Mycobacterial infectious disease

This study tests a new vaccine called MTBVAC to see if it can prevent tuberculosis (TB) disease in teens and adults aged 14 to 45 who live in areas where TB is common. About 5,500 volunteers will receive either the vaccine or a placebo, and researchers will track who develops TB …

This study is testing a new tuberculosis vaccine called MTBVAC in 276 adolescents and adults in South Africa, some of whom have HIV. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants will receive either MTBVAC or the standard BCG vaccin…

This phase 2 trial tests whether adding nicotinamide (a form of vitamin B3) to a standard three-drug regimen can safely and effectively treat drug-susceptible pulmonary tuberculosis. About 165 adults with newly diagnosed TB will receive one of two doses of nicotinamide plus the s…

This study tests a new antibiotic called telacebec for Buruli ulcer, a bacterial skin infection that can cause large open sores. About 200 adults will take telacebec tablets for 14 to 28 days. Researchers will check if the ulcers heal completely within a year without needing surg…

This study tests new combinations of drugs for adults with lung tuberculosis (TB). The goal is to see if these new regimens work faster and are safer than the current standard treatment. About 315 participants will receive either an experimental drug combo or the usual care for 8…

This Phase III trial in sub-Saharan Africa tests whether giving higher doses of rifampicin plus linezolid, along with aspirin, can reduce deaths from tuberculous meningitis (TBM) in both HIV-positive and HIV-negative people. About 768 adolescents and adults will receive either th…

This trial investigates whether specially grown immune cells, called pathogen-specific cytotoxic T lymphocytes (CTLs), can safely and effectively treat stubborn infections like EBV, CMV, and adenovirus in people with weakened immune systems, such as stem cell or organ transplant …

This study tests whether the antibiotic rifabutin can improve treatment for people with a stubborn lung infection caused by Mycobacterium abscessus that has become resistant to the common antibiotic clarithromycin. Researchers will enroll 60 adults with active lung disease and me…

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study tests a drug called bedaquiline in children and teens (0 months to under 18 years) with multidrug-resistant tuberculosis (MDR-TB), a lung infection that does not respond to standard antibiotics. About 60 participants will receive bedaquiline along with other TB medicat…

This phase 2 trial tests whether adding the antibiotic doxycycline to standard treatment can reduce deaths and severe brain damage in adults with tuberculosis of the brain or its lining. About 200 participants will receive either doxycycline or a placebo for 8 weeks, alongside us…

This study tests whether a 2-month combination of four drugs can cure drug-susceptible tuberculosis in children under 10 as safely and effectively as the standard 4- to 6-month regimen. Researchers will enroll 860 children, including those with HIV, to compare the shorter treatme…

This study tests whether a new drug called TBD09, when used with other TB medicines, is safe and works well in adults with drug-sensitive tuberculosis (TB). About 150 people will take part. The main goals are to see how quickly the drug combination kills TB bacteria and to check …

This study compares a 6-month treatment using high doses of four antibiotics against the standard 9-month therapy for tuberculous meningitis, a serious brain infection. About 330 adults and teens without HIV will take part. The goal is to see if the shorter regimen is as safe and…

This study tests four approaches to help adults with drug-resistant tuberculosis and HIV stick to their treatments. Participants receive either standard care, counseling, phone reminders via a special pill bottle, or both counseling and reminders. The goal is to see which method …

This study is testing whether the BCG vaccine, originally developed for tuberculosis, can safely treat Mycobacterium avium complex (MAC) lung disease. Researchers will give 48 adults either a single BCG injection or a placebo and monitor them for side effects, immune responses, a…

This study tests an experimental drug called dovramilast in 45 adults with moderate to severe leprosy type 2 reaction, a painful skin condition. Participants receive either dovramilast (100 mg or 150 mg) or standard treatments like prednisolone or thalidomide. The goal is to see …

This study tests whether adjusting the dose of the antibiotic linezolid based on regular blood tests can reduce harmful side effects in people being treated for multidrug-resistant tuberculosis (MDR-TB). The trial will enroll 150 patients in Guinea who are on a standard 6-month r…

