Could a 2-Month TB cure replace 6 months of pills for kids?
NCT ID NCT06253715
First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 4 times
Summary
This study tests whether a 2-month combination of four drugs can cure drug-susceptible tuberculosis in children under 10 as safely and effectively as the standard 4- to 6-month regimen. Researchers will enroll 860 children, including those with HIV, to compare the shorter treatment to the usual one. The goal is to make TB treatment easier for children and their families.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- isoniazid, rifapentine, pyrazinamide, moxifloxacin
- What this could lead to
- If successful, this could offer a shorter, easier-to-tolerate treatment for children with TB, reducing side effects and caregiver burden.
- What could go wrong
- This is a large phase 3 trial, but the shorter regimen may prove less effective or cause more side effects than the standard treatment. Results are not yet known.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Africa Health Research Institute (AHRI)
RECRUITINGDurban, South Africa
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Arthur Davison Children's Hospital
RECRUITINGNdola, Zambia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dr. D.Y. Patil Medical College, Hospital and Research Center
RECRUITINGPune, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Faculty of Medicine, Universitas Padjadjaran
RECRUITINGBandung, Indonesia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Harare Health and Research Consortium (HHRC)
RECRUITINGHarare, Zimbabwe
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Indian Council of Medical Research - National Institute for Research in Tuberculosis
RECRUITINGChennai, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Instituto Nacional de Saúde (INS)
RECRUITINGMaputo, Mozambique
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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MU-JHU Care Ltd
RECRUITINGKampala, Uganda
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Zambia, School of Medicine
RECRUITINGLusaka, Zambia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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