University Of Alberta

This study compares two different approaches for treating aneurysms (weak spots in blood vessels) in the brain's middle cerebral artery. Researchers want to determine whether traditional surgery or a less invasive endovascular procedure (performed through blood vessels) leads to …

This study aims to find out if a medication called vasopressin works better than the current standard drug, epinephrine, to restart the heart in newborns who need emergency CPR at birth. The hospital will use one drug or the other for a year, and researchers will compare how quic…

This study is testing a new hospital program designed to improve care for babies born with Neonatal Abstinence Syndrome (NAS), which occurs when a baby is exposed to drugs in the womb. The program focuses on 'rooming-in,' where mothers and babies stay together in a quiet hospital…

This study is testing if using a precise, non-surgical radiation treatment called Gamma Knife very early for a severe facial pain condition (trigeminal neuralgia) works better than the usual approach of trying medications first. It will involve 80 adults who have had the pain for…

This study is testing whether a medication called sotatercept can improve how well the lungs absorb oxygen during exercise in people with pulmonary arterial hypertension (PAH). Twenty-seven adult participants who are already on stable PAH medications will receive sotatercept inje…

This study is comparing three diets to see which is best for managing heart disease and diabetes risk. It will test a keto diet using canola oil, a traditional high-saturated-fat keto diet, and a standard low-fat diet. About 175 adults who are overweight and at high risk for type…

This study is creating and testing a new support program for Indigenous young adults in Maskwacis, Alberta, who are living with long-term health conditions. The program pairs them with a trained, community-based Indigenous Patient Navigator who helps them manage their health as t…

This study is testing a new training program to help people with above-elbow amputations use advanced bone-anchored prosthetic arms more effectively. Researchers are working with 5 participants who have received both bone-anchored implants and nerve rerouting surgery. The goal is…

This study aims to improve care for critically ill patients who need emergency dialysis in Alberta's intensive care units (ICUs). It will test a new, standardized approach to delivering this life-sustaining treatment across 18 hospitals. The goal is to improve patient recovery, r…

This pilot study aims to find out if a lower dose of continuous dialysis is as safe and effective as the current standard dose for critically ill patients with sudden kidney failure. It will involve 100 patients in intensive care units. The goal is to see if the lower dose works …

This study is testing if a special dental appliance that widens the upper jaw can help guide the lower jaw to grow forward in children. It will involve 60 children, aged 9-11, who have a lower jaw that sits too far back. Researchers will use special 3D X-rays to measure changes i…

This study is testing if a special home exercise bike that connects to a video game is a safe and practical way to help children who have had a heart transplant get stronger. Researchers want to see if this 12-week program can improve the kids' fitness, activity levels, and quali…

This study is investigating whether common orthodontic treatments can help children with specific jaw alignment issues breathe better. Researchers will treat 90 children, aged 8-14, who have a small upper jaw and a recessed lower jaw, using devices to expand the upper jaw and rep…

This study is testing whether a simple computer program can help people regain peripheral vision lost after a stroke or brain injury. Researchers will have 40 participants either watch regular online news or use a special PowerPoint slideshow for 15 minutes, three times a week. T…

This study is testing if combining a fiber supplement with the medication metformin works better than either alone to help teens with severe obesity and insulin resistance. Over 12 months, researchers will measure changes in weight, blood sugar control, and gut bacteria in 90 par…

This study is testing whether adding a second blood-thinning medication (clopidogrel) to standard aspirin treatment better prevents repeat strokes in the critical first 21 days after an initial stroke. Researchers will enroll 200 stroke patients who have received clot-busting tre…

This study tests whether stroke survivors in rural Alberta can improve arm and hand movement using a home-based video game therapy system when they can't access standard outpatient rehab. 200 participants will use wearable sensors and game-like exercises guided remotely by therap…

This study is testing whether a structured care program led by community pharmacists can help people with type 2 diabetes manage their condition better than their usual doctor's care. It will involve 600 Albertans whose blood sugar is not yet at a healthy target. The goal is to s…

This study aims to see if a special ultrasound scan (FibroScan) can help doctors safely reduce the amount of strong anti-rejection drugs that liver transplant patients must take for life. These drugs prevent organ rejection but can cause serious long-term side effects like kidney…

