Type 2 diabetes mellitus

This study is testing whether limiting all food intake to a 10-hour window each day can help people with type 2 diabetes better manage their blood sugar. About 102 adults will follow this eating pattern for one year, tracking their first and last meals by text. Researchers will c…

This study tests a new automatic insulin pump (Omnipod M) in 350 adults with type 2 diabetes who already use insulin. The pump adjusts insulin delivery on its own to keep blood sugar in a healthy range. The goal is to see if it improves blood sugar control and is safe to use.

This study compares a new insulin pump system, Omnipod 6, to the current Omnipod 5 in 200 people with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a healthy range more effec…

This study tests a new medicine called HM15275 in people with type 2 diabetes. The goal is to see if it can lower blood sugar levels (HbA1c) safely over 36 weeks. About 180 adults who manage their diabetes with diet, exercise, or metformin will take part. Half will get the drug, …

This study tests whether a real-time continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes keep their blood sugar in a healthy range better than standard finger-prick testing. About 240 women in early pregnancy will either wear the CGM device for most of thei…

This 12-month pilot study tests whether a nurse-led smartphone app can help Medicaid patients with insulin-treated type 2 diabetes improve their blood sugar control. The program combines educational messages, phone-based problem-solving with a nurse, and remote monitoring via a d…

This Phase 3 trial will test a new once-daily insulin, GZR33, against the standard insulin degludec (Tresiba) in 350 adults with type 2 diabetes whose blood sugar is not well controlled by oral medications. The main goal is to see how well GZR33 lowers blood sugar over 26 weeks c…

This trial tests whether a pulse electric field ablation system can help adults with type 2 diabetes whose blood sugar is not well controlled by oral medications. The study enrolls 20 people aged 18 to 70 with a specific range of blood sugar levels. Researchers will measure chang…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study tests a program for adults with type 2 diabetes who are leaving the hospital. Participants will work with a patient navigator to address unmet social needs like food, housing, or transportation. The goal is to see if this support reduces emergency visits and readmissio…

This study tests whether a 12-week personalized exercise program done at home and guided by a mobile app and wearable device can improve blood sugar control and physical fitness in adults with type 2 diabetes. Participants are 40 to 69 years old, newly diagnosed or with diabetes …

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…

This study tests a new once-weekly injection called NNC0662-0419 in 270 adults with type 2 diabetes. It compares the drug against a placebo and an approved medication, semaglutide, to see how well it controls blood sugar and promotes weight loss. The trial is currently recruiting…

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This study compares continuous glucose monitoring (CGM) to standard fingerstick testing for pregnant women with type 2 diabetes. Researchers want to see if CGM leads to better blood sugar control and fewer complications for both mother and baby. Participants wear a CGM device or …

This study follows 630 people with type 1 diabetes in Japan who are already prescribed Awiqli, a once-weekly injection. Researchers will track side effects and blood sugar control over one year to see how the drug works in everyday life. The goal is to manage diabetes, not cure i…

This study tests whether a continuous glucose monitor (CGM) paired with a coaching app helps pregnant women with type 2 diabetes achieve better blood sugar control compared to standard care. Participants use a Dexcom G7 CGM sensor and receive guidance through a mobile app and car…

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether a fully closed-loop insulin system (which automatically adjusts insulin delivery) works better than a standard insulin pump for people with type 2 diabetes. Eighty adults who have used an insulin pump for at least six months will try both methods for 12 w…

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs …

This study tests an experimental drug called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The drug is given as a shot under the skin, either alone or combined with the existing weight-loss drug tirzepatide. The main goal is to check safety and how…

This study tests whether taking three cholesterol-lowering drugs together works better than taking two in people with type 2 diabetes and high LDL cholesterol. 126 adults aged 35-60 will be split into three groups: one gets rosuvastatin plus ezetimibe, another gets bempedoic acid…

This study tests a new once-weekly medicine called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for around 75 weeks. Researchers will measure changes in body weight, fat, waist …

This study tests whether a 12-week low-calorie meal replacement diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who are also obese. 63 adults will be randomly assigned to either the diet or standard care. …

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will receive the drugs or a placebo for 48 weeks. The main goal is to see how much weight the…

This study compares two advanced heart procedures—stenting guided by imaging and blood flow tests (PCI) versus bypass surgery (CABG)—in 1,500 people with diabetes and three blocked coronary arteries. The goal is to see which approach better prevents major events like death, heart…

This early-stage study tests a new drug, AMG 127, to see if it is safe for people. It involves 162 healthy adults and people with type 2 diabetes. Researchers will give single or multiple doses and watch for side effects. This is a first step to see if the drug can be developed f…

This study tests whether meals designed for South Asian and Filipino cultures, following diabetes guidelines, can improve blood sugar control in people with type 2 diabetes. Thirty participants will wear a continuous glucose monitor for a month while eating their usual diet and t…

This study is testing a new approach for people with obesity and type 2 diabetes. It combines two procedures done through the mouth: one uses mild electric pulses to regenerate the lining of the upper intestine, and the other reduces stomach size by stitching it like a sleeve. Th…

This study tests a new medicine called LY3938577 against a standard insulin (degludec) in 100 adults with type 2 diabetes who already use basal insulin. The goal is to see if the new drug helps keep blood sugar in a healthy range more safely and effectively over about 26 weeks. P…

This Phase 2 trial tests an experimental drug called LY3457263 in 240 adults with type 2 diabetes who still have high blood sugar despite taking stable doses of semaglutide or tirzepatide. Participants receive weekly injections of either the new drug or a placebo for about 9 mont…

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This study compares two ways of tracking blood sugar in people with type 2 diabetes who use insulin after leaving the hospital. One group uses a continuous glucose monitor (CGM) that shows real-time levels and trends, while the other group uses traditional fingerstick tests. The …

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This early-phase study tests a new oral drug called GS-4571 in healthy people, non-diabetic obese individuals, and non-obese people with type 2 diabetes. The main goals are to see how the drug moves through the body, how safe it is, and how food or acid-reducing drugs affect it. …

This study compares two different strength training schedules—non-linear and linear periodization—in people with type 2 diabetes. Over 8 weeks, 48 participants will do supervised workouts three times a week or receive usual care. Researchers will measure changes in exercise capac…

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned…

This early-stage trial is testing a new experimental medicine called NNC1679-0001 for type 2 diabetes. Researchers want to see if it is safe and how well the body tolerates it. The study includes both healthy volunteers and people with type 2 diabetes, who will receive either a s…

This Phase 3 trial tests a new drug called KAI-9531, given as a weekly injection, in 1700 adults who are overweight or obese and have type 2 diabetes. The study compares KAI-9531 to a placebo to see if it leads to greater weight loss and better blood sugar control over 76 weeks. …

This study compares two digital approaches—live video classes and simple text messages—against traditional in-person classes to help 150 Hispanic/Latino adults with type 2 diabetes better manage their condition. The goal is to see if these digital tools can improve blood sugar co…

This study tests two higher doses (3.0 mg and 4.5 mg) of the diabetes drug dulaglutide in teenagers aged 10 to 17 with type 2 diabetes. The goal is to see if these doses are safe and help control blood sugar and weight. Participants will receive weekly injections for about 8 mont…

This study tests whether a special anti-inflammatory diet can lower inflammation and improve blood sugar control in people with type 2 diabetes. 88 adults will be randomly assigned to either the anti-inflammatory diet or standard diabetes dietary advice for 4 weeks. Researchers w…

This phase 2 trial tests clofutriben, a drug that lowers cortisol, in 1500 adults with hard-to-control type 2 diabetes and signs of high cortisol. Participants receive either clofutriben or a placebo daily for 24 weeks. The study measures changes in blood sugar and cortisol level…

This study tests whether peer coaching can help older adults (55+) with uncontrolled type 2 diabetes in rural Kentucky better manage their condition. Participants are paired with trained peer coaches who call them weekly or bi-weekly to discuss self-care and goals. The study will…

This study tests whether regular phone calls from a trained peer coach can help older adults (55+) with type 2 diabetes in rural Kentucky improve their self-care. Participants are divided into groups that receive weekly or bi-weekly coaching calls to discuss goal-setting and diab…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study looks at whether THC, the active part of marijuana, can change how the body handles sugar and affects blood vessel health in people with type 2 diabetes. About 30 adults will take THC or a placebo for two weeks, then have their blood sugar and blood vessel function tes…

This study compares a continuous glucose monitor (CGM) to standard fingerstick testing in 270 adults with type 1 or type 2 diabetes who use insulin injections. Participants wear the Accu-Chek SmartGuide sensor to track blood sugar levels continuously. The goal is to see if the CG…

This study tests a new daily pill, icovamenib, for people with type 2 diabetes who still have high blood sugar despite taking Ozempic. About 60 adults will receive either the pill or a placebo for 12 weeks. The main goal is to see if the pill lowers HbA1c (a measure of blood suga…

This study is testing an education program for people with type 2 diabetes who also have chronic kidney disease. The program provides patients with information about their kidney health and suggests medications that could slow kidney damage. Researchers will see if this approach …

