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New TB vaccine candidate MTBVAC enters key safety trial in south africa

NCT ID NCT05947890

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: HIV Vaccine Trials Network Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study is testing a new tuberculosis vaccine called MTBVAC in 276 adolescents and adults in South Africa, some of whom have HIV. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants will receive either MTBVAC or the standard BCG vaccine for comparison.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
MTBVAC vaccine (a live, weakened tuberculosis vaccine)
What this could lead to
If successful, this could lead to a safer and more effective TB vaccine for people living with HIV, who are at high risk for TB.
What could go wrong
This is an early phase 2a trial focused on safety and immune response, not yet on preventing TB. The vaccine may not work as hoped, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV I INFECTION TUBERCULOSIS

Contacts and locations

Locations

  • Cape Town - Emavundleni

    TERMINATED

    Cape Town, Western Cape, 7750, South Africa

  • Cape Town - Groote Schuur

    RECRUITING

    Cape Town, Western Cape, 7784, South Africa

  • Cape Town - Khayelitsha

    RECRUITING

    Cape Town, South Africa

  • Cape Town - UCTLI

    RECRUITING

    Cape Town, Western Cape, 7700, South Africa

  • Durban - Botha's Hill CRS

    RECRUITING

    Durban, KwaZulu-Natal, 4001, South Africa

  • Durban - Chatsworth

    RECRUITING

    Chatsworth, South Africa

  • Durban - Isipingo

    RECRUITING

    Isipingo, South Africa

  • Durban - Wentworth

    TERMINATED

    Durban, KwaZulu-Natal, 4052, South Africa

  • Durban eThekwini

    TERMINATED

    Durban, South Africa

  • Johannesburg - CHRU

    RECRUITING

    Westdene, Gauteng, 2092, South Africa

  • Klerksdorp

    RECRUITING

    Klerksdorp, South Africa

  • Ladysmith

    RECRUITING

    Ladysmith, South Africa

  • Rustenburg CRS

    TERMINATED

    Rustenburg, South Africa

  • Soshanguve

    TERMINATED

    Soshanguve, South Africa

  • Soweto - Gauteng

    TERMINATED

    Johannesburg, Gauteng, 1862, South Africa

  • Worcester - SATVI

    RECRUITING

    Worcester, Western Cape, 6850, South Africa

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