This clinical trial is testing different combinations of antibiotics to find the best way to treat a lung infection caused by Mycobacterium abscessus, a bacteria that is hard to kill. About 300 adults and children with this infection will receive various drug regimens, including …

This study tests whether a new drug called quabodepistat can shorten treatment for drug-resistant tuberculosis (TB) from 6 months to 4 months. About 532 adults and teens with rifampicin-resistant or multidrug-resistant TB will be randomly assigned to receive either the new shorte…

This study tests whether regularly measuring linezolid levels in the blood can prevent dangerous side effects and keep people on their tuberculosis treatment. About 280 adults with rifampin-resistant TB will be randomly assigned to either standard care or dose adjustments based o…

This study tests a drug called epetraborole for people with a chronic lung infection caused by Mycobacterium abscessus. About 84 adults will take either a low or high dose of the drug or a placebo for 84 days. Researchers will check if symptoms improve and if the infection clears…

This study tests whether offering small financial rewards and using video calls to watch people take their medicine can help more people complete treatment for latent tuberculosis. About 399 adults in Baltimore will be randomly assigned to usual care, video check-ins alone, or vi…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study tests whether an 8-week or 24-week pulmonary rehabilitation program (exercise and breathing training) helps people recover lung function after completing tuberculosis (TB) treatment. About 690 adults with confirmed TB will be randomly assigned to one of two rehab progr…

This study tests a new way to help doctors in Mozambique and Zambia decide if a sick child has tuberculosis (TB). The approach uses simple checklists and decision guides, supported by a computer system, to improve diagnosis and treatment, especially for children with HIV or sever…

This study is testing whether a powerful antibiotic called piperacillin/tazobactam can be given as a continuous shot under the skin instead of through an IV line. About 240 adults with serious bacterial infections will be randomly assigned to receive the drug either subcutaneousl…

This study tests whether people with asymptomatic tuberculosis (TB) can be treated effectively with a shorter course of standard antibiotics—17 weeks instead of the usual 6 months. Researchers will compare the shorter regimen to standard treatment in 426 participants in China. Th…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests a new drug called JDB0131, combined with other TB medications, in 60 people with rifampin-resistant tuberculosis. Participants will receive one of two doses of JDB0131 or a standard drug (delamanid) for 8 weeks. The goal is to see which combination clears the bac…

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can improve treatment outcomes. Researchers will enroll 200 adults and children with active, drug-sensitive tuberculosis in Tanzania. The goal is to see if personalized dosing helps m…

This study tests whether a shorter treatment regimen (13-24 weeks) using a combination of drugs (bedaquiline, linezolid, pretomanid, and moxifloxacin) works as well as the standard longer treatment for people with a type of drug-resistant tuberculosis. About 400 adults with fluor…

This study tests whether a higher dose of the antibiotic rifampicin (1800 mg daily) is safe and works better than the standard dose for adults with pulmonary tuberculosis. About 164 participants will be randomly assigned to either the optimized or standard dose. Researchers will …

This study tests a new inhaled medicine called RESP30TB in 24 adults with newly diagnosed, drug-sensitive tuberculosis of the lungs. The main goals are to see if the drug is safe and how well it kills TB bacteria in the early days of treatment. Participants will inhale the drug a…

This study tests whether a 4-week course of two TB drugs works as well as the standard 3-month course to prevent active TB in students and staff who have been exposed. About 3,520 people from schools will take either the short or standard regimen. The goal is to see if the shorte…

This study tests whether adding Chinese herbs to standard treatment can help people with a hard-to-treat lung infection called Mycobacterium abscessus. The herbs aim to clear the bacteria from sputum and prevent the infection from coming back. About 352 adults who have finished t…

This phase 2 trial tests whether adding adalimumab (an arthritis drug) to standard tuberculosis meningitis treatment can reduce deaths in HIV-positive adults. About 130 participants in Brazil, Mozambique, and Zambia will receive adalimumab injections every two weeks for 10 weeks …