This study tests a single dose of a new drug, ALN-4324, to see if it improves how the body uses insulin in people with type 2 diabetes. About 40 adults who are on a stable dose of metformin will take part. The main goal is to measure changes in insulin sensitivity using a glucose…

This early-stage study tests an experimental drug called ALN-4324 in two groups: healthy overweight volunteers and overweight patients with type 2 diabetes. The goal is to check the drug's safety and how well it controls blood sugar. Participants receive either the drug or a plac…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This pilot study is testing whether combining cognitive behavioral therapy (CBT) with guided exercise can improve blood sugar control, reduce depression, and boost quality of life in Black men with type 2 diabetes. Eighty participants will receive 8 sessions of CBT, with half als…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to standard care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device for 13 weeks or continue their usual routine. The goal is to see if the devic…

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This early-stage study tests an experimental oral drug called ONO-3310 in healthy Japanese men and in people with type 2 diabetes who also have chronic kidney disease. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure its eff…

This study tests whether a special nutritional supplement, designed using artificial intelligence, can help adults with type 2 diabetes lower their blood sugar over 24 weeks. One hundred participants will receive either the active supplement or a placebo, alongside their usual di…

This study tests whether regularly screening for diabetes-related emotional distress and offering support can improve blood sugar control in adults with type 2 diabetes. About 1,250 participants with high blood sugar (A1C over 8%) will take part. The goal is to see if addressing …

This study looks at whether adding menopausal hormone therapy to a GLP-1 drug (semaglutide) improves blood sugar control in early postmenopausal women who have or are at risk for type 2 diabetes. About 96 women with menopausal symptoms and a BMI of 27 or higher will be enrolled. …

This study tests if a new insulin that is injected just once a week works as well as daily insulin shots to control blood sugar in people with type 2 diabetes. About 586 adults who have never used insulin before will take either the weekly insulin or a standard daily insulin for …

This study is tracking 145 adults with type 2 diabetes in Argentina who are starting semaglutide (either as a pill or injection) as part of their normal care. Researchers will measure changes in blood sugar, weight, waist size, and grip strength over 12 months, along with how sat…

This study tests whether combining two experimental drugs, MET233 and MET097, can help adults with obesity or overweight lose weight, including those with type 2 diabetes. About 381 participants will receive either the drug combination or a placebo to check safety and how well th…

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study tests whether walking at least 10,000 steps a day and avoiding snacks after 8 p.m. can improve metabolic health in teenagers aged 12-18 with prediabetes. Eighty participants will be randomly assigned to either the lifestyle program or standard care for 8 weeks. The mai…

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This study tests whether a continuous glucose monitor (CGM) helps control blood sugar better than standard finger-stick checks for people with diabetes who are recovering at home through Mayo Clinic's Advanced Care at Home program. About 100 participants will use the Dexcom G6 PR…

This study tests whether a drug called chiglitazar, combined with anti-inflammatory and liver-protecting therapies, can improve liver health in people who have both MASH (a severe fatty liver disease) and type 2 diabetes. About 300 adults will receive either the drug combo or a p…

This study is testing a new tool called MODI, which is a smart algorithm that helps people with diabetes figure out the right amount of insulin to take. About 100 adults with type 1 or type 2 diabetes will use the MODI system along with a continuous glucose monitor for 13 weeks. …

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist help, community health worker help, or both…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This early-stage study tests an experimental drug called MK-1403 in people with type 2 diabetes. The main goals are to check if the drug is safe and tolerable, and to see how it behaves in the body. Researchers will also measure its effect on a marker of inflammation (hsCRP). Abo…

This study is testing a gel that turns into a gel when warmed, used alongside standard gum disease treatment. It includes 70 adults, some with type 2 diabetes and some without, to see if the gel helps gums heal better and if healing differs between the two groups. Participants wi…

This study tests whether a special high-protein shake can help overweight or obese adults with type 2 diabetes preserve lean muscle mass when they start taking GLP-1 drugs like Ozempic or Mounjaro. About 60 participants will be randomly assigned to drink the shake or follow stand…

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This Phase 3 study tests whether a new drug called CagriSema helps people with severe obesity (with or without type 2 diabetes) lose more weight than the existing drug semaglutide. About 2,500 participants will receive either CagriSema or semaglutide for 83 weeks. The main goal i…

This study tests a new medication, CX11, for people with type 2 diabetes who need better blood sugar control despite taking metformin. About 240 adults will receive different doses of CX11 or a placebo for 24 weeks to see if it safely lowers blood sugar. The goal is to find the b…

This study tests whether a diode laser, apple cider vinegar, or the herb Gymnema Sylvestre can better disinfect root canals in people with type 2 diabetes who have a tooth infection called apical periodontitis. Ninety participants will be split into groups receiving different com…

This pilot study tests whether providing culturally appropriate food bundles and easy-to-read recipes can help adults with type 2 diabetes who face food insecurity. About 25 participants will receive food bundles and education, then complete surveys at 3 and 6 months. The goal is…

This study looks at why some people diagnosed with diabetes in the emergency room don't follow up with a regular doctor. Researchers will test whether a telehealth visit soon after diagnosis helps patients get connected to outpatient care. The trial involves 200 adults in New Yor…

This study tests a new magnetic device that creates a shortcut in the gut to help with weight loss and blood sugar control, comparing it to the popular drug semaglutide (Ozempic/Wegovy). Twenty adults with obesity and type 2 diabetes will be randomly assigned to either the one-ti…

This study is testing whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages from an AI chatbot can help them become more active and improve their health. Thirty-six sedentary adults will wear the Fitbit daily for 12 weeks and receive week…

This study tests tirzepatide, a once-weekly injection, in 344 Indian adults with type 2 diabetes or obesity. Over 46 weeks, researchers will check for serious side effects and measure weight loss and blood sugar control. The goal is to see if this drug is safe and effective for t…

This study looks at how well the drug tirzepatide works in everyday life for people with obesity (without diabetes) or type 2 diabetes (with or without obesity). About 160 adults in Paraguay will take the drug as part of their regular care and be followed for 52 weeks. Researcher…

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This Phase 3 trial tests an experimental drug called HM11260C in adults with type 2 diabetes whose blood sugar is not well controlled with metformin and dapagliflozin. About 118 participants will receive either HM11260C or a placebo, and researchers will measure changes in HbA1c …

This early study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for people with chronic spinal cord injury. Six adults will try the 20-minute exercise sessions over 6 weeks. The goal is to see if this approach can be us…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study compares taking insulin glargine once versus twice daily in pregnant women with type 2 diabetes who need insulin. Two hundred participants will be randomly assigned to one of the two dosing schedules, and their blood sugar levels will be tracked continuously. The goal …

This study tests whether semaglutide, a diabetes drug, can help heal foot ulcers in people with type 2 diabetes. About 52 adults will receive either semaglutide or a placebo for 20 weeks. The main goal is to see if more ulcers heal completely with the drug. This is an early-phase…

This Phase 2 trial tests whether a new drug called icovamenib can help people with type 2 diabetes who still have high blood sugar despite taking other medications. About 60 adults aged 18 to 70 will receive either icovamenib or a placebo daily for 12 weeks. The main goal is to s…

This study tests whether drinking traditional kefir every day for 12 weeks can improve blood sugar control and heart health in 156 adults who are overweight and either at risk for or already have type 2 diabetes. Participants will drink either kefir or plain milk. The main goal i…

This study explores whether spending time in the cold enough to shiver can improve how the body handles sugar in people with type 2 diabetes. Fifteen adults aged 40-75 with type 2 diabetes will undergo 10 days of cold exposure with shivering. Researchers will measure changes in i…

This study tests whether adding communication counseling to a step-tracking program helps couples where one partner has type 2 diabetes walk more and improve blood sugar. About 200 couples will use Fitbits and get step goals. Half will also attend counseling sessions to improve t…

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study tests a new surgical device (a metal clip) to create a second food pathway in the stomach for people with type 2 diabetes who are overweight or mildly obese (BMI 25-35). The goal is to improve blood sugar control without causing too much weight loss or needing lifelong…

This study tests two ways to help Chinese immigrants with type 2 diabetes control their blood sugar: watching educational videos, or videos plus a community health worker. 540 adults in NYC will join. The goal is to see if these tools lower HbA1c levels and boost confidence in ma…

This study tests whether breathing a special mix of low and high oxygen air (called intermittent hypoxic-hyperoxic training) can help lower blood sugar in people with type 2 diabetes. About 250 adults aged 50-74 will be split into groups receiving either a 3-day or 10-day course …

This pilot study tests whether canagliflozin, a diabetes medication, can reduce inflammation in the arteries of people with type 2 diabetes and stable coronary artery disease. Researchers will compare the drug to a placebo over 6 months in 16 participants. The main goal is to mea…

This study tests whether using a sit-stand desk at work can improve insulin sensitivity and reduce diabetes risk in 198 overweight, sedentary adults with prediabetes or other risk factors. Participants are randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to…

