New TB cocktails aim to speed up recovery

NCT ID NCT06192160

Recruiting now Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 8 times

Summary

This study tests new combinations of drugs for adults with lung tuberculosis (TB). The goal is to see if these new regimens work faster and are safer than the current standard treatment. About 315 participants will receive either an experimental drug combo or the usual care for 8 weeks, then standard treatment for 18 more weeks. The study tracks how quickly the TB bacteria are cleared from sputum and monitors for side effects.

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Conditions

The condition(s) this trial relates to.

pulmonary tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY TUBERCULOSIS

Contacts and locations

Locations

11101, University of the Witwatersrand Helen Joseph (WITS HJH) CRS
RECRUITING

Johannesburg, 2193, South Africa
11201, Durban International CRS
RECRUITING

Durban, 4091, South Africa
11301, Barranco CRS
RECRUITING

Lima, 1010, Peru
11302, San Miguel CRS San Miguel
RECRUITING

Lima, Peru
12001, Malawi CRS
NOT_YET_RECRUITING

Lilongwe, A-104, Malawi
12101, Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS
RECRUITING

Rio de Janeiro, 21040, Brazil
12201, Instituto de Pesquisas em AIDS do Rio Grande do Sul - IPARGS CRS
RECRUITING

Porto Alegre, 91350, Brazil
12301, Soweto ACTG CRS
RECRUITING

Johannesburg, 1864, South Africa
12401, Joint Clinical Research Centre (JCRC)/Kampala CRS
RECRUITING

Kampala, 10005, Uganda
12501, Kenya Medical Research Institute/Walter Reed Project Clinical Research Center (KEMRI/WRP) CRS
RECRUITING

Kericho, 20200, Kenya
12601, Moi University Clinical Research Center (MUCRC) CRS
RECRUITING

Eldoret, 30100, Kenya
12701, Gaborone CRS
RECRUITING

Gaborone, 0000, Botswana
30022, Les Centres GHESKIO Clinical Research Site (GHESKIO-INLR) CRS
RECRUITING

Port-au-Prince, 6110, Haiti
30293 MU-JHU Research Collaboration (MUJHU CARE LTD) CRS
NOT_YET_RECRUITING

Kampala, 23491, Uganda
30301, Blantyre CRS
NOT_YET_RECRUITING

Blantyre, 265, Malawi
30313, Milton Park CRS
NOT_YET_RECRUITING

Harare, 30313, Zimbabwe
31422, CAPRISA eThekwini CRS
RECRUITING

Durban, 40001, South Africa
31441, Byramjee Jeejeebhoy Medical College (BJMC) CRS
NOT_YET_RECRUITING

Pune, 411001, India
31684, Rustenburg CRS
RECRUITING

Rustenburg, South Africa
31730, GHESKIO Institute of Infectious Diseases and Reproductive Health (GHESKIO - IMIS) CRS
RECRUITING

Port-au-Prince, 6110, Haiti
31784, Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS
RECRUITING

Chiang Mai, 50200, Thailand
31792, University of Cape Town Lung Institute (UCTLI) CRS
RECRUITING

Cape Town, 7700, South Africa
31793, South African Tuberculosis Vaccine Initiative (SATVI) CRS
RECRUITING

Cape Town, 6850, South Africa
31802, Thai Red Cross AIDS Research Centre (TRC-ARC) CRS
RECRUITING

Pathum Wan, 10330, Thailand
31981, TB HIV Innovations and Clinical Research Foundation Corp.
NOT_YET_RECRUITING

Cavite, 4114, Philippines
31985, Socios En Salud Sucursal Perú CRS
RECRUITING

Lima, Lima Province, 15046, Peru
32078, Nutrición-Mexico CRS
NOT_YET_RECRUITING

Mexico City, 14080, Mexico
32483 National Lung Hospital CRS
RECRUITING

Hanoi, 100000, Vietnam
5116 Chiangrai Prachanukroh Hospital NICHD CRS
RECRUITING

Chiang Rai, Changwat Chiang Rai, 57000, Thailand

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