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This program provides Lamprene (clofazimine), a drug normally used for leprosy, to adults with NTM infections that haven't responded to other treatments or caused intolerable side effects. Patients take 100 mg of clofazimine daily as part of a multi-drug regimen. The goal is to o…

This study looks at whether a higher dose of the TB medicine rifampicin is safe and works well in children with both HIV and TB. Twenty children will take their usual HIV and TB drugs, but for two weeks the rifampicin dose will be increased. Researchers will measure drug levels i…

This study tests a new ultra-short treatment for both drug-sensitive and drug-resistant tuberculosis (TB). The goal is to see if a 2-3 month regimen works as well as or better than the standard 4-6 month treatment. About 610 adults with active TB will take part. The approach coul…

This study tests whether adding an inhaled form of the antibiotic amikacin (ARIKAYCE) to standard treatment helps clear Mycobacterium xenopi from the lungs faster. About 190 adults with this rare, hard-to-treat lung infection will receive either standard care alone or standard ca…

This study compares two antibiotics, clarithromycin and azithromycin, for treating MAC lung infections, a serious bacterial lung disease. About 424 adults with MAC infection will receive one of the two drugs alongside standard treatments. The goal is to see if azithromycin works …

This study compares nurse-led treatment for drug-resistant tuberculosis (TB) in local clinics to standard doctor-led care in hospitals. About 2,944 people will take part across South Africa. The goal is to see if nurse-led care works just as well, is safe, and lowers costs for pa…

This study tests whether adding the antibiotic contezolid to standard drugs can shorten treatment for Mycobacterium Avium Complex (MAC) lung disease. About 188 adults with the nodular bronchiectatic form of the disease will either receive contezolid plus standard therapy for 6 mo…

This study tests new drug combinations to treat pulmonary tuberculosis (TB) faster than the standard 24-week regimen. About 2500 adults with TB will receive one of several experimental combinations, including two new drugs (BTZ-043 and GSK3036656), for 8 to 16 weeks. Researchers …

This clinical trial is testing new combinations of tuberculosis (TB) drugs to see if they work better than the standard treatment. The study involves 390 adults with newly diagnosed, drug-sensitive TB. Researchers are comparing different drug regimens, including a new drug called…

This study is testing the safety of a drug called gallium nitrate in 40 adults with cystic fibrosis who have a difficult-to-treat lung infection called NTM. Participants will receive two 5-day cycles of the drug through an IV. The main goal is to see if the treatment is safe and …

This study tests whether adding atorvastatin, a widely used cholesterol-lowering drug, to standard tuberculosis (TB) antibiotics can help clear the infection faster and reduce lung damage. About 440 adults with pulmonary TB will receive either standard treatment alone or with dif…

This study tests whether a two-drug HIV regimen (dolutegravir plus lamivudine) works as well as the standard three-drug regimen in people who also have tuberculosis and are on TB treatment. About 150 participants who have never taken HIV medication will be randomly assigned to on…

This study tests whether adding the antibiotic contezolid to the usual three-drug regimen can better reduce bacteria in the sputum of adults with Mycobacterium avium complex (MAC) lung disease. About 188 participants will receive either the standard treatment alone or with contez…

This study tests whether a smartphone app can tell the difference between a TB cough and other coughs by analyzing audio recordings. Researchers will collect cough sounds from 1,751 people with a cough lasting at least two weeks, then use machine learning to build a quick screeni…

This study aims to find faster, simpler, and cheaper ways to diagnose tuberculosis (TB), a disease that kills over a million people each year. Researchers will test new diagnostic tools on over 26,000 adults in 10 countries who have a cough lasting two weeks or more, or who have …

This study is testing whether measuring TB DNA in blood and urine can help diagnose tuberculosis and track treatment progress. Current TB tests can be slow or require invasive procedures. The trial will enroll 85 people with active TB, latent TB, or no TB to see how accurate the …

This study is developing an artificial intelligence system that analyzes CT and MRI scans to diagnose and predict outcomes for digestive diseases like Crohn's disease, ulcerative colitis, and intestinal tuberculosis. Researchers are using data from 21 hospitals in China to train …