This study aims to improve surgery for children with tight ankle muscles that limit their ability to walk properly. Researchers are testing if cutting a small, often-overlooked leg muscle (the plantaris) first, before the larger calf muscles, leads to better ankle movement and a …

This study is testing a personalized treatment called CAR T-cell therapy for people with aggressive lymphoma or acute lymphoblastic leukemia that has returned or not responded to standard treatments. Doctors collect a patient's own immune cells, genetically modify them in a lab t…

This is a small, early-stage study to see if a specific protein found in processed egg whites (called IRW) can be absorbed by the body and help manage high blood sugar and high blood pressure. Researchers will give participants smoothies with different protein powders and measure…

This study is testing if adding one of two existing drugs (empagliflozin or ranolazine) to standard care helps people with right-sided heart failure caused by high lung blood pressure. It will enroll 30 adults to see if this approach is practical for a larger future trial. The ma…

This study is testing a new therapy for teenagers with cerebral palsy who have weakness on one side of their body. The therapy combines a special cap that reads brain signals with gentle electrical stimulation to move the weak arm. The goal is to see if this high-tech, game-like …

This study aims to find the best time to exercise for people with type 1 diabetes. It will compare doing aerobic exercise before breakfast versus after breakfast over 12 weeks. Researchers want to see if exercising on an empty stomach helps control blood sugar better and reduces …

This study is testing if home blood pressure monitoring with extra support from a nurse case manager works better than monitoring alone for people with kidney disease and high blood pressure who live far from clinics. About 150 patients in remote Northern Alberta will use a smart…

This international study aims to find the safest amount of oxygen to use when helping very premature babies breathe right after birth. It will compare starting with 30% oxygen versus 60% oxygen in about 1,200 infants born before 29 weeks. The main goal is to see which approach le…

This study is testing if a brief session of electrical stimulation right before surgery can help people with severe cubital tunnel syndrome recover better. Researchers will compare patients who get the stimulation plus surgery to those who get surgery alone. They will measure imp…

This study aims to find the best way to prevent wound complications in women who need repeat breast cancer surgery after previous radiation treatment. Researchers will compare three approaches: a week of antibiotics, a special wound vacuum dressing, or no extra treatment. The goa…

This study is testing whether exercise can help protect the hearts of older breast cancer survivors. Many survivors face increased risk of heart problems after chemotherapy. Researchers will compare a 12-week exercise program to a gentle stretching program in 60 survivors over ag…

This study is testing whether a team-up between community pharmacists and physiotherapists can help people manage early knee osteoarthritis. It aims to see if this coordinated approach improves pain, function, and a person's confidence in managing their own condition. The goal is…

This study is testing a new digital care plan to help people recover after a sudden kidney injury during a hospital stay. It uses a patient's electronic health record to calculate their personal risk of future kidney or heart problems and creates a tailored plan for their care af…

This study is testing if adding a freeze-dried fecal microbiota transplant (FMT) to standard biologic medications helps people with active ulcerative colitis get better. It will involve 40 adults in Canada who are starting new treatment with either vedolizumab or ustekinumab. Par…

This study is testing whether drinking traditional kefir daily for 12 weeks can help control blood sugar, improve cholesterol, and reduce inflammation in adults who have or are at high risk for Type 2 Diabetes. Participants will be randomly assigned to drink either kefir or a mil…

This study is testing if a pill called midodrine can help intensive care unit (ICU) patients safely stop using strong intravenous (IV) blood pressure medications earlier. It involves 870 adults in the ICU whose blood pressure is improving but still needs support. The goal is to s…

This study is testing a 9-week education program for family members who support a young adult with a psychotic illness. The program teaches communication and coping skills to help reduce stress on the family and potentially improve the patient's long-term stability in the communi…

This study is testing whether adding a daily fish oil supplement to the standard medication metformin can better protect the heart health of women with Polycystic Ovary Syndrome (PCOS). It will involve 146 overweight or obese women with PCOS who are already at higher risk for hea…

This study tests whether a digital wellness platform with professional guidance can help endometrial cancer survivors adopt healthier lifestyles. Researchers will measure changes in waist size, body composition, and heart health markers over 24 weeks. The program focuses on nutri…

