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Could a simple supplement soothe diabetic nerve damage?

NCT ID NCT07689214

Recruiting now Symptom relief Sponsor: University of Roma La Sapienza Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study tests whether a supplement called Normast3 can reduce nerve pain and improve nerve function in adults with diabetic polyneuropathy, a common complication of diabetes. About 40 participants will take either Normast3 or a placebo twice daily for 12 weeks, while researchers measure pain levels, nerve health, and autonomic function. The goal is to see if this supplement offers a safe, effective way to manage nerve-related symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Normast3 (a supplement containing palmitoylethanolamide, rutin, and hydroxytyrosol)
What this could lead to
If it works, this supplement could offer a new way to ease nerve pain and improve nerve function for people with diabetic polyneuropathy.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. As a supplement, its effects may be modest, and it is not a cure.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy diabetic polyneuropathy neuralgia type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETE TYPE 2

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Department of Human Neuroscience

    RECRUITING

    Rome, Italy, 00185, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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