This study is testing whether a new approach—using ultrasound to guide a tiny needle to collect fluid near the ulnar nerve, then analyzing it for leprosy bacteria DNA—can more accurately diagnose leprosy and confirm when it's cured. Researchers will follow 108 participants for on…

This study is testing a new laboratory method that looks for DNA fragments from tuberculosis bacteria in fluid around the lungs (pleural effusion). The goal is to see if this test can diagnose tuberculous pleurisy more accurately than current tests. Researchers will study 400 adu…

This study is testing whether a special PET scan tracer called 18F-FAPI-74 can detect scarring (fibrosis) in the lungs of people with active tuberculosis. About 30 adults with confirmed TB will get the tracer and a whole-body PET/CT scan during and after treatment. The goal is to…

This study is testing new, non-invasive ways to diagnose tuberculosis (TB) in children under 15. Researchers will evaluate oral swabs, cough sound analysis, and lung sound analysis as potential alternatives to sputum tests. The goal is to find faster, simpler, and cheaper diagnos…

Every year, millions of people with tuberculosis (TB) go undiagnosed. This study tests new, faster diagnostic tools that use a simple tongue swab instead of the usual sputum sample. Researchers will enroll 1,350 adults with cough or TB risk factors to see how accurate these point…

This study tests a special PET/CT scan that uses a tracer called FAPI-74 to find fibrosis (scar-like tissue) in the body. It includes 45 adults with conditions like head and neck cancer or tuberculosis that can cause fibrosis. The goal is to see how well the scan shows fibrosis, …

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study tests whether a DNA sequencing test can help doctors choose the right antibiotics for people with drug-resistant tuberculosis (TB). Researchers will collect samples from 2,500 participants in clinics and use targeted sequencing to identify which drugs the TB bacteria a…

This study tests whether an artificial intelligence (AI) system can help doctors find tuberculosis (TB) faster in primary-care clinics in Yichang, China. About 22,000 people with TB symptoms will get a chest X-ray, and the AI will help flag possible cases. The goal is to see if A…

This study tests a new skin test (C-TST) to find hidden tuberculosis (TB) infection in people with rheumatic diseases like rheumatoid arthritis who are about to start powerful medications called biologics. These drugs can reactivate dormant TB, so accurate screening is critical. …

This study tests a new type of ultrasound called super-resolution ultrasound (SRUS) to see if it can better tell the difference between benign (non-cancerous) and malignant (cancerous) swollen lymph nodes. About 779 adults with abnormal lymph nodes will receive an injection of ul…

This study is testing a new blood test called CRISPR-TB to diagnose tuberculosis (TB) in children more accurately. Current tests often miss TB in kids because they have fewer bacteria. The study will enroll 1,220 children in Bolivia to see if this test can detect TB better than s…

This Phase 3 trial is testing a new skin test called EEC to see how well it detects tuberculosis (TB) infection in people aged 3 and older. The study will compare EEC to existing tests like EC, TB-PPD, and IGRA in about 1,784 participants, including TB patients, healthy people, a…

This study tests whether a 4-week course of the drug bedaquiline can prevent tuberculosis (TB) as well as standard longer treatments. It involves 2,530 people living with HIV and close contacts of TB patients. The goal is to find a safer, easier-to-complete prevention option.

This phase 3 trial tests whether a combination of two antibiotics (bedaquiline and rifampicin) can better prevent leprosy than the current standard single dose of rifampicin. Over 124,000 people living near a leprosy patient in the Comoros will receive either the new two-dose reg…

This study aims to find a shorter, safer treatment for latent tuberculosis (TB) infection to prevent it from becoming active disease. About 1800 adults and children with a positive TB test will try one of several daily pill regimens lasting 1 to 4 months. The goal is to identify …

This study tests whether the drug ORC-13661 can prevent hearing loss in people receiving intravenous amikacin for a lung infection called NTM. About 105 adults will take either a high dose, low dose, or placebo daily for up to 90 days. Researchers will compare hearing changes amo…

This study compares a new 6-week daily rifapentine regimen to the standard 12-16 week rifamycin-based treatment for latent tuberculosis infection (LTBI). The goal is to see if the shorter treatment is just as safe and effective at preventing active TB. About 3,400 people at highe…

