Bacterial infectious disease

This trial compares different surgical and antibiotic approaches to treat infections in artificial hip and knee joints. It tests whether cleaning the joint while keeping the implant in place (DAIR) or replacing the joint entirely leads to better cure rates. It also examines wheth…

This study compares two oral treatments for trichomonas, a common sexually transmitted infection. About 1,200 women and men with a positive test will receive either a single dose of secnidazole or multiple doses of metronidazole over several days. The goal is to see which approac…

This study tests whether a vaccine can prevent C. difficile infection in adults 65 and older. About 32,000 participants will receive either the vaccine or a placebo shot. The study will track infections and side effects over up to three and a half years.

This first-in-human trial tests an experimental vaccine called LTB-NG6, designed to protect against gonorrhea. The study will enroll healthy adults aged 18-50 to evaluate the vaccine's safety and its ability to trigger an immune response. Participants will receive either the vacc…

This first-in-human trial tests a new vaccine designed to protect against Group A Streptococcus (Strep A), a bacteria that can cause sore throats, skin infections, and more serious illnesses. Healthy adults aged 18 to 25 will receive one of two vaccine formulations, each with a d…

This Phase 3 trial tests a new vaccine designed to protect infants aged 3 to 5 months against four strains of meningococcal bacteria that cause meningitis and sepsis. About 880 healthy babies will receive either the experimental vaccine or a licensed comparator vaccine. Researche…

This Phase 3 trial tests a new vaccine against four types of meningococcal bacteria (A, C, Y, W135) that cause meningitis. About 1,040 healthy infants aged 6 to 11 months will receive either the experimental vaccine or a licensed comparator. Researchers will measure immune respon…

This study tests a new vaccine to protect young children (12-23 months old) against four types of meningococcal bacteria that can cause meningitis. About 1,040 toddlers will receive either the new vaccine or an existing one to see if the new vaccine is as safe and effective. The …

This study tests a new pneumococcal vaccine in about 2400 healthy infants starting at 2 months old. The goal is to see if the new vaccine is as safe as the current vaccine, Prevnar 20, and if it can protect against more types of bacteria that cause pneumonia, meningitis, and ear …

This trial evaluates an experimental vaccine called 20vPnC, designed to protect against 20 types of pneumococcal bacteria. Healthy infants aged 42 to 98 days will receive either 20vPnC or the approved 13vPnC vaccine at 2, 4, 6, and 12-15 months. The study aims to compare safety a…

This study tests a new vaccine (PCV24) designed to protect against 24 types of pneumococcal bacteria, which can cause pneumonia, meningitis, and ear infections. The trial includes 854 healthy people aged 2 months and older, split into two phases to check safety and immune respons…

This early-stage study tests a new pneumococcal vaccine booster in 45 toddlers aged 12-15 months who already received their routine pneumonia shots. The goal is to check for side effects like tenderness, fever, and sleepiness. The study compares the new vaccine to an existing one…

This study will monitor the safety of the MenQuadfi vaccine in 706 people aged 6 weeks to 55 years in South Korea. Researchers will track side effects like injection-site reactions and serious adverse events as the vaccine is used in real-world clinics. The goal is to confirm the…

This trial tests a new oral cholera vaccine called PanChol in healthy adults aged 18 to 55 in Zambia. The vaccine is designed to be safer and more effective than current options. Researchers will monitor participants for side effects and measure their immune response after vaccin…

This study tests a new quadrivalent Pan-Salmonella vaccine designed to protect against several types of Salmonella bacteria that cause typhoid and paratyphoid fevers. Healthy adults aged 18 to 45 in Africa receive either a low or full dose of the vaccine, with or without an adjuv…

This study tests a new pneumococcal vaccine in healthy infants to see if it is safe and works better than the current vaccine. About 3,230 babies will receive either the new vaccine or the existing one at routine checkups. Researchers will compare side effects and immune response…

This study tests a new pneumococcal vaccine (PG4) in healthy children aged 15 months to 18 years. About 1,200 participants will receive either the new vaccine or the current Prevnar 20. Researchers will compare safety and immune response over 6 months. The goal is to see if the n…

This early-stage trial tests a new vaccine called VAX-A1 in 80 healthy adults aged 18-40. The vaccine aims to prevent infections caused by Group A Streptococcus bacteria, which can cause strep throat and more serious illnesses. The study focuses on safety and immune response, wit…

This study tests whether a fifth dose of Pfizer's Lyme disease vaccine (VLA15) is safe and boosts immunity in people who already received four doses. About 1,700 healthy volunteers aged 7 and older will get either the vaccine or a saltwater shot. Researchers will compare side eff…

This study tests a new vaccine designed to prevent urinary tract infections (UTIs) caused by E. coli bacteria. Researchers will check safety and immune response in 448 adults aged 18-64, and then see if it works in women of the same age. Participants receive either the vaccine or…

This study is testing a new vaccine called iNTS-TCV in 537 infants in Africa. The vaccine is designed to protect against two serious bacterial infections: invasive nontyphoidal salmonella (iNTS) and typhoid fever. Researchers are giving the vaccine to infants starting at either 6…

This study tests whether a two-shot pneumonia vaccine series (PCV20 and PPSV23) can help people with chronic lymphocytic leukemia (CLL) build a stronger immune defense against pneumococcal infections. About 61 adults with CLL who have not yet had treatment, or who are on a specif…

This study tests a new mRNA vaccine designed to prevent chlamydia, a common sexually transmitted infection. About 1,560 adults aged 18 to 29 who are at higher risk of infection will receive either a low, medium, or high dose of the vaccine or a placebo. Researchers will monitor s…

This early-stage trial is testing a new vaccine called DX-104 to see if it is safe and triggers an immune response against group B meningococcal bacteria, which can cause meningitis. The study involves 30 healthy adults aged 18 to 50 who will receive either the new vaccine or an …

This study tests a new cholera vaccine (OSP:rTTHc CCV) in 390 healthy adults and children aged 1 to 45 in a region where cholera is common. The goal is to see if the vaccine is safe and triggers a strong immune response. Some participants get the vaccine with or without an adjuva…

This study in Nairobi, Kenya, is testing whether giving the oral cholera vaccine Euvichol-S at longer intervals (3 months or 12 months) works as well as the standard 2-week schedule. Over 1,000 healthy participants aged 1 year and older will be randomly assigned to one of three d…

This study is testing a new tuberculosis vaccine called MTBVAC in 276 adolescents and adults in South Africa, some of whom have HIV. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants will receive either MTBVAC or the standard BCG vaccin…

This Phase 3 trial is testing a new 13-valent pneumococcal conjugate vaccine (PCV13) in over 3,000 healthy infants and children aged 6 weeks to 5 years. The goal is to see if the vaccine is safe and triggers a strong immune response compared to an existing vaccine. If it works, i…

This study tests a new vaccine (PCV24) designed to protect children aged 2 to 23 months against 24 types of pneumococcal bacteria, which can cause serious infections like pneumonia and meningitis. Around 180 healthy children will receive either the new vaccine or an existing one …

This study tests a new oral cholera vaccine (Biovac OCV-S) to see if it works as well as a currently approved vaccine (Euvichol-Plus). About 2,824 healthy people aged 1 to 45, including some adults living with HIV, will receive two doses. Researchers will check immune responses a…

This study tests a new drug called AZD7760 in healthy volunteers and people with end-stage kidney disease who are on dialysis. The goal is to see if the drug is safe and how the body processes it. If it works, it could help prevent serious staph infections that often occur in dia…

This study investigates whether inhaling the antibiotic amikacin can better treat pneumonia caused by gram-negative bacteria in patients on veno-arterial ECMO (a heart-lung bypass machine). Standard antibiotics often fail in these patients, possibly because the bypass reduces blo…

This study tests a new combination of three drugs—sorfequiline, pretomanid, and linezolid—in 100 adults with newly diagnosed, drug-sensitive tuberculosis. Participants take the pills daily for 17 weeks. The goal is to see if the combo is safe and can clear the infection faster th…

This trial tests whether a simpler dental procedure called pulpotomy works as well as the standard pulpectomy for treating severe tooth decay in children's baby molars. Pulpotomy removes only the infected part of the pulp and seals it, while pulpectomy removes the entire pulp and…

This study tests how the drug rifaximin (Xifaxan) works in children aged 6 to 11 with acute diarrhea likely caused by bacteria. Half the children get the drug plus oral rehydration therapy, the other half get rehydration alone. Researchers want to see if adding the drug helps dia…

This study tests new combinations of drugs for adults with lung tuberculosis (TB). The goal is to see if these new regimens work faster and are safer than the current standard treatment. About 315 participants will receive either an experimental drug combo or the usual care for 8…

This phase 2 trial tests an oral drug called ibezapolstat in 20 people who have had three or more C. diff infections in the past year. The goal is to see if the drug can cure the current infection and reduce the chance of it coming back. Participants will take the drug twice a da…

This trial tests whether using a blood marker called procalcitonin (PCT) to guide antibiotic decisions can safely shorten treatment duration in children with bacterial infections in intensive care. About 296 children will be randomly assigned to either PCT-guided care or standard…

This study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 9…

This study tests a new treatment called FB301 in 120 women aged 18-45 with bacterial vaginosis (BV). Before FB301, some women will receive an antibiotic or a vaginal wash to see if that helps restore healthy bacteria. The goal is to improve the balance of good bacteria in the vag…

This trial tests whether using calcium hypochlorite or sodium hypochlorite to clean the pulp wound during a partial pulpotomy can improve the success of saving painful, deeply decayed permanent molars. Adults aged 18-40 with symptomatic irreversible pulpitis will undergo the proc…

This study tests whether adding doxycycline to the standard penicillin shot works better for treating early syphilis in people with HIV. About 688 adults will be randomly assigned to get either penicillin alone or penicillin plus a week of doxycycline pills. The main goal is to s…

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This trial is testing whether a 4-month treatment for drug-sensitive pulmonary tuberculosis works as well as the standard 6-month regimen. The study involves 270 adults with newly diagnosed TB. If the shorter course proves effective, it could make treatment easier to complete and…

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complicat…

This study tests whether a new drug called TBD09, when used with other TB medicines, is safe and works well in adults with drug-sensitive tuberculosis (TB). About 150 people will take part. The main goals are to see how quickly the drug combination kills TB bacteria and to check …

