Atherosclerosis

This study tests a drug called selnoflast in 162 people with atherosclerosis (hardened arteries) who are at high risk for heart attacks or strokes. The goal is to see if selnoflast can reduce inflammation inside the arteries, measured by a special PET scan, compared to a placebo.…

This phase 3 trial is testing an experimental daily pill called AZD0780 in about 15,100 people who have had a heart attack, stroke, or are at high risk for one. The drug works by blocking a protein called PCSK9 to lower cholesterol. Researchers want to see if it reduces the chanc…

This early-stage trial tests whether an experimental drug called UDP-003 is safe in healthy volunteers and people with heart disease. Researchers will give single or multiple doses of the drug or a placebo and monitor for side effects. The study includes 84 participants and is th…

This pilot study tests whether the drug colchicine can reduce artery plaque in 120 heart attack survivors who have a specific genetic change (TET2-CHIP). Participants take colchicine or standard care for 12 months. The goal is to see if this genetic marker can guide personalized …

This study tests whether a digital support program (called DEEPER) helps heart patients maintain their health after completing cardiac rehab. About 306 adults with heart disease or heart failure will be split into two groups: one gets standard follow-up care, the other gets stand…

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaq…

This study tests a new device called ShockFast IVL against an existing one, ShockWave IVL, for treating hardened calcium deposits in heart arteries. Both devices use sound waves to break up calcium so a stent can be placed more easily. The trial will involve 120 adults with coron…

This phase 2 trial tests Kylo-11, an experimental drug, in 204 adults with heart disease and high levels of lipoprotein(a) – a genetic risk factor for heart attacks and strokes. Participants receive either Kylo-11 or a placebo injection for about a year. The main goal is to see i…

This Phase 3 trial tests an oral drug called muvalaplin in over 10,000 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease and stroke. Participants either have had a prior cardiovascular event or are at high risk for a first one. The study measures …

This study tests whether anifrolumab, a drug that blocks certain immune signals, can improve blood vessel function and reduce inflammation in people with lupus. About 45 adults with lupus will receive either the drug or a placebo over 8 months. Researchers will measure changes in…

This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are eithe…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests whether doing wall squat exercises for 14 minutes, three times a week, can lower blood pressure and slow the buildup of plaque in arteries. Researchers will compare 100 people doing the squats with 100 people doing gentle stretching, all with high blood pressure.…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study tests whether adding pelacarsen to inclisiran can further lower a type of cholesterol called Lp(a) in people with heart disease. About 340 adults with high Lp(a) and LDL-C will receive either pelacarsen or a placebo, plus inclisiran. The main goal is to see if Lp(a) le…

This study tests whether canakinumab, an anti-inflammatory drug, can reduce blood vessel inflammation in people with coronary artery disease. Some participants have a genetic change called TET2 clonal hematopoiesis, which may increase inflammation. 120 adults will receive either …

This program provides access to pelacarsen, a drug for atherosclerotic cardiovascular disease, for patients who have no other treatment options and cannot join a clinical trial. It is for those with serious or life-threatening conditions where the potential benefit outweighs the …

This phase 3 study is testing whether a new drug called maridebart cafraglutide (MariTide) can reduce the risk of heart attacks, strokes, and death in people with heart disease who are overweight or obese. About 12,800 participants will receive either the drug or a placebo, added…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This study compares two cholesterol-lowering strategies in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate-dose statin plus ezetimibe, the other gets a high-dose statin alone. The goal is to see if the combo is just as g…

This study is for people with high levels of Lp(a), a genetic risk factor for heart disease, who have already completed a prior pelacarsen trial. It will give them continued access to the drug while monitoring long-term safety and how well it keeps Lp(a) levels low. About 600 par…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study tests whether using HEPA air filters at home can slow the progression of heart disease in adults aged 65-84 who have a history of ischemic heart disease. Over 112 participants in Los Angeles will use real or sham filters for several months, and researchers will measure…

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This Phase 3 trial is testing an injectable drug called HRS9531 in about 9,200 people with atherosclerotic cardiovascular disease (hardened arteries). The goal is to see if it can lower the chance of major heart problems like heart attack, stroke, or death. Participants receive e…

This study looks at whether combining two different cholesterol-lowering drugs (inclisiran and alirocumab) works better than using either alone. About 60 adults with high heart risk who cannot take statins will be assigned to one of three groups. The goal is to see if the combo l…