This study compares two drugs, choline fenofibrate and policosanol, in 56 Korean adults with type 2 diabetes and high cholesterol who have early signs of artery plaque. The goal is to see if choline fenofibrate can reduce plaque buildup in the carotid artery, measured by 3D ultra…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This study compares two diabetes medications, enavogliflozin and pioglitazone, when added to standard metformin treatment. It includes 120 adults with type 2 diabetes whose blood sugar is not well controlled. The goal is to see which drug works better at lowering blood sugar and …

This study tests whether community health workers can help women in urban slums of India get screened for type 2 diabetes after having gestational diabetes. 330 women will either receive home-based testing or a referral to a clinic, plus diabetes education. A smaller part of the …

This study compares two medications, clopidogrel and cilostazol, to see if they can slow down the buildup of plaque in the neck arteries of people with type 2 diabetes. The goal is to prevent future heart attacks and strokes. About 120 adults with diabetes and early signs of arte…

This study looks at whether adding omega-3 to a common statin (atorvastatin) can better reduce plaque buildup in the neck arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to get either atorvastatin plus omega-3 or atorvastat…

This study tests whether continuous glucose monitors (CGMs) can improve blood sugar control in underserved people with type 2 diabetes who are uninsured or on Medicaid. Fifty participants will wear a CGM replaced every 14 days for 6 months. The goal is to see if this technology h…

This early-stage trial is testing a new drug, HMS1005, in 40 people with type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. Researchers will also look at how it affects blood sugar levels over 24 hours. Participants will receive either the…

This pilot study is testing whether a 12-week combination of two common diabetes drugs—dapagliflozin (Farxiga) and semaglutide (Ozempic)—is safe and helpful for people who have received a kidney transplant. The 20 participants will take both drugs and be monitored for changes in …

This large study tests a new way of managing type 2 diabetes in community health centers. The approach uses a team of providers and technology to personalize care. Researchers will compare blood sugar control in clinics that start the program at different times. The goal is to se…

This early study tests a device that uses radiofrequency energy to create vapor and ablate (remove) a small part of the upper intestine. The idea is that this might improve how the body handles sugar. The study will enroll 20 adults with type 2 diabetes to see if the procedure is…

This study compares standard gastric bypass surgery to bypass plus a nerve-cutting procedure (truncal vagotomy) in 40 adults with obesity and type 2 diabetes. The goal is to see if the added nerve cut helps more people achieve diabetes remission without medication for at least a …

This study tests whether starting two diabetes drugs early—metformin plus either oral semaglutide or empagliflozin—controls blood sugar better than metformin alone in adults recently diagnosed with type 2 diabetes. About 90 participants will take the combination or just metformin…

This study is observing 300 adults with type 2 diabetes who are already taking luseogliflozin as part of their routine care. Researchers will track changes in blood sugar levels, body weight, and side effects over time. The goal is to see how well the drug works in real-world set…

This study is looking at how semaglutide, a drug used for diabetes and weight loss, changes the amount of fat stored inside the heart and leg muscles. Researchers want to see if semaglutide can shift fat away from these organs, which might improve health beyond just lowering bloo…

This study tests whether a total diet replacement of just 850 calories per day for 3 months, followed by weight maintenance, can help people with type 2 diabetes achieve remission. Participants are randomly assigned to follow-up via an eHealth app or in-person visits. The goal is…

This study tests whether GLP-1 receptor agonists, a class of diabetes medications including semaglutide, can improve heart nerve damage in people with type 2 diabetes. 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers w…

This study tests whether using a continuous glucose monitor (CGM) for short periods, combined with personalized feedback, helps adults with type 2 diabetes control their blood sugar better than standard finger-prick testing. About 400 participants will be randomly assigned to eit…

This study tests whether a new combination drug works better than taking two separate medicines for people with both high blood pressure and type 2 diabetes. About 228 adults will take either the combo pill or a single-ingredient pill for 12 weeks. Researchers will check changes …

This early-stage study tests how a new medicine, NNC0487-0111, affects insulin sensitivity and pancreas function in adults with type 2 diabetes. About 80 participants will receive either the study drug or a placebo. The goal is to see if the drug can help the body use insulin bet…

This study is testing a new continuous glucose monitoring system called ROME GS in 60 adults with type 1 or type 2 diabetes. The goal is to see if it measures blood sugar accurately and is safe to use. Participants will wear the sensor and have their glucose levels checked agains…

This study is testing a new glucose monitoring system called Eversense Gemini, which includes a flash glucose measurement feature. The goal is to see how accurate and safe it is for adults with type 1 or type 2 diabetes. About 80 participants will wear the device and have their g…

This Phase 2 trial tests HP-211, a botanical extract from common vegetables like endive and lettuce, in 300 people with type 2 diabetes. The goal is to see if it can improve how the body uses insulin and lower blood sugar levels over 90 days. Participants take HP-211 or a placebo…

This pilot study tests whether having a pharmacist oversee continuous glucose monitoring (using a FreeStyle Libre device) can improve blood sugar control and health behaviors in people with type 2 diabetes. Forty participants will use the monitor for 12 weeks, and their results w…

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study looks at how fat cells work differently in normal-weight people with type 2 diabetes compared to those without diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adults aged 30-7…

This study tests a single pill containing three diabetes drugs (empagliflozin, linagliptin, and metformin) in 800 adults with type 2 diabetes. The goal is to see if the triple combination improves blood sugar control, weight, quality of life, and treatment satisfaction compared t…

This Phase 1 trial tests a new injectable drug called SHR-3167 in 55 adults with type 2 diabetes. The study measures how the drug moves through the body and how well it controls blood sugar. Participants will receive either SHR-3167 or insulin degludec to compare their effects an…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study tests whether the drug tirzepatide, given once weekly, helps adults with obesity (but without diabetes) lose weight and avoid developing type 2 diabetes. About 3,000 participants will receive either tirzepatide or standard care for up to 5 years. The goal is to see if …

This study tests whether a single daily dose of long-acting insulin can control blood sugar as well as the usual regimen of long-acting insulin plus mealtime insulin in pregnant women with diabetes. About 176 participants will be randomly assigned to one of the two approaches and…

This study tests whether an AI app called SnapD, which recognizes Thai food and estimates nutrition, can help people with type 2 diabetes and overweight improve their blood sugar control. Some participants will also use a continuous glucose monitor (CGM) that tracks sugar levels …

This study tests whether a supplement called NMN can improve kidney health in people with type 2 diabetes and diabetic kidney disease. About 156 adults will take either NMN or a placebo twice daily for 6 months. The main goal is to see if NMN reduces protein in the urine, a key s…

This study is testing whether a continuous glucose monitor (CGM) can help older adults with type 2 diabetes who do not use insulin achieve better blood sugar control. Participants will either wear a CGM every two months or use standard finger-stick monitoring for six months. The …

This study compares two common diabetes drug classes—SGLT2 inhibitors and GLP-1 receptor agonists—to see which better prevents heart attacks, strokes, kidney failure, and death in 6,000 people with type 2 diabetes and heart disease or high risk. Participants are randomly assigned…

This study tests whether a low-fat vegan diet and nutrition classes can improve health and lower medical costs for people with type 2 diabetes. Seven hundred Blue Cross Blue Shield subscribers will follow the diet for 16 weeks. Researchers will measure changes in weight, blood su…

This early-stage study tests an experimental drug called ARO-ALK7 in 138 adults with obesity, some of whom also have type 2 diabetes. The drug is given as an injection and aims to help with weight loss and blood sugar control. The main goal is to check safety and how the body pro…

This study tests whether semaglutide (Ozempic), a drug used for type 2 diabetes, works well for people with spinal cord injury (SCI) who also have diabetes. SCI patients are at higher risk for diabetes, but it's unclear if standard treatments are effective. The trial will measure…

This study tests whether an AI-enhanced digital tool called iMatter2 can help people with type 2 diabetes better manage their condition. About 353 participants will use the tool to report their symptoms and receive feedback, while researchers track changes in blood sugar levels o…

This study tests a program called Glycemic Excursion Minimization (GEM) for people newly diagnosed with type 2 diabetes. Participants use a continuous glucose monitor to see how food and activity affect their blood sugar, then make personalized changes. The goal is to lower blood…

This early-phase trial is testing a single dose of a new type of exenatide injection (CR059) in 9 Chinese adults with type 2 diabetes. The exenatide is delivered using circular RNA wrapped in lipid nanoparticles, a technology similar to some vaccines. The main goal is to check sa…

This study compares weekly semaglutide injections to a calorie-restricted diet in 100 adults with type 2 diabetes and fatty liver disease. Over 12 weeks, researchers will measure changes in blood sugar, weight, inflammation, and liver fat. The goal is to see which approach works …

This study tests a program that gives fresh fruits and vegetables to Native American adults aged 55 and older who face food insecurity and have type 2 diabetes or are at risk. Participants receive vouchers to buy healthy food at local centers, along with nutrition education. The …

