Antibiotics after bladder botox may cut infection risk

NCT ID NCT04791579

Recruiting now Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking a short course of antibiotics (ciprofloxacin) after Botox injections into the bladder can reduce the chance of urinary tract infections. About 160 adults with neurogenic overactive bladder (due to conditions like multiple sclerosis or spinal cord injury) will be randomly assigned to receive either antibiotics or a placebo. The goal is to see if this simple step can make a common procedure safer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ciprofloxacin (antibiotic)
What this could lead to: If it works, this could provide a simple way to prevent bladder infections after Botox injections, improving safety and reducing antibiotic overuse.
What could go wrong: This is a small Phase 2 trial, so results may not apply to everyone. Ciprofloxacin can cause side effects like nausea, and overuse may contribute to antibiotic resistance.

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Conditions

The condition(s) this trial relates to.

bacterial urinary tract infection Urinary Bladder, Neurogenic urinary tract infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROGENIC BLADDER POST-OPERATIVE URINARY TRACT INFECTIONS

Contacts and locations

Locations

University of Alberta
RECRUITING

Edmonton, Alberta, T6G2R3, Canada

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