects …

This early-stage trial asks whether ganfeborole, an experimental tuberculosis drug, changes how the body processes an oral contraceptive containing ethinyl estradiol and levonorgestrel. Healthy women aged 18 to 65 who cannot become pregnant will take the contraceptive alone and t…

This large Phase 3 trial is testing an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. Participants receive either a single dose of tozorakimab or a placebo, added to standard care. The main goal is to see…

This pilot study will test a program that combines a trauma-focused therapy (STAIR) with peer-led HIV prevention (PrEP) support for transgender and nonbinary people who have experienced violence. The goal is to see if this combined approach is acceptable, feasible, and helps impr…

This study is testing a drug called zilucoplan in children aged 2 to 17 with generalized myasthenia gravis, a disease that causes muscle weakness. The goal is to see how the drug works in the body, if it is safe, and if it helps control the disease. Only 8 children will take part…

This study at the National Institutes of Health evaluates and treats people aged 3 and older with known or suspected parasitic infections, such as malaria, intestinal worms, and others. Participants receive standard medical care, not experimental treatments. The goal is to monito…

This early-stage trial tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people vulnerable to severe infections. Researchers take a participant's own white blood cells, use mRNA to correct the genetic defect, and infuse the cells back. …

This study tests whether giving people with HIV or those taking PrEP two dedicated case managers helps them achieve better financial stability, food security, and health outcomes. Participants will work with their case managers to set goals and stay connected to care. The trial c…

This study tests whether a newer drug, letermovir, is safer and more effective than the standard valganciclovir for preventing CMV infection in heart transplant recipients. About 150 moderate- to high-risk adults will be enrolled. The main focus is on reducing side effects like l…

This Phase 3 trial tests whether adding steroid eye drops to standard anti-parasitic treatment improves vision in people with acanthamoeba keratitis, a rare but serious eye infection. About 232 participants who still have eye inflammation after one month of standard care will rec…

This study tests whether the antiviral drug remdesivir can help treat RSV (a common respiratory virus) in people whose immune systems are weakened by certain cancer treatments or autoimmune therapies. About 60 adults with confirmed RSV will receive remdesivir intravenously. The m…

This study tests whether special wraps made from human placental membrane can help heal diabetic foot ulcers and venous leg ulcers that won't close on their own. About 50 adults with diabetes or venous disease will receive weekly applications of one of four placental membrane pro…

This study looks at whether the current dosing of the antibiotic gentamicin is safe and effective for newborns up to 7 days old who have early-onset sepsis. Researchers will measure drug levels in the blood and check for kidney or hearing problems. The goal is to confirm that giv…

This study tests whether replacing an infected heart device immediately after removal is as safe and effective as waiting for a later procedure. About 176 adults with device infections will be randomly assigned to either immediate or delayed reimplantation. The main goal is to se…

This study tests whether a blood thinner (heparin) can help hospitalized adults with pneumonia avoid serious complications like needing a breathing machine or intensive care. About 4000 participants will receive either heparin or standard care. The goal is to see if heparin reduc…

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This study tests whether a medicine called XEMBIFY, given every two weeks alongside standard care, can reduce serious bacterial infections in adults with certain blood cancers (chronic lymphocytic leukemia, multiple myeloma, or non-Hodgkin lymphoma) who also have low antibody lev…

This study tests an experimental antiviral drug called S-337395 in adults with RSV who are at high risk for severe illness. Participants must have symptoms for less than 72 hours and a confirmed RSV infection. The goal is to see if the drug can lower the amount of virus in the bo…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study tests whether a medicine called Panzyga can prevent major infections in people with autoimmune or rheumatic conditions who have low antibody levels after receiving B-cell depletion therapy. About 360 adults will receive either Panzyga or a placebo, and researchers will…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This study tests whether a new ultra-long-acting injectable HIV medication works as well as the current long-acting version. About 564 adults and teens with well-controlled HIV will receive either the ultra-long-acting or the standard long-acting shots. The goal is to see if the …

Researchers at two Indonesian referral hospitals are studying whether a paper-based sepsis chart, called Koran Sepsis, helps emergency teams follow the one-hour sepsis bundle more closely and reduces deaths within seven days. The study includes 304 adults with sepsis who arrive a…

This phase 2 trial is testing two antivirals—molnupiravir (used for COVID-19) and a lab-made antibody called VIS513—in 500 people with early dengue. Participants must have had fever for less than 48 hours and a positive rapid test. The goal is to see if these drugs can clear the …

This early-stage study tests a new drug called IB-001 for chronic hepatitis B. It will first check safety in up to 60 healthy volunteers, then test multiple doses in about 30 people with chronic hepatitis B. The main goal is to see if the drug is safe and how the body handles it.

This phase 2a trial tests an experimental antibiotic called OMN6 in 54 adults with hospital-acquired or ventilator-associated pneumonia caused by Acinetobacter baumannii. Participants receive either OMN6 or a placebo, plus standard antibiotics, for one day. The main goal is to ch…

This early-stage trial is testing an experimental drug called GIGA-2339 in 48 adults with chronic hepatitis B. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either GIGA-2339 or a placebo by IV infusion, and researchers will…

This study tests whether an HMB-enriched amino acid supplement can reverse muscle loss and improve recovery in 48 patients with alcoholic liver disease and COVID-19 pneumonia. Participants receive either the HMB supplement or a balanced amino acid mix for 90 days. Researchers wil…

This study tests whether baricitinib, a drug used for arthritis, can improve thinking, physical function, and quality of life in people with Long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

Lower respiratory tract infections are a leading cause of hospitalisation and death in young African children, and doctors often prescribe antibiotics even when a virus is the cause. This trial tests whether combining a bedside CRP blood test with a clinical severity score can sa…

This study tests whether a digital health program—short videos and text message reminders—can help close contacts of tuberculosis patients start and complete preventive treatment. Researchers in South Ethiopia will enroll 304 people and compare those who get the digital intervent…

This study looks at whether using a combination of antibiotics is more effective than a single antibiotic for treating serious staph infections in the blood. About 2,096 adults with either methicillin-sensitive or methicillin-resistant staph will be randomly assigned to one group…

This pilot study tests a program where a clinical pharmacist talks with people with HIV about the risks of drinking alcohol (with or without cannabis) while taking multiple medications, especially those that affect the brain. The goal is to see if this approach can reduce falls a…

This study looks at whether switching from aspirin to clopidogrel (another blood thinner) can reduce heart complications in people with a serious staph bloodstream infection. About 300 adults already taking aspirin for heart disease will be randomly assigned to stay on aspirin or…