This study is comparing two different surgical techniques for wrist arthritis caused by an old injury. It will involve 170 adults who need surgery to fuse some of their wrist bones. Researchers will measure grip strength, pain, and movement over a year to see if removing one smal…

This project is testing a new, standardized digital support system for children in Alberta who need a tracheostomy (a breathing tube in the neck). The goal is to help these medically complex children leave the hospital sooner and reduce the mental stress on their families and car…

This study is testing a home exercise program that uses a special video game-linked exercise bike to help young people with congenital heart disease get fitter. Researchers want to see if this fun, supervised 8-week program improves exercise ability, physical activity levels, and…

This study is testing a custom-made mouthpiece, called the OrthoApnea NOA, to see if it can effectively control obstructive sleep apnea. It will follow 150 people for three years to see if the device cuts their breathing pauses in half and improves sleep quality. The research wil…

This study aims to find out if a newer, high-resolution micro-ultrasound is as good as the current standard MRI for detecting prostate cancer that needs treatment. About 1,300 men aged 50-70 will be randomly assigned to get one of the two imaging tests. The goal is to see which t…

This study aims to find the best way to locate the source of gastrointestinal bleeding when the first stomach exam comes back clear. Researchers will compare two approaches: one group will get a pill-sized camera to check the small bowel next, while the other group gets a standar…

This study is testing a new molecular diagnostic system to improve how doctors detect rejection in lung transplant patients. It will compare the new test, which analyzes the molecular 'fingerprint' of tissue samples, to the current standard biopsy method, which can sometimes be w…

This study aims to improve a blood test that detects rejection in kidney transplant patients. Researchers will compare the blood test results to more advanced biopsy analysis methods in 300 patients who need a biopsy for medical reasons. The goal is to make the blood test accurat…

This study is testing a new molecular test to better understand why a transplanted liver might not be working properly. Researchers will analyze small pieces of tissue from 300 liver transplant biopsies that are already being taken for standard medical care. The goal is to see if…

This study is testing an improved version of a special PET scan called 18F-DOPA. The goal is to see if using a newer scanner and a common medication (furosemide) can make the images clearer, especially in the lower abdomen. This could help doctors better detect and plan treatment…

This study is testing a new molecular diagnostic system to improve how doctors detect rejection in heart transplant patients. It will involve analyzing heart tissue biopsies from 900 patients to see if the new test provides more accurate results than the current standard method. …

This study is testing a new, more accurate diagnostic system for kidney transplant biopsies. It combines molecular analysis with traditional methods to better understand why a transplanted kidney might be failing. The goal is to provide doctors with clearer information to choose …

This study aims to see if a simple blood test can be as good as or better than current biopsy methods for spotting rejection in lung transplant patients. Researchers will compare the new blood test results to two other diagnostic methods in 600 patients. The goal is to find safer…

This large study is testing a new type of PET/CT scan that uses a special tracer to find prostate cancer cells that have spread in the body. It aims to see if this scan is safe and accurate for men whose cancer may be returning or who are at high risk of it spreading. The main go…

This study aims to see if a new blood test can accurately detect heart transplant rejection, potentially replacing the need for frequent, painful heart biopsies. Researchers will compare the blood test results to two other advanced diagnostic methods in 300 heart transplant recip…

This study is looking at whether a third dose of the measles, mumps, rubella, and chickenpox (MMRV) vaccine can help protect women whose immunity from their childhood shots has worn off. Researchers will measure immune responses in about 200 pregnant women in Alberta who have alr…

This study aims to see if taking antibiotics for three days after receiving Botox injections for overactive bladder can prevent painful urinary tract infections, which are a common side effect. Researchers will compare infection rates in 202 women who receive either real antibiot…

This study is testing custom-made, 3D-printed masks for children who use non-invasive breathing machines at night. The goal is to see if masks designed specifically for each child's face are more comfortable, fit better, and help kids use their breathing machines more consistentl…

This small, early-stage study is testing whether an inhaled medication called treprostinil can help people with mild COPD feel less short of breath and exercise longer. Twenty participants will perform cycling tests and lung scans to see if the drug improves their breathing comfo…

This study is testing if using portable oxygen during physical activity can help people with a scarring lung disease feel better and be more active. It will involve 60 participants who have normal oxygen levels at rest but drop during exertion. Researchers will provide oxygen for…

