University Of Alberta

This study tests a new muscle-training program for people with above-elbow amputation who have a bone-anchored prosthetic arm. The goal is to help them control a myoelectric (muscle-signal) prosthetic hand and elbow more reliably in daily life. Five adults scheduled for osseointe…

This study tests whether adding a freeze-dried fecal transplant (LFMT) to standard biologic drugs (vedolizumab or ustekinumab) is safe and helps more people with ulcerative colitis reach remission. About 40 adults with active UC will receive either LFMT or a placebo alongside the…

This study looks at whether taking fish oil supplements along with the standard medicine metformin can improve heart health in women with Polycystic Ovary Syndrome (PCOS). The study will include 146 women with PCOS who are overweight and have high blood fats or blood sugar issues…

This study looks at how well a custom mouthpiece called OrthoApnea NOA helps people with obstructive sleep apnea (OSA). OSA causes breathing to stop and start during sleep, and some people find the standard CPAP machine uncomfortable. The NOA mouthpiece may be a simpler option. R…

This study looks at whether taking antibiotics after getting Botox injections in the bladder can lower the chance of getting a urinary tract infection (UTI). People with neurogenic overactive bladder (caused by conditions like multiple sclerosis or spinal cord injury) often get U…

This study tests whether adding empagliflozin or ranolazine to standard treatment can improve right heart function in 30 adults with pulmonary hypertension and right heart failure. Participants are randomly assigned to one of the two drugs plus usual care, or usual care alone. Th…

This study looks at whether taking fiber supplements along with the diabetes drug metformin can help teenagers with severe obesity and insulin resistance. The goal is to see if the combination works better than either treatment alone for improving blood sugar control, reducing in…

This study tests whether drinking traditional kefir for 12 weeks can improve blood sugar control and heart health in people who are overweight and either at risk for or already have type 2 diabetes. Researchers will measure changes in HbA1c (average blood sugar) and other health …

This study tests whether a pill called midodrine can help intensive care unit (ICU) patients with dangerously low blood pressure stop using intravenous (IV) blood pressure drugs sooner. About 870 adults whose IV medications are already being reduced will receive midodrine or a pl…

This study is testing whether transplanting healthy stool bacteria into people with ulcerative colitis can help control the disease. It involves 85 adults with active colitis who will receive either the transplant or a placebo. The goal is to see if this approach is worth testing…

This study tests a drug called MTX228 to see if it can help regrow insulin-producing beta cells in adults with type 1 diabetes. About 24 participants will receive different doses to find the best one. The goal is to reduce the amount of insulin they need to inject and improve blo…

This study tests a 24-week digital wellness program combined with online support from healthcare professionals to help endometrial cancer survivors reduce waist size and improve overall health. About 148 participants who have completed cancer treatment will use a smartphone app a…

This study looks at whether giving a lower dose of continuous dialysis (CRRT) to critically ill patients with sudden kidney failure is safe and works as well as the standard dose. About 100 adults in the ICU who need dialysis will be randomly assigned to receive either the standa…

This study tests a personalized care plan for people leaving the hospital after acute kidney injury (AKI). About 6,000 adults in Alberta hospitals will be randomly assigned to either receive a tailored care plan based on their risk or usual care. The plan uses digital tools in th…

This study tests whether the drug sotatercept can improve how well the lungs take in oxygen in people with pulmonary arterial hypertension (PAH). About 27 adults with PAH will receive the drug every 21 days for 29 weeks. Researchers will measure lung function, heart health, and e…

This study looks at whether a special dental appliance that expands the upper jaw can also encourage the lower jaw to grow forward in children aged 9-11 with a deep overbite. Sixty kids will receive either an active or inactive expander and have their jaw measured with 3D X-rays …

This study tests whether a 12-week online program of exercise, nutrition advice, and behavioral support can improve physical function in adults with cirrhosis who are waiting for a liver transplant. About 177 participants from six Canadian transplant centers will be randomly assi…

This study tests whether a special pharmacist-led program helps people with type 2 diabetes control their blood sugar better than usual doctor care. About 600 adults with uncontrolled diabetes will join. The goal is to see if easier access to pharmacists can lower A1C levels and …

This study compares two surgical techniques for treating wrist arthritis caused by old injuries. 170 adults with specific types of wrist collapse will be randomly assigned to have either a four-corner fusion or a three-corner fusion (which removes one small bone). The goal is to …

This study tests a personalized treatment using a patient's own immune cells, modified to target and attack cancer cells. It is for people with aggressive lymphoma or acute lymphoblastic leukemia that has come back or not responded to standard treatments. The goal is to find the …

