Diabetic neuropathy

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study tests a sensory neuroprosthesis—implanted electrodes that send small electrical currents to remaining nerves—to restore sensation of a missing lower limb in people with diabetic peripheral neuropathy and amputation. The 15 participants will also have the option of musc…

This study tests whether GLP-1 receptor agonists, a class of diabetes medications including semaglutide, can improve heart nerve damage in people with type 2 diabetes. 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers w…

This study tests whether injecting stem cells from umbilical cords into the legs can help people with moderate to severe diabetic nerve damage. 140 adults will get either stem cell shots plus standard care, or standard care alone, and be followed for 24 weeks. The goal is to see …

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study tests a new type of shoe, called the LEEF-shoe, designed to prevent foot ulcers in people with diabetes and nerve damage. About 30 adults will wear both the LEEF-shoe and standard orthopedic shoes for several weeks to compare how well they relieve pressure on the feet.…

This study tests whether a 12-week program of supervised foot and ankle exercises can help people with diabetes who have nerve damage in their feet. The exercises are done in groups at primary care clinics. Researchers will measure changes in symptoms, foot movement, and quality …

This study tests a portable DNA device called MinION that can identify bacteria and fungi in foot wounds of people with diabetes in under 4 hours. Standard lab cultures take longer and may miss some germs. The goal is to see if this faster method gives a more complete picture of …

This study is translating and testing a questionnaire called PainPREDICT for Thai-speaking people with diabetes. The goal is to create a mobile app that can screen for painful diabetic neuropathy, a common complication that causes nerve pain. Researchers will check if the Thai ve…

This study