DNA test could revolutionize treatment for Drug-Resistant TB

NCT ID NCT05553236

Recruiting now Diagnosis Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a DNA sequencing test can help doctors choose the right antibiotics for people with drug-resistant tuberculosis (TB). Researchers will collect samples from 2,500 participants in clinics and use targeted sequencing to identify which drugs the TB bacteria are resistant to. The goal is to reduce time on ineffective drugs and improve cure rates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: targeted next-generation sequencing (diagnostic test)
What this could lead to: If successful, this approach could help doctors choose the most effective drugs for drug-resistant TB sooner, improving cure rates and reducing ineffective treatment.
What could go wrong: This is a diagnostic strategy, not a new drug, so its impact depends on how well it integrates into real-world clinics. The trial is still recruiting, and results may vary by setting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coinfection drug-resistant tuberculosis HIV infectious disease multidrug-resistant tuberculosis rifampicin-resistant tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COST-BENEFIT ANALYSIS DRUG-RESISTANT TUBERCULOSIS HIV COINFECTION

Contacts and locations

Locations

South African National Health Laboratory Service
RECRUITING

Cape Town, South Africa

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