This study in Uganda tests whether offering HIV self-testing and PrEP (a daily pill to prevent HIV) at home during routine TB contact tracing can increase HIV prevention. About 2,480 people from households with a TB patient will be randomly assigned to either home-based HIV testi…

This study tests whether giving tuberculosis (TB) prevention drugs immediately to children and teens who live with someone with active TB can stop them from getting infected. About 647 participants aged 5 to 17 will be randomly assigned to receive either immediate treatment or st…

This study tests whether a daily cordyceps sinensis capsule (Bailiing Capsule) can prevent the recurrence of Mycobacterium avium complex (MAC) lung disease in adults who have already been cured. 300 participants will take either the cordyceps capsule or a placebo for 12 months, w…

This study in Bangladesh tests whether giving a single dose of the antibiotic rifampin to people who live with or near leprosy patients can prevent infection. Researchers will use a new fingerprick blood test to measure infection markers before and after treatment. The goal is to…

This study tests whether inhaling a salty mist (3% hypertonic saline) can improve breathing symptoms in people with nontuberculous mycobacterial (NTM) lung disease who haven't yet started antibiotics. About 262 adults will either start the saltwater treatment right away for 6 mon…

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines proven methods to support smoking cessation and improve HIV/TB treatment results. Researchers will enroll 86 daily…

This study tests whether a 6-week exercise program can improve fitness and quality of life in people with nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic lung infection. Researchers will enroll 50 adults aged 40-80 and randomly assign them to start exercise rig…

This study tests whether adding balloon blowing to standard breathing exercises helps children with tuberculosis cough up mucus, reduce shortness of breath, and improve their ability to walk. Thirty-four children aged 8 to 14 will be randomly assigned to either breathing exercise…

This study tests whether adding remimazolam to standard sedation (propofol and alfentanil) can lower the risk of low oxygen levels in high-risk patients during painless tracheoscopy. About 360 participants with serious health conditions (ASA class 3-4) will be randomly assigned t…

This study tests if press-needle ear acupuncture can reduce nausea and vomiting caused by tuberculosis (TB) medicines. About 58 people with TB who experience these side effects will be randomly assigned to receive real ear acupuncture or a placebo. Researchers will compare sympto…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study aims to learn more about non-tuberculous mycobacterial (NTM) infections, which cause repeated lung and other organ infections. Researchers will study up to 1,000 participants to understand the genetics, symptoms, and best treatments for these infections. The study also…

This study follows 150 people with active or latent tuberculosis (TB) to collect blood, sputum, and tissue samples. The goal is to better understand how TB behaves in the body and how the immune system responds. Participants receive standard TB treatment as part of the study, but…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study looks at whether a substance in the blood called soluble PD-1 can help predict if a certain type of lung disease caused by NTM bacteria will get worse. Researchers will follow 500 adults from different countries to see if higher levels of this marker are linked to more…

This study is collecting skin and blood samples from 830 people with chronic inflammatory skin diseases like psoriasis, eczema, and lupus. Researchers want to find biological markers that can predict how well a person will respond to treatment after one year. The goal is to move …

This study will follow 2000 adults in France who are starting treatment for tuberculosis. Researchers will collect health data and samples like blood, urine, and breath over two years to see how well treatments work. The goal is to learn more about TB care and build a biobank for…

This study looks at how different types of mycobacterial infections, including drug-resistant tuberculosis and nontuberculous mycobacteria, change the body's immune response. Researchers will collect blood and other samples from 120 participants, including healthy people and thos…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study compares two strategies for finding undiagnosed tuberculosis (TB) in peri-urban Uganda. One strategy sets up screening at a large health clinic, while the other sends mobile screening teams into local hotspots where TB is thought to be most common. Researchers will tra…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study helps U.S. healthcare centers figure out if patients are getting NTM lung infections from the hospital environment. Researchers will compare germs from patients' lungs with germs from water and dust in the hospital and homes. The goal is to create a standard method to …

