Could a 'Microbiome Transplant' stop recurring vaginal infections?

NCT ID NCT04046900

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests whether transplanting vaginal fluid from healthy donors can restore a healthy bacterial balance in women with recurrent bacterial vaginosis (BV). Participants receive either the transplant or a placebo after antibiotic treatment. The goal is to see if the transplant helps maintain protective Lactobacillus bacteria and prevent BV from coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Vaginal microbiome transplant (donor vaginal fluid)
What this could lead to
If successful, this approach could offer a new way to prevent recurrent bacterial vaginosis by restoring healthy vaginal bacteria.
What could go wrong
This is an early-phase trial with a small number of participants. The transplant may not take hold, or side effects could occur. Results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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