This trial investigates how a weekly TB prevention regimen (rifapentine and isoniazid) affects levels of the HIV drug dolutegravir in children living with HIV. Researchers will measure drug concentrations in the blood to see if the combination remains safe and effective. The stud…

This trial compares two oral antibiotics—trimethoprim-sulfamethoxazole (TMP-SMX) and clindamycin—to see which works better for children with invasive MRSA infections, such as bone, joint, or deep tissue infections. About 100 children aged 60 days to 18 years will take one of the …

This study compares a dental procedure called direct pulp capping for two types of deep cavities in adult molars: deep and extremely deep. The goal is to see if the treatment works equally well for both, measuring success by tooth survival, lack of pain, and healing on X-rays. Pa…

This study compares two antibiotic approaches for a serious heart valve infection caused by staph bacteria. One group gets a standard treatment that includes the drug rifampin, while the other group gets a treatment without it. The goal is to see if skipping rifampin is just as e…

This early-stage trial tests MP101, a mix of two viruses that attack bacteria (phages), in 18 adults with Pseudomonas aeruginosa pneumonia. Participants receive a single dose of MP101 or a placebo alongside standard antibiotics. The main goal is to check safety and how the body h…

This study tests whether a digital health program—short videos and text message reminders—can help close contacts of tuberculosis patients start and complete preventive treatment. Researchers in South Ethiopia will enroll 304 people and compare those who get the digital intervent…

This trial compares a steam mask — a fabric mask with self-hydrating beads heated in a microwave — to the traditional warm compress (a towel soaked in warm water) for treating chalazion, a common eyelid lump, in children aged 5 to 16. Researchers will measure whether the steam ma…

This study compares two doses of the antibiotic ceftriaxone—500 mg versus 1000 mg—given as a single shot to treat uncomplicated gonorrhea. Researchers want to see if the lower dose works just as well, which could mean fewer side effects and less antibiotic use. The trial involves…

This trial investigates whether giving the protein albumin together with standard intravenous fluids during the first hours of treatment can reduce deaths in people with septic shock. About 2,400 adults arriving at emergency departments with septic shock will be randomly assigned…

This first-in-human trial tests an experimental drug called CTX-187 for safety and tolerability. It starts with healthy volunteers to assess single and multiple doses, then moves to patients with bronchiectasis who have a chronic Pseudomonas infection. The goal is to see if the d…

This phase 1 study tests whether inhaling high doses of the antibiotic isoniazid is safe and tolerable for people with tuberculosis. Eight adults with known drug-sensitive TB will receive single inhaled doses of 200, 600, and 1200 mg, plus one intravenous dose for comparison. Res…

This registry study is following 200 adults with sepsis or septic shock who receive ARTICE® therapy in the ICU. Researchers are tracking organ function, survival, and complications to see how well the treatment works in everyday practice. The goal is to identify which patients be…

This study tests whether transplanting healthy gut bacteria from a donor can help clear a hard-to-treat H. pylori infection. Adults aged 18 to 70 who have failed at least four standard treatments will receive a fecal microbiota transplant through the anus. The goal is to see if t…

This study tests whether a 4-week course of two TB drugs works as well as the standard 3-month course to prevent active TB in students and staff who have been exposed. About 3,520 people from schools will take either the short or standard regimen. The goal is to see if the shorte…

This trial tests a special bone graft that releases the antibiotic tobramycin to treat infected knee replacements. The graft is placed during the first stage of revision surgery, with the goal of clearing the infection and promoting new bone growth. About 200 adults with infected…

This trial investigates whether adding antibiotics (vancomycin and tobramycin) to bone graft material during hip replacement surgery can reduce the risk of serious joint infections. The study includes adults undergoing hip replacement who need bone graft, comparing those who rece…

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolv…

This trial tests whether using infection surveillance data to guide antibiotic selection can reduce antibiotic resistance in hospitalized cirrhosis patients with bacterial infections. About 198 adults with decompensated cirrhosis and a confirmed or suspected infection will be ran…

This study tests whether transplanting vaginal fluid from healthy donors can restore a healthy bacterial balance in women with recurrent bacterial vaginosis (BV). Participants receive either the transplant or a placebo after antibiotic treatment. The goal is to see if the transpl…

This study tests whether a peer-led education program helps adults with drug-susceptible tuberculosis complete treatment successfully. Researchers in southern Ethiopia will enroll 250 adults and provide structured education, counseling, and follow-up from trained peers. The goal …

This trial tests a new antibiotic eye drop called SUM-191 for bacterial conjunctivitis (pink eye). It has three parts: first, healthy volunteers get a single dose to check safety; second, healthy volunteers get multiple doses for 6 days; third, patients with pink eye get the drop…

This study tests two different drug combinations for pleural infection, a serious infection of the lung lining that often requires surgery. The standard treatment uses two drugs (alteplase and DNase) given through a chest tube. This trial compares that to a new combination using …

This Phase III trial in sub-Saharan Africa tests whether giving higher doses of rifampicin plus linezolid, along with aspirin, can reduce deaths from tuberculous meningitis (TBM) in both HIV-positive and HIV-negative people. About 768 adolescents and adults will receive either th…

This trial investigates whether specially grown immune cells, called pathogen-specific cytotoxic T lymphocytes (CTLs), can safely and effectively treat stubborn infections like EBV, CMV, and adenovirus in people with weakened immune systems, such as stem cell or organ transplant …

This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2…

This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The stud…

This study tests whether the antibiotic rifabutin can improve treatment for people with a stubborn lung infection caused by Mycobacterium abscessus that has become resistant to the common antibiotic clarithromycin. Researchers will enroll 60 adults with active lung disease and me…

This study looks at whether the position of a deep cavity (on the chewing surface or between teeth) affects how well a tooth-saving procedure called direct pulp capping works. Researchers will treat 154 people aged 15-40 with reversible pulpitis, a condition where tooth pain goes…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This phase 2 trial tests whether adding the antibiotic doxycycline to standard treatment can reduce deaths and severe brain damage in adults with tuberculosis of the brain or its lining. About 200 participants will receive either doxycycline or a placebo for 8 weeks, alongside us…

This study tests three ways to give the antibiotic vancomycin during knee replacement surgery: into the joint, into the bone, or through a vein. The goal is to see if the simpler joint injection works as well as the others to prevent serious infections. Thirty adults having a fir…

This pilot study tests whether adding fludrocortisone (a steroid pill) to standard hydrocortisone treatment helps people with septic shock. Only 32 critically ill adults will take part. The main goal is not to see if the combo works, but to check if a larger, more definitive tria…

This study compares a 6-month treatment using high doses of four antibiotics against the standard 9-month therapy for tuberculous meningitis, a serious brain infection. About 330 adults and teens without HIV will take part. The goal is to see if the shorter regimen is as safe and…

This study compares two pneumococcal vaccination strategies in 160 adults with lymphoma who have had chemotherapy. One group gets two vaccines (Prevenar 13 followed by Pneumovax 23), while the other gets a single newer vaccine (Prevenar 20). Researchers will measure immune respon…

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the othe…

This study tests whether a new surgical irrigation solution called XPERIENCE can lower the risk of joint infection after hip or knee replacement better than the standard dilute Betadine wash. About 7,600 adults having primary hip or knee replacement will be randomly assigned to r…

This study tests four approaches to help adults with drug-resistant tuberculosis and HIV stick to their treatments. Participants receive either standard care, counseling, phone reminders via a special pill bottle, or both counseling and reminders. The goal is to see which method …

This study is testing whether the BCG vaccine, originally developed for tuberculosis, can safely treat Mycobacterium avium complex (MAC) lung disease. Researchers will give 48 adults either a single BCG injection or a placebo and monitor them for side effects, immune responses, a…

This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The stu…

This study tests whether a non-invasive ultrasound device, aimed at the spleen, can safely reduce dangerous inflammation in people with septic shock. Septic shock is a life-threatening condition where the body's response to infection causes organ damage. Forty adults in the inten…

This study is testing a new medical device called the REMEDY SPECTRUM GV IM Spacer Nail for treating ankle-related infections. About 60 adults with ankle infections will receive the nail and be followed for 6 months. The goal is to see if the nail safely clears the infection and …

This study tests whether giving children with a severe E. coli infection extra fluids through an IV can prevent kidney failure. About 1,040 children aged 9 months to 21 years will take part. The goal is to see if this simple approach reduces the need for dialysis or long-term kid…

This phase 3 trial compares a 5-day course of the antibiotic flucloxacillin to the standard 7-day course for adults with leg cellulitis. About 334 participants will receive either 5 days of active drug plus 2 days of placebo, or 7 days of active drug. The goal is to see if the sh…

This study is testing whether a drug called tadalafil (often used for erectile dysfunction) combined with a home cycling program can help boys with Duchenne muscular dystrophy. The drug aims to improve blood flow to muscles, which is often poor in DMD, while exercise builds stren…

This study tests whether adjusting the dose of the antibiotic linezolid based on regular blood tests can reduce harmful side effects in people being treated for multidrug-resistant tuberculosis (MDR-TB). The trial will enroll 150 patients in Guinea who are on a standard 6-month r…

This clinical trial is testing different combinations of antibiotics to find the best way to treat a lung infection caused by Mycobacterium abscessus, a bacteria that is hard to kill. About 300 adults and children with this infection will receive various drug regimens, including …

This study looks at whether treating a common stomach infection (H. pylori) can improve symptoms and lung function in people with COPD. Researchers will give standard antibiotic therapy to 54 H. pylori-positive COPD patients and then measure changes in their breathing tests and s…

This study tests whether taking a short course of antibiotics (ciprofloxacin) after Botox injections into the bladder can reduce the chance of urinary tract infections. About 160 adults with neurogenic overactive bladder (due to conditions like multiple sclerosis or spinal cord i…

This study tests whether adding bismuth to a 14-day course of vonoprazan and amoxicillin works better at clearing H. pylori infection than the two-drug regimen alone. About 990 adults who have not been treated before will take part. The main goal is to see which approach eradicat…

This study tests whether tinidazole, a drug already approved for other infections, can cure Mycoplasma genitalium in men with urethritis. About 40 men will take the medication and be checked 21 days later to see if the bacteria are gone. The goal is to find a new treatment option…