This phase 2 trial tests an experimental drug called AHB-137 in 70 adults with chronic hepatitis B who are already on antiviral pills. The drug is given as a shot under the skin. The goal is to see if it can lower the virus to undetectable levels and allow some people to stop the…

This early study tests whether immune cells from a donor can safely fight cytomegalovirus (CMV) or adenovirus (AdV) infections in people who have had a stem cell or solid organ transplant. About 20 participants will receive these virus-specific T-cells intravenously. The main goa…

This study tests whether adding the HIV drug rilpivirine to standard treatment can help people with HIV whose immune systems haven't fully recovered. About 21 adults with low CD4 counts despite years of successful viral suppression will receive rilpivirine for 48 weeks. The goal …

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are also receiving a beta-lactam antibiotic. The goal is to see which combination helps patients leave the hospital sooner and reduces the need f…

This study looks at how well the flu drug baloxavir marboxil works in children under 12 and whether it stops the flu from spreading to family members. About 1,100 kids with flu symptoms will take the drug, and researchers will check for drug resistance and track infections in hou…

This study looks at whether switching to the blood thinner dabigatran can improve outcomes for people with a serious staph bloodstream infection who are already taking other blood thinners. Researchers will compare those who switch to dabigatran with those who stay on their curre…

This study looks at whether adding L-carnitine, a natural substance, to standard care can improve outcomes for critically ill adults with liver disease in the ICU. About 58 participants with conditions like liver failure or severe infections will be enrolled. Researchers will tra…

This study tests whether a once-daily pill containing doravirine, lamivudine, and tenofovir can quickly control HIV in people who have never taken HIV drugs before. One hundred newly diagnosed adults will take the pill for 48 weeks. The main goal is to see how many have undetecta…

This study compares two dental treatments—pulpotomy and pulpectomy—for deep cavities in baby teeth that cause pain. About 40 children aged 4 to 6 will receive one of the treatments. Researchers will check x-rays and symptoms to see which approach works better and is more comforta…

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This study tests whether a new type of Foley catheter, called NowCath, can reduce urinary tract infections and blockages in people who need a long-term indwelling catheter. The NowCath catheter has extra drainage holes and a soft silicone cover that may improve bladder emptying a…

This early-stage trial is testing an experimental drug called GS-0415 in people with HIV who already have the virus well-controlled by standard antiretroviral therapy. The study will give single and multiple doses of GS-0415 to evaluate its safety, tolerability, and how the body …

Researchers are testing a PET/CT scan that uses a tracer called FAPI to measure fibrotic activity in the lungs of adults with pulmonary fibrosis. The study checks whether lung FAPI uptake drops after patients start anti-fibrotic treatment, and whether those changes match clinical…

Many children hospitalized with community-acquired pneumonia receive antibiotics even when a virus is the cause, and those antibiotics do not help viral cases. Researchers are testing whether a blood test called MeMed BV, which measures immune markers, can help doctors identify c…

This study is testing new, non-invasive ways to diagnose tuberculosis (TB) in children under 15. Researchers will evaluate oral swabs, cough sound analysis, and lung sound analysis as potential alternatives to sputum tests. The goal is to find faster, simpler, and cheaper diagnos…

This study is testing whether new biomarkers in urine can more accurately diagnose urinary tract infections (UTIs) in two groups where current tests often fail: young children not yet toilet-trained and adults aged 65 and older. In these groups, standard urine tests can be mislea…

This study is testing a new blood test called CRISPR-TB to diagnose tuberculosis (TB) in children more accurately. Current tests often miss TB in kids because they have fewer bacteria. The study will enroll 1,220 children in Bolivia to see if this test can detect TB better than s…

Researchers at the University of Southern Denmark compare how much staff time two chest imaging methods require when adults arrive at the emergency department with suspected community-acquired pneumonia. One method is conventional chest radiography, the other is ultra-low-dose ch…

This study tests whether an AI-powered app can help doctors more accurately diagnose ear infections in young children (6-24 months) with cold symptoms. Researchers will compare standard ear exams with the AI app's analysis of eardrum photos. The goal is to see if the AI reduces u…

Researchers are evaluating a new molecular test called the UllCORE BSI Test, which aims to detect bacteria, fungi, and antibiotic resistance markers directly from whole blood in people with suspected bloodstream infection or sepsis. The study enrolls about 1,500 participants of a…

This Phase 1 trial tests a new radioactive tracer called [18F]-Fluorocellobiose ([18F]FCB) for PET/CT scans. The goal is to see if it can help find invasive mold infections in the body. The study includes healthy volunteers and people with known fungal infections. Participants re…

This pilot study is testing whether a rapid, point-of-care blood test can help identify early signs of infection and sepsis in preterm infants. Researchers will measure inflammatory markers like IL-6, PCT, CRP, and MxA in blood samples from about 40 to 80 premature babies, compar…

This study looks at whether measuring oxygen levels in a central vein can help doctors decide if a patient with septic shock needs more fluids. About 115 adults with septic shock will have their oxygen levels checked before and after a fluid challenge. The results will be compare…

People living with HIV face a higher risk of oral HPV infection and related throat cancer, but little is known about how the infection behaves in this group. This study asks whether saliva samples collected at home with a mail-delivered kit can detect oral HPV as reliably as samp…

Researchers are studying whether a blood marker called presepsin can accurately diagnose sepsis in adults with severe burns covering at least 20% of their body. Burn patients face a high risk of sepsis, and spotting it early is critical. The study compares presepsin results with …

ToolCAP tests whether portable lung ultrasound can help doctors decide which children with pneumonia need antibiotics. Most childhood lung infections are viral, yet doctors often prescribe antibiotics that only work on bacteria. The study enrolls children aged 2 months to 12 year…

This study tests a community-based screening strategy for tuberculosis (TB) in migrant communities in New York City. A mobile van offers digital chest X-rays with AI interpretation, along with TB symptom checks, blood tests for latent TB, and HIV testing. The goal is to see wheth…

This study is testing a new rapid diagnostic device called TruPlex that can detect HIV, Hepatitis B, and Syphilis from a small blood sample. Researchers will enroll 1000 adults at risk for these infections to see how accurate and easy the test is to use in clinics and point-of-ca…

This study tests whether a special PET scan (FAPI PET) can better detect active scarring in the lungs of people with fibrotic lung disease. About 50 adults with idiopathic pulmonary fibrosis or fibrotic hypersensitivity pneumonitis will get up to 4 PET/MRI scans. The goal is to i…