After a liver transplant, patients must take lifelong anti-rejection drugs that can cause kidney problems, diabetes, heart disease, and cancer. This study tests whether a simple ultrasound-like test called a fibroscan can identify patients who can safely reduce their anti-rejecti…

This study tests whether a keto diet using canola oil (healthy fats) is better for heart health than a traditional keto diet high in saturated fat or a low-fat diet. Researchers will measure cholesterol, blood sugar, and inflammation in 175 adults with prediabetes or type 2 diabe…

This study looks at whether giving both clopidogrel and aspirin for 21 days after a stroke is safe and works better than aspirin alone to prevent another stroke. About 200 adults who had a mild to moderate stroke and received clot-removal treatment will take part. The goal is to …

This study compares two ways to treat aneurysms in the middle cerebral artery (MCA) of the brain: open surgery (clipping) and less invasive endovascular methods (like coiling or stents). About 400 adults with a ruptured or unruptured MCA aneurysm will be randomly assigned to one …

This study looks at whether doing aerobic exercise before breakfast (fasted) or after breakfast (fed) is better for people with type 1 diabetes. Twenty adults with type 1 diabetes will train for 12 weeks. Researchers will track insulin use and blood sugar levels to find the best …

This study looks at whether checking blood pressure at home and sharing readings with a case manager can improve blood pressure control for people with chronic kidney disease who live far from clinics. About 146 adults in northern Alberta will either use home monitoring with usua…

This study tests a new molecular test (Molecular Microscope Diagnostic System) to better detect rejection in heart transplant patients. Researchers will analyze biopsies from 900 participants to see if the test can identify rejection more accurately than current methods. The goal…

This study is testing whether a blood test (called Prospera) can accurately detect kidney transplant rejection without needing a needle biopsy. Researchers will compare the blood test results with standard biopsy and antibody tests in 300 kidney transplant recipients. If successf…

This study is testing a new radioactive tracer called 68Ga-HA-DOTATATE to see how well it finds neuroendocrine tumors on PET/CT scans. About 600 people with known or suspected tumors will receive the tracer and be scanned. The goal is to check if this new method is safer and more…

This study is testing a special PET scan (18F-DOPA) to see if it can better detect and measure several conditions, including congenital hyperinsulinism in children, neuroblastoma, neuroendocrine tumors, Parkinson's disease, Lewy body dementia, and brain tumors. About 800 children…

This study tests whether a brain-computer interface (BCI) game can assess cognitive skills like attention and memory in children aged 7-16 with motor impairments. Traditional tests require physical responses, which may underestimate these children's abilities. By using brain sign…

This study is testing a new imaging tracer called 18F-PSMA-1007 for PET/CT scans to see if it can better detect where prostate cancer has spread in the body. About 2800 adults who have already had treatment for prostate cancer (such as surgery or radiation) and have signs that th…

This study tests whether a new type of ultrasound (microUS) is as good as MRI for finding prostate cancer. About 1,284 men aged 50-70 with elevated PSA will be randomly assigned to get either a microUS or an MRI. The goal is to see which method better detects serious prostate can…

This study aims to improve how doctors diagnose problems in kidney transplant biopsies. Current methods can be inaccurate, leading to wrong treatments. Researchers have developed a new system that combines genetic information with standard tissue analysis. The study will test thi…

This study aims to see if giving women a short course of antibiotics after bladder Botox injections can prevent urinary tract infections, which are a common side effect. Researchers will compare infection rates between women who receive real antibiotics versus placebo pills for t…

This study looks at whether a specific protein (IRW) from egg whites can help control blood sugar and blood pressure. About 28 people who are overweight or have high blood sugar will drink a smoothie with this protein and have their blood and pressure measured. The goal is to see…

This study tests whether early physical therapy can prevent or reduce jaw stiffness (trismus) in people with head and neck cancer who are getting radiation. Thirty participants will do jaw exercises and manual therapy if their mouth opening decreases. The goal is to see if this a…

This study tests whether taking taurine, a natural supplement, can improve thinking, memory, and energy in people with Long COVID. Researchers will enroll 300 adults who have had COVID-19 and still struggle with brain fog or fatigue. Participants take taurine or a placebo for thr…

This study tests whether viewing images on a PowerPoint slideshow can help people with hemianopsia (blindness in half the visual field) after a stroke or brain injury see more of their surroundings. Researchers will measure changes in the visual field using a standard eye test. T…