This study tests a magnetic device that creates a new connection between parts of the small intestine, aiming to improve blood sugar control in people with type 2 diabetes. Five adults with diabetes and a BMI between 25 and 50 will undergo the procedure. The main goal is to see i…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests whether a 6-month program of problem-solving training, community health worker support, and exercise coaching at a YMCA can improve fitness and heart health in 210 adults with type 2 diabetes, obesity, and low income. Participants are compared to those who receiv…

This study tests a new treatment using clonal fetal mesenchymal stem cells (cfMSCs) for people with type 2 diabetes. The goal is to see if it is safe and can improve blood sugar control. Thirty adults with poorly controlled diabetes will receive the stem cell therapy and be monit…

This study tests whether a structured lifestyle program, including a total diet replacement phase, can help Malaysian adults with early type 2 diabetes achieve remission. 92 participants will be randomly assigned to either the intensive program or standard care. The goal is to se…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This study looks at whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to fresh groceries. About 80 participants from Baltimore will be randomly assigned to receive either standa…

This Phase 3 trial tests whether a cell therapy called REACT (rilparencel) can slow kidney decline in 685 adults with type 2 diabetes and chronic kidney disease. Participants receive either two injections of their own kidney cells or sham procedures. The study measures changes in…

This early study is testing a new treatment for type 2 diabetes. Doctors will take a small amount of fat from each patient, use a special laser to prepare it, and then inject it into the lining of the small intestine. The goal is to see if this can safely improve blood sugar cont…

This study tests a smartphone app called StenoFood that gives dietary advice and self-monitoring tools to people with type 2 diabetes and early kidney disease. The goal is to see if the app helps them follow low-sodium and moderate-protein diet guidelines. About 104 participants …

This study tests whether specially trained community pharmacists can help people with type 2 diabetes and early kidney disease start and stick with medications that protect the kidneys and heart. The trial will include 120 adults in Nova Scotia who don't have a family doctor. Par…

This study tests a program called Regulation of Cues (ROC) in 30 Latina women with prediabetes and obesity. The program teaches awareness of eating triggers and coping strategies to reduce weight and prevent type 2 diabetes. Researchers are first checking if participants find the…

This study tests whether adding SMS reminders with diet and exercise advice to a standard lifestyle program helps people with prediabetes lose more weight. 300 participants in Réunion will be split into two groups: one gets the standard program alone, the other also receives 72 t…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study tests a new weekly injection called GL0034 in 285 adults with type 2 diabetes who are overweight or obese. Participants will receive either the study drug or a placebo for about 36 weeks. The main goal is to see if GL0034 helps lower blood sugar levels more than a plac…

This study tests whether a combination insulin drug (iGlarLixi) works better than standard insulin (Gla-100) at keeping blood sugar within a healthy range throughout the day. About 678 Chinese adults with type 2 diabetes who are not well controlled on oral medications will use a …

This 5-year study tests whether dapagliflozin, a diabetes drug, can prevent serious liver complications in people with chronic hepatitis B and diabetes who already have early liver scarring. 412 participants will receive either dapagliflozin or a placebo daily. The goal is to see…

This early study tests a new treatment called REGEND003, made from human kidney progenitor cells, in 15 people with type 2 diabetes and chronic kidney disease. The main goal is to check if the treatment is safe and tolerable. Participants will receive either the cell therapy or a…

This study tests a once-weekly injection called tirzepatide in about 2,500 adults with obesity or overweight who do not have type 2 diabetes. Participants receive either the drug or a placebo, along with diet and exercise advice. The main goal is to see how much weight they lose …

This study tests whether 12 weeks of high-intensity interval training (HIIT) can improve how muscles store sugar (glycogen) and use insulin in people with type 2 diabetes. Researchers will also check if HIIT reduces liver fat. The trial involves 36 overweight or obese adults aged…

This study tests whether a supplement called AMPK Charge+® can help control blood sugar in adults with prediabetes or type 2 diabetes, both on its own and when combined with the drug semaglutide. About 90 participants will take the supplement daily, with some also receiving semag…

This study tests whether a fully closed-loop insulin delivery system (an "artificial pancreas") can better control blood sugar in adults with type 2 diabetes who use insulin, compared to their usual insulin therapy with a continuous glucose monitor. About 224 participants will us…

This study tests whether short, controlled sessions of low oxygen (intermittent hypoxia) can improve blood flow to the brain and memory in adults aged 60-85 with type 2 diabetes. Researchers will compare the training to a placebo in 80 participants. The goal is to find a new way …

This study looks at whether empagliflozin, a medicine used for diabetes, can help blood vessels and heart muscle recover after a heart attack. About 80 people who had a severe heart attack will either receive empagliflozin or standard care. Researchers will measure artery stiffne…

This study looks at whether combining two common diabetes drugs (GLP-1 agonists and SGLT2 inhibitors) can improve heart function and artery health in people with type 2 diabetes who are at high risk for heart problems. About 240 adults will be split into four groups, each receivi…

This study tests whether a nutrition program that provides twice-daily meal delivery for up to 90 days after hospital discharge, plus diet education, can reduce food insecurity in people with type 1 or type 2 diabetes. About 160 hospitalized patients who screen positive for food …

This early-phase trial tests transplanting insulin-producing cells into the front chamber of the eye in legally blind people with diabetes. The goal is to see if the cells survive and work safely using only eye drops for immune suppression. Only 2 participants are enrolled, so th…

This large phase 3 trial is testing whether colchicine (a gout medication) and low-dose aspirin, taken together or alone, can prevent heart attacks, strokes, and cardiac death in 10,000 high-risk people with type 2 diabetes who have not yet had a heart-related event. Participants…

This Phase 3 study tests whether a daily pill combining obicetrapib and ezetimibe, or obicetrapib alone, can lower LDL (bad) cholesterol more than placebo in 300 people with type 2 diabetes or metabolic syndrome. Participants continue their standard cholesterol medications. The m…

This study tests whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes. The health workers will lead group meetings, provide health education, and coordinate care with local clinics. About 398 adults with both c…

This study tests whether weekly diabetes education videos sent by text message, plus help from a community health worker, can improve blood sugar control in Chinese immigrants with type 2 diabetes. 270 participants in New York City will be randomly assigned to receive the program…

This study is testing whether a personalized approach to lowering 'bad' cholesterol (LDL-C) works better than standard moderate-dose statins for preventing first heart attacks, strokes, or related events in people aged 70 and older with type 2 diabetes. About 2,186 participants w…

This phase 3 trial compares two initial drug combinations for people recently diagnosed with type 2 diabetes. One group gets pioglitazone plus tirzepatide (Mounjaro), the other gets metformin plus sitagliptin. The study will track how well each combo lowers blood sugar and how lo…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, high cholesterol, and overweight. About 1,780 adults will take part in cooking demonstrations and learn how to eat more traditional Hawaiian foods. The goal is to…

This study is testing whether adding a continuous glucose monitor (CGM) to a text-message diabetes education program helps people with type 2 diabetes better manage their blood sugar. About 140 participants who do not use insulin will receive daily texts about diabetes care and a…

This study tests a program called PILI 'Āina that combines lifestyle lessons, home gardens, and cooking classes to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity. About 210 overweight or obese Native Hawaiian adults with these conditions will take …

This 76-week study tests whether mazdutide, a weekly injection already used for diabetes, can slow memory and thinking decline in 420 adults aged 50-75 with type 2 diabetes and early dementia. Half receive the drug, half a placebo. Researchers will measure changes in thinking ski…

This pilot study compares two approaches to reduce type 2 diabetes risk in 40 overweight adults with prediabetes. One group follows the standard Diabetes Prevention Program (DPP) focusing on diet and exercise. The other group uses an enhanced version (DPP++) that also includes a …

This Phase 1 study tests retatrutide, a new injectable drug, in 95 adults with type 2 diabetes who already take metformin. The goal is to see if retatrutide improves insulin sensitivity and beta-cell function better than placebo or semaglutide over 28 weeks. Participants will rec…

This study looks at whether a high-carbohydrate diet combined with exercise can help people with type 2 diabetes achieve remission. It involves 24 overweight adults recently diagnosed with diabetes who are not on insulin. The goal is to see if this approach is practical and safe,…

This study tests four different drug combinations in 178 adults with type 2 diabetes whose blood sugar is not well controlled on metformin and an SGLT-2 inhibitor. Over 12 weeks, researchers will measure how much and how often blood sugar swings. The goal is to find which combo o…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study is for Chinese adults aged 18-50 with type 2 diabetes and obesity. It tests a 3-year program that combines medical treatment, counseling, an AI chatbot, and peer support to help with weight loss and improve physical and mental health. The goal is to see if this team-ba…

This Phase 2 trial tests dapansutrile, an oral drug that reduces inflammation, in 300 adults with type 2 diabetes. The goal is to see if it improves blood sugar control and lowers the risk of diabetes-related complications. Participants are randomly assigned to receive either the…