This study tests a drug called epetraborole for people with a chronic lung infection caused by Mycobacterium abscessus. About 84 adults will take either a low or high dose of the drug or a placebo for 84 days. Researchers will check if symptoms improve and if the infection clears…

This study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well…

This study tests whether offering small financial rewards and using video calls to watch people take their medicine can help more people complete treatment for latent tuberculosis. About 399 adults in Baltimore will be randomly assigned to usual care, video check-ins alone, or vi…

This study tests a new hip replacement device coated with silver to see if it can prevent infections in people at high risk, such as those with diabetes or weak immune systems. About 70 participants will receive the implant and be followed for infection rates and silver safety. T…

This early-stage study tests whether a mixture of viruses (called phages) that specifically kill E. coli bacteria is safe for people with spinal cord injuries who have bacteria in their bladder. Thirty adults will receive the phage solution directly into the bladder twice daily f…

This study tests whether a microbiome therapy—a capsule of healthy gut bacteria—can reduce drug-resistant bacteria living in the gut of hospitalized patients. About 40 adults who carry these superbugs will receive either the therapy or a placebo. The goal is to see if the treatme…

This study provides free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15-26 in New Orleans. Those who test positive can get treatment at no cost and are encouraged to bring their partners. The goal is to reduce STI rates and health disparities in this c…

This study looks at 600 adults with infections caused by a hard-to-treat bacteria called Pseudomonas aeruginosa. Researchers will compare newer and older antibiotics to see which works best to cure the infection. The goal is to find the most effective treatment for these dangerou…

This study tests whether penicillin works better than the usual antibiotic cloxacillin for people with a Staph blood infection that is sensitive to penicillin. About 420 adults will be randomly assigned to one of the two treatments. The main goal is to see who survives 90 days wi…

This study tests whether adding hyperbaric oxygen treatment (breathing pure oxygen in a pressurized chamber) to standard care can lower the death rate in people with severe, fast-spreading soft-tissue infections. About 1,480 adults with surgically confirmed infection will be rand…

This study is testing a 14-day treatment for Helicobacter pylori, a stomach infection that can cause ulcers and cancer. The treatment uses two drugs, vonoprazan and clarithromycin, and is guided by a stool test to check if the bacteria are resistant to clarithromycin. The goal is…

This trial is testing whether a 7-day course of doxycycline works as well as the standard 14-day course for people with multiple erythema migrans, a sign of early Lyme disease. About 200 participants will be randomly assigned to one of the two treatment durations. Researchers wil…

This study tests whether taking capsules made from healthy donor stool (fecal microbiota transplantation, or FMT) can prevent another bout of C. diff infection in people who have had it come back at least twice. 76 adults will receive either active FMT capsules or placebo, and re…

This study compares two treatments for H. pylori infection, a common stomach bug. One uses a newer drug called tegoprazan, while the other uses a standard proton pump inhibitor. The trial will enroll 400 adults in South Korea, where antibiotic resistance makes treatment difficult…

This study compares two antibiotic treatments for H. pylori, a stomach infection. 600 adults will get either a 10-day standard treatment or a 7-day treatment tailored to their bacteria's drug resistance. The goal is to see which approach eradicates the infection more effectively.

This study looks at how well a 14-day course of tegoprazan (a stomach acid reducer) combined with two antibiotics works to clear H. pylori infection. About 200 adults who need a stomach scope will take the treatment, and researchers will check if the bacteria are gone using a bre…

This study tests whether giving the drug norepinephrine early and adjusting the dose quickly can improve survival in adults with septic shock. Researchers will compare this approach to standard care with a placebo. Six hundred participants will be monitored for 28 days to see if …

This study tests whether a newer acid-reducing drug (vonoprazan) works better than a standard one (esomeprazole) for clearing H. pylori, a bacteria that can cause stomach ulcers and indigestion. About 80 adults with H. pylori will take one of the two drug combinations for 14 days…

This study looks at whether a special blood filter called oXiris helps people with septic shock and kidney failure survive. Researchers will review medical records of 360 adults in the ICU who needed continuous blood filtering. They will compare those who got the oXiris filter wi…

This study compares two fluids—sodium lactate and a concentrated saline solution—in 40 adults with septic shock. The goal is to see which one better supports blood flow and acid balance. Participants will receive either fluid in a double-blind setup, and researchers will measure …

This study tests whether plasma transfusion and a blood-filtering procedure called hemoperfusion can prevent lung damage and death in people with leptospirosis, a bacterial infection spread by animals. Researchers will also check if a blood marker called CFI can predict who will …

This trial tests two surgical methods for repeat eyelid surgery in people with trichiasis, a condition where eyelashes rub against the eye. About 1,000 participants in Tanzania will receive either the B-RAP or BLTR procedure. The goal is to see which technique better prevents eye…

This study tests a special wound dressing made from pig tissue (Cytal Wound Matrix and MicroMatrix) to see if it helps heal wounds from necrotizing fasciitis (a severe flesh-eating infection) faster than standard dressings. Fifty adults with large wounds (at least 30 cm²) will be…

This pilot study tests whether a mild electrical pulse to the ear (vagus nerve stimulation) can reduce inflammation and improve heart rate balance in people with septic shock. 34 participants will be randomly assigned to receive either active stimulation or a sham (placebo) for 4…

This study looks at whether giving antibiotics to children with a certain type of Shigella infection (non-dysentery watery diarrhea) helps them recover faster and grow better. About 700 children in Bangladesh and Zambia will receive either azithromycin or a placebo. Researchers w…

This study tests a new way to help doctors in Mozambique and Zambia decide if a sick child has tuberculosis (TB). The approach uses simple checklists and decision guides, supported by a computer system, to improve diagnosis and treatment, especially for children with HIV or sever…

This study tests whether a single surgery to replace an infected artificial knee works as well as the standard two-surgery approach. About 153 patients with a chronic knee infection will be randomly assigned to one of the two treatments. Researchers will track pain, function, and…

This study looks at whether switching from aspirin to clopidogrel (another blood thinner) can reduce heart complications in people with a serious staph bloodstream infection. About 300 adults already taking aspirin for heart disease will be randomly assigned to stay on aspirin or…

This study is testing whether a powerful antibiotic called piperacillin/tazobactam can be given as a continuous shot under the skin instead of through an IV line. About 240 adults with serious bacterial infections will be randomly assigned to receive the drug either subcutaneousl…

This study tests whether giving several fecal transplants (instead of just one) works better to clear repeat C. diff infections in people with ulcerative colitis. About 64 adults with active colitis and repeat C. diff will receive either one or multiple infusions of healthy donor…

This study is testing two different ways of giving a combination of two antibiotics (ceftazidime-avibactam and aztreonam) to treat serious infections caused by bacteria that are resistant to many drugs. The researchers want to see if giving the drugs one after the other works as …

This study tests whether adding a special virus mixture (phage therapy) to standard antibiotics can improve outcomes for people with a serious heart valve infection called infective endocarditis. About 30 participants will receive either the phage therapy or a placebo alongside t…

This study tests whether a heart-lung bypass machine (ECMO) can help children with severe septic shock survive. Researchers will enroll 60 children and track how many leave the hospital alive. They also want to find the best time to start ECMO and which factors affect success.

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part,…

This pilot study tests whether giving angiotensin II early in the emergency department can help stabilize blood pressure in patients with septic shock. Twenty adults who need a standard drug called norepinephrine will receive angiotensin II as an add-on. The main goal is to see i…

This study tests whether applying Prontosan antimicrobial gel to the skin during shoulder replacement surgery can reduce bacteria that might cause infections. It involves 60 adult men having their first shoulder replacement. Researchers will compare infection-related bacteria lev…

This study tests whether giving oral antibiotics instead of IV antibiotics is just as safe and effective for patients with common infections like pneumonia, urinary tract infections, and cellulitis. About 4,000 adults in Danish emergency rooms will be randomly assigned to start o…

This 6-month study tests whether a daily D-Mannose drink mix (FLUSH) can help women with a history of recurrent UTIs have fewer infections and better urinary health. About 210 adult women will be randomly assigned to one of three groups. Researchers will track how long it takes f…

This study tests whether taking a daily probiotic capsule (Lactobacillus rhamnosus GG) for six weeks after surgery can improve immune markers and recovery in people treated for a hip or knee joint infection. About 152 adults aged 18–90 will be enrolled. Researchers will measure b…

This study tests whether giving two steroids—hydrocortisone and fludrocortisone—for up to 7 days can lower the risk of death in adults with septic shock. About 336 patients will be randomly assigned to receive either the steroid combo or standard care alone. The main goal is to s…

This study tests a new way to treat H. pylori, a bacteria that can cause stomach ulcers and cancer. During an endoscopy, doctors fill the stomach with a saltwater solution that is activated by argon plasma to kill the bacteria. The trial will compare two methods of making this so…

This study tests a new drug called AV-001 in 120 hospitalized adults with pneumonia who need extra oxygen. The drug is given daily for up to 28 days alongside standard care. The goal is to see if it is safe and helps patients recover faster from pneumonia caused by COVID-19 or ot…

This study tests custom-made, 3D-printed hip implants for 15 adults whose previous hip replacements failed due to severe bone loss or infection. The implants are designed from CT scans to fit each person's unique bone damage. Researchers will track complications, pain, mobility, …

This early study tests whether a lactic acid gel (Phexxi) used twice weekly can change the vaginal microbiome to help prevent recurrent bacterial vaginosis and yeast infections. 22 premenopausal women with a history of these infections will use the gel for 4 weeks. Researchers wi…

This study is testing whether transplanting stool from a healthy donor into the colon can prevent recurrent C. diff infections. The procedure, done via colonoscopy, aims to restore good bacteria that keep C. diff in check. Researchers are tracking 500 people to see if this stops …

This study compares two dental procedures to treat deep cavities in back molars that have moderate pulpitis (inflamed tooth nerve). In one method, the dentist removes only part of the decay and places a protective material over the remaining decay. In the other, all decay is remo…

This study tests whether people with asymptomatic tuberculosis (TB) can be treated effectively with a shorter course of standard antibiotics—17 weeks instead of the usual 6 months. Researchers will compare the shorter regimen to standard treatment in 426 participants in China. Th…