This study investigates whether urine samples can be used to screen for cervical cancer in women living with HIV. Researchers will compare the accuracy of urine HPV testing with self-collected and provider-collected samples to detect cervical precancer (CIN2 or worse). The goal i…

This study is testing a new rapid test for gonorrhea called the iStatis Gonorrhea Antigen Test. The test uses a vaginal swab and gives results quickly at the clinic. Researchers want to see how accurate and easy it is to use when performed by trained staff. About 650 women will t…

Researchers in Sweden are analyzing health records from about 130,000 women who had a positive HPV test during cervical screening. The study asks whether the specific HPV genotype, how long the infection lasts, and whether past test results are available can predict the risk of c…

Researchers test whether a rapid, 15-minute molecular flu test used directly in long-term care facilities helps older residents get diagnosed and treated faster than standard lab-based PCR testing. The trial enrolls residents aged 65 and older with symptoms like fever or low oxyg…

This large Australian study is testing whether offering a finger-stick point-of-care test for hepatitis C can increase diagnosis and treatment rates. Adults at risk for hepatitis C will be offered the rapid test at services they already use. Those who test positive for the virus …

This large Australian study is testing whether offering finger-stick point-of-care testing for hepatitis C in community settings—like drug treatment clinics, homeless shelters, and prisons—can increase the number of people diagnosed and linked to treatment. The study will include…

Researchers at an Indonesian national referral hospital are comparing standard blood culture with two molecular diagnostic methods, Hybrispot DNA Flow and metagenomic 16S rRNA sequencing, for identifying microorganisms in patients with sepsis. The study enrolls 415 adults with se…

This phase IV trial will enroll 5,500 people with liver cirrhosis or chronic hepatitis B—conditions that raise liver cancer risk. Participants are randomly assigned to either standard ultrasound screening or a new blood test called GALAD, which measures three proteins. The goal i…

This study tests whether new, easier-to-use diagnostic tests for tuberculosis (TB) can help find more cases in Indonesia. About 40,000 people with TB symptoms will take part. Some clinics will use the new tests, while others will use standard methods. The goal is to see if the ne…

Prosthetic joint infection is a leading reason hip and knee replacements fail, and current tests often miss it. This study uses nanopore sequencing to compare bacteria and immune gene activity in tissue, joint fluid, and blood from people having revision surgery, both with and wi…

This study evaluates a new PCR test (Bioneer Q-RFIA kit) for quickly and accurately detecting tuberculosis (TB) and resistance to key antibiotics. About 2,350 adults with TB symptoms will provide samples to see how well the test works compared to standard methods. The goal is to …

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

This study will test whether using two heat probes instead of one to treat cervical precancer works better for women living with HIV. Researchers in Rwanda will enroll 300 women to see if the two-probe approach is safe, acceptable, and more effective at clearing HPV. The goal is …

Researchers are testing whether a protein called Pancreatic Stone Protein (PSP) can identify emergency room patients with infection who are at risk of developing sepsis. Adults with suspected infection receive either a single dose of the antibiotic meropenem or a placebo. The tri…

This study tests a long-acting injectable PrEP (lenacapavir) program designed specifically for Latine gay, bisexual men and transgender women. Researchers want to see if offering the shots at community organizations helps more people stay on HIV prevention compared to standard cl…

This study tests a 28-day daily combination of two drugs, rifapentine and isoniazid, to prevent tuberculosis (TB) in children under 13. About 144 children, some with HIV and some without, will join to find the right dose and check for side effects. The goal is to see if this shor…

This early-stage study tests a vaginal gel containing specially modified bacteria that produce an anti-HIV drug. The goal is to see if it is safe for healthy women and whether it can be cleared with antibiotics. If successful, this could become a long-lasting, woman-controlled HI…

Researchers are testing whether adding the antibiotic clarithromycin to standard antibiotic therapy can prevent new infections and secondary sepsis in adults hospitalized with community-acquired pneumonia and sepsis. The trial enrolls 252 adults who receive either clarithromycin …

This study tests whether taking the antibiotic doxycycline can prevent bacterial sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in adolescent and young adult females. About 760 participants aged 13-29 who have had an STI in the past year and recent…

This study tests an investigational nasal spray called INNA-051 to see if it can safely prevent or reduce the severity of viral respiratory infections like colds and flu. It involves 1100 healthy adults aged 18 to 45 who are at higher risk due to their living or work conditions. …

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience. The goal is to prevent substance …

This study tests a new way to help young people (ages 13-24) stick with PrEP, a medication that prevents HIV. Participants get PrEP delivered to a community spot (like home or a mobile van) and use a smartphone app for reminders and support. The goal is to see if this combo impro…

Researchers are testing whether a strengths-based patient navigation program helps men start and stay on PrEP, a daily pill that greatly lowers the risk of getting HIV. The trial enrolls 300 men who have sex with men and receive care at community health centers. Half receive the …

This phase 3 trial is testing whether a single dose of CD388, a long-acting antiviral injection, can prevent the flu in 10,000 adults and teens at higher risk of complications. Participants receive either CD388 or a placebo and are monitored for flu-like illness over 24 weeks. Th…

Researchers at Kaiser Permanente Southern California are testing whether reminder messages that highlight COVID-19 vaccine choices increase vaccination among adults at high risk of severe illness. The trial randomly assigns eligible members to receive either a standard reminder o…

Odense University Hospital changed its protocol so that patients having surgical heart valve replacement receive targeted dental screening instead of mandatory screening. Researchers are comparing the rate of infective endocarditis, a serious heart infection, in patients treated …

Researchers are testing a single dose of an omicron-based COVID-19 vaccine called Nuvaxovid in people aged 65 and older, and in people aged 12 to 64 who have a health condition that raises their risk of severe COVID-19. All participants received a COVID-19 vaccine at least 90 day…

This trial tests whether a daily supplement called Immune X can help prevent common colds in healthy adults who often get upper respiratory infections. Over 16 weeks during winter, participants take either Immune X or a placebo and track any cold symptoms. The study compares how …

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This trial tests whether adding chlorine to water supplies and disinfecting surfaces in rural Kenyan maternity wards reduces infections in newborns and their mothers. Facilities receive automated water chlorinators, chlorine solution, and cleaning supplies, along with infection p…

This study tests a mobile health program called PrEP Choice to help young people ages 13-24 start and stick with HIV prevention pills or shots. It also looks at whether taking the antibiotic doxycycline after sex (DoxyPEP) can prevent other sexually transmitted infections. About …

This trial tests a handheld light device (RD-X19) to see if using it for 5 minutes every other day can prevent upper respiratory infections like COVID-19 and flu. It involves 130 military personnel and their families at a single base. Half will get the real device, half a sham de…