This study looks at whether a 24-week program of healthy eating and exercise helps post-menopausal women with type 2 diabetes and heart-kidney problems stick to their new GLP-1 medication. Researchers will track how many women stop taking the drug and measure changes in heart dis…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This study tests whether a special toothpaste and mouthwash containing natural 'para-probiotics' can improve gum health and help control blood sugar in people with type 2 diabetes. Forty adults with gum disease and diabetes will use either the para-probiotic products or a standar…

This early-phase study tests whether adding Arestin (minocycline microspheres) to standard deep cleaning (scaling and root planing) improves gum healing and blood sugar control in adults with type 2 diabetes and moderate to severe gum disease. About 42 participants will be random…

This study looks at whether using ultrasound to find fatty lumps (lipohypertrophy) caused by insulin injections can help people with diabetes improve their blood sugar levels. About 50 adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor will get…

This study tests whether time-restricted eating—fasting for 18 hours and eating only during a 6-hour window each day—can help preserve the pancreas's ability to produce insulin and improve blood sugar control in people with type 2 diabetes. Over 52 weeks, 112 overweight adults wi…

This study tests whether a fully automated insulin delivery system (CamAPS HX) can improve kidney oxygen levels in people with type 2 diabetes and chronic kidney disease. About 76 adults will use either the automated system or standard insulin therapy with a glucose monitor for 2…

This study tests whether adding semaglutide (a drug used for diabetes and weight loss) to a standard topical cream can improve psoriasis symptoms and reduce body-wide inflammation. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will receive eithe…

This study tests whether giving a healthy food voucher to people with type 2 diabetes or prediabetes who have low income can improve their blood sugar control. About 390 participants will be randomly assigned to receive the voucher or not. The main goal is to see if hemoglobin A1…

This study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will track changes in blood pressure and blood sugar over 6 months in 100 adults aged 18-60. The goal is to see if home-based care leads to better control o…

This study tests whether using a smart insulin pen (InPen) along with a continuous glucose monitor and telemedicine can improve blood sugar control in veterans with type 2 diabetes who take multiple daily insulin injections. Fifty participants will be randomly assigned to use eit…

This trial tests whether a smart telemonitoring system can help people with type 2 diabetes who use insulin. Participants will use a continuous glucose monitor, insulin pen, and Fitbit at home. One group will also get decision-support algorithms to guide insulin adjustments. The …

This Phase 3 trial is testing whether the experimental drug HDM1005 can help people with type 2 diabetes control their blood sugar better than a placebo. About 240 adults who have not used diabetes medication for at least 12 weeks will receive either HDM1005 or a placebo injectio…

This study tests whether a 4-week online education program about continuous glucose monitors (CGMs) helps youth aged 8-21 with type 2 diabetes improve their blood sugar control compared to standard care. Participants will attend virtual sessions with a diabetes educator and use t…

This study is tracking 3000 adults with type 2 diabetes who are starting a new combination pill called Proline Plus Empagliflozin. Researchers want to see how well it controls blood sugar and if it is safe when used in everyday medical practice. The study does not change how doct…

This early study tests a herbal effervescent tablet taken twice daily before meals in 14 adults with type 2 diabetes. The goal is to see if it safely helps lower blood sugar levels (HbA1c, fasting, and after meals). Participants include those managing diabetes with diet or supple…

This Phase 3 trial is testing a drug called Neovasculgen, given as injections into the leg muscles, to see if it can help heal foot ulcers in people with diabetes. The study will include 144 adults with type 1 or type 2 diabetes who have a non-healing foot ulcer. Participants wil…

This study tests whether using an AI-driven retinal camera during regular diabetes checkups can increase the number of young people screened for diabetic retinopathy, a leading cause of blindness. Researchers will enroll 500 youth with type 1, type 2, or cystic fibrosis-related d…

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

This study tests whether a device that shines light through the toe (photoplethysmography) can quickly detect peripheral artery disease in people with diabetes. The new method measures how long it takes blood to refill the toe after a heartbeat, and researchers compare it to the …

This study is testing a new, non-invasive liver scan called iLivTouch to see if it can accurately detect a serious liver condition called MASH in people who have both type 2 diabetes and fatty liver disease. The scan measures liver inflammation, fat, and stiffness without any nee…

This study collects breath samples from 235 people with type 2 diabetes or obesity to improve a device that estimates blood sugar from exhaled air. Participants breathe into a portable analyzer that measures volatile organic compounds. The goal is to gather data to refine the dev…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study will enroll nearly 3,000 people with type 2 diabetes to improve how diabetic retinopathy (an eye disease) is diagnosed and managed. Researchers will use eye exams, blood tests, and continuous glucose monitors to build better models for predicting and treating the condi…

This study from the University of Oxford is testing whether a finger-prick blood test, done at home, can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and mult…

This study tests whether an AI software can help doctors spot diabetic retinopathy (an eye disease caused by diabetes) earlier. About 340 adults with type 2 diabetes who have not been diagnosed with eye disease will be randomly assigned to get either standard care or standard car…

This study is testing a new blood test called Avantect to see if it can find pancreatic cancer early in people who were diagnosed with type 2 diabetes in the last 6 months. About 15,000 adults aged 50-84 will give blood samples and fill out anxiety questionnaires over a year. The…

This pilot study tests whether a family-centered health and wellness coaching program can help prevent type 2 diabetes in South Asian and Black African/Caribbean families in Ontario, Canada. Each family dyad includes an adult caregiver and a youth aged 14–24. Participants receive…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This study is testing whether a digital tool that encourages self-reflection and healthy habits can prevent type 2 diabetes. Over 40,000 adults without diabetes will use the app or receive usual care for three years. Researchers will track how many people develop diabetes in each…

This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and qu…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This study is testing whether a special software that analyzes CT scans of the heart's arteries can better prevent heart attacks, strokes, and other cardiovascular events compared to usual care based on risk factors like cholesterol and blood pressure. The trial will enroll 7,500…

This study tests whether a natural bile acid called 7-Ketolithocholic Acid, taken as a supplement, can lower blood sugar levels in 100 adults with prediabetes. Participants will also follow a healthy diet and exercise plan. The goal is to see if this supplement can help prevent o…

This study looks at whether adding brewer's spent grain (a beer-making byproduct) to cookies can help control blood sugar after eating. Twenty healthy adults will eat regular cookies and special high-fiber cookies on different days, and their blood sugar will be checked over two …

This study tests whether giving adults at risk for type 2 diabetes free fresh fruits and vegetables, along with a proven lifestyle program, can help them lower blood sugar and lose weight. One hundred adults with prediabetes will either get the standard diabetes prevention progra…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

This study looks at whether drinking regular milk can lower the risk of type 2 diabetes in people with lactose intolerance who also have pre-diabetes. Researchers will compare regular milk to lactose-free milk over 12 weeks in 40 adults. They will measure changes in gut bacteria,…

This study tests whether teaching basic carbohydrate counting can lower blood sugar levels in people with prediabetes. About 120 adults with prediabetes will either get standard lifestyle advice or extra training on counting carbs. Researchers will check HbA1c levels at 3 and 6 m…

This study looks at whether taking a daily supplement made from artichoke by-products, combined with a calorie-controlled Mediterranean diet, can help prevent type 2 diabetes in people who are overweight or obese. Researchers will measure changes in insulin resistance and weight …

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick with healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will receive DPP coa…

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This study aims to develop a better system to support breastfeeding for women who had gestational diabetes, with the goal of preventing type 2 diabetes later. Researchers will work with patients, healthcare providers, and hospital leaders to design a practical strategy. Only 10 p…

This study tests whether wearing a continuous glucose monitor (CGM) and watching AI-generated health videos can help people with prediabetes control their blood sugar. Fifty adults aged 35 and older with prediabetes will wear a CGM and receive smartphone feedback. The goal is to …

This phase II trial tests whether a special form of nicotinic acid (a B vitamin) can reverse prediabetes and prevent type 2 diabetes. About 390 adults with prediabetes will take either a low or high dose of the drug or a placebo daily for 26 weeks, along with lifestyle advice. Th…

This pilot study tests whether a 12-week family-centered, non-calorie restricted whole foods diet can help prevent type 2 diabetes in adults with prediabetes. About 30 adult-child pairs will participate, with adults having prediabetes and children aged 6-18. The study measures fe…

This study tests whether extra lifestyle coaching plus medically tailored meals can help prevent type 2 diabetes in mothers who had gestational diabetes. Nearly 1,000 pregnant or recently postpartum women from home visiting programs will be randomly assigned to receive either enh…

This study tests a mobile health app designed to help Hispanic adolescents (ages 12-18) who are overweight improve their diet, physical activity, and sleep. The goal is to see if the app can help prevent type 2 diabetes. The study will enroll 30 participants and last 30 days, foc…

This study looks at two different ways to help adults in rural communities prevent type 2 diabetes. Participants will either join group video sessions or follow a self-directed program. The goal is to see which method works better for weight loss and blood sugar control.