This study tests a newer acid-blocking drug (vonoprazan) against a standard one, each combined with vitamin D or probiotics, to treat H. pylori infection. About 66 adults with confirmed H. pylori will receive one of three treatments for two weeks. The goal is to see which combina…

This study compares a 48-hour course of antibiotics to a standard 7-day course for people with severe, life-threatening skin infections called necrotizing soft tissue infections. Researchers want to see if the shorter treatment is just as safe and effective. The trial will enroll…

This study tests whether giving vasopressin early, along with norepinephrine, is better than waiting to use it as a rescue treatment for people with septic shock. About 2,800 critically ill adults will be randomly assigned to one of two strategies. The main goal is to see which a…

This pilot study is testing whether giving activated charcoal within 6 hours of swallowing a poisonous substance can prevent the poison from getting worse and shorten hospital stays. About 100 adults and children who have ingested a substance that charcoal can absorb will be rand…

This study tests whether a simpler way of dosing the antibiotic vancomycin (targeting a trough level of 10-15 mg/L) works as well as the more complex method (targeting AUC/MIC 400-600) for treating serious MRSA infections. About 700 adults with infections like bloodstream, lung, …

This study compares two 14-day antibiotic treatments for Helicobacter pylori infection, a common stomach bug that can cause ulcers. The triple therapy uses bismuth, amoxicillin, and vonoprazan, while the quadruple therapy adds rabeprazole, tetracycline, and metronidazole. Researc…

This study tests three different antibiotic combinations to treat a dangerous, drug-resistant bacteria called CRAB that causes infections in intensive care patients. Researchers will compare colistin combined with either fosfomycin, ampicillin/sulbactam, or eravacycline in 108 su…

This study tests whether a higher dose of the antibiotic rifampicin (1800 mg daily) is safe and works better than the standard dose for adults with pulmonary tuberculosis. About 164 participants will be randomly assigned to either the optimized or standard dose. Researchers will …

This study tests three different 14-day treatments for H. pylori, a bacteria that can cause stomach ulcers and cancer. About 390 infected adults will receive either a new triple therapy with bismuth, a dual therapy, or a standard treatment. The goal is to see which works best and…

This study tests three different anti-ulcer medications (Dexlansoprazole, Lansoprazole, and Vonoprazan) combined with two antibiotics (Levofloxacin and Amoxicillin) to see which works best for eradicating H. pylori infection. About 942 adults in Pakistan with H. pylori will take …

This study tests a new inhaled medicine called RESP30TB in 24 adults with newly diagnosed, drug-sensitive tuberculosis of the lungs. The main goals are to see if the drug is safe and how well it kills TB bacteria in the early days of treatment. Participants will inhale the drug a…

This study looks at whether the antibiotic clindamycin works as well as other drugs for treating Streptococcus infections in artificial joints. Researchers will compare success rates in 260 adults who had surgery for this infection. The goal is to see if clindamycin can be a good…

This study is testing a special silver coating on hip implants to see if it can prevent infections after revision hip replacement surgery. The trial will enroll 268 adults who need a hip revision due to a chronic infection. Participants will receive either the coated implant or a…

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study compares two dental treatments—pulpotomy and pulpectomy—for deep cavities in baby teeth that cause pain. About 40 children aged 4 to 6 will receive one of the treatments. Researchers will check x-rays and symptoms to see which approach works better and is more comforta…

This study tests a micropulse laser for diabetic macular edema, a condition causing vision loss in people with diabetes. Fifty participants with initial or stubborn swelling will receive the laser treatment. Researchers will measure changes in vision and retinal thickness to see …

This study looks at 330 adults with a serious heart valve infection (prosthetic valve endocarditis) caused by S. aureus bacteria. It compares the standard approach of giving the antibiotic rifampin against not giving it, to see if skipping it is just as safe and effective. The go…

This study tests whether adding bismuth to standard antibiotics works better than antibiotics alone to clear H. pylori infection and heal peptic ulcers in 80 children. Participants take a 14-day treatment, then continue acid-reducing medication for a few more weeks. Researchers w…

This study tests a new ultra-short treatment for both drug-sensitive and drug-resistant tuberculosis (TB). The goal is to see if a 2-3 month regimen works as well as or better than the standard 4-6 month treatment. About 610 adults with active TB will take part. The approach coul…

This study tests whether proteins in joint fluid, such as alpha-defensin, can quickly and accurately detect bacterial joint infections (septic arthritis) in children. Currently, doctors rely on cultures that take days, forcing tough decisions about emergency surgery. The trial co…

This study will test a new diagnostic device called the Nanopath assay, which aims to quickly detect bacteria or yeast causing vaginitis. Up to 1000 women with symptoms like itching or discharge will provide vaginal swab samples, either collected by a clinician or themselves. The…

This study tests whether a rapid finger-prick blood test for syphilis and HIV can be used in a prenatal clinic for pregnant people at risk. The test gives results in five minutes, potentially speeding up diagnosis and treatment. Participants will provide feedback on their experie…

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study is testing a new rapid test for gonorrhea called the iStatis Gonorrhea Antigen Test. The test uses a vaginal swab and gives results quickly at the clinic. Researchers want to see how accurate and easy it is to use when performed by trained staff. About 650 women will t…

This study tests whether measuring a substance called IL-6 in the blood can quickly predict if an emergency room patient with a suspected infection will develop sepsis or septic shock. Researchers will enroll 450 adults admitted from the ER and track their outcomes for up to 30 d…

This study tests whether artificial intelligence (AI) can help doctors better detect H. pylori infection and precancerous stomach changes during routine endoscopy. The goal is to see if AI assistance can reduce deaths from stomach cancer. The trial will enroll 6,000 adults aged 2…

This study investigates whether a urine test called Nephrocheck can predict which patients with septic shock will develop severe acute kidney injury. The test measures two markers of kidney damage (TIMP2 and IGFBP7). Researchers will analyze data from previous studies involving a…

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study is testing a new blood test that looks at RNA (genetic material) to quickly tell if a person with belly pain has an infection inside the abdomen, like appendicitis or diverticulitis. About 1,000 adults and children over age 7 with abdominal pain will give a blood sampl…

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual physical exam versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound improves acc…

This study aims to increase syphilis testing and treatment for pregnant women who haven't had prenatal care or a syphilis test during their pregnancy. Researchers will offer rapid point-of-care tests in the emergency department and obstetrical triage, then help connect those who …

This study tests whether a smartphone app can tell the difference between a TB cough and other coughs by analyzing audio recordings. Researchers will collect cough sounds from 1,751 people with a cough lasting at least two weeks, then use machine learning to build a quick screeni…

This study is testing a new rapid diagnostic device called TruPlex that can detect HIV, Hepatitis B, and Syphilis from a small blood sample. Researchers will enroll 1000 adults at risk for these infections to see how accurate and easy the test is to use in clinics and point-of-ca…

This study aims to develop a better blood test for early Lyme disease in children. Current tests often miss early infections or give false positives. Researchers will also study the immune response and the types of Lyme bacteria involved. About 500 children with suspected Lyme di…

This pilot study tests a new blood test that looks at markers on white blood cells to tell if a feverish baby under 3 months has a serious bacterial infection. Researchers will collect an extra small blood sample from 180 infants in the emergency department. The goal is to see if…

This study is testing a new, quick test for gonorrhea in pregnant women and women with symptoms in South Africa. About 1,239 women will provide samples to see if the new test works as well as standard lab methods. The goal is to make diagnosis faster and easier, especially in cli…

This study is developing an artificial intelligence system that analyzes CT and MRI scans to diagnose and predict outcomes for digestive diseases like Crohn's disease, ulcerative colitis, and intestinal tuberculosis. Researchers are using data from 21 hospitals in China to train …

This study is testing whether a new approach—using ultrasound to guide a tiny needle to collect fluid near the ulnar nerve, then analyzing it for leprosy bacteria DNA—can more accurately diagnose leprosy and confirm when it's cured. Researchers will follow 108 participants for on…

This study is testing a new laboratory method that looks for DNA fragments from tuberculosis bacteria in fluid around the lungs (pleural effusion). The goal is to see if this test can diagnose tuberculous pleurisy more accurately than current tests. Researchers will study 400 adu…

This study tests a new device that uses artificial intelligence to help diagnose ear infections, strep throat, and asthma flare-ups in children. About 84 kids aged 3 to 17 will either use the device at home with a doctor's video visit or receive standard in-person care. The goal …

This study is testing new, non-invasive ways to diagnose tuberculosis (TB) in children under 15. Researchers will evaluate oral swabs, cough sound analysis, and lung sound analysis as potential alternatives to sputum tests. The goal is to find faster, simpler, and cheaper diagnos…

Every year, millions of people with tuberculosis (TB) go undiagnosed. This study tests new, faster diagnostic tools that use a simple tongue swab instead of the usual sputum sample. Researchers will enroll 1,350 adults with cough or TB risk factors to see how accurate these point…

This study is testing three new diagnostic tests to see if they can correctly identify a gene mutation that makes gonorrhea resistant to the antibiotic ciprofloxacin. Researchers will use leftover samples from over 3,000 people who already tested positive for gonorrhea. If the te…

This study is testing a new, non-invasive stool test that looks for specific gene changes in H. pylori bacteria linked to stomach cancer. Researchers will compare the test's accuracy with a standard risk questionnaire in 15,000 adults aged 40 and older. The goal is to see if this…

This study is testing two new blood test kits designed to diagnose syphilis. Researchers will collect blood samples from 1000 people, including those with symptoms, those at high risk, and healthy controls. The goal is to see how accurate these new kits are compared to standard l…

This study tests a special PET/CT scan that uses a tracer called FAPI-74 to find fibrosis (scar-like tissue) in the body. It includes 45 adults with conditions like head and neck cancer or tuberculosis that can cause fibrosis. The goal is to see how well the scan shows fibrosis, …

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study explores whether a special thermal camera can help doctors quickly detect infections in children's bones, joints, or soft tissues. About 30 children with suspected infections will have a 10-second video taken of the affected area to see if the heat pattern matches the …

This study is testing whether a blood test called Karius Spectrum can help doctors find infections faster in adults with weakened immune systems (e.g., organ transplant recipients, cancer patients). The test looks for DNA from bacteria, fungi, viruses, and parasites in the blood.…

