Can a blood vessel drug beat aspirin at preventing heart attacks in diabetes?
NCT ID NCT07719894
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This trial compares two blood-thinning drugs—aspirin and cilostazol—to see which one better prevents major heart and blood vessel events in people with type 2 diabetes who are already at high risk. About 1,200 participants will be randomly assigned to take one of the two medications daily. The study tracks heart attacks, strokes, hospitalizations, and related deaths over time to determine which drug offers stronger protection.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cilostazol or aspirin
- What this could lead to
- If cilostazol proves more effective than aspirin, it could offer a better option for preventing heart attacks and strokes in people with type 2 diabetes.
- What could go wrong
- This is a phase 4 trial, so both drugs are already approved, but cilostazol may cause side effects like headache or palpitations, and it is unclear if it will outperform aspirin.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 1,200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2026
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Individuals with type 2 diabetes mellitus were eligible if they were aged ≥19 years * Individuals with subclinical atherosclerosis or metabolic syndrome, defined as at least one of the following: * Carotid intima-media thickness ≥ 1 mm * Ankle-brachial index \< 0.9 - Pulse wave velocity ≥ 9 m/s * Flow-mediated vasodilatation \< 5% * Coronary artery calcium score ≥ 40 * Coronary artery stenosis ≥ 20% or ≤ 70% * Peripheral artery occlusive disease ≥ 20% * Metabolic syndrome * Individuals with HbA1c ≤ 9.9% * Individuals who voluntarily agree to participate in the study and provide written informed consent Exclusion Criteria: * Patients with a history of major cardiovascular events, including myocardial infarction, stroke, or heart failure * Patients with heart failure (NYHA I\~IV) * Patients with current active bleeding or suspected bleeding * Patients with suspected bleeding tendency or hematologic disorder, such as hemophilia or thrombocytopenia * Patients recently diagnosed with gastrointestinal ulcerative disease * Patients with inadequately controlled hypertension, defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg * Patients with severe renal dysfunction, defined as estimated glomerular filtration rate \< 30 mL/min/1.73 m² * Patients with liver enzyme levels greater than 3 times the upper limit of normal or chronic liver disease * Individuals currently taking antiplatelet or antithrombotic agents * Individuals who are pregnant or breastfeeding * Patients with a history of hypersensitivity to any component of the study drugs * Patients with complications of coronary artery stenosis * Patients with QT prolongation * Patients with a sigmoid-shaped ventricular septum or risk of sigmoid-shaped ventricular septum * Individuals with alcohol addiction * Patients with asthma * Patients deemed unsuitable for participation in the study based on the investigator's judgment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Gyeonggi-do, 13620, South Korea
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