New TB cocktail aims to shorten treatment

NCT ID NCT07672405

Recruiting now Disease control Sponsor: Global Alliance for TB Drug Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 6 times

Summary

This study tests a new combination of three drugs—sorfequiline, pretomanid, and linezolid—in 100 adults with newly diagnosed, drug-sensitive tuberculosis. Participants take the pills daily for 17 weeks. The goal is to see if the combo is safe and can clear the infection faster than standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sorfequiline, pretomanid, and linezolid
What this could lead to: If successful, this could lead to a shorter, simpler treatment regimen for drug-sensitive tuberculosis, potentially reducing side effects and improving cure rates.
What could go wrong: This is an early phase 2b trial with only 100 participants, so results may not apply to everyone. The drugs can cause side effects like nerve damage or vision problems, and the regimen may not work better than current treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBERCULOSIS, PULMONARY

Contacts and locations

Locations

Durban International Clinical Research Site
RECRUITING

Durban, Wentworth, 4052, South Africa
INUKA Africa
NOT_YET_RECRUITING

Dar es Salaam, Tanzania
Isango Lethemba TB Research Unit
RECRUITING

Port Elizabeth, Bethelsdorp, 6200, South Africa
Kibong'oto Infectious Diseases Hospital
NOT_YET_RECRUITING

Moshi, Tanzania
Madiberg Centre for Research
RECRUITING

Brits, North West Provinvce, 0250, South Africa
NIMR-Mbeya
NOT_YET_RECRUITING

Mbeya, Tanzania
NIMRI-Mwanza
NOT_YET_RECRUITING

Mwanza, Tanzania
Perinatal HIV Research Unit, Tshepong Hospital
NOT_YET_RECRUITING

Klerksdorp, Northwest, 2571, South Africa
Setshaba Research Centre
RECRUITING

Soshanguve, Guateng, 0152, South Africa
Synergy Biomed Research Institute
NOT_YET_RECRUITING

East London, 5201, South Africa
The Aurum Institute, Rustenburg
RECRUITING

Rustenburg, North West, 2999, South Africa
University of Capetown Lung Institute
RECRUITING

Cape Town, Mowbray, 7700, South Africa

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