This study tests different strategies to increase HPV vaccination among 9- to 12-year-olds in rural North Central Florida. Clinics will be randomly assigned to offer clinician training alone, training plus parent reminders, or all three including help accessing healthcare. Resear…

This study tests a program called Shamba Maisha that provides farming tools, training, and school gardens to families in Kenya. The goal is to reduce food insecurity and poverty, which are linked to higher STI and HIV risk in adolescent girls. Researchers will follow 900 girls an…

Pregnant women with hepatitis B can pass the virus to their babies during birth. To prevent this, guidelines recommend treating women with high levels of the virus using the drug tenofovir. However, many clinics in low-income countries cannot measure virus levels. This trial comp…

Researchers at Columbia University are studying whether dental clinics can play a bigger role in HIV prevention and care. The trial compares two ways of running a dental practice: a standard model and an enhanced model that adds electronic prompts for HIV testing plus a care navi…

Researchers are testing a hydrogel coating called MectaShield that is applied to hip revision implants during surgery. The coating is designed to act as a barrier against bacteria that can cause joint infections. The trial compares two groups: one receives implants with the coati…

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

This study tests whether a single dose of nirsevimab, an antibody that targets RSV, can prevent respiratory infections in Aboriginal and Torres Strait Islander children aged 6 months. Around 1,000 children will be randomly assigned to receive either the antibody or standard care.…

This trial tests whether a peer-led program that lets women choose and switch HIV prevention methods can increase consistent use compared to standard care. The program includes peer mentor support, HIV testing, access to PEP, and STI care. It enrolls HIV-negative women at elevate…

This study tests a new vaccine (PCV21) designed to protect babies against 21 types of pneumococcal bacteria, which can cause pneumonia and other serious infections. About 2,200 healthy infants will receive four doses of either the new vaccine or an existing one starting at 2 mont…

This early-stage study tests a new antibody drug (GSK4425689A) designed to prevent malaria. Researchers will give the drug to 40 healthy adults either through an IV or a shot under the skin to check for side effects and how the body processes it. The goal is to see if it is safe …

This phase 3 trial tests whether the drug U101 (pentosan polysulfate sodium) can prevent recurrent urinary tract infections (UTIs) in women aged 20 to 75. About 348 women with a history of frequent UTIs will take either U101 or a placebo daily for 24 weeks. Researchers will track…

This study looks at how well people stick to a new HIV prevention shot called lenacapavir. About 3,000 people in the U.S. who want or need HIV prevention will take part. Researchers will track who stays on the shot and how it works in everyday clinic settings.

This study tests whether the drug ORC-13661 can prevent hearing loss in people receiving intravenous amikacin for a lung infection called NTM. About 105 adults will take either a high dose, low dose, or placebo daily for up to 90 days. Researchers will compare hearing changes amo…

This phase 3 trial is testing whether adding Gamunex-C (an immune globulin) to standard care can prevent serious infections in people with chronic lymphocytic leukemia, multiple myeloma, or non-Hodgkin lymphoma. About 49 participants will receive Gamunex-C through an IV every 4 w…

This study tests whether leaving the white, creamy coating (vernix caseosa) on a newborn's skin for at least 24 hours after birth can prevent eczema (atopic dermatitis) during the first year of life. Over 1,300 mother-infant pairs in Chile will be randomly assigned to either keep…

Researchers are testing whether a program called the LINK model helps breastfeeding women in Malawi start and stay on HIV prevention medicine (PrEP). The program ties HIV testing and PrEP to infant vaccination visits, screens for HIV risk, involves male partners, and provides pee…

Researchers are studying how well two chikungunya vaccines, IXCHIQ and VIMKUNYA, prevent infection in adults during outbreaks on Réunion Island and in French Guiana. The study includes about 1,505 adults who are eligible for vaccination. By comparing infection rates between vacci…

Researchers are testing whether a bacterial lysate, a mix of inactivated bacteria, can reduce respiratory tract infections and wheezing in late-moderate preterm infants during their first years of life. The trial enrolls 500 infants born between 30 and 35 weeks of gestation, givi…

Researchers at one French hospital test whether repeated on-site simulation training helps ICU staff follow standard precautions more consistently. The training uses realistic scenarios that mimic common resuscitation situations, including interruptions and high cognitive load. T…

This study looks at how to keep an HIV prevention program running well in Bahamian schools over several years. Researchers will test different support strategies for teachers, like regular check-ins and mentorship. About 3,705 students and teachers will take part, and the study w…

This trial tests whether a single oral dose of lotilaner, a drug currently used in animals, can make human blood lethal to Anopheles gambiae mosquitoes, the main carriers of malaria. Healthy adults in Mali will receive either a low or high dose of lotilaner or a placebo, with or …

This study looks at whether the measles, mumps, and rubella (MMR) vaccine is safe and works well in children aged 1 to 17 who have had a heart transplant. About 60 children will receive the standard MMR vaccine and be monitored for side effects and immune response. The goal is to…

Researchers compare three influenza vaccine formulations, standard dose, MF59 adjuvanted, and high dose, in adults aged 65 and older. The trial measures antibody levels before and after vaccination to see whether the formulations produce different immune responses. A younger refe…

This study will test a chatbot designed to increase awareness and use of PrEP, a daily pill that prevents HIV, among Black men who have sex with men (MSM) in the Southern United States. About 145 participants will interact with the chatbot over 90 days, answering questions and re…

This study tests whether letting people choose where they get their follow-up HIV prevention injections (home, community, or clinic) helps them stick with the treatment. 400 HIV-negative adults in Massachusetts will receive the same-day injectable drug lenacapavir and be randomly…

This study explores whether a type of hands-on therapy called osteopathic manipulation can improve how well the seasonal flu vaccine works in people who are more vulnerable to severe flu, including older adults and those with higher body weight. Participants will receive several …

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placeb…

This phase 3 trial tests whether a gradual taper of vancomycin is as good as a 10-day course of fidaxomicin at preventing another C. difficile infection. About 500 adults with a first or second C. diff episode will be randomly assigned to one of the two treatments. The main goal …

This study tests an oral drug called vapendavir in 180 adults with COPD who catch a rhinovirus (common cold). The goal is to see if it can reduce the severity and length of breathing symptoms compared to a placebo. Participants are randomly assigned to one of two doses or a place…

Researchers are testing transcranial direct current stimulation (tDCS), a non-invasive technique that applies weak electrical currents to the scalp, in people with persistent COVID who have headaches, migraines, and chronic body pain. The study enrolls about 87 participants aged …