This study tests a 'rooming-in' program where mothers and babies stay together in a quiet hospital room instead of separating the baby to the NICU. About 240 full-term infants exposed to opioids during pregnancy will take part across Alberta hospitals. The goal is to reduce NICU …

This study tests whether a type of light therapy called photobiomodulation can help people with obstructive sleep apnea use their CPAP machine more comfortably. About 30 adults who currently use CPAP but have trouble tolerating it will receive the light treatment. The goal is to …

This study looks at whether a supervised, stationary cycling program can help reduce nerve pain and improve daily function in people who have chemotherapy-induced peripheral neuropathy (CIPN). Thirty adults with cancer who have mild CIPN will cycle twice a week for 12 weeks. The …

This study tests whether a team of pharmacists and physiotherapists can help 125 people with early knee osteoarthritis manage their pain and stay active. Participants will get education, exercise advice, and medication support. The goal is to improve knee function and help people…

This study tests whether using virtual reality (VR) games during speech therapy helps adults with voice disorders stick with their exercises and get better results. Researchers will compare VR-enhanced therapy to standard care in 30 patients at a rehabilitation hospital. The goal…

This study is testing a program from Denmark, called GLA:D Back, for people with persistent low back pain. The goal is to see if it works in Canada and help patients manage their pain better. About 2200 people with low back pain lasting at least one month will take part.

This study tests a new therapy that uses brain signals to activate muscle stimulation, helping children with cerebral palsy move their weak arm and hand. Eight children aged 12 to 17 will complete 15-20 sessions over two months. The goal is to improve daily activities like dressi…

This study looks at whether a 12-week exercise program can improve heart and muscle function in women over 60 who had chemotherapy for breast cancer. Chemo can sometimes weaken the heart, and exercise might help. Researchers will compare a structured exercise program to a stretch…

This study looks at whether wearing a lumbar brace for 4 weeks after an ER visit for low back pain can lower pain, improve spine function, and reduce the need for painkillers. About 152 adults aged 18-65 in Edmonton will be enrolled. The goal is to find a safer, non-drug option f…

This study tests a home-based telerehabilitation program for stroke survivors who have trouble using their arms and hands but cannot access outpatient therapy. About 200 participants across Alberta will use a system of game-like exercises with wearable sensors, guided remotely by…

This study looks at whether Schroth exercises, a type of physical therapy, can reduce pain and improve daily life for adults over 50 with degenerative scoliosis (a curved spine). Twenty people with mild to moderate curves and ongoing pain will either do the exercises or just be o…

This study looks at whether adding a text-message support program (Text4Support) to repetitive transcranial magnetic stimulation (rTMS) helps people with treatment-resistant depression more than rTMS alone. About 200 adults who have not gotten better with at least two antidepress…

This study tests if giving a mild electrical stimulation to the nerve just before surgery can speed up recovery for people with severe cubital tunnel syndrome (a pinched nerve in the elbow that weakens the hand). About 30 adults with severe nerve damage will receive either real o…

This study tests whether a home-based, video game-linked exercise bike (MedBIKE) can help 10 kids aged 10-18 who have had a heart transplant improve their fitness. Participants will do high-intensity interval training (short bursts of hard exercise with rest) for 12 weeks. The ma…

This study looks at whether eating more traditional Inuit foods (like fish and game) and taking part in cultural activities can help reduce depression and anxiety in Inuit adults aged 18-65 in Arviat, Nunavut. About 40 participants will be followed for 12 weeks to see if their mo…

This study tests a 9-week education program for families of young adults (ages 17-27) with psychosis. The program teaches practical skills to reduce the burden on caregivers and help keep patients stable in the community. Researchers will measure changes in family stress, patient…

This study tests whether giving Gamma Knife radiosurgery very early after diagnosis of trigeminal neuralgia (a severe facial pain condition) provides longer-lasting pain relief than waiting until medications stop working. About 80 adults with a recent diagnosis will either receiv…

This study tests whether sildenafil, a pill that widens blood vessels in the lungs, can help people with mild COPD exercise longer and feel less short of breath. Researchers will measure exercise capacity and breathing patterns in 160 participants. The goal is to see if improving…

This study aims to see if custom-made non-invasive ventilation (NIV) masks improve comfort and treatment adherence in children aged 8-12 who currently use standard masks but have poor adherence. Participants will have their face scanned to create a personalized mask, then compare…

This study tests whether a smartphone app called MyIBDDiet can help people with inflammatory bowel disease (IBD) learn about and follow an anti-inflammatory diet. Forty adults with IBD who are not currently in a flare will use the app for one month. Researchers will measure how e…

