Pee test could spot TB patients skipping meds

NCT ID NCT06526221

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Tufts University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study in India will test a low-cost urine check (IsoScreen) on 900 adults being treated for tuberculosis. The test detects whether they have taken their medication recently. Researchers want to see if the test can reliably find people who are missing doses, so that doctors can offer extra help. The goal is to reduce deaths, treatment failure, and TB coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: urine isoniazid test (IsoScreen)
What this could lead to: If successful, this could give doctors a cheap, quick way to spot when TB patients miss their pills, allowing them to offer extra support and reduce deaths or relapse.
What could go wrong: This is an observational study, not a treatment trial. The test may not work well in routine clinic visits, and even if it detects missed doses, it may not improve outcomes on its own.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Medication Adherence pulmonary tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MEDICATION ADHERENCE TUBERCULOSIS, PULMONARY

Contacts and locations

Locations

ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)

Chennai, Tamil Nadu, India
ICMR-National Institute for Research in Tuberculosis (ICMR-NIRT)

Thanjavur, Tamil Nadu, India

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