Could nurses replace doctors for TB treatment? major trial underway

NCT ID NCT05671718

Recruiting now Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares nurse-led treatment for drug-resistant tuberculosis (TB) in local clinics to standard doctor-led care in hospitals. About 2,944 people will take part across South Africa. The goal is to see if nurse-led care works just as well, is safe, and lowers costs for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nurse-led treatment (care delivery model)
What this could lead to: If successful, this could make drug-resistant TB treatment more accessible and affordable by shifting care from hospitals to local clinics.
What could go wrong: This is a large trial but still early in testing a new care model. Results may vary by location, and nurse-led care might not match hospital safety or outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DRUG-RESISTANT TUBERCULOSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

AIDS drug-resistant tuberculosis multidrug-resistant tuberculosis rifampicin-resistant tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG-RESISTANT TUBERCULOSIS

Contacts and locations

Locations

Doris Goodwin Hospital
RECRUITING

Pietermaritzburg, KwaZulu-Natal, 3201, South Africa
Jose Pearson Hospital
RECRUITING

Port Elizabeth, South Africa
King Dinuzulu TB Hospital
RECRUITING

East London, South Africa
Murchison Hospital
RECRUITING

Port Shepstone, KwaZulu-Natal, 7007, South Africa
Nkquebela TB Hospital
RECRUITING

East London, South Africa

More trials for these conditions

Other studies related to the condition(s) this trial covers.