This study tests a new way to screen for heart failure risk in people with type 2 diabetes. Doctors use a blood test (NT-proBNP) and a risk score to identify high-risk patients, then offer early prevention treatments. About 300 patients are taking part. The goal is to see if this…

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This pilot study is testing whether a virtual reality (VR) cognitive training program can help protect memory and thinking skills in adults aged 45-80 with type 2 diabetes and mild cognitive impairment. Forty participants will be randomly assigned to either 16 weeks of VR-based t…

This study tests whether the Thrive AI Health app can help adults with type 2 diabetes or overweight improve their daily habits like diet, exercise, and sleep. About 20 participants will either use the app or not, and researchers will compare changes over time. The app uses artif…

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study will give a steroid and numbing injection to 60 people with carpal tunnel syndrome, half of whom also have type 2 diabetes. Researchers will track pain, nerve function, and hand strength for 12 weeks to see if the diabetes group recovers as well as those without diabet…

This small study in Uganda looks at how meals made with local fruits and vegetables affect blood sugar and fat levels in people with type 2 diabetes. Eight participants will eat five different test meals over five weeks, with blood samples taken over three hours after each meal. …

This early-stage study tests a new drug called ALV-100 in 180 adults who are overweight or obese, with or without type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo, and researchers will mo…

This study looks at whether counseling sessions can help people with type 2 diabetes become more physically active and sit less. Researchers will compare standard care with informational sessions on exercise benefits, with or without practical guidance from a kinesiologist. The g…

This study looks at whether a 12-week home-based strength training program, supported by technology and telehealth, is practical for 20 adults aged 55-80 with type 2 diabetes and mild cognitive impairment. Participants will start with supervised sessions and gradually exercise on…

This study tests whether semaglutide, a drug used for diabetes, can help people with type 2 diabetes quit smoking. About 100 adults in Ontario who smoke at least 5 cigarettes daily will receive the drug alongside nicotine replacement therapy. The main goal is to see if a larger s…

This study tests whether soaking your feet in hot water for 12 weeks can improve blood sugar control and blood vessel function in adults with type 2 diabetes. Researchers will compare hot water foot baths to neutral temperature foot baths in 44 people aged 45-75. The goal is to s…

This study tests whether a whole-food, plant-based diet (no added oils) can reduce painful diabetic neuropathy better than standard medication. Forty adults with type 2 diabetes and nerve pain will be randomly assigned to either the diet or medication optimization. The main goal …

This study tests whether taking 3 mg of melatonin each night for 8 weeks can improve sleep and daily body rhythms in people with diabetic retinopathy. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65 with type 2 diabetes and moderate eye damage. Th…

This study tests an 8-week program that combines positive psychology and motivational interviewing to help people with type 2 diabetes increase their physical activity. The program is delivered remotely via phone and text messages. Researchers will measure changes in activity lev…

This study looks at whether drinking whey protein twice a day can improve blood sugar and insulin levels in people with prediabetes or type 2 diabetes. Researchers will measure blood sugar control and appetite in 40 adults aged 50-70 over two 7-day periods. The goal is to see if …

This study looks at whether a ketone ester supplement can improve heart function and exercise ability in people with type 2 diabetes. About 30 adults will take either the supplement or a placebo and undergo heart scans and fitness tests. The goal is to see if this simple drink ca…

This study tests a virtual health coaching program for adults with type 2 diabetes who also face mental health challenges like anxiety or diabetes distress. Participants receive weekly coaching calls, support from a care team, and online tools to help manage both conditions. The …

This study tests whether a 12-week multimodal exercise program—combining supervised training, home exercises, and digital support—can improve muscle function, physical performance, and blood sugar control in adults aged 45 to 85 with both type 2 diabetes and sarcopenia (age-relat…

This study tests whether a four-week online self-compassion course can reduce diabetes-related distress, self-criticism, and shame in adults with type 1 or type 2 diabetes. Researchers will enroll 50 participants to see if the program is feasible and acceptable. The course includ…

This study looks at whether giving a carbohydrate drink before coronary artery bypass surgery can improve insulin sensitivity and recovery in people with type 2 diabetes. About 50 participants will be enrolled. The goal is to see if this simple step can reduce complications and s…

This study tests a program that gives people with diabetes a continuous glucose monitor (CGM) when they leave the hospital. The goal is to see if it makes patients more satisfied and improves their quality of life. About 37 adults with Type 1 or Type 2 diabetes who use insulin wi…

This study tests a culturally adapted diabetes education program for Arab Americans with type 2 diabetes. Participants will receive peer-led classes in Arabic and text message support for 3 months. The goal is to see if this approach improves diabetes knowledge, self-care, and bl…

This study tests whether adding antimicrobial photodynamic therapy (aPDT) – a light-based treatment – to standard gum cleaning can reduce bad breath (halitosis) in people with type 2 diabetes and advanced gum disease. Thirty-two participants will receive either standard care or s…

This study tests a 6-week virtual program called the Diabetes Body Project 2, designed to prevent eating disorders in women aged 18-40 with type 2 diabetes. The program includes weekly group sessions and home exercises to improve body image and reduce disordered eating. Researche…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This early-stage study tests whether taking vitamin B1 (thiamine) daily for three months can improve brain function and repair the blood-brain barrier in adults with type 2 diabetes. Researchers will use brain scans, memory tests, and blood markers to compare results between the …

This early-stage study tests a new drug called LY4057996 in 124 healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. Participants receive the drug as a shot under the skin or into a vein, and…

This study tests whether a combination of sensory-motor exercises (like pelvic rocking and strength training) can reduce pain and improve balance in postmenopausal women with polyneuropathy. One hundred women with type 2 diabetes and numbness in their arms and legs will be random…

This study looks at whether using a continuous glucose monitor (CGM) after hospital discharge helps people with diabetes feel more in control and satisfied with their care. About 60 adults with type 1 or type 2 diabetes who need insulin will use a CGM at home and answer questionn…

This study looks at whether using a foam roller on the feet and calves before exercise can improve foot function, balance, and walking in people with type 2 diabetes. About 40 adults aged 30 to 65 with controlled diabetes will either do exercise alone or exercise plus foam-roller…

This study follows 600 Indigenous families in Manitoba to understand how maternal health, genetics, and early-life environment contribute to obesity and type 2 diabetes in children. Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes are enrolled, and their …

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

This study looks at children with suspected or confirmed genetic and metabolic disorders to find new disease-causing gene mutations. Researchers will analyze blood samples for DNA and metabolites, and in some cases take a small skin sample. The goal is to better understand these …

This study investigates how two days of forearm immobilization (keeping the arm in a cast or sling) changes the way muscles take up glucose and amino acids. Researchers will compare these effects in people with type 2 diabetes and healthy volunteers. The goal is to understand why…

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. …

This study investigates how muscle fiber type and protein makeup relate to early insulin resistance, a key step before type 2 diabetes develops. Researchers will follow 250 healthy adults aged 20-30 for up to 20 years, using muscle biopsies, scans, and wearable sensors. The goal …

This study investigates whether 6 weeks of treadmill walking with blood flow restriction cuffs on the legs can improve immune cell function in adults with type 2 diabetes. Participants walk three times per week, with some wearing inflatable cuffs that partially limit blood flow. …

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study explores the link between sleep duration and blood sugar control in adolescents aged 12-20 with type 2 diabetes. Researchers will first measure sleep and blood sugar in 67 teens, then test a program using Fitbits and text messages to encourage longer sleep in 15 teens …

This study will follow 500 adults with chronic kidney disease and type 2 diabetes who are taking finerenone, a drug that helps protect the kidneys and heart. Researchers want to see if a tool called the Klinrisk score, which estimates the risk of kidney disease getting worse, imp…

This research study follows 500 adolescents with type 2 diabetes to understand why some develop kidney problems. Researchers are looking at biological factors like blood sugar and blood pressure, as well as psychological and social factors such as stress, mental health, and pover…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study is checking if the diabetes medicine exenatide (Byetta, Bydureon) increases the risk of pancreatic cancer. Researchers will look at health records from 24,000 patients across seven European countries, comparing those who started exenatide with those who started other d…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study tests a program called SPARK-CGM that helps primary care clinics prescribe continuous glucose monitors (CGM) to people with diabetes. CGM devices track blood sugar in real-time, but they are underused in primary care. The program provides training, workflow support, an…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study will give 100 adults with diabetes a thermal camera that attaches to their smartphone to take daily pictures of their feet. The goal is to collect temperature data and see if hot spots can predict where foot ulcers might form. Participants will use the device at home f…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study looks at tiny particles called extracellular vesicles (EVs) released from fat cells. Researchers want to understand how these particles carry signals that may affect heart and liver health in people with obesity. About 100 adults having weight-loss surgery will provide…

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will follow 104 overweight adults, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will f…

This observational study will follow 50,000 people in Asia and the United States who have chronic kidney disease and type 2 diabetes and are already taking finerenone as part of their regular care. Researchers will collect data from electronic health records and insurance claims …