This study checks if a new self-test for HIV and syphilis is accurate and easy for people to use at home. About 900 adults in Canada will try the test and compare results to lab tests. The study also looks at how peer support can help homeless people in Toronto get tested and tre…

This study tests whether a DNA sequencing test can help doctors choose the right antibiotics for people with drug-resistant tuberculosis (TB). Researchers will collect samples from 2,500 participants in clinics and use targeted sequencing to identify which drugs the TB bacteria a…

This study is testing a new diagnostic tool that helps doctors quickly tell if a respiratory infection is caused by bacteria or a virus. The goal is to see if using this test leads to better treatment decisions, fewer unnecessary antibiotics, and lower healthcare costs. About 100…

This study looks at whether measuring a substance called D-lactate in spinal fluid can help doctors diagnose meningitis (a brain infection) in patients who have a brain drain (ventriculostomy). About 185 adults with suspected meningitis will have their spinal fluid tested. The go…

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placeb…

This phase 3 trial will give a single dose of the dTpa vaccine (Boostrix) to 95 healthy Japanese pregnant women between 27 and 37 weeks of pregnancy. The goal is to see if the vaccine triggers strong immunity in the mothers and passes protective antibodies to their babies at birt…

This study tests a new medicine called siltartoxatug to prevent tetanus in people who have been injured. About 6,000 adults in China will receive either the new drug or a standard tetanus shot. Researchers will check how well each treatment prevents tetanus over 90 days and monit…

This trial investigates whether a professional dental cleaning and instruction on proper brushing and flossing can reduce the amount of bacteria that enter the bloodstream during tooth brushing. Such bacteria can sometimes lead to infective endocarditis, a serious infection of th…

This study tests whether a specific diet can change gut bacteria and help prevent another C. difficile infection in adults who have had one. Twenty participants will receive prepared meals and health counseling, then follow a similar diet for 6 more weeks. Researchers will track …

This study tests a targeted approach to stop cholera spread in Dhaka, Bangladesh. When someone tests positive for cholera, their household and nearby neighbors (within about 20–40 meters) are offered an oral cholera vaccine. The goal is to see if this ring vaccination reduces the…

This study will test whether screening pregnant women for chlamydia and gonorrhea can reduce the risk of preterm birth. About 2,000 women in Botswana will be randomly assigned to receive either standard care or additional STI testing early in pregnancy and again in the third trim…

This phase 3 trial tests whether a gradual taper of vancomycin is as good as a 10-day course of fidaxomicin at preventing another C. difficile infection. About 500 adults with a first or second C. diff episode will be randomly assigned to one of the two treatments. The main goal …

This study in Botswana tests whether offering sexually transmitted infection (STI) testing alongside HIV prevention medication (PrEP) helps more pregnant women start and continue using PrEP. About 600 pregnant women without HIV will be split into two groups: one gets standard car…

This study tests if using antiseptic washes and placing antibiotics directly into the wound during hip or knee replacement surgery can lower the chance of a serious infection that requires another operation. Over 21,000 adults getting a joint replacement will be randomly assigned…

This study tests a new vaccine (PCV21) designed to protect babies against 21 types of pneumococcal bacteria, which can cause pneumonia and other serious infections. About 2,200 healthy infants will receive four doses of either the new vaccine or an existing one starting at 2 mont…

This phase 3 trial tests whether a combination of two antibiotics (bedaquiline and rifampicin) can better prevent leprosy than the current standard single dose of rifampicin. Over 124,000 people living near a leprosy patient in the Comoros will receive either the new two-dose reg…

This study aims to find a shorter, safer treatment for latent tuberculosis (TB) infection to prevent it from becoming active disease. About 1800 adults and children with a positive TB test will try one of several daily pill regimens lasting 1 to 4 months. The goal is to identify …

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study compares a new 6-week daily rifapentine regimen to the standard 12-16 week rifamycin-based treatment for latent tuberculosis infection (LTBI). The goal is to see if the shorter treatment is just as safe and effective at preventing active TB. About 3,400 people at highe…

This study in Uganda tests whether offering HIV self-testing and PrEP (a daily pill to prevent HIV) at home during routine TB contact tracing can increase HIV prevention. About 2,480 people from households with a TB patient will be randomly assigned to either home-based HIV testi…

This study tests a program called CHoBI7, which teaches handwashing, water treatment, and safe water storage to diarrhea patients and their families in Bangladesh hospitals. Researchers want to see if this program reduces diarrhea and improves hygiene behaviors compared to standa…

This study tests a program called Shamba Maisha that provides farming tools, training, and school gardens to families in Kenya. The goal is to reduce food insecurity and poverty, which are linked to higher STI and HIV risk in adolescent girls. Researchers will follow 900 girls an…

This study tests whether using a device that measures blood flow to the skin (called the peripheral perfusion index) can help doctors give fluids more precisely to elderly ICU patients with sepsis or shock. The goal is to prevent acute skin failure, a serious condition where the …

This study tests whether taking the antibiotic doxycycline shortly after sex can prevent bacterial STIs like syphilis, gonorrhea, and chlamydia. It involves 200 men, transgender women, and travestis in Rio de Janeiro who are at higher risk. Participants choose whether to use doxy…

This study tests whether increasing kangaroo care (skin-to-skin contact) in neonatal intensive care units can reduce severe infections and antibiotic-resistant bacteria in very premature infants (born before 32 weeks). Over 3,000 babies across multiple hospitals will be involved.…

This trial tests a prevention bundle for hospital patients who carry C. difficile bacteria but have no symptoms. The bundle includes enhanced room cleaning and special precautions. Researchers hope to prevent these carriers from developing active infections and spreading the bact…

This study compares two common hand rubs—chlorhexidine and alcohol—used by medical staff before touching premature babies in the NICU. The goal is to see which one better prevents healthcare-associated infections. One hundred premature infants will be monitored with blood culture…

This study looks at whether the R21/Matrix-M malaria vaccine can also reduce the risk of invasive non-typhoidal Salmonella (iNTS), a serious bacterial infection. Researchers will follow 10,000 children under 5 in the Democratic Republic of Congo who come to health centers with fe…

This study tests whether taking a single 200 mg dose of doxycycline within 24–72 hours after unprotected sex can prevent gonorrhea, chlamydia, and syphilis in men who have sex with men. Researchers in Bangkok will enroll 400 participants and follow them for 12 weeks. If effective…

This study tests whether screening surgery outpatients for Staphylococcus aureus (staph) and giving them a 5-day decolonization treatment (nasal ointment, mouth rinse, and special soap) can prevent surgical site infections. About 250 adults scheduled for various surgeries will be…

This study tests whether taking a daily vitamin C pill for 10 days can prevent catheter-associated urinary tract infections in women having elective gynecologic surgery. Half of the 180 participants will receive vitamin C, and half will receive a placebo. The goal is to see if th…

This pilot study tests whether VM100, a nutritional supplement made from ten natural ingredients, can improve quality of life for people with Duchenne muscular dystrophy (DMD). About 20 participants aged 8 and older will take VM100 or a placebo for 10 weeks. Researchers will meas…

This trial tests three pain-relief approaches after a single-visit root canal in people with symptomatic irreversible pulpitis, a painful tooth condition. Participants receive either acetaminophen, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen for three da…

This study tests whether adding balloon blowing to standard breathing exercises helps children with tuberculosis cough up mucus, reduce shortness of breath, and improve their ability to walk. Thirty-four children aged 8 to 14 will be randomly assigned to either breathing exercise…

This study compares two ways to numb a painful lower back tooth before a root canal. One method uses a standard injection near the jaw nerve, while the other uses a different numbing medicine injected near the tooth. The goal is to see which approach provides better pain relief d…

This study compares two types of dental sealers used after root canal treatment to see which causes less pain. About 118 adults with painful tooth inflammation will receive either a tricalcium silicate sealer or a resin-based sealer. Pain levels will be measured at 24 hours, 72 h…

This study compares two sedation methods for elderly ICU patients (65+) who need a breathing tube. One group gets a mix of propofol and ketamine, the other gets propofol alone. The goal is to see which causes fewer dangerous drops in blood pressure. The trial involves 41 particip…

This early-stage study tests whether LCFA-01, a natural gel containing oleic acid, is safe and comfortable when placed in the vagina. Thirty healthy women aged 18-40 will use the gel and be monitored for side effects, discomfort, and how much of the product enters the bloodstream…

This study tests whether injecting the steroid dexamethasone near the tooth ligament or under the gum helps numb the tooth better and reduces pain during root canal treatment. It includes 84 adults with severe, irreversible pulpitis in a lower molar. Participants receive one of t…

This study tests whether inhaling a salty mist (3% hypertonic saline) can improve breathing symptoms in people with nontuberculous mycobacterial (NTM) lung disease who haven't yet started antibiotics. About 262 adults will either start the saltwater treatment right away for 6 mon…

This study tests whether a specially prepared (buffered) numbing shot works better than the standard shot to reduce pain and anxiety in children aged 6 to 12 who need a tooth filling or root canal for an infected baby tooth. Researchers will measure pain using a behavior scale, h…

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study compares two methods of numbing the lower back teeth in children who need emergency dental treatment. One method is a standard injection near the jaw nerve, and the other uses a computer-controlled device to deliver numbing medicine directly into the tooth area. Resear…

This study tests three treatments for teeth with deep cavities and severe, constant pain: total pulpotomy, radicular pulpotomy, and standard root canal. About 99 adults will receive one of these procedures, and their pain and healing will be tracked for a year. The goal is to fin…

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 kids who are stable enough for home care will receive the pump instead of multiple daily hospital injectio…

This study tests a new way to treat brain fog in people with post-treatment Lyme disease. Participants will play computer-based thinking games at home while receiving either real or fake brain stimulation (tDCS) for 4 weeks. Researchers will check if the active stimulation improv…

This study compares two ways to clean the area before placing a temporary bladder catheter: Betadine (the current standard) versus sterile water. Researchers want to see if sterile water leads to fewer bacteria in the urine and less pain during the procedure. About 148 adults who…

This study looks at whether children with pneumonia caused by Mycoplasma bacteria need antibiotics to get better. About 376 children aged 3-17 will receive either a placebo (inactive pill) or a common antibiotic. Researchers will track how long symptoms like fever and fast breath…