This study tests if a drug called inclisiran can reduce fatty plaque buildup in the arteries of people who recently had a heart attack and have high cholesterol. About 318 adults will receive either inclisiran or standard care, and doctors will use special imaging to measure plaq…

This study tests a new device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 408 adults with coronary artery disease will receive this treatment. The goal is to see if the device is safe and effective at clearing blockages to im…

This study looks at how safe and effective a special stent (VBX) is for treating blocked arteries near the aorta in the lower belly. About 158 people who already had this stent placed at least a year ago will be followed. The goal is to see if the artery stays open and if there a…

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study follows about 52 people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol and early heart disease. Researchers will compare those who get evinacumab (a cholesterol-lowering antibody) added to their usual t…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study tests whether a fabric-covered stent (GORE VBX) works better than standard bare metal stents for people with severe blockages in the iliac arteries, which supply blood to the legs. About 244 participants with leg pain or tissue loss will be randomly assigned to receive…

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study tests whether a drug called icosapent ethyl (Vascepa) can reduce inflammation in the arteries of people hospitalized with pneumonia. Pneumonia can trigger body-wide inflammation that may harm blood vessels. Researchers will give 168 adults either Vascepa or a placebo t…

This study tests whether a targeted lipid optimization program—combining clinic visits and virtual sessions—helps high-risk heart disease patients in Abu Dhabi achieve better LDL cholesterol control. About 326 adults with atherosclerotic cardiovascular disease will be randomly as…

This study compares two drugs, choline fenofibrate and policosanol, in 56 Korean adults with type 2 diabetes and high cholesterol who have early signs of artery plaque. The goal is to see if choline fenofibrate can reduce plaque buildup in the carotid artery, measured by 3D ultra…

This study compares two medications, clopidogrel and cilostazol, to see if they can slow down the buildup of plaque in the neck arteries of people with type 2 diabetes. The goal is to prevent future heart attacks and strokes. About 120 adults with diabetes and early signs of arte…

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study looks at whether adding omega-3 to a common statin (atorvastatin) can better reduce plaque buildup in the neck arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to get either atorvastatin plus omega-3 or atorvastat…

This study tests whether a smartphone app can help people with atherosclerosis (hardening of the arteries) stick to their new statin medication. About 250 adults who need to start a high-dose statin will either receive standard care or standard care plus the app. The main goal is…

This study compares two medical devices used to break up hard calcium deposits in heart arteries before placing a stent. It involves 50 adults with coronary artery disease who will be randomly assigned to receive either orbital atherectomy or intravascular lithotripsy. The goal i…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study tests a new daily pill called ABP-745 in 200 adults with atherosclerosis (hardening of the arteries from plaque buildup). Participants will take either a low, medium, or high dose of ABP-745 or a placebo for 52 weeks. The main goal is to see if the drug can reduce the …

This study looks at whether high-dose statins can reduce or stabilize fatty plaques in the brain's arteries that cause strokes. About 100 recent stroke patients will get intensive statin therapy and have their arteries scanned with a special MRI. The goal is to see if the plaques…

This study looks at 110 women with blocked heart arteries who need bypass surgery. It compares using the arm artery versus a leg vein (prepared with a special no-touch method) to reroute blood flow. The goal is to see which graft stays open longer and leads to fewer heart problem…

This study tests whether a procedure to open narrowed kidney arteries (renal artery stenting) helps high-risk patients with resistant high blood pressure, declining kidney function, or heart failure. About 80 participants will either receive the real procedure or a sham procedure…

This early-stage trial tests an injectable drug called IMC-001 in 18 people who recently had a heart attack or unstable angina. The goal is to see if it can safely stabilize fatty plaques in the arteries, making them less likely to cause future heart problems. Participants are ra…

This Phase 3 trial tests olpasiran, a drug that lowers lipoprotein(a), a genetic risk factor for heart disease. About 406 adults with stable heart disease and high Lp(a) will receive either olpasiran or a placebo. The main goal is to see if olpasiran reduces non-calcified plaque …

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study compares two common diabetes drug classes—SGLT2 inhibitors and GLP-1 receptor agonists—to see which better prevents heart attacks, strokes, kidney failure, and death in 6,000 people with type 2 diabetes and heart disease or high risk. Participants are randomly assigned…

