Could immune cells in fat hold the key to Obesity-Related diseases?

This study investigates how immune cells in fat tissue, called macrophages, handle fats and whether this affects metabolism in people with obesity. Researchers will compare adults with obesity and type 2 diabetes or fatty liver to lean individuals, using imaging, blood tests, and tissue samples. Participants with obesity will also receive dietary counseling to lose 10% of their body weight, allowing researchers to see how weight loss changes these cellular processes. The goal is to better understand why some people with obesity develop metabolic problems, which could lead to new prevention or treatment strategies.