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This study tests whether giving patients an extra injection of a long-acting anesthetic (bupivacaine with epinephrine) right after a root canal can lower pain, improve quality of life, and reduce the need for painkillers. About 150 adults with tooth pain will be randomly assigned…

This study tests whether placing an ice pack on the gum for 5 minutes before a numbing injection can improve pain control during root canal treatment. It involves 98 adults with severe, irreversible tooth nerve pain. The goal is to see if this simple cold therapy reduces the need…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines proven methods to support smoking cessation and improve HIV/TB treatment results. Researchers will enroll 86 daily…

This study tests whether a 6-week exercise program can improve fitness and quality of life in people with nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic lung infection. Researchers will enroll 50 adults aged 40-80 and randomly assign them to start exercise rig…

This study looks at whether standing in the shower instead of sitting on the toilet helps women urinate more easily after having a catheter removed following vaginal surgery. The goal is to see if this position reduces pain, lowers the amount of urine left in the bladder, and dec…

This study tests two materials, MTA and Biodentine, for treating a painful tooth condition called irreversible pulpitis. 60 adults with severe tooth pain will get a pulpotomy (removing infected pulp) and one of the materials. They will be followed for 3 months to see which materi…

This study tests a dietary supplement called lumbrokinase in 120 adults with Long Covid, post-treatment Lyme disease syndrome, or ME/CFS. Participants take the supplement daily for 6 weeks. The goal is to see if it improves overall health and quality of life, as measured by a sim…

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This study tests whether adding remimazolam to standard sedation (propofol and alfentanil) can lower the risk of low oxygen levels in high-risk patients during painless tracheoscopy. About 360 participants with serious health conditions (ASA class 3-4) will be randomly assigned t…

This study looks at whether regularly flushing chest drains with salt water helps keep them from getting blocked in people with serious lung infections (empyema). The goal is to see if this simple step can shorten the time the drain needs to stay in, reduce hospital stays, and im…

This study looks at two types of dental sealers used in root canals to see which one causes less pain afterward. About 50 adults with tooth pain will get one of the two sealers and report their pain for three days. The goal is to help dentists choose the sealer that makes root ca…

This study tests whether exposure to bright blue light can reduce inflammation and organ damage in people hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. Participants will be randomly assigned to receive either blue-enriched light or…

This study tests a new way to do root canals that skips the manual step of scouting and widening the canal by hand. Instead, dentists use a special rotary file from the start. The goal is to see if this causes less pain after the procedure compared to the traditional method. The …

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

This study compares a laser-based procedure to the standard method for treating severe toothache (irreversible pulpitis) in adult molars. Sixty participants will receive either laser or conventional treatment, and healing will be tracked using X-rays and AI analysis. The goal is …

This study tests if press-needle ear acupuncture can reduce nausea and vomiting caused by tuberculosis (TB) medicines. About 58 people with TB who experience these side effects will be randomly assigned to receive real ear acupuncture or a placebo. Researchers will compare sympto…

This study compares pain levels after root canal treatment using two different sealing materials: a resin-based sealer and a bioceramic sealer. 180 adults with a single-rooted tooth needing a root canal will be randomly assigned to one of the two sealers. Pain will be measured 24…

This study aims to understand how Staphylococcus aureus bacteria interact with human cells to cause infections, especially in the spine. Researchers will use tonsil tissue discarded after routine tonsillectomies to create lab models. About 500 participants aged 2 and older who ar…

This study aims to better understand trisomy 8 mosaicism, a rare genetic condition where some cells have an extra copy of chromosome 8, and its link to autoinflammatory disease (TRIAD). Researchers will follow affected individuals and their healthy relatives over time, collecting…

This registry study follows pregnant individuals aged 10 to 25 who received PENBRAYA, a vaccine against meningococcal disease, during pregnancy or within 30 days before their last period. The goal is to collect information on pregnancy outcomes and infant health during the first …

This study follows 150 people with active or latent tuberculosis (TB) to collect blood, sputum, and tissue samples. The goal is to better understand how TB behaves in the body and how the immune system responds. Participants receive standard TB treatment as part of the study, but…

This study looks at whether a rapid fingerstick test that gives results in 10-20 minutes can help more people get screened for HIV, hepatitis C, and syphilis during mobile clinic visits. About 200 patients of the WVU Street Medicine team can choose the rapid test, a traditional b…

This study is tracking how adults with meningitis are treated in about 30 hospitals across Brazil. Researchers will follow 624 patients during their hospital stay and after discharge to see what treatments work best and how patients recover. The goal is to gather real-world evide…

This study looks at whether adding certain nutrients to blood cells from people with septic shock can help restore the cells' energy-making machinery (mitochondria). Researchers will collect blood samples from 55 patients in the ICU and test these nutrients in the lab. The goal i…

This early study tests whether transferring nasal bacteria from a parent to a child can restore the child's nasal microbiome after they have been treated with antibiotics for staph bacteria. The study involves 175 children who have had staph in their nose and recently finished an…

This study follows 500 people with active Lyme disease to learn more about the infection. Participants receive standard FDA-approved treatments and undergo tests like blood draws and leukapheresis. The goal is to explore biological markers, track clinical outcomes, and understand…

This study investigates whether the bacteria causing Lyme disease can survive antibiotic treatment and cause ongoing symptoms. Researchers will follow 700 participants, including those with chronic Lyme disease, recovered individuals, and healthy volunteers, using blood tests, sp…

This study looks at how a Campylobacter gut infection changes the bacteria and lining of the bowel, and whether these changes can help identify who might later develop irritable bowel syndrome (IBS). Researchers will follow people with a confirmed Campylobacter infection who do n…

This study looks at how two antibiotics, ceftriaxone and benzathine penicillin G, are processed by the body during pregnancy. Up to 78 pregnant women in the U.S. will take one of these drugs as part of their regular care, and researchers will measure drug levels in their blood. T…

This study aims to develop a predictive model for mortality in critically ill patients who carry multidrug-resistant gram-negative bacteria (MDR-GNB). Researchers will follow about 1,500 adults in intensive care units (ICUs) who are colonized with these bacteria, tracking their i…

This study looks at whether the color-coded triage system (Red, Yellow, Green) used in Turkish emergency departments can accurately predict which children with fever will become seriously ill. Researchers will track 3,000 children aged 0-18 who come to the emergency room with a f…

This study looks at whether preterm infants in the NICU can safely stop taking the antibiotic ampicillin after 24 to 36 hours instead of the usual 48 hours. Researchers will measure drug levels in the blood and monitor the babies for any problems. The goal is to see if a shorter …

This study follows intensive care unit (ICU) patients over at least 28 days to see how two types of bacteria—Klebsiella pneumoniae and Enterobacter cloacae—change and evolve in their gut. By analyzing weekly stool samples, researchers hope to understand how these bacteria become …

This study follows 400 adults who receive a Double-J ureteral stent—a tube that helps drain urine from the kidney to the bladder. The goal is to identify risk factors for bacteria sticking to the stent and to see how this colonization relates to urinary tract infections, antibiot…

This trial tests whether button-sized wireless sensors can accurately measure heart rate, oxygen levels, and skin temperature in extremely preterm infants in the NICU. The sensors aim to replace bulky wired monitors that can stress fragile babies. Ten stable preterm infants will …

This study looks at whether the presence and distribution of H. pylori bacteria in the stomach, along with tissue features of early gastric cancer, can help predict how the cancer will behave and what the long-term outlook may be. Researchers will analyze data from about 1,500 pe…

This study tests whether it is possible to set up a system to monitor antibiotic resistance at a general referral hospital in semirural Kinshasa, Democratic Republic of Congo. Researchers will enroll about 210 patients with suspected bloodstream infections to collect blood sample…

This study tests whether adding electrochemical sensors to standard blood culture bottles can identify bacteria early, while the sample is still growing. Researchers will collect extra blood samples from 200 patients with suspected bloodstream infections and spike them with known…

This registry collects detailed information from 1,000 patients with infective endocarditis, a serious heart infection. Researchers will track demographics, microbiology, imaging, and outcomes to understand current treatment effectiveness and guide future studies. The goal is to …

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This observational study follows 800 adults who receive Myriad™ during soft tissue reconstruction for wounds like abdominal dehiscence, pressure injuries, or anal fistulas. Researchers track healing time, complications, and side effects to understand how well the material works i…

This study looks at whether blood cancer patients with a serious infection can safely stop antibiotics sooner if they are stable for 72 hours, instead of the usual 10-day course. About 172 adults will be randomly assigned to either a personalized short course or standard long cou…

This early-stage study tests the safety of a new drug called AZD7760 in 18 healthy Japanese adults. Participants receive a single intravenous dose and are monitored for side effects and how the drug moves through the body. The study does not aim to treat any disease; it only gath…

This study investigates why some patients with septic shock develop a weakened immune system after the initial crisis, making them prone to further infections. Researchers will analyze blood samples from 305 intensive care unit patients to find biological markers that indicate im…

This study looks at over 500,000 patient records to see if diagnostic codes in electronic health records accurately identify chlamydia infections. Researchers will compare these codes with lab test results. The goal is to improve how real-world data is used for chlamydia research…

This study looks at whether muscle measurements from a CT scan taken when a patient is admitted to the ICU for septic shock can predict their risk of dying within 3 months after leaving the ICU. Researchers will analyze muscle size, density, and fat content from the scan and comp…

This study follows 300 health workers in Cape Town, South Africa, who are at high risk of tuberculosis (TB) infection. Researchers will use a combination of existing and new tests every three months to track immune responses at the time of infection. The goal is to better underst…

This study looks at whether measuring certain immune and inflammatory markers in the blood can help predict how critically ill patients will fare. Researchers are following 200 adults in intensive care who have infections, have had major surgery, or have weakened immune systems. …

This study tests whether a rapid lab test can help doctors choose the right antibiotic sooner for patients with bloodstream infections. About 400 adults with positive blood cultures will be randomly assigned to either the rapid test or standard testing. The goal is to see if the …

This study explores the real-life experiences of people who had Lyme disease during or before pregnancy and are now raising children. Participants fill out surveys about their health, mental well-being, and child development, then take part in an interview to share their personal…