This study tests a new device that freezes dangerous plaque in heart arteries to see if it can reduce blockages and prevent future heart problems. About 30 people with stable angina or recent heart events will receive the freezing treatment during a planned procedure. Researchers…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study is testing whether a 12-week supervised exercise program can improve artery health and reduce inflammation in people with coronary artery disease. Fifty patients aged 40-70 will do aerobic, resistance, and flexibility exercises three times a week. Researchers will meas…

This study tests if using a single device (orbital atherectomy) to sand away calcium in heart arteries works as well as letting doctors choose from several methods based on each patient's calcium type. About 310 adults with severely calcified arteries will be randomly assigned to…

This study tests whether adding a Chinese herbal medicine called Yiyang Huoluo Decoction to standard heart medications can improve symptoms and blood vessel health in older adults with coronary heart disease and atherosclerosis. About 30 participants aged 50-75 will be randomly a…

This study tests a special balloon that uses shockwaves to crack calcium buildup in the iliac arteries, making it possible to deliver large aortic stents. About 40 adults with severe aortic disease and hardened arteries will be enrolled. The goal is to see if this approach is saf…

This study tests whether ziltivekimab, a monthly injection that reduces inflammation, can improve artery health in people who have recently had a heart attack. About 332 participants will receive either the drug or a placebo, alongside standard care. Researchers will use special …

This early-stage trial is testing an experimental drug called TB-500 in 80 adults with stable atherosclerotic cardiovascular disease. The main goal is to see if the drug is safe and tolerable. Researchers will also measure changes in blood vessel function and inflammation as earl…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and heart disease risk. The program includes a smartphone app for tracking cholesterol, medication reminders, and education, plus training for doctors to improve cholest…

This study looks at whether two common statins (pitavastatin and rosuvastatin) affect male sex hormones and erectile function in men aged 40-65 with high heart risk. Researchers will monitor 150 men for 6 months, checking hormone levels, erectile function, and blood vessel health…

This study tests a program designed to help people with high blood pressure and high cholesterol lower their risk of heart disease. About 1,980 adults from Penn Medicine primary care clinics in West/Southwest Philadelphia and Lancaster will take part. The program uses tools and b…

This study tests whether pharmacy interns, working under supervision, can help people with heart disease lower their cholesterol. About 1,000 adults who are not meeting their LDL cholesterol goals will receive phone counseling from a student pharmacist. The goal is to see if this…

This study tests two ways to break up heavy calcium buildup in heart arteries before placing a stent: a super high-pressure balloon versus a special shockwave balloon (lithotripsy). About 78 adults with severe coronary artery disease will be randomly assigned to one method. The g…

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with severe calcium deposits in their heart arteries. After using special tools to break up the calcium, 656 participants will be randomly assigned to one of the two treatments. Resear…

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent heart attacks and strokes in people at risk. About 130 adults aged 40-75 who are in the ER for possible heart issues will receive guideline-based care. The goal is to low…

This study tests a new medicine called YN001 in people with coronary atherosclerosis (hardening of the arteries in the heart). The goal is to see if YN001 can reduce plaque buildup in the arteries when added to standard care. About 24 adults in Australia with at least one blocked…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. Participants receive either orticumab or a placebo for 24 weeks. The main goal is to see if orticumab lowers inflammation measured by a special …

This study tests whether a team of healthcare professionals using a special algorithm can lower 'bad' cholesterol (LDL-C) more effectively than standard care in people with heart or blood vessel disease. About 100 adults with high cholesterol and known vascular disease will be ra…

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

The EPOCA trial is testing whether a daily 'polypill' (combining blood pressure, cholesterol, and blood-thinning medications) plus the anti-inflammatory drug colchicine can reduce major heart and limb events in people with established heart disease. Over 7,700 participants aged 4…

This study tests whether a drug-coated balloon can reduce fatty deposits in heart arteries better than standard medications alone. Researchers will enroll 400 adults who recently had a heart-related event (acute coronary syndrome). Participants will get either the balloon treatme…

This study tests whether rapidly adjusting cholesterol-lowering medications, based on frequent blood tests, helps heart disease patients reach their LDL cholesterol targets faster. Researchers will enroll 1000 adults with coronary artery disease and monitor their cholesterol leve…

This study is testing whether taking clopidogrel (a blood thinner) every day for at least 5 years can prevent heart attacks, strokes, and death in people who have early signs of coronary artery disease on scans but no symptoms. About 11,000 adults aged 40 and older will be assign…