This study reviews medical records of 400 adults aged 40-70 who were recently diagnosed with type 2 diabetes in five Southeast Asian countries. Researchers will look at health data from before and after diagnosis to understand how heart disease risk is distributed. No new treatme…

This study is testing whether mixed reality (using a Meta Quest 3 headset) can reliably measure walking ability, balance, and leg strength in people with type 2 diabetes. Researchers will compare the digital versions of three common physical tests (6-minute walk, timed up and go,…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study looks at whether sending home test kits or ordering standard lab tests can help more people with type 2 diabetes get screened for chronic kidney disease (CKD). About 750 adults who are missing key kidney function tests will be enrolled. The goal is to see if these appr…

This observational study is gathering detailed metabolic data from 25 adults with insulin-dependent type 2 diabetes. After drinking a standard liquid meal, participants will have frequent blood tests to measure glucose, insulin, and other markers. They will also wear continuous g…

This study watches 500 adults in South Korea who have chronic kidney disease and type 2 diabetes and are taking finerenone as part of their normal care. Researchers will collect information from medical records and doctor visits over up to 12 months to see why doctors prescribe i…

This study looks at how blood sugar changes day-to-day in people with ketosis-prone diabetes as they go into remission. Researchers will use this data to build a math model that describes the remission process. The study involves 12 African American adults with a BMI of 28 or hig…

This study is collecting health data from 1,500 adults with diabetes in Switzerland to see how well current treatments work in everyday life. Researchers will track complications, quality of life, and survival over time. The goal is to find out what's working and what needs impro…

This study looks at how an FDA-approved diabetes drug, Canagliflozin (Invokana), might protect the kidneys in people with type 2 diabetes. Twenty adults aged 18-80 with type 2 diabetes for at least 3 years will take the drug daily for 6 months. Researchers will use kidney biopsie…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study reviews medical records of 500 adults treated for benign or malignant pancreatic diseases since 2005. The goal is to understand how well different treatments worked over time. No new treatments are given—just careful analysis of past cases.

This study tests a smartphone app designed to help adults taking GLP-1 medications for obesity or type 2 diabetes eat better. About 50 participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if the app is helpful and easy to use…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study follows 30 people aged 16–80 with obesity who are starting weight-loss medication. Researchers will track changes in hunger, fullness, cravings, and portion size using questionnaires and interviews at 0, 3, 12, and 18 months. The goal is to understand how eating behavi…

This study looks at whether using a continuous glucose monitor and a Fitbit activity tracker can help people aged 55 and older with type 2 diabetes sit less and control their blood sugar better. Researchers will track how often participants respond to prompts to stand up and how …

This study is testing whether a mobile app called Fabla-diabetesMM, which lets people record audio diaries, is easy and helpful for older adults with type 1 or 2 diabetes who also have other health conditions. Thirty participants will use the app and answer questions about their …

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …

This study looks at how social factors and health literacy affect the ability of people with diabetes to manage their own care. Researchers will survey 400 adults with type 1 or type 2 diabetes to understand these connections. The goal is to design better support programs that he…

This study is testing whether wearable devices like continuous glucose monitors and smart bracelets, combined with smartphone apps, can help predict and prevent complications in people with type 2 diabetes. Researchers will enroll 6,000 adults and follow them for 3 months, using …

This study looks at whether a genetic risk score can predict which people with newly diagnosed diabetes will eventually need insulin. Researchers will follow about 3,000 patients aged 14 to 50 for up to 3 years, tracking their C-peptide levels (a marker of insulin production) and…

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study tests whether giving doctors a geriatric assessment—a quick check of frailty and function—helps them set safer blood sugar goals for patients aged 60+ with type 2 diabetes. 220 participants will be randomly assigned to usual care or to have their doctor receive the ass…

This study is checking how accurate the Dexcom G7 continuous glucose monitor is for patients in the intensive care unit after major abdominal surgery or organ transplant. Researchers will place two sensors on each patient—one that is calibrated and used to guide insulin dosing, a…

This study looks at how cutting calories affects the way the liver processes amino acids, sugars, and fats in people with type 2 diabetes. Researchers want to see if weight loss helps the liver respond better to a hormone called glucagon. About 20 adults with type 2 diabetes and …

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medi…

This study is recruiting 3,000 adults with type 2 diabetes to collect basic health information and a small blood sample. The goal is to identify people who may be eligible for other clinical trials. No experimental treatment is given. Participants simply help researchers understa…

This study is looking for early warning signs of diabetes and its complications. Researchers will give a high-fat drink to 150 adults (ages 50-70) with prediabetes, type 2 diabetes, or healthy blood sugar. They will measure fats and inflammation in the blood before and after the …

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study is testing whether a substance in the blood called 1,5-anhydroglucitol can serve as a marker for how well the pancreas is working in obese children, with or without type 2 diabetes. Researchers will measure levels of this marker in 50 children aged 12 to 16 and compare…

This early study looks at how two diabetes drugs, empagliflozin and pioglitazone, interact in the body. Researchers want to see if pioglitazone can reduce the ketones (a type of acid) that empagliflozin sometimes produces. The study involves 64 adults with type 2 diabetes and mea…

This study looks at how semaglutide, a drug used for diabetes and weight loss, changes fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers will compare patients taking semaglutide to those not taking it. The goal …

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study aims to find out how many adults with type 2 diabetes experience severe diabetes-related distress—a feeling of being overwhelmed by the demands of managing the disease. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their em…

This study follows 296 Vietnamese adults with type 2 diabetes for one year to compare how insulin-producing beta cells change in people diagnosed before age 40 versus those diagnosed at 40 or older. Researchers will measure blood markers like C-peptide and HbA1C at 3, 6, 9, and 1…

This study follows 3,600 overweight or obese teenagers who are at high risk for developing type 2 diabetes. Researchers will monitor changes in blood sugar, insulin, and other factors over time to learn how the disease starts. No treatments or medications are given—the goal is si…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This study looks at whether the standard A1C blood sugar test works correctly in people with a Left Ventricular Assist Device (LVAD), a type of heart pump. Researchers will compare A1C results with continuous glucose monitor (CGM) readings over 3 months in 20 adults with type 2 d…

This study tests whether an AI tool called EchoGo can help doctors spot early signs of heart failure in people with type 2 diabetes who have no symptoms. Researchers will send alerts to doctors about patients at risk, and see if this leads to more prescriptions of heart-protectin…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study looks at how well the pancreas can produce insulin in people with type 2 diabetes. Participants drink a meal replacement shake, and blood is taken five times over two hours to measure insulin and blood sugar levels. The goal is to understand differences in insulin prod…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study tests whether a machine learning program can detect lipohypertrophy—hidden lumps under the skin caused by insulin injections—using portable ultrasound. About 100 people with diabetes will first have their injection sites scanned. In a second phase, 40 people found to h…

This study aims to understand how social needs like food or housing insecurity affect self-care in African American adults with diabetic kidney disease. Researchers will interview patients and community stakeholders, then survey 300 participants to measure blood pressure, blood s…

This study looks at how a 12-week physical activity program, delivered through smartphone apps and a Fitbit, affects brain function in cancer survivors who report 'chemo-brain' (cognitive problems after chemotherapy). Researchers will compare survivors with and without type 2 dia…

This study uses advanced MRI scans with a special manganese dye to look at how the heart handles calcium and energy in people with heart failure with preserved ejection fraction (HFpEF). Researchers will compare 40 people with HFpEF (half with type 2 diabetes) and 20 healthy volu…

This study looks at why people with type 2 diabetes often develop heart problems. Researchers will collect blood and urine from 90 volunteers—some with diabetes and heart disease, some with diabetes only, and some healthy—to study special cells called endothelial progenitor cells…

This study looks at how a drug called diazoxide, which activates certain brain centers, can change how much sugar the liver makes. People with type 2 diabetes often have livers that produce too much sugar, leading to high blood sugar. The study will involve 100 participants (both…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to track changes in blood sugar, kidney function, heart health, and emotional well-being over many years. The goal is to better understand how the disease progresses and impro…

This study tests different ways to help teenagers and young adults with type 2 diabetes address social needs like food or housing. About 104 teens and their caregivers will try either tailored resource lists or a universal empowerment approach. The goal is to see which method is …

This study looks at how a 12-week exercise program affects the way older adults (over 65) with type 2 diabetes use protein from their diet. Thirty participants will do moderate-to-vigorous aerobic and strength training, and researchers will measure changes in protein balance, gut…

This study tests whether cinematic virtual reality (VR) is more effective than traditional lectures for teaching medical students about geriatric care. One hundred students at Ohio University will be randomly assigned to either VR training or a lecture. The VR group will experien…

This study uses advanced MRI scans to track changes in muscle and fat in the body and heart over 12 months in 50 adults starting semaglutide for type 2 diabetes or weight loss. Participants will undergo MRI scans, physical tests, blood samples, and questionnaires. The goal is to …

This study looks at how exercise changes the amount of sugar the liver makes in people with type 2 diabetes and fatty liver disease. Researchers will measure liver sugar production during rest and exercise in 12 adults aged 25-55. The goal is to better understand how exercise hel…