This study follows 40 pregnant women with Lyme disease to see how the infection might affect their baby's development. Researchers will monitor pregnancies and check infant growth, thinking, and motor skills from birth to 18 months. The goal is to learn if Lyme exposure in the wo…

This study looks at 790 adults with S. maltophilia infections, a hard-to-treat bacteria. Researchers will compare patients who got one antibiotic versus those who got a combination, to see which group has fewer deaths within 30 days. The goal is to find the best treatment approac…

This study looks at whether a substance in the blood called soluble PD-1 can help predict if a certain type of lung disease caused by NTM bacteria will get worse. Researchers will follow 500 adults from different countries to see if higher levels of this marker are linked to more…

This study is collecting skin and blood samples from 830 people with chronic inflammatory skin diseases like psoriasis, eczema, and lupus. Researchers want to find biological markers that can predict how well a person will respond to treatment after one year. The goal is to move …

This study is observing 200 patients who received a large leg implant (megaprosthesis) between 2020 and 2023. Researchers want to learn how many get infections, what puts them at risk, and how those infections turn out. The goal is to gather information, not to test a new treatme…

This study looks at how doctors can improve antibiotic prescriptions for urinary tract infections (UTIs) after patients leave the emergency department. Researchers will check if adjusting antibiotics based on lab test results reduces the use of strong drugs like fluoroquinolones.…

This study will follow 2000 adults in France who are starting treatment for tuberculosis. Researchers will collect health data and samples like blood, urine, and breath over two years to see how well treatments work. The goal is to learn more about TB care and build a biobank for…

This study looks at how different types of mycobacterial infections, including drug-resistant tuberculosis and nontuberculous mycobacteria, change the body's immune response. Researchers will collect blood and other samples from 120 participants, including healthy people and thos…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study looks at whether sleep habits of 11-12 year olds affect their immune response to the meningococcal vaccine (MCV4). About 66 healthy teens will wear a sleep tracker and keep their normal sleep schedule for 5 weeks. Researchers will measure antibody levels after vaccinat…

This study looks at whether charcoal-filtered cigarettes change how people smoke and how much harmful chemicals they breathe in. About 252 adult smokers who smoke at least 5 cigarettes a day will be randomly assigned to smoke either charcoal-filtered or regular cigarettes for 4 w…

This study looks at whether taking common acid-reducing drugs (proton pump inhibitors, or PPIs) affects the accuracy of a stool DNA test for H. pylori, a stomach bacteria. Researchers will test 25 adults who need PPIs, first while on the drug and then after stopping it for 4 week…

This study looks at how the cystic fibrosis drug ETI affects the way the body handles antibiotics. Researchers want to see if people on ETI need lower antibiotic doses to treat lung infections, which could reduce harmful side effects like hearing loss or kidney damage. The study …

This study looks at how well the MenFive (NmCV-5) meningitis vaccine still works more than five years after a single shot. Researchers will test the blood of 450 people in Mali and The Gambia who got the vaccine when they were 2 to 29 years old. The goal is to see if their immune…

This study looks at small molecules called miRNAs in the blood of patients with septic shock. The goal is to understand why some patients develop a weakened immune system after sepsis, which can lead to more infections and higher risk of death. Researchers will compare miRNA patt…

This study examines why some people with a painful tooth infection (irreversible pulpitis) don't get fully numb from a standard dental injection. Researchers will measure levels of certain genes and inflammatory markers in the tooth pulp to see if they predict anesthesia success.…

This study looks at three different scoring systems to see which one best predicts the risk of death in patients with severe tetanus in the intensive care unit. Researchers will follow 115 adults with tetanus for up to 90 days. The goal is to find the most accurate tool to help d…

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study helps U.S. healthcare centers figure out if patients are getting NTM lung infections from the hospital environment. Researchers will compare germs from patients' lungs with germs from water and dust in the hospital and homes. The goal is to create a standard method to …

This study looks at whether a simple ultrasound measurement of how well the right side of the heart works with the lungs can predict which sepsis patients are at higher risk of dying in the hospital. Researchers will follow 215 adults with sepsis in the ICU, measuring this heart-…

This study is testing whether a continuous glucose monitor (CGM) designed for diabetes can work in intensive care patients with septic shock. Currently, nurses must prick patients' fingers every 2 hours to check blood sugar, which is painful and disruptive. The CGM uses a small s…

This study is observing 200 hospitalized adults with carbapenem-resistant Acinetobacter baumannii (CRAB) infections—a type of superbug—who are treated with the antibiotic sulbactam-durlobactam. Researchers will compare their outcomes to patients receiving other treatments to see …

This study prepares medical sites in Kenya, Malawi, Mozambique, and Uganda for future trials of a vaccine against Group B Streptococcus (GBS), a leading cause of serious infections in newborns. Researchers will track pregnancy and infant health data and monitor GBS cases in babie…

This study looks at whether urine samples can show immune markers of chlamydia infection in women. Participants provide urine, vaginal, and blood samples to compare immune responses. The goal is to find easier ways to study chlamydia immunity, which could help develop better test…

This study is measuring cortisol levels in 183 adults with sepsis or septic shock in the ICU to see if those levels can predict who is at higher risk of dying. Researchers will track deaths in the ICU and at 28 and 90 days. The goal is to help doctors identify high-risk patients …

This study aims to figure out where bloodstream infections in children with central lines actually come from. By comparing the DNA of bacteria from the blood with bacteria from the gut, mouth, and skin, researchers hope to tell whether the infection started from the line itself o…

This study aims to collect blood and saliva samples from 2000 adults who come to the emergency room with a suspected respiratory infection. Researchers will use these samples to better understand how the body responds to infections and to find new ways to diagnose and treat them.…

This study looks at whether frailty—measured by a simple scale—can predict death in adults aged 18 to 65 admitted to intensive care for septic shock. Researchers will track 200 patients to see if those who are frail have a higher risk of dying within 28 days, even after accountin…

This study looks back at 15 years of medical records and will also follow new patients with intestinal tuberculosis to find out which factors—like age, other illnesses, or treatment habits—make death more likely. Researchers will collect data from 500 adults diagnosed with intest…

This study tests whether offering a small cash payment to households can encourage more people to get screened for tuberculosis (TB) in rural Tanzania. Researchers will enroll 360 people recently diagnosed with TB and their families. Half will receive the usual care, and half wil…

This study is creating a registry of 600 children under 18 with meningitis treated at hospitals across Brazil. Researchers will collect data during and after hospitalization to see how well current treatments work and what long-term problems, like hearing loss, occur. The goal is…

This study looks at the bacteria living in the lungs of people with active tuberculosis (TB) and how they change with treatment. Researchers will compare lung bacteria in diseased and healthy areas, and also check the mouth, nose, and gut. They aim to understand how these microbe…

This study looks at how healthy people's skin and immune system respond to tick bites. Researchers will place clean, lab-bred ticks on volunteers' skin and take small skin samples and blood to track changes. The goal is to understand tick resistance and help design future vaccine…

This study tests whether a web-based educational program can improve pregnant women's knowledge about influenza and Tdap vaccines and increase their intention to get vaccinated. Researchers will compare the program to standard antenatal care in 351 pregnant women in Malaysia. Par…

This study collects blood from 50 women in Uganda who previously received an experimental group B strep (GBS) vaccine during pregnancy. The blood is used to create quality control panels that help labs accurately measure vaccine-induced antibodies. The goal is to improve testing …

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study looks at whether what patients expect before treatment for early Lyme disease (a red rash called erythema migrans) influences how well they recover. Researchers will follow 200 patients for up to a year, checking for lingering symptoms and comparing them to healthy peo…

This study is a national observatory that will follow 10,000 children and newborns with bacterial meningitis. Researchers aim to understand which bacteria are causing infections, how often treatments fail, and how well vaccines are working. The goal is to improve future treatment…

This study aims to create a new scoring system (SOFA-OBS) that better predicts death risk for pregnant and postpartum women in intensive care. Researchers will collect routine data from 130 patients and test if a simple pulse oximeter can replace painful blood draws. The goal is …

This study is observing 2,500 children in France to understand how pneumococcal vaccines have changed the severity and types of pneumococcal infections. Researchers will look at which bacterial strains cause disease, how severe the infections are, and whether children were vaccin…

This study looks at two different ultrasound techniques to help doctors decide how much fluid to give patients with septic shock. One method measures the heart's left ventricle, while the other checks blood flow in the carotid artery. The goal is to see which is more accurate at …

This study looks at how a patient's symptoms before treatment and how deep the cavity is affect the success of partial decay removal in adult teeth. One hundred adults with deep cavities will be treated and followed for 12-24 months. The goal is to see if these factors influence …

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, and bone infections. Researchers will collect medical data and biological samples to describe the infections and their treatments. The goal is to better under…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This pilot study is testing how much irrigation fluid is needed to clear contaminants during revision knee replacement surgery for infection. Surgeons will apply a blue dye to the knee joint and wash it out in measured steps until the dye is gone. The goal is to gather data to de…

This study looks at why the antibiotic doxycycline, when taken after sex, prevents bacterial STIs in some people but not others. Researchers will measure doxycycline levels in hair, blood, and urine from 48 volunteers to develop better ways to track if people are taking the medic…

This study compares the immune response to COVID-19 vaccines between people being treated for tuberculosis (TB) and healthy individuals. About 133 participants in the Thailand-Myanmar border area will receive one of three vaccines (Pfizer, AstraZeneca, or Janssen). Researchers wi…

This study explores whether measuring tiny DNA fragments from the TB bacteria in the blood can help doctors monitor how well treatment is working. Researchers will enroll 140 adults with newly diagnosed TB in Thailand, taking blood samples over time to see if the DNA levels drop …

This study looks for immune markers that show whether a person is protected from cholera after vaccination or natural infection. About 1,200 people will receive either a cholera vaccine or a typhoid vaccine (as a comparison) and give blood samples over two years. The goal is to f…

This study looks at how people recover after infective endocarditis, a serious heart infection. Researchers want to see if a 12-week exercise program can improve physical fitness, fatigue, and quality of life. About 50 adults who had the infection will take surveys, do interviews…

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants under 2 months old with a fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to find ou…

This registry will follow 10,000 people in Shandong, China, who are being treated for H. pylori infection. Doctors will prescribe standard treatments based on guidelines, and researchers will track how well each treatment works and any side effects. The goal is to learn which str…