This study tests two materials, MTA and Biodentine, for treating a painful tooth condition called irreversible pulpitis. 60 adults with severe tooth pain will get a pulpotomy (removing infected pulp) and one of the materials. They will be followed for 3 months to see which materi…

This study looks at whether taking antibiotics before a procedure to treat stress urinary incontinence (leaking urine with cough or sneeze) can lower the chance of getting a urinary tract infection (UTI) afterward. About 138 women will receive either antibiotics or a placebo befo…

This study tests whether an extended-release form of nalbuphine, a pain medication, can safely reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. About 306 adults with IPF and a cough lasting at least 8 weeks will receive either t…

This trial tests a pillow with a spine-shaped opening in the middle, designed to keep pressure off the surgical wound after back surgery. Standard pillows can rub against the incision, increasing the risk of infection and pain. The study will enroll 10 adults who have had lumbar …

People with idiopathic pulmonary fibrosis often develop a chronic cough that no approved treatment targets. This Phase 3 trial tests nalbuphine extended-release tablets, an opioid-related medicine, against placebo in about 200 adults with the condition. Over 12 weeks, researchers…

Sepsis is a life-threatening reaction to infection, and some patients have weakened immune function that makes recovery harder. This trial tests whether adding thymalfasin, a synthetic version of a thymus hormone, to standard sepsis care helps restore immune function. Sixty adult…

This pilot study tests whether VM100, a nutritional supplement made from ten natural ingredients, can improve quality of life for people with Duchenne muscular dystrophy (DMD). About 20 participants aged 8 and older will take VM100 or a placebo for 10 weeks. Researchers will meas…

Researchers compare two flexible scopes used to remove kidney or upper ureter stones through the urinary tract. One scope has built-in suction to pull out stone fragments and fluid during laser breaking; the other is the standard reusable scope without suction. The trial enrolls …

This study tests whether analyzing a patient's phlegm can help doctors choose better treatments for chronic cough in interstitial lung disease (ILD). About 120 adults with ILD and daily cough for at least 8 weeks will be randomly assigned to either phlegm-guided treatment or stan…

Researchers test whether pomegranate peel extract can serve as a pulpotomy agent for primary molars with deep decay. Thirty children with restorable baby teeth and no signs of severe infection receive the extract after part of the tooth pulp is removed. The trial measures pain, s…

This Phase 3 trial tests two repurposed drugs—upadacitinib and pirfenidone—against a placebo in 348 adults with Long COVID. Participants from six countries will take the drugs for three months to see if they ease symptoms like fatigue, breathing trouble, memory issues, muscle pai…

This study tests whether Xdemvy eye drops can reduce eyelash mite irritation and improve comfort for people who wear special scleral lenses. Five adult lens users with moderate to severe Demodex blepharitis will use the drops and report changes in symptoms like dryness, itching, …

Frozen shoulder causes pain and stiffness that make daily tasks and sleep difficult. Researchers are testing whether adding a stroking release technique of the rotator cuff muscles to standard Maitland mobilization improves pain, range of motion, and disability. The trial enrolls…

Researchers are testing whether a 3-month program of adapted physical activity and patient education can help adults who have had symptoms attributed to Lyme disease for more than six months. Participants are randomly assigned to either the supervised program, which includes twic…

Researchers compare two ways to perform a total pulpotomy, a procedure that removes the top part of a tooth's inner pulp while leaving the root pulp intact, in mature molars with painful irreversible pulpitis. One group receives standard bleeding control with sodium hypochlorite,…

Researchers are testing whether Daoyin, a traditional Chinese practice combining gentle movement and breathing exercises, can improve exercise endurance in adults with idiopathic pulmonary fibrosis. The trial enrolls 236 people aged 40 to 85 who can tolerate the training, includi…

This study tests whether giving medication once a day through a chest tube works as well as giving it twice a day for people with serious infections around the lungs. Participants are adults already in the hospital with a chest tube draining infected fluid. They will be randomly …

Women living with HIV face two to four times the risk of heart disease compared with women without HIV, and those in the Southern US are especially affected. Researchers at the University of Alabama at Birmingham are adapting an 8-week stress management program that uses meditati…

Researchers are studying whether pulmonary rehabilitation and airway clearance training can improve lung function, ease symptoms, and raise quality of life for adults with nontuberculous mycobacterial pulmonary disease (NTM-PD). About 500 adults with NTM-PD will take part in an 8…

Researchers are investigating the genetic and immune factors that make some children develop multisystem inflammatory syndrome (MIS-C) after a COVID-19 infection. The study enrolls children with MIS-C or Kawasaki disease and their family members. Scientists will collect clinical …

The MunichFlu study investigates whether attending the Munich Oktoberfest, one of the world's largest mass gatherings, is linked to respiratory viral infections. Researchers recruit adults at the festival and follow up one to two weeks later with an online questionnaire about sym…

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study looks at whether sleep habits of 11-12 year olds affect their immune response to the meningococcal vaccine (MCV4). About 66 healthy teens will wear a sleep tracker and keep their normal sleep schedule for 5 weeks. Researchers will measure antibody levels after vaccinat…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study aims to understand why some people with tuberculosis (TB) experience a paradoxical reaction, where they initially improve on treatment but then suddenly get worse. Researchers will follow 140 adults with TB, with or without signs of this reaction, using blood tests, ur…

This study aims to understand how Staphylococcus aureus bacteria interact with human cells to cause infections, especially in the spine. Researchers will use tonsil tissue discarded after routine tonsillectomies to create lab models. About 500 participants aged 2 and older who ar…

This study aims to better understand trisomy 8 mosaicism, a rare genetic condition where some cells have an extra copy of chromosome 8, and its link to autoinflammatory disease (TRIAD). Researchers will follow affected individuals and their healthy relatives over time, collecting…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study tracks the health of people with HIV over time to learn more about the infection and related conditions. It is for adults 18 and older in the Washington, D.C., area who have or may have HIV. Participants visit the clinic every few months for check-ups and blood tests, …

This study aims to find the safest and most effective dose of a specific flu virus to give to healthy adults in a controlled setting. About 90 volunteers aged 18 to 55 will be exposed to the virus or a placebo and closely monitored. The goal is to create a reliable model for test…

This study collects blood, bone marrow, and tumor samples from 500 adults with cancer or pre-cancerous conditions. Researchers will use these samples to learn more about how cancers behave and why some respond differently to treatments. Participants provide samples over time and …

