New trial aims to crack code of Drug-Resistant lung bug

NCT ID NCT04310930

Recruiting now Disease control Sponsor: The University of Queensland Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This clinical trial is testing different combinations of antibiotics to find the best way to treat a lung infection caused by Mycobacterium abscessus, a bacteria that is hard to kill. About 300 adults and children with this infection will receive various drug regimens, including amikacin and tigecycline. The goal is to see which approach clears the infection with the fewest side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Amikacin and tigecycline (antibiotics)

What this could lead to

If successful, this trial could identify the most effective and least toxic antibiotic regimen for a hard-to-treat lung infection, improving clearance rates and quality of life.

What could go wrong

This is a mid-stage trial with 300 participants, so results may not apply to everyone. The antibiotics can cause serious side effects, and the infection may still recur.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

disease lung disorder Mycobacterium Infections, Nontuberculous pulmonary non-tuberculous mycobacterial infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY DISEASE DUE TO MYCOBACTERIA (DIAGNOSIS)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Alder Hey Children NHS Foundation Trust
NOT_YET_RECRUITING

Liverpool, United Kingdom
Austin Hospital
RECRUITING

Heidelberg, Victoria, Australia
Belfast City Hospital
NOT_YET_RECRUITING

Belfast, United Kingdom
Birmingham Children's Hospital
NOT_YET_RECRUITING

Birmingham, United Kingdom
Birmingham Heartlands Hospital
NOT_YET_RECRUITING

Birmingham, United Kingdom
Bristol Royal Hospital for Children
NOT_YET_RECRUITING

Bristol, United Kingdom
Carmel Medical Centre
NOT_YET_RECRUITING

Haifa, Israel
Erasmus MC Sophia Children's Hospital
NOT_YET_RECRUITING

Rotterdam, Netherlands
Gold Coast University Hospital
RECRUITING

Gold Coast, Australia
Greenslopes Private Hospital,
RECRUITING

Greenslopes, Australia
Hadassah Ein Kerem Hospital
NOT_YET_RECRUITING

Jerusalem, Israel
John Hunter Children's Hospital
NOT_YET_RECRUITING

New Lambton Heights, Australia
John Hunter Hospital
NOT_YET_RECRUITING

New Lambton, Australia
Kaohsiung Medical University Hospital
NOT_YET_RECRUITING

Kaohsiung City, Taiwan
Macquarie University Hospital
NOT_YET_RECRUITING

Sydney, Australia
Mater Adult Hospital
RECRUITING

South Brisbane, Australia
National Taiwan University Hospital
NOT_YET_RECRUITING

Taipei, Taiwan
Noah's Ark Childrens Hospital for Wales
NOT_YET_RECRUITING

Cardiff, United Kingdom
Nottingham Children's Hosptial
NOT_YET_RECRUITING

Nottingham, United Kingdom
Perth Children's Hospital
RECRUITING

Perth, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, Australia
Queen Elizabeth University Hospital, Glasgow
NOT_YET_RECRUITING

Glasgow, United Kingdom
Queens Medical Centre
NOT_YET_RECRUITING

Nottingham, United Kingdom
Queensland Children's Hospital
RECRUITING

South Brisbane, Queensland, 4101, Australia

Contact Phone: •••-•••-•••• Email: •••••@•••••
Rambam Health Care Campus
NOT_YET_RECRUITING

Haifa, Israel
Rigshospitalet
RECRUITING

Copenhagen, Denmark
Royal Adelaide Hospital
RECRUITING

Adelaide, Australia
Royal Brompton Hosptial
NOT_YET_RECRUITING

London, United Kingdom
Royal Hospital for Children and Young People, Edinburgh
NOT_YET_RECRUITING

Edinburgh, United Kingdom
Royal Manchester Children's Hospital
NOT_YET_RECRUITING

Manchester, United Kingdom
Royal Melbourne Hospital
RECRUITING

Parkville, Victoria, Australia
Royal Perth Hospital
RECRUITING

Perth, Western Australia, 6000, Australia
Royal Prince Alfred Hospital
NOT_YET_RECRUITING

Camperdown, Australia
Schneider
NOT_YET_RECRUITING

Petah Tikva, Israel
Sheba Medical Centre
NOT_YET_RECRUITING

Ramat Gan Tel Aviv, Israel
Sir Charles Gairdiner Hospital
RECRUITING

Nedlands, Australia
Soroka Medical Centre
NOT_YET_RECRUITING

Beer-Sheeva, Israel
Southampton General Hospital
NOT_YET_RECRUITING

Southampton, United Kingdom
St George Hospital
RECRUITING

Kogarah, New South Wales, Australia
Sunshine Coast University Hospital
RECRUITING

Birtinya, Australia
Sydney Children's Hospital
NOT_YET_RECRUITING

Randwick, Australia
Tan Tock Seng Hospital Pte Ltd
NOT_YET_RECRUITING

Singapore, 308433, Singapore
The Alfred
RECRUITING

Prahran, Australia
The Children's Hospital at Westmead
NOT_YET_RECRUITING

Westmead, Australia
The Prince Charles Hospital
RECRUITING

Chermside, Australia
University Hospital Llandough
NOT_YET_RECRUITING

Penarth, United Kingdom
Welcome Wolfson Adult CF Centre (City Hospital Campus)
NOT_YET_RECRUITING

Nottingham, United Kingdom
Western General Hospital
NOT_YET_RECRUITING

Edinburgh, United Kingdom
Westmead Hospital
NOT_YET_RECRUITING

Westmead, Australia
Wythenshawe Hospital
NOT_YET_RECRUITING

Wythenshawe, United Kingdom