This study looks at how a type of immune cell called neutrophils affects the body's response to the pneumococcal vaccine in young (21-40) and older (65+) adults. Researchers will measure how well neutrophils kill pneumonia bacteria after vaccination. The goal is to understand why…

This study looks at whether a new blood gas ratio can help predict which patients with septic shock are more likely to survive. Researchers will measure this ratio and compare it to standard lactate levels in 30 adults with septic shock. The goal is to see if the ratio gives earl…

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study looks at how common Helicobacter pylori infection is in people newly diagnosed with stomach cancer in Martinique. Researchers will collect tumor samples, healthy tissue, and blood to build a biobank. The goal is to understand why stomach cancer is more common in the We…

This study looks at whether substances in the blood from a decayed tooth can predict if a tooth-saving procedure called vital pulp treatment will succeed. Researchers will collect a small blood sample from the tooth during treatment and check for specific metabolic markers. They …

This study from the University of Zurich is looking at how tiny organisms (microbes) and the immune system interact in the bladder. Researchers will collect samples from 800 adults with various urinary conditions, including infections, bladder pain, and overactive bladder, as wel…

This study gives healthy adults the licensed oral typhoid vaccine (Vivotif) and collects blood, saliva, and stool samples over up to eight years. Researchers want to learn how the vaccine triggers protective immune responses, which could help design better vaccines for typhoid an…

This study tracks how fecal microbiota transplantation (FMT) alters the gut microbiome in 20 adults with recurrent Clostridioides difficile infection. Researchers will analyze stool samples before and up to 90 days after FMT to see which bacteria take hold. The goal is to underst…

This study will follow 3,000 children hospitalized with severe bacterial infections to understand what makes them so dangerous. Researchers will collect data on the bacteria, the children's health, and the care they receive. The goal is to find risk factors and early warning sign…

This study is observing about 1,950 emergency patients with suspected sepsis to see if new blood tests (like calprotectin and bacterial DNA tests) can detect infections faster and more accurately than current methods. The goal is to find better ways to diagnose sepsis and tailor …

This study looks at the sticky layer (biofilm) that can form on arterial catheters in intensive care patients. About 60 adults in the ICU will have their catheters examined after removal to see what types of bacteria or fungi are present and how the biofilm is structured. The goa…

This study follows 50 adults with infected hip replacements treated at University Hospitals Leuven. Researchers will track which treatments (antibiotics or surgery) work best and note complications. The goal is to gather real-world data to help doctors and patients make better de…

This study follows 329 adults who need surgery for an infection after a hip, knee, or other joint replacement. Researchers will track which treatments—surgery and antibiotics—lead to the best outcomes. The goal is to find patterns that help cure infections more reliably and impro…

This study looks at how the antibiotic cefiderocol behaves in the bodies of people with severe burns. Researchers want to find the best dose to kill bacteria and prevent resistance. The study will enroll 12 adults with burns who have good kidney function.

This study looks at how common Helicobacter pylori (a stomach germ linked to cancer) is in adults without stomach symptoms who are already getting a screening colonoscopy. About 1,000 participants will also have a stomach exam (gastroscopy) during the same visit, with small tissu…

This study compares two strong antibiotics, polymyxin B and colistin, in treating serious infections caused by bacteria that are resistant to many common drugs. Researchers will look at medical records of 480 adults with pneumonia or bloodstream infections to see which antibiotic…

This study follows 100 hospitalized patients with Clostridioides difficile infection to track how quickly the bacteria clears from the gut during and after standard antibiotic treatment. Researchers will also analyze gut bacteria and immune responses in stool samples to identify …

This study looks at how certain immune cells (monocytes and macrophages) behave in sarcoidosis and tuberculosis. Researchers will compare blood and tissue samples from 100 adults to find patterns that explain why these cells stay overactive in sarcoidosis. The goal is to better u…

This study looks at how well the Triathlon Hinge Knee System works in people who need knee replacement surgery, either for the first time or to fix a previous one. Researchers will follow about 200 patients for up to 10 years to see how long the implant lasts and how well patient…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis who may also have an NTM infection. Researchers will collect sputum and airway samples from 1000 participants to compare the lung microbiome of those with and withou…

This study follows 3,000 adults aged 40 and older who carry Helicobacter pylori, a common stomach bug. Researchers want to see if people with certain high-risk subtypes of the bacteria develop stomach cancer more often than those with other subtypes or no infection. Participants …

This study looks at children ages 5 to 15 who test positive for strep throat to understand why some become carriers—meaning they have the bacteria but no symptoms. Researchers will collect throat samples and analyze gene activity to compare carriers with those who have active inf…

This study is observing up to 2,000 people in Russia who have or may have rickettsiosis, a tick-borne illness. Researchers will collect leftover blood or swab samples from standard tests to identify the specific germ causing the infection. They will then compare the germ type wit…

This study measures the amount of free cloxacillin in the blood of adults receiving the drug as a continuous infusion for severe staph infections. Researchers want to ensure levels are not too high or too low. They will use this data to create a model that predicts the right dose…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study looks at how well the Oxiris blood filter removes harmful toxins in adults with septic shock in the ICU. Researchers will take blood samples before and after the filter over 24 hours to see when it stops working. No new treatment is given—just observation. The goal is …

This study looks at 60 people with septic shock, a severe infection that causes dangerously low blood pressure. Doctors need to give fluids carefully, but too much can be harmful. The trial compares two methods—a heart monitor (cardiometry) and an ultrasound of a large vein (IVC …

This study aims to find epigenetic markers in the blood that could predict whether a patient with sepsis will develop the more dangerous septic shock. Researchers will take blood samples from 25 male patients after major digestive cancer surgery who develop sepsis. By comparing m…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study tests a rapid PCR test that identifies bacteria and drug resistance in about an hour, compared to standard methods that take 1-3 days. 300 adults with bloodstream infections will be randomly assigned to get either the rapid test plus standard care or standard care alon…

This study looks at stool samples from 100 critically ill patients to understand how a common bacteria, Pseudomonas aeruginosa, becomes dangerous in the gut. Researchers will test if the gut environment makes the bacteria more harmful. No treatment is given; the goal is to learn …

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system in people with sepsis. Researchers will analyze blood samples from 116 ICU patients with sepsis to see if these elements are linked to higher de…

This study watches 200 adults with C. diff infection to see how standard antibiotics and fecal microbiota transplantation (FMT) help people recover. Researchers will collect stool, blood, and urine samples over up to 5 years to understand why some treatments succeed and others fa…

This study is investigating whether germs called non-tuberculous mycobacteria (NTM) found in home water systems and dust can cause lung infections in people with cystic fibrosis. Researchers will collect samples from the homes of 120 CF patients—some with NTM infections and some …

This study looks at how the cholesterol-lowering drug atorvastatin behaves in the body when taken alongside standard tuberculosis (TB) medicines. Researchers will measure drug levels in 80 adults with pulmonary TB to find the best dose of atorvastatin that could help treat TB mor…

This study is a registry that collects information from 520 patients diagnosed with central nervous system (CNS) infections, such as meningitis or encephalitis. Researchers will track how many patients survive to discharge. The goal is to better understand these rare but serious …

This study looks at 300 adults hospitalized with rare but life-threatening flesh-eating infections (necrotizing soft tissue infections). Researchers want to find out which early signs and routine lab tests can predict who is most likely to die during their hospital stay. The goal…

This study tests whether artificial intelligence can predict if a less invasive procedure called full pulpotomy (removing only the infected pulp) will succeed in treating painful molars, compared to standard root canal treatment. Researchers will enroll 58 adults with irreversibl…

This study is a national registry that will follow up to 4,000 people who receive a fecal microbiota transplant (FMT) for C. diff infection or other gut conditions. Researchers will track side effects, infections, and whether the disease comes back. The goal is to better understa…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study looks at how a person's sex and gender might change their immune system's reaction to the meningitis B vaccine. Researchers will compare immune responses in transgender and cisgender adults aged 18 to 50. The goal is to better understand why men and women often respond…

This study looks at a severe condition called mixed cardiogenic-vasoplegic shock, where the heart fails to pump and blood vessels widen too much. Researchers will review medical records from 2,500 patients in three French hospitals to understand who gets this condition and how th…

This study looks at how well two different software programs measure heart function in people with septic shock, a life-threatening infection that affects the whole body. Researchers will use existing heart ultrasound data from 60 adults to see if the measurements agree and can b…

This study looks at cases of severe Lyme disease (disseminated borreliosis) in patients who have received anti-CD20 therapy, a type of immune-suppressing treatment. Researchers want to describe the symptoms, severity, and progression of the infection in these patients. The study …

This study is looking back at medical records of 400 adults hospitalized with a serious strep blood infection (Streptococcus anginosus group). The goal is to find out which factors are linked to a higher chance of dying within 28 days. By understanding these risk factors, doctors…

This study looks back at cases of recurrent borreliosis, a bacterial infection spread by ticks or lice, diagnosed in France between 2013 and 2025. Researchers will describe the symptoms, where patients got infected, which Borrelia species caused the illness, and how it was diagno…

This study collects information from about 100 adults in Alsace who have had a confirmed case of human anaplasmosis, a bacterial infection spread by ticks. Researchers want to learn more about how common it is, what symptoms people have, and how serious it can be. The goal is to …

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is…

This study uses a technique called microdialysis to measure antibiotic levels directly inside the hip joint after surgery for an infected hip replacement. Researchers want to see how well local antibiotics from a cement spacer work and compare them to levels in the blood. The goa…

This study uses a technique called microdialysis to measure antibiotic levels inside the knee joint after surgery for a knee replacement infection. Researchers will place a tiny probe in the joint to collect fluid samples during the hospital stay (about 14 days). They want to see…

This study follows 600 people at higher risk for stomach cancer to track precancerous changes in the stomach lining. Researchers collect tissue, blood, and saliva samples during routine endoscopies. The goal is to understand why some people's stomach changes progress to cancer wh…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This study aims to create a safe, controlled human infection model for whooping cough. Healthy adults aged 18-50 will receive a nasal dose of the bacteria to cause a mild infection. Researchers will monitor symptoms and test nasal samples to find the best dose that infects most p…