This study is testing if a supervised heavy weight lifting program is practical and helpful for people who have survived head and neck cancer. It will compare 60 survivors doing 12 weeks of heavy lifting against a group receiving usual care. The main goal is to see if the program…

This study is testing if a single dose of oral sildenafil (the active ingredient in Viagra) can help people with mild COPD exercise longer and feel less short of breath. Researchers believe sildenafil may improve blood flow in the lungs, which could reduce breathlessness during a…

This study is exploring whether increasing access to traditional Inuit country foods and participating in cultural activities can help reduce symptoms of depression and anxiety. It involves 40 Inuit adults in Arviat, Nunavut, who will take part in community wellness programs. The…

This study is testing whether a 12-week stationary cycling program is a practical and acceptable way to help reduce nerve pain and numbness caused by chemotherapy. Researchers will recruit 30 adult cancer survivors with mild nerve symptoms to participate in twice-weekly, supervis…

This study is testing if a common anti-inflammatory drug (ketorolac) can be used at lower doses to safely reduce pain in ICU patients, with the goal of decreasing their need for strong opiate painkillers. It's a small pilot study with 30 participants to see if a larger trial is p…

This study is testing whether taking taurine, a common dietary supplement, can help reduce the brain fog and severe fatigue experienced by people with Long COVID. Researchers at the University of Alberta are recruiting 300 adults who have had lingering COVID symptoms for at least…

This study is testing whether a program of early monitoring and physical therapy is practical and acceptable for people with head and neck cancer. It aims to see if starting jaw exercises and manual therapy early during radiation treatment can help prevent or reduce severe jaw st…

This study is testing whether a 10-week exercise program is practical and helpful for people with multiple myeloma who are getting chemotherapy before a stem cell transplant. Researchers want to see if patients can and want to participate in a tailored exercise plan, delivered in…

This study is testing a new way to help children with disabilities get more out of their therapy. Researchers want to see if letting kids help set their own therapy goals, using a method called ENGAGE, leads to better results than the usual approach where therapists and parents s…

This study is testing if wearing a supportive back brace for four weeks can help people who go to the emergency room for common low back pain. Researchers want to see if the brace reduces pain, improves movement, and helps people use fewer painkillers, including opioids. The goal…

This study is testing a 12-week wellness program designed to help men recover after prostate removal surgery. The program combines online education, group exercise, and pelvic floor muscle training to improve bladder control, sexual function, and overall fitness. Researchers want…

This study is testing a new way to help children with disabilities get more out of their therapy. It involves teaching therapists how to help kids aged 5-12 set their own personal goals for treatment. Researchers want to see if this child-focused approach, called ENGAGE, leads to…

This study aims to see if artificial intelligence (AI) can translate health information as effectively as professional human translators. Researchers will recruit 350 adults in Canada whose first language is French, Spanish, Ukrainian, Tagalog, Arabic, Chinese, or Punjabi. Partic…

This study aims to learn how often a dangerous virus called CMV breaks through preventive medication in high-risk lung transplant patients. Researchers will follow 40 patients who receive standard preventive treatment after transplant to monitor infection rates and medication sid…

This study aims to create better, nationwide guidelines for preventing and treating ventilator-associated pneumonia (VAP) in very small, premature babies. Researchers will collect data from 1,500 infants across Canadian hospitals to understand how often these infections happen, w…

This study aims to understand why the standard dose of the drug nimodipine, given after a life-threatening brain bleed (aneurysmal subarachnoid hemorrhage), might not work the same for everyone. Researchers will measure drug levels in the blood of 500 adult patients in North Amer…

This study aims to understand how different types of exercise affect blood sugar levels in post-menopausal women with type 1 diabetes. Researchers will monitor 20 participants' blood sugar during and after rest, treadmill walking, and weight-lifting sessions. The goal is to gathe…

This study aims to understand a condition called 'augmented renal clearance,' where the kidneys work faster than normal, in patients with severe brain injuries, strokes, or infections. Researchers will measure kidney function and drug levels in over 500 adult ICU patients to see …

This University of Alberta study aims to understand why healthy men and women regulate blood pressure differently. Researchers will measure how blood vessels in the forearm respond to small doses of blood pressure medications and record nerve activity using tiny needles. The find…