This study tests whether adding inclisiran (a twice-yearly injection) to standard care lowers LDL cholesterol more than standard care alone in 520 patients who recently had a heart attack, stroke, or urgent heart procedure. Participants are randomly assigned to receive inclisiran…

This study tests whether dulaglutide, a once-weekly diabetes injection, can improve blood flow in the brains of people with severely narrowed arteries. About 130 participants who recently had a mini-stroke or mild stroke will receive either standard care or dulaglutide plus stand…

This study compares two treatments for stroke patients whose brain arteries remain blocked after initial clot removal, due to underlying hardening of the arteries (atherosclerosis). About 498 participants will be randomly assigned to receive either urgent stenting or continued st…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The…

This study looks at whether taking fish oil and/or metformin for 12 months can improve heart health in women with Polycystic Ovary Syndrome (PCOS). PCOS raises the risk of heart disease and diabetes. The trial will enroll 146 women with PCOS who are overweight and have high blood…

This study tests whether a simple, non-invasive procedure called remote ischemic conditioning (RIC) can protect major organs in people with very high-risk atherosclerotic cardiovascular disease (ASCVD). RIC involves inflating a blood pressure cuff on the arms for short periods to…

This study tests a new device called the SoniCracker IVL, which uses tiny shockwaves to break up hard calcium deposits in heart arteries. The goal is to make it easier to place stents and improve blood flow. About 40 adults with calcified coronary arteries will be enrolled. Resea…

This study tests whether a digital heart health program (a web app, online classes, and special foods) added to usual care can lower cholesterol and reduce heart attacks in people with heart disease or risk factors. About 1,100 participants will be randomly assigned to the progra…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed for people with long blockages in their heart arteries. The goal is to see if the stent is safe and works well at keeping arteries open for up to 12 months. About 100 pa…

This study compares a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time, to a standard permanent metal stent. About 1,859 people with coronary artery disease will receive one of the two stents. The goal is to see if the dissolving stent …

This study compares two techniques for treating severely hardened heart arteries: using a special drill (rotational atherectomy) plus shockwave therapy versus shockwave therapy alone. About 120 adults with coronary artery disease will be randomly assigned to one of the two approa…

This phase 3 trial tests whether ziltivekimab, a drug that targets inflammation, can reduce swelling in the arteries of 40 people with coronary artery disease. Participants receive either the drug or a placebo, and researchers use advanced imaging and blood tests to measure chang…

This study compares two approaches to stabilize fatty plaque in heart arteries: a moderate-dose statin plus ezetimibe versus a high-dose statin alone. Over 400 adults with coronary artery disease will be followed for a year, using advanced ultrasound to measure plaque changes. Th…

This phase 3 trial is testing whether two drugs—colchicine (used for gout) and ticagrelor (a blood thinner)—can prevent future strokes, heart attacks, and other vascular events in people who have already had a stroke. About 2,800 high-risk participants will be enrolled. The goal …

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to s…

This study compares two types of CT scans—PET/CT and ultra-high-resolution CT—to see which one better detects early signs of coronary artery disease in people with symptoms like chest pain. Researchers will measure the amount of plaque in the arteries and check how accurately eac…

This study is testing whether a device that measures how long it takes for a pulse to travel through the arms and legs can detect peripheral artery disease (PAD), a condition where leg arteries become narrowed. Researchers will compare this new method to the standard ankle-brachi…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study tests a new computer program that helps doctors diagnose blocked heart arteries more accurately using CT scans. The software combines several checks into one step, which may reduce the need for invasive procedures like heart catheterization. Researchers will look at pa…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study tests a new MRI technique that uses a special iron-based contrast agent (ferumoxytol) to detect calcium buildup in heart arteries. Researchers will compare this method to standard CT scans in 100 adults with known calcified arteries. The goal is to see if the MRI can a…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study is testing whether taking daily aspirin (100 mg) along with a high-intensity statin can prevent heart attacks, strokes, and other serious cardiovascular events in people aged 40–75 who have severe coronary artery calcification (calcium score ≥300). About 5,000 particip…

This study tests whether using a carotid ultrasound (a neck scan) to find hidden plaque in arteries can help prevent heart attacks and strokes in people with inflammatory rheumatic diseases like rheumatoid arthritis or lupus. About 1,944 participants aged 50 and older will be spl…