This study looks at whether letting children with disabilities (like autism or cerebral palsy) help set their own therapy goals leads to better results. About 96 kids aged 5-12 and their therapists will either use a special child-focused goal-setting method called ENGAGE or conti…

This study looks at whether people with multiple myeloma can and want to join a 10-week exercise program while getting chemotherapy before a stem cell transplant. The program includes both in-person and online sessions. Researchers want to see if it helps maintain physical fitnes…

This study looks at whether using portable oxygen during physical activity can improve quality of life, exercise ability, and shortness of breath in people with mild-to-moderate interstitial lung disease. About 60 participants will receive oxygen for 8 weeks, with some also getti…

This study tests if a home-based video game exercise bike (MedBIKE) can improve fitness in 44 teens aged 10-18 with repaired congenital heart disease. Participants do high-intensity interval training at home, guided by a telemedicine coach. The goal is to see if this fun, remote …

This study looks at whether a low dose of ketorolac, an NSAID painkiller, can safely reduce the need for opiates in critically ill ICU patients. Opiates are effective but can lead to dependence after leaving the hospital. The trial will enroll 30 adults in the ICU who are in pain…

This study tests whether a heavy lifting strength training program can help head and neck cancer survivors regain muscle strength, reduce fatigue, and improve quality of life. About 60 adults who finished cancer treatment at least one year ago will be randomly assigned to either …

This study looks at women who have had breast surgery and radiation before and need another breast surgery. Because radiation makes healing harder, researchers want to find the best way to prevent wound problems. They will compare three options: a week of antibiotics, a wound vac…

This study looks at how semaglutide (a diabetes and weight-loss drug) changes fat deposits around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers want to understand if these fat changes help slow kidney damage. About 52 adults …

This study is testing whether a special wearable shirt and home devices can safely monitor children (ages 8-18) with heart failure. The goal is to see if this approach is practical and acceptable for families, especially those living far from hospitals or with limited resources. …

This study is for people who are getting an allogeneic bone marrow transplant for blood cancer. The treatment is very intense and can cause long-term physical and emotional side effects. The researchers want to learn if a smartphone app, along with phone support from nurses, exer…

This study looks at whether orthodontic treatment with twin block and hyrax devices can improve breathing in children aged 8-14 who have a small lower jaw and a narrow upper jaw. Researchers will measure changes in airway size and airflow using 3D scans and models. The goal is to…

This study tests whether MRI can accurately measure fluid buildup in the lungs of people hospitalized for acute heart failure. Researchers will track how lung water changes during treatment and see if these measurements can predict who is at higher risk of returning to the hospit…

This study looks at how much protein people with colorectal or breast cancer need to prevent severe muscle loss, which can lead to disability and poor quality of life. Researchers will use a simple, non-invasive test to measure protein needs in 40 patients. The goal is to create …

This study looks at how often very small or premature babies get lung infections while on breathing machines in hospitals across Canada. Researchers will compare how different hospitals diagnose and treat these infections to create a shared, evidence-based plan. The goal is to re…

This study follows 106 men who have had surgery for prostate cancer to see how their bladder control, sexual function, and overall health improve over time. Participants receive standard care resources and are monitored for physical activity, fitness, and quality of life. The goa…

This study looks at liver transplant biopsy samples to find patterns linked to organ rejection. Researchers will analyze gene activity in 300 biopsies to create a tool that can predict rejection more accurately. The goal is to improve diagnosis, not to test a new treatment. Parti…

This study looks at using a new molecular test on lung biopsy samples to better diagnose rejection in lung transplant patients. Researchers will compare the test results with standard methods to see if it can improve accuracy and potentially allow for a safer biopsy procedure. Ab…

This study will test a new, evidence-based approach to delivering emergency dialysis (renal replacement therapy) to 4500 patients in Alberta intensive care units. The goal is to improve patient outcomes and reduce healthcare costs by standardizing care. Researchers will track key…

This study is testing a new program where an Indigenous patient navigator helps young adults (ages 16-25) with chronic health conditions as they move from pediatric to adult healthcare. The program was co-designed with community Elders and members in Maskwacis, Alberta. Researche…

This study looks at a small leg muscle called the plantaris and its role in treating tight ankles (ankle equinus) in children aged 4-17. About 42 kids having surgery for this condition will have the plantaris and larger calf muscles lengthened in a random order. The goal is to se…

This study looks at whether using a small camera pill (video capsule endoscopy) right after a negative stomach scope can help find the source of bleeding faster in people with suspected upper gastrointestinal bleeding. The standard approach usually does a colonoscopy first. The s…