This study looks at 80 adults—40 with NTM lung disease (not on antibiotics) and 40 with bronchiectasis alone—to see if their health needs differ. Using questionnaires and simple physical tests, researchers will assess quality of life, nutrition, mood, and muscle strength. The goa…

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This study looks back at 15 years of medical records and will also follow new patients with intestinal tuberculosis to find out which factors—like age, other illnesses, or treatment habits—make death more likely. Researchers will collect data from 500 adults diagnosed with intest…

This study tests whether offering a small cash payment to households can encourage more people to get screened for tuberculosis (TB) in rural Tanzania. Researchers will enroll 360 people recently diagnosed with TB and their families. Half will receive the usual care, and half wil…

This study looks at the bacteria living in the lungs of people with active tuberculosis (TB) and how they change with treatment. Researchers will compare lung bacteria in diseased and healthy areas, and also check the mouth, nose, and gut. They aim to understand how these microbe…

This study aims to understand why some people with tuberculosis (TB) experience a paradoxical reaction, where they initially improve on treatment but then suddenly get worse. Researchers will follow 140 adults with TB, with or without signs of this reaction, using blood tests, ur…

This trial tests whether actively searching for leprosy cases in communities finds more people with the disease than waiting for them to come to clinics. Researchers will raise awareness, train healthcare workers, and use questionnaires and rapid tests in high-risk areas. About 1…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study compares the immune response to COVID-19 vaccines between people being treated for tuberculosis (TB) and healthy individuals. About 133 participants in the Thailand-Myanmar border area will receive one of three vaccines (Pfizer, AstraZeneca, or Janssen). Researchers wi…

This study explores whether measuring tiny DNA fragments from the TB bacteria in the blood can help doctors monitor how well treatment is working. Researchers will enroll 140 adults with newly diagnosed TB in Thailand, taking blood samples over time to see if the DNA levels drop …

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This early-stage study is testing whether a single dose of an experimental antibiotic combination (sulopenem etzadroxil plus probenecid) is safe and tolerable in 12 adolescents already receiving standard antibiotics for a bacterial infection. Researchers will measure how the drug…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at how certain immune cells (monocytes and macrophages) behave in sarcoidosis and tuberculosis. Researchers will compare blood and tissue samples from 100 adults to find patterns that explain why these cells stay overactive in sarcoidosis. The goal is to better u…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis who may also have an NTM infection. Researchers will collect sputum and airway samples from 1000 participants to compare the lung microbiome of those with and withou…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study is investigating whether germs called non-tuberculous mycobacteria (NTM) found in home water systems and dust can cause lung infections in people with cystic fibrosis. Researchers will collect samples from the homes of 120 CF patients—some with NTM infections and some …

This study looks at 750 people who have finished treatment for drug-sensitive tuberculosis. Researchers will test new sputum and blood-based methods to see if they can predict whether the disease will come back within a year. The goal is to find better ways to measure treatment s…

This study looks at how the cholesterol-lowering drug atorvastatin behaves in the body when taken alongside standard tuberculosis (TB) medicines. Researchers will measure drug levels in 80 adults with pulmonary TB to find the best dose of atorvastatin that could help treat TB mor…

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is…

This study tests whether using computer models to personalize tuberculosis (TB) drug doses can help patients reach optimal drug levels faster. Researchers will monitor 30 adults with pulmonary TB who are already on standard treatment. The goal is to see if this approach helps doc…

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is recruiting 100 adults with hard-to-treat nontuberculous mycobacterial (NTM) lung infections to see if phage therapy—using viruses that kill bacteria—can help. Researchers will collect blood and airway samples to find biological markers that show whether the treatmen…

This study aims to find more tuberculosis (TB) cases by improving diagnostic tools already available in local health clinics. About 1,584 adults with TB symptoms in Guinea-Bissau and Ethiopia will be randomly assigned to either standard care or an enhanced testing approach that i…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This study will check the lung health of 50 adults who finished treatment for tuberculosis (TB) in Liverpool, UK, about one year after their treatment ended. Participants will take a breathing test and answer questions about their health and wellbeing. The goal is to find out how…