This study looks at whether adding a heart disease prevention program to standard lung cancer screening can improve the health of heavy smokers. Researchers will use chest CT scans already taken for lung cancer screening to also check for hidden heart disease. 1000 participants w…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This pilot study looks at whether an 8-week stress reduction program can reduce inflammation in the arteries of adults aged 30-65 who feel stressed. Researchers will use special PET scans to measure changes in artery inflammation before and after the program. The goal is to see i…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether metformin, a standard diabetes drug, can improve walking ability in people with peripheral artery disease (PAD) who experience leg pain during activity. Researchers will give 200 Veterans either metformin or a placebo for several months and measure change…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a new type of supervised exercise for people with peripheral artery disease (PAD), which causes leg pain when walking due to blocked arteries. Researchers want to see if using muscle oxygen levels to guide exercise is better than standard therapy. The study invol…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study tests whether music therapy delivered by the BeatMove device can help people with leg artery disease walk farther during a 3-month outpatient walking program. Fifty-four participants will either get real music therapy or a sham version while doing 36 walking sessions. …

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This study compares two methods of pain control for people having open abdominal surgery. One group gets a single injection of a long-lasting numbing medicine into the belly muscles during surgery. The other group gets a standard numbing medicine through small tubes placed in the…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about lipid disorders—conditions that affect fats like cholesterol in the blood. Researchers will observe up to 2,000 people with abnormal cholesterol levels to better understand how these disorders develop and how to diagnose them. Participants will…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study tracks 98 people with peripheral artery disease who had a stent placed in their iliac artery. Researchers want to see which patients later develop serious limb complications, like needing another procedure or amputation. They will also check if frailty plays a role. Th…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study looks at whether severe gum disease (periodontitis) is linked to stiffer arteries, which is a sign of heart risk. Researchers will compare 206 adults aged 40-69—half with advanced gum disease and half with healthy gums—using a simple test that measures artery stiffness…

This study follows 300 adults aged 30–60 with genetically confirmed familial hypercholesterolemia, a condition causing very high cholesterol. Researchers use CT scans to see how coronary artery plaques change over 5 years. The goal is to better understand disease progression and …

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study looks at how the body's innate immune system responds to certain environmental exposures by measuring inflammation markers in blood. Researchers will collect blood samples from up to 725 healthy volunteers aged 18-45 to analyze how specific genes and proteins react. Th…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of people with mild heart disease. Researchers will use advanced CT scans to measure changes in plaque size and type over 3 months, and then check if those changes las…

This study investigates whether high-protein meals, especially from animal sources, activate immune cells in a way that could worsen atherosclerosis (hardening of the arteries). Researchers will give 24 adults different protein-rich meals and measure changes in blood cells. The g…

This observational study will enroll 10,000 adults who are already scheduled for a cardiac CT scan. Researchers will use artificial intelligence to analyze the scans, looking for subtle signs of dangerous plaque that might predict future heart attacks. Participants will also give…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study uses a survey to find out how well people with existing heart disease understand their risk factors and their chances of having another heart problem. Researchers will compare answers from 200 women and men to see if there are differences. The goal is to learn where aw…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study looks at whether bacteria in your mouth can influence the buildup of fatty plaques in the neck arteries that supply blood to the brain. Researchers will collect samples from 200 adults having surgery to remove these plaques and compare the bacteria found in the mouth, …

This study looks at whether a lower daily dose of aspirin (50 mg) is as effective and safer than the standard dose (100 mg) for preventing heart attacks and strokes in Chinese patients aged 60 and older with heart disease. Researchers will follow over 5,400 participants for up to…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study looks at whether a gene called TMEM230 plays a role in atherosclerosis, the buildup of fatty plaques in arteries that can lead to heart attacks and strokes. Researchers will collect blood and artery tissue from 12 adults undergoing vascular surgery. They aim to underst…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study looks at how animal-based and plant-based proteins change metabolism and immune signals in healthy adults. Twenty participants will drink three different protein smoothies on separate visits and give blood samples. Researchers want to see if adding leucine to plant pro…

This study looks at whether telling people their genetic risk for coronary artery disease helps them lower cholesterol and improve heart health over one year. Researchers will enroll 500 adults aged 30-75 who are not on cholesterol medication. Half will get their genetic risk sco…

This natural history study tracks people aged 10 and older with rare genetic lipid disorders over up to 20 years. Researchers will monitor changes in cholesterol and fat levels, and how these conditions progress. The goal is to better understand these diseases and develop new dia…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed will take part. Researchers will use special PET/MRI scans to measure changes in artery and brain activity …