This study follows 40 lung transplant patients whose donor had CMV but who themselves had never been exposed to the virus. Researchers want to see how often CMV breaks through while patients take the antiviral drug valganciclovir, and what side effects occur. The goal is to bette…

This study is building a large collection of health data and biological samples from 150 people with ALS and related conditions. Researchers will track changes in muscle strength, breathing, speech, and quality of life over time. No new treatments are being tested, but the inform…

This study compares two imaging methods—micro-ultrasound and MRI—for monitoring prostate cancer in men on active surveillance. About 210 men with low-risk prostate cancer will receive both types of scans and biopsies to see which method better detects cancer progression. The goal…

This study looks at a new way to set breathing machine pressure for people with obesity who need a ventilator. It involves 30 patients with a BMI of 30 or higher. The goal is to see if this method is practical and safe enough to test in a larger study.

This study aims to see if a blood test (dd-cfDNA) can accurately detect rejection in lung transplant patients compared to the standard biopsy method. Researchers will enroll 600 adult lung transplant recipients and compare blood test results with biopsy findings and antibody test…

This study tests whether a noninvasive technique called transcutaneous spinal cord stimulation can improve arm and hand function in 30 adults with either a spinal cord injury or stroke. Participants will receive electrical stimulation through electrodes placed on the skin over th…

This study looks at how the body's 'fight or flight' system controls blood pressure differently in healthy men and women. Researchers will measure nerve activity, blood flow, and give tiny doses of blood pressure drugs to understand these differences. The goal is to learn more ab…

This study is testing whether a blood test that measures donor DNA can accurately detect organ rejection in heart transplant recipients. Researchers will compare the blood test results with standard heart biopsies and antibody tests in 300 participants. If successful, the blood t…

This study looks at whether a hands-on anatomy review using donated bodies (cadavers) can help physiotherapists place dry needling needles more accurately and avoid hitting risky areas like lungs or organs. About 60 physiotherapists who already do dry needling will be split into …

This study tests a new MRI technique using ferumoxytol, an iron-based dye, to get clearer images of blood vessels in the hippocampus—a brain area key to memory and seizures. Researchers will compare images from 50 adults (healthy volunteers and epilepsy patients) to see if this m…

This study is testing a new care pathway for children who need a tracheostomy (a breathing tube in the neck). The goal is to help them leave the hospital sooner and reduce stress for their families. The pathway includes digital tools, education, and support for caregivers. About …

This study looks at how much of the drug nimodipine gets into the blood of people who have had a bleeding brain aneurysm. The goal is to see if different levels of the drug affect recovery and disability 90 days later. Researchers will study 500 adults in Canada and the USA to fi…

This study looks at whether using a higher (60%) or lower (30%) oxygen concentration when resuscitating extremely premature babies (born before 29 weeks) leads to better survival and brain development by 18-24 months of age. About 1,200 babies across multiple hospitals will take …

This study looks at whether a child-focused goal-setting approach called ENGAGE helps kids with neurodevelopmental disabilities do better in therapy. About 96 children aged 5-12 and their therapists will take part. Researchers will compare the ENGAGE method to usual care to see i…

This study compares AI-generated translations of health resources to professional human translations. About 350 adults in Canada whose first language is French, Spanish, Ukrainian, Tagalog, Arabic, Chinese, or Punjabi will review one version and answer questions. The goal is to s…

This study is for post-menopausal women with type 1 diabetes. It will compare how aerobic exercise (like walking) and resistance exercise (like lifting weights) affect blood sugar levels compared to rest. The goal is to learn more about how different types of exercise impact gluc…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and remove medications from the body too quickly. It focuses on adults in the intensive care unit with life-threatening brain problems like stroke, severe injury, or infection.…

This study looks at whether a third dose of the MMR vaccine can improve immune protection in women whose antibody levels have dropped below protective levels after the standard two doses. Researchers will measure both antibody and cell-mediated immune responses in 200 pregnant wo…

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans and physical tests to see how the drug affects muscle mass and function. The goal is to understand risks of muscle loss an…

This study will use special MRI scans taken during exercise to learn how the heart and skeletal muscles work together in children with heart disease or who have had a heart transplant. Researchers want to understand why these children often have trouble being active. The study in…

Background Effective management of spasticity, a debilitating and challenging condition afflicting many recovering from and living with neurological conditions, may reduce long term consequences such as limb contracture, skin breakdown, compromised mobility, caregiver burden and …