Can fish oil and metformin protect hearts in PCOS?
NCT ID NCT06424860
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether taking fish oil and/or metformin for 12 months can improve heart health in women with Polycystic Ovary Syndrome (PCOS). PCOS raises the risk of heart disease and diabetes. The trial will enroll 146 women with PCOS who are overweight and have high blood fats or blood sugar. Researchers will measure changes in artery thickness, plaque, and heart function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fish oil and metformin
What this could lead to
If it works, this could point toward a simple, low-cost way to reduce heart disease risk in women with PCOS.
What could go wrong
This is an early phase 1 trial with a small number of participants, so results may not be conclusive or apply to everyone. The interventions are generally safe, but benefits may be modest.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Human Nutrition Research Unit - Li Ka Shing Health Research Center
RECRUITINGEdmonton, Alberta, T6G 2E1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mazankowski Alberta Heart Institute
RECRUITINGEdmonton, Alberta, T6G-2B7, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Alberta Hospital - Division of Endocrinology
RECRUITINGEdmonton, Alberta, T6G-2B7, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••