Your DNA may determine if Weight-Loss drugs work — a trial hunts for clues

NCT ID NCT05071898

Recruiting now Knowledge-focused Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This study investigates whether genetic differences influence how people respond to semaglutide, a GLP-1 drug used for weight loss and diabetes. Overweight or obese volunteers of Amish descent will receive weekly semaglutide injections for six weeks. Before and after treatment, researchers measure insulin secretion and glucose clearance using intravenous glucose tests. The goal is to link specific DNA variants to these responses, potentially paving the way for personalized medicine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide (Ozempic, Wegovy) injected under the skin weekly for 6 weeks
What this could lead to: If successful, this could help doctors predict who will benefit most from GLP-1 drugs like semaglutide, leading to more personalized obesity and diabetes treatment.
What could go wrong: This is an early-phase study focused on genetic markers, not on proving the drug works. Results may not apply to the general population, as it only includes Amish volunteers.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES TYPE 2 OBESITY

Contacts and locations

Locations

Amish Research Clinic
RECRUITING

Lancaster, Pennsylvania, 17602, United States

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