This study follows 2000 adults with suspected heart artery disease who undergo special imaging and pressure measurements during a heart catheterization. Researchers want to see which test results best predict future heart problems like heart attacks or the need for another proced…

This study is for people with familial hypercholesterolemia (inherited high cholesterol) who have no heart symptoms yet. Researchers will use a special CT scan to check for hidden blockages in the heart arteries. The goal is to learn which factors are linked to these blockages, s…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study aims to create a smart computer program that helps doctors better understand the sounds from a handheld device used to check blood flow in arteries. Many doctors lack formal training in using this device, which can lead to missed or wrong diagnoses. The study will coll…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study uses advanced 3D-rotational angiography to track how fatty plaques in brain arteries change over one year in 140 people who have had a stroke or mini-stroke. Participants will have two scans 12 months apart while managing heart risk factors. The goal is to understand p…

This study looks at fatty buildup in brain arteries that can break off and cause strokes. Researchers want to see if high-risk plaques look different from harmless ones. They will use special imaging to compare plaques in 140 people who have had a stroke with those who have not.

This study is building a biobank of blood, spinal fluid, and tissue samples from 500 Chinese adults, including stroke patients, their families, and healthy volunteers. Researchers will analyze the samples to find genetic markers linked to stroke and its complications. The goal is…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study looks at how moderate wine consumption changes tiny particles called extracellular vesicles, which help cells communicate. Eight healthy adults aged 35-65 will drink red wine, white wine, or water, and researchers will analyze their blood for changes in these particles…

This study looks at 200 people with a family history of heart disease but no symptoms. They will get a special CT scan and a blood test to find hidden, high-risk plaque in their arteries. The goal is to see if the scan can better predict who needs early treatment compared to stan…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study is observing 800 people who recently had an ischemic stroke or have significant artery narrowing. All are taking high doses of statins (atorvastatin or rosuvastatin) for at least a week. Researchers want to see how much their cholesterol drops and what factors influenc…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

People with rheumatoid arthritis have double the risk of heart attack. This study is testing whether a blood test for troponin, along with a heart scan, can catch heart disease early. Researchers will enroll 120 adults aged 40-79 with RA and at least one heart risk factor. The go…

This study is tracking 500 patients who received rotational atherectomy, a procedure that uses a tiny rotating burr to grind away hardened plaque in heart arteries. Researchers want to see how safe and effective it is in real-world settings. The main goal is to measure how many p…

This study is testing a new, noninvasive MRI technique to see if it can better predict stroke risk in people with narrowed arteries in the brain (ICAS). Researchers will measure blood flow pressure using a special MRI scan and follow 400 participants for one year to see who has a…

This study tests a non-invasive device that measures blood flow in the skin of people with severe leg artery disease. Researchers will compare results from 15 patients before and after a procedure to open blocked arteries, and also compare them to 15 healthy volunteers. The goal …

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study will use advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in 10 people with PTSD who also have heart disease or risk factors. Participants will follow a gradually increasing exercise program. The goal is to understand whet…

This study looks at 1000 adults (ages 40-80) with high cholesterol but no heart symptoms. Researchers want to see if using special scans of the neck and heart arteries can find hidden plaque better than the standard risk calculator. The goal is to improve early detection and prev…

People with type 2 diabetes are at high risk for heart disease. This study will follow 1,000 such patients who have already had a heart CT scan. Researchers will repeat the scan and track how plaque buildup in the heart's arteries changes over time. The goal is to better understa…

This study looks at a fast-progressing type of coronary artery disease that may be driven by inflammation. Researchers will compare 20 patients with this condition to 10 patients with typical heart disease, using lab tests, imaging, and physical assessments. The goal is to better…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study tests whether wearing noise-canceling earplugs can lower stress and reduce heart disease risk in people annoyed by traffic noise. Researchers will use brain and blood vessel scans to measure changes over 6 months in 26 adults with heart risk factors. The goal is to see…

This study looks at why people with angina but no blocked arteries (ANOCA) often have poor fitness. Researchers will test whether a 4-week, remotely supervised high-intensity interval training (HIIT) program can safely improve heart function, exercise capacity, and quality of lif…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…

This study tests whether giving young and middle-aged adults with high blood pressure a personalized genetic risk score helps them lower their blood pressure and adopt healthier habits. 300 participants will either receive standard care or get their genetic risk results along wit…