This study collects blood, urine, bone marrow, and tumor samples from people with hairy cell leukemia and other blood cancers, as well as from healthy volunteers. Researchers will use these samples to study the diseases and develop new treatments called immunotoxins, which use an…

This study looks at HIV that stays hidden in the body even when the virus is under control. Researchers will measure the 'latent HIV reservoir' in 130 Ugandans with HIV and compare it to similar groups in the US. Participants give blood samples and answer health questions. No new…

This study aims to learn more about non-tuberculous mycobacterial (NTM) infections, which cause repeated lung and other organ infections. Researchers will study up to 1,000 participants to understand the genetics, symptoms, and best treatments for these infections. The study also…

This study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…

This study collects blood, urine, bone marrow, and tissue samples from over 1,200 adults with lymphoid cancers or precancerous conditions. The goal is to help researchers better understand cancer biology, which may lead to new methods for diagnosing or treating these diseases. No…

This study aims to learn more about how infections and inflammation harm the brain and nerves. Researchers will collect samples and perform tests on people aged 2 and older who have or may have these conditions. The goal is to better understand these diseases so that better tests…

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or the flu. Researchers want to find out if these people have hidden immune system or genetic problems that make them more vulnerable. Up to 600 participa…

This study aims to understand how HIV behaves differently in the blood compared to lymph nodes and bone marrow. Researchers will take samples from 400 people living with HIV and some without HIV to measure virus levels and immune system changes. The goal is to learn more about wh…

This study enrolls up to 400 people with known or suspected infections or inflammatory diseases that are not covered by other research protocols. The goal is to evaluate patients using standard medical practices, generate new ideas for future studies, and train doctors. No experi…

Researchers are testing an experimental long-acting injectable drug called S-892216-LAI in healthy adults. The trial measures how safe and tolerable the drug is, and how the body absorbs and clears it after one or more doses. Participants receive either the drug or a saline place…

This study collects white blood cells from HIV patients through a process called leukapheresis to examine how the immune system responds to early treatment. Researchers aim to enroll 60 adults—30 with early HIV and 30 with chronic HIV—who are not yet on antiretroviral therapy. Pa…

This study looks at 800 healthy adults who have cryptococcosis, a fungal infection that usually only harms people with weak immune systems. Researchers want to learn why these otherwise healthy people get sick, how their immune system responds, and how the disease progresses over…

This study looks at how leishmaniasis infections progress and respond to treatment. It involves up to 289 people aged 3 to 100 with known or suspected leishmaniasis. Researchers will collect blood and tissue samples to learn more about the disease and test different treatments. T…

This study collects white blood cells and plasma from 400 people with HIV, including rare 'non-progressors' who control the virus without medication. Researchers will analyze immune responses and genetic markers to understand what makes these individuals special. The goal is to u…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

This study follows 150 adults with Kaposi sarcoma (KS) for up to 10 years to learn how the disease behaves, why it comes back, and how it affects the immune system and organs. Participants will have regular check-ups, scans, and biopsies, but no new treatments are being tested. T…

Researchers are studying blood samples from 60 adults who receive a liver transplant to see how immune markers change over the first year. The study measures cytokines, interferons, immunoglobulins, lymphocyte populations, and other immune signals before transplant and at set tim…

This study follows 1,590 adults who have had COVID-19 to track their symptoms and recovery over three years. Participants complete phone interviews and online surveys every three months. The goal is to describe the range of recovery experiences and identify factors that lead to p…

This study asks whether a simple, non-invasive reading from a standard pulse oximeter—the perfusion index—can help predict survival in people with sepsis or septic shock. Sepsis can impair blood flow to small vessels even when blood pressure looks normal, and this 'hidden' poor p…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will join groups based on their contraceptive choice…

This study uses special PET scans to measure brain synapse density in people with HIV who are on effective treatment. Researchers want to understand why some still develop thinking or memory problems. They will compare 70 participants (with and without HIV) over two years using b…

This study looks at whether sharing results from a blood test that shows recent alcohol use can help people with HIV drink less. Researchers will enroll 80 people in Uganda who drink heavily. Half will get standard counseling plus their blood test results, and half will get couns…

This study looks at proteins in lung fluid from 750 people with pneumonia to find biomarkers that could reveal what's causing the lung inflammation. Participants undergo a standard bronchoscopy with lung washings, plus a blood draw. The goal is to better understand different type…

This study looks at people with severe or hard-to-treat Valley Fever, a lung infection caused by a fungus found in the southwestern U.S. Researchers want to understand why some people get seriously ill by studying their immune systems and genetics. Up to 400 participants will giv…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study gathers fluid and tissue from the lungs and nose of healthy volunteers and people with a history of lung infections. Researchers will compare samples to find differences in immune function that might explain why some people are more prone to infections. Participants un…

This study looks at why some people with HIV who have very low virus levels in their blood still develop thinking and memory problems. Researchers will follow 1,150 participants—including healthy volunteers—for up to 10 years, using brain scans, blood tests, and spinal fluid samp…

This study looks at why a common gut bacterium, Enterococcus faecalis, sometimes travels to the heart and causes a serious infection called infective endocarditis. Researchers will analyze the gut bacteria of 90 adults with this bloodstream infection to see if an imbalance in the…

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study tests whether short educational videos can help young adults who survived childhood cancer learn about and get the HPV vaccine. The researchers will enroll 55 survivors aged 18-26 who haven't finished the vaccine series. Participants will watch the videos on Facebook a…

This study follows 500 people with active Lyme disease to learn more about the infection. Participants receive standard FDA-approved treatments and undergo tests like blood draws and leukapheresis. The goal is to explore biological markers, track clinical outcomes, and understand…

This study screens up to 2,000 people who have or may have immune disorders that make them prone to infections, along with their healthy relatives. Researchers will use medical history, physical exams, blood tests, and genetic testing to better understand these conditions. The go…

This study follows 600 people with GATA2 deficiency, a genetic disorder affecting the immune system and other body systems. Researchers aim to understand the full range of health problems it causes and why it affects people differently. Participants will have yearly check-ups for…

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood samples from up to 2,419 adults, both with and without HIV. Researchers will analyze these samples to compare genetic and protein differences. The goal is to better underst…

This completed observational study at a single hospital in China enrolled 16 adults with sepsis in the ICU. Researchers measured specific memory CD8+ T cells in the blood at several time points to see if their numbers or activity relate to how severe the sepsis is or whether pati…

This study looks at how the hepatitis B virus changes over time in people taking antiviral drugs. Researchers will analyze blood samples from 700 adults in Turkey to see if the virus becomes resistant to treatment. The goal is to help doctors choose the best medications for each …