This study aims to create a questionnaire that measures how actively people with type 2 diabetes manage their health. Researchers will test the tool with 600 patients and healthcare workers to ensure it is accurate and reliable. The goal is to better understand patients' behavior…

This study looks at 3,000 people with type 2 diabetes to see if certain signs of inflammation in the blood are linked to diabetes-related health problems. Researchers hope to find early clues that could help identify patients at higher risk for complications. The study is purely …

This study looks at how resistance training (like lifting weights) affects fat breakdown in obese postmenopausal women who also have prediabetes. Researchers want to see if this type of exercise can improve how the body uses fat, which might help prevent type 2 diabetes. The stud…

This study follows 800 adults with type 2 diabetes to see how their lifestyle choices relate to long-term complications like heart or kidney problems. Researchers will track participants over time and record any complications that develop. The goal is to find early warning signs …

This study looks at how a person's genetic makeup influences their response to oral semaglutide (Rybelsus), a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes a 14-day course of the drug and measure blood sugar, insulin, and other factors after a s…

This study looks at how three common blood pressure medications (ephedrine, phenylepinephrine, and norepinephrine) affect the ability of the uterus to contract after a C-section in women with type 2 or gestational diabetes. Researchers will take small tissue samples from the uter…

This observational study will examine how the pancreas works in 310 adults with type 2 diabetes. Researchers will use blood tests, stool samples, and ultrasound to measure both hormone and digestive functions. The goal is to identify a different form of diabetes called pancreatog…

This study looks at how a common diabetes drug (SGLT2 inhibitor) changes the way the heart and muscles use energy from ketones. Researchers want to see if these changes can improve exercise ability and daily function in 30 adults with type 2 diabetes and heart failure. Participan…

This study looks at how antipsychotic drugs might cause metabolic problems in women by affecting how the brain responds to insulin. Researchers will give 15 healthy women a single dose of the antipsychotic olanzapine and insulin nasal spray, then use brain scans to see changes. T…

This study follows over 500 adults with type 2 diabetes who had a heart CT scan years ago. Researchers will repeat the scan to see how plaque builds up in heart arteries over time and identify factors that increase risk. The goal is to better understand heart disease in diabetes,…

This study looks at how different exercise intensities affect the brain in people with type 2 diabetes. 75 inactive adults aged 30-75 will do supervised cycling at high or moderate intensity for 6 months, three times a week. Researchers will use brain scans, cognitive tests, and …

This study is observing 3000 adults with type 2 diabetes in Italy to see how well their heart risks are managed according to current guidelines. Researchers will check if patients are getting the right medications and care. No new treatments are being tested.

This study looks at how long people with type 2 diabetes need to stop taking GLP-1 medications (like semaglutide) before surgery to make sure their stomach is empty. These drugs slow down digestion, which can increase the risk of food or liquid entering the lungs during anesthesi…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This observational study will follow 2000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Researchers hope to identify patterns that could help improve care. Participants must be 18 or older and able to complete ba…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome by analyzing immune cells from a blood sample. Researchers will compare calcium and inflammation signals in these cells between patients with and without heart probl…

This early-stage study looks at how taking a new tablet called CX11 with or without food changes the amount of drug in the blood. It involves 32 healthy adults and does not aim to treat any disease. The results will help researchers decide how to give the drug in future studies f…

This study is creating a large digital registry to find and understand rare forms of diabetes caused by a single gene (monogenic diabetes). Researchers will enroll up to 5,000 people in China who were diagnosed with diabetes at a young age and test their DNA. The goal is to learn…

This study looks at how exercise affects insulin resistance and heart function in people with type 2 diabetes. Researchers will have 150 participants do 15 weeks of cardiovascular exercise, 3 times a week. They will measure changes in oxygen use and insulin sensitivity to see if …

This study looks at how people with type 2 diabetes break down polyphenols—natural compounds found in plants—compared to healthy individuals of the same age. Researchers will measure polyphenol levels in urine after participants take a special pill. The goal is to understand how …

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is connected to type 2 diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure the fat and see how it relates to the cells that make insulin. The goal is to better u…

This study aims to better understand how blood flow and sugar use in the brain are altered in Alzheimer's disease, especially in people who also have type 2 diabetes. Researchers will use advanced PET scans to measure these changes in 60 participants across three groups: people w…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…

This study looks at why having low 'bad' cholesterol (LDL) might actually increase the risk of type 2 diabetes. Researchers think LDL entering fat tissue may cause problems that lead to diabetes. They will test if taking omega-3 fish oil supplements for 6 months can reduce that r…

This study follows 100 people with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to vision loss. Researchers will use advanced eye scans and imaging to track changes in the retina over two years. The goal is to find better ways to pre…

This early-stage study tests how a single dose of the diabetes drug GL0034 behaves in people with different levels of kidney function. About 40 adults with type 2 diabetes will be grouped by kidney health, from normal to severe impairment. Researchers will measure drug levels in …

This study is looking for new, less invasive ways to diagnose and track Parkinson's disease, Alzheimer's disease, and type 2 diabetes. Researchers will study 500 participants using blood tests, brain scans, and genetic analysis to find early signs of these conditions. The goal is…

This study is looking for early warning signs in the blood that could predict chronic heart failure in people with type 2 diabetes. Researchers will follow 500 participants over time, using heart scans and blood tests to see if certain biomarkers can spot trouble before symptoms …

This study looks at how people with type 2 diabetes imagine movements, sense their own bodies, and perform thinking tasks. Researchers will test 100 adults aged 18–65 who have had diabetes for at least 5 years. No treatments or drugs are given—only questionnaires and simple tasks…

This pilot study is testing whether wearing a continuous glucose monitor (CGM) for just 24 hours after giving birth can help predict a woman's long-term risk of developing type 2 diabetes. The study involves 50 women who had gestational diabetes and will wear the CGM immediately …

This observational study examines kidney tissue from adults with diabetic kidney disease who are already having a kidney biopsy or surgery as part of their regular care. Researchers want to see if people taking SGLT2 inhibitors (a type of diabetes medicine) show different biologi…

This observational study will follow 1,000 people with type 2 diabetes for one year to see if changes in the eye's blood vessels and tissues can predict worsening diabetic retinopathy and related heart problems. Researchers will use advanced imaging and medical records to track e…

This study will follow 1,000 adults in Hong Kong who have both type 2 diabetes and a common fatty liver condition called MASLD. Researchers will collect health data and blood samples over time to see how the liver disease progresses and to find early markers of serious liver scar…

This study is surveying 500 adults with type 2 diabetes to see how much they know about nutrition and how closely they follow the Mediterranean diet. Researchers will also measure blood sugar, cholesterol, and muscle strength. The goal is to understand the link between diet knowl…

This study looks at why people with diabetes have a higher risk of memory problems and dementia. Researchers will use brain scans and thinking tests to see if brain insulin resistance and damaged blood vessels play a role. About 150 adults aged 50-80 with type 1 or type 2 diabete…

This pilot study is testing a new smartphone app called Healthmine that pairs data from a continuous glucose monitor and a Fitbit. Thirty young adults aged 16-24 who were diagnosed with type 2 diabetes before age 18 will use the app for 30 days. The goal is to see if the app is e…

This study follows 50 adults who are about to start GLP-1 therapy for obesity or type 2 diabetes. Researchers will track how their eating habits change over 12 weeks using diet quality scores and body weight. The goal is to understand what dietary support people need while on the…

This study looks at why diabetes can damage the heart even without clogged arteries. Researchers will examine heart tissue and use advanced imaging in 500 adults with heart failure, with or without type 2 diabetes. The goal is to find early warning signs and new treatment targets…

This observational study aims to understand why some adults with diabetes find it hard to take their medicines as prescribed. Researchers will survey 220 patients to examine factors like medication knowledge, family support, communication with doctors, and access to care. The goa…

This study looks at how adding different types and combinations of dietary fiber to scones affects blood sugar, feelings of fullness, and gut bacteria. Overweight but otherwise healthy adults will eat seven different fiber-enriched scones over several days. Researchers will track…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study uses MRI scans to look for brain differences in people with metabolic diseases compared to healthy volunteers. Researchers will track changes over time and link them to body fat and other health measures. About 126 adults will take part at Ulm University Hospital. No d…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study uses advanced full-body PET scans to see how natural gut hormones (GIP and GLP-1) affect how the body takes up sugar and blood flow. It includes healthy adults and people with type 2 diabetes. The goal is to better understand how these hormones work after eating, which…

This study looks at why type 2 diabetes often goes away quickly after bariatric surgery. Researchers will measure how the body stores and uses fat from food in 40 people having the surgery, half with diabetes and half without. The goal is to find out if better fat storage in bell…

This study looks at how SGLT2 inhibitors, a type of diabetes medicine, change energy levels in the heart and muscles. Researchers will measure key energy molecules in 71 adults with type 2 diabetes and heart failure. The goal is to understand how these drugs work, not to test a n…