Cleaner air, healthier heart? trial tests HEPA filters against atherosclerosis

NCT ID NCT05867381

Recruiting now Disease control Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using HEPA air filters at home can slow the progression of heart disease in adults aged 65-84 who have a history of ischemic heart disease. Over 112 participants in Los Angeles will use real or sham filters for several months, and researchers will measure changes in blood pressure, artery stiffness, and blood markers. The goal is to see if reducing indoor air pollution can help manage heart disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HEPA air filter
What this could lead to: If it works, this could show that cleaning indoor air helps slow heart disease, offering a simple way to protect heart health.
What could go wrong: This is a small, early-stage trial with 112 people, so results may not apply to everyone. The effect of air filters on heart disease is still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis cardiovascular disorder myocardial ischemia thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AIR POLLUTION ATHEROSCLEROSIS

Contacts and locations

Locations

Keck School of Medicine, University of Southern California
RECRUITING

Los Angeles, California, 90033, United States

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