This study aims to understand why some children develop severe bacterial infections that require intensive care. Researchers will analyze blood samples and medical histories from 1,401 children who were hospitalized for such infections between 2015 and 2018 in France. By comparin…

This observational study will compare blood cultures taken from arterial lines versus standard vein punctures in 1,500 ICU patients. The goal is to see if the arterial method reduces contamination and improves detection of bloodstream infections. Researchers will also check if mo…

This study tests whether people with fibrotic interstitial lung disease can use home monitoring devices—like a spirometer, pulse oximeter, and scale—to help detect serious lung events such as flare-ups or hospitalizations. About 200 participants will use these devices connected t…

This study looks at whether giving out special syringes with less leftover space (low dead-space) can help reduce the spread of HIV and hepatitis among people who inject drugs. Researchers will talk with participants and track their health in several countries. The goal is to fin…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study looks at whether the phase of a woman's menstrual cycle changes how well dental numbing works for treating a painful tooth condition called pulpitis. Researchers will give 150 women a standard numbing shot and measure pain during treatment. The goal is to see if certai…

This study looks at how people's immune systems react to infections from parasitic worms, which can cause serious health problems like swelling, blindness, or heart disease. Researchers will evaluate and treat up to 500 participants aged 3 to 100 using standard medical tests and …

This study looks at whether getting an mRNA COVID-19 vaccine within three months before starting immunotherapy improves outcomes for people with liver cancer. Researchers will review medical records of 200 patients in Austria to compare response rates, survival, and side effects …

Researchers at the State University of New York at Buffalo are creating a biorepository, a collection of blood and liver tissue samples, from people with and without liver diseases. The goal is to give future scientists high-quality specimens to study how conditions like hepatiti…

This study aims to understand where HIV hides in the body when people stop their daily antiretroviral therapy (ART) for a short time. Fifty adults with HIV will either stay on ART or pause it for up to 90 days. Researchers will use PET/CT scans and take small tissue samples from …

This study looks at why some people with HIV develop Immune Reconstitution Inflammatory Syndrome (IRIS) after starting HIV medications. Researchers will use PET scans and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is to better understand…

Sepsis and acute respiratory distress syndrome (ARDS) can look very different from one patient to the next, and doctors lack reliable ways to predict who will recover. This observational study follows 6,000 adults with sepsis, ARDS, or both at hospitals across China. Researchers …

This study follows 540 adults admitted to the intensive care unit (ICU) to see how their immune and inflammatory responses relate to their recovery. Researchers will collect extra blood samples at several time points over one year to measure immune cells and inflammation markers.…

This study looks at how the COVID-19 pandemic impacted out-of-pocket costs, lost wages, and unemployment for 600 breast cancer patients undergoing surgery. Participants will fill out questionnaires about their financial experiences. The goal is to understand the financial toxicit…

This study investigates whether the diversity of gut bacteria is linked to liver and kidney injury in people with sepsis. Researchers will collect stool and blood samples from 200 sepsis patients in intensive care and compare them with samples from healthy volunteers. By analyzin…

This study uses a 10-minute questionnaire to learn how the COVID-19 pandemic impacted the quality of life, mental health, finances, and social connections of people with melanoma. Researchers will also look at what factors, like social support, helped people cope. About 1,152 par…

This study, run by the National Institute of Allergy and Infectious Diseases, collects blood and stool samples from up to 5,000 people of all ages who have or had COVID-19, as well as those heavily exposed but uninfected. Researchers will analyze immune responses and genetic fact…

Researchers are following adults who were admitted to intensive care with sepsis to understand what shapes their recovery over six months. The study collects medical data during the ICU stay and checks in by phone at 3 and 6 months to measure quality of life, thinking, mental hea…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…

Researchers follow 150 healthy children aged 2 to 5 in South Africa through a flu season to see how immune responses in blood and the nose relate to protection against influenza. Nurses collect nasal swabs three times a week and blood samples before, during, and after the season.…

Researchers at the University of Leicester are following 500 people admitted to hospital with acute respiratory conditions such as pneumonia, asthma attacks, and COPD flare-ups. The study also includes people with chronic lung disease seen in outpatient clinics and healthy volunt…

This study tests whether a short 'inoculation' message can help young women in South Africa resist misinformation about lenacapavir, a new twice-yearly injection for HIV prevention. 1,500 women aged 18-29 will be randomly assigned to receive either the inoculation message or unre…

This study follows about 800 people who have recovered from COVID-19 to learn how long the virus can stay in different parts of the body, such as the nose, stool, semen, and breast milk. Researchers will also track how the immune system responds and look for any long-term health …

Researchers across Europe are building a registry of people with hepatitis B to study how the virus behaves and how the immune system responds. The registry aims to collect health information from about 3,000 participants, including those with hepatitis B alone or with other infe…

This study looks at whether preterm infants in the NICU can safely stop taking the antibiotic ampicillin after 24 to 36 hours instead of the usual 48 hours. Researchers will measure drug levels in the blood and monitor the babies for any problems. The goal is to see if a shorter …

Rift Valley fever spreads from livestock such as cattle, sheep, goats, and camels to people, and East and Central Africa have seen more than 15 major epidemics in 50 years. Researchers are studying hotspots in Kenya, Uganda, Tanzania, and the Democratic Republic of Congo to measu…

This study collects biological samples like blood, saliva, and urine from 300 adults aged 18-70, both with and without blood disorders such as sickle cell disease and thalassemia. The goal is to use these samples for research to better understand these conditions and related dise…

Researchers at Sohag University Hospital are studying how often Klebsiella pneumoniae bacteria appear in respiratory samples from adults treated in the respiratory intensive care unit. The team will also test how resistant these bacteria are to antibiotics and record patients' cl…

Researchers in Bogota, Colombia, are reviewing the medical records of 370 women treated for breast cancer between 2014 and 2024. They want to see how different molecular subtypes of the disease relate to survival, recurrence, treatment response, and side effects. The study also l…

This study aims to find out how often people with chronic hepatitis B also have hepatitis D, and which types of the virus are most common. Researchers will interview about 2,400 participants and take blood samples to look for links with vaccination history, lifestyle, and other f…

This study is working to create better exercise tests for children with cystic fibrosis, sickle cell disease, or long COVID. Current tests are designed for healthy athletes and may not be safe or useful for these kids. Researchers will track 240 children over 3-4 years, measuring…

Researchers are asking whether people who reach a functional cure for chronic hepatitis B feel less stigma and report better physical and mental health than those who are not cured or who relapse. The study enrolls about 400 adults from an existing hepatitis B cohort in China, so…

This study will compare frailty and other age-related health problems in 600 older adults (60+) in Burkina Faso, Côte d'Ivoire, and Togo — half living with HIV, half without. Researchers will use surveys, medical checks, and interviews to understand how HIV affects aging and what…

Vascular infections are rare but serious conditions that affect the artery wall, bypass grafts, or stents. Researchers at Zhongshan Hospital in Shanghai are following 2,000 adults with suspected or confirmed vascular infections to see how well blood-based pathogen detection and 1…

This study aims to learn more about liver diseases like hepatitis B, C, and D by observing up to 8,050 participants over time. Participants will have yearly check-ups, blood and urine tests, and liver ultrasounds. Some may be offered experimental treatments if they qualify. The g…

Hepatitis D is the most severe form of viral hepatitis, often leading to liver failure and death. Researchers at Hannover Medical School are running a multicenter cohort study to screen blood and liver samples from 750 adults with hepatitis D for biomarkers linked to disease cont…

Researchers at four French hospitals are measuring how often patients and health care workers catch influenza, COVID-19, or RSV during a hospital stay. Anyone over 18 with fever, cough, or sore throat is offered a nose swab and a questionnaire about health, vaccination, and sympt…

This study reviews medical records from up to 400,000 U.S. Veterans to see how COVID-19 treatments like Paxlovid and remdesivir are used and how well they work. It also looks at RSV and flu patterns. The goal is to improve treatment strategies for respiratory viruses in the VA he…

This early-stage study tests the safety and how the body handles a new antibiotic called BWC0977. It involves 48 healthy adults aged 18 to 55 who will receive either the drug or a placebo by IV. The goal is to find safe doses for future studies targeting drug-resistant bacterial …

Researchers in Barcelona survey 200 young adults aged 18 to 25 about their sexual behavior, condom use, number of partners, and experiences of sexual pressure. The study measures how much risk participants perceive in different sexual situations using a validated scale. It then c…

This study tests whether a two-day employment program can help young Black men who have sex with men stay engaged in HIV care. Researchers will ask 132 participants about their satisfaction and track changes in job-seeking confidence and sexual health visits over 13 months. The g…

This study measures how much of the antibiotic gepotidacin passes into breast milk after a single 3000 mg dose. Eight healthy lactating women will provide milk and blood samples over 72 hours. The goal is to understand drug exposure for nursing infants, which could guide future u…

Some people feel certain they have a parasite or infestation, yet doctors examine them and find no cause. Vanderbilt University researchers want to understand what that experience is like. They will interview 25 adults aged 18 to 70 who are at least half certain they have an acti…

Researchers want to know whether mild inflammation, like what happens after a flu shot, affects how healthcare providers make decisions about patients. The trial enrolls emergency medicine and internal medicine providers who receive either a seasonal influenza vaccine or a saline…

This study looks at three different scoring systems to see which one best predicts the risk of death in patients with severe tetanus in the intensive care unit. Researchers will follow 115 adults with tetanus for up to 90 days. The goal is to find the most accurate tool to help d…

This study tests a smartphone app designed to teach emergency room patients about hepatitis C (HCV) and help them connect to follow-up care. Researchers will enroll 308 HCV-positive patients at an urban ER. The app provides personalized information on liver health and care option…

Researchers at university hospitals across Germany are building a large observational cohort of adults and children hospitalized with infections. The study collects standardized clinical data, pathogen samples, and biosamples at the start and end of each hospital stay. A pre-scre…

This study is testing whether a quick finger-stick test can help find more people with hepatitis C and get them into treatment. About 60,000 adults at risk for hepatitis C will take the test at clinics, shelters, or prisons. The study itself does not provide treatment, but will c…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes skin and lung infections. Researchers will follow 600 patients and their relatives over time, examining their health and genetics. The goal is to better understand the disease and improve c…

This study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…

This study looks at whether frailty—measured by a simple scale—can predict death in adults aged 18 to 65 admitted to intensive care for septic shock. Researchers will track 200 patients to see if those who are frail have a higher risk of dying within 28 days, even after accountin…

This study aims to understand why some people develop Long COVID—persistent symptoms after a COVID-19 infection—by tracking symptoms over time and analyzing saliva samples. Researchers will follow 500 adults aged 18 to 75 who have previously tested positive for SARS-CoV-2, collec…

Researchers are studying whether secure video visits can effectively monitor people with Creutzfeldt-Jakob disease (CJD) over time. The study enrolls adults with definite or probable prion disease, along with a study partner who joins each video session. Participants complete rem…

This study aims to understand how the human body responds to dengue virus infection, including in people who have had dengue before. Healthy volunteers aged 18 to 50 receive a single injection of a weakened dengue virus and are closely monitored for six months. Researchers measur…

This study gives healthy adults a controlled malaria infection using donated blood containing the P. vivax parasite. Researchers will monitor how the infection develops, how the immune system responds, and whether mosquitoes can pick up the parasite from participants. The goal is…

This study looks at why oral rotavirus vaccines are less effective in some low-income countries like Zambia. Researchers will collect blood, stool, and tissue samples from 43 adults to study how gut health and the immune system affect vaccine response. The goal is to find biologi…

This study looks at how to help hospital units reduce the use of vancomycin, an antibiotic, in preterm infants. Researchers will compare two approaches to implementing new guidelines across 13 NICUs. The goal is to see which method works better at safely lowering antibiotic use.

This study looks at whether blood cancer patients with a serious infection can safely stop antibiotics sooner if they are stable for 72 hours, instead of the usual 10-day course. About 172 adults will be randomly assigned to either a personalized short course or standard long cou…

Researchers are collecting information on pregnant women who took the antifungal medicine ibrexafungerp, which treats vaginal yeast infections. The study follows their babies from birth through the first year of life, looking for birth defects, growth problems, and developmental …

Researchers are studying the penile microbiome of male partners of women with recurrent bacterial vaginosis (BV) to see whether BV-linked bacteria live on the penis and whether a cleaning routine can remove them. About 100 men whose female partners are enrolled in a vaginal micro…

This study looks at how sepsis causes lasting damage to the immune system, making people more likely to get serious infections later. Researchers will track 150 ICU patients with sepsis over 28 days, analyzing their blood cells and immune markers. The goal is to uncover the biolo…

Researchers in Cambodia are studying blood samples from people hospitalized with dengue, influenza, or sepsis, plus healthy volunteers, to understand why dengue becomes severe in some patients. They collect clinical information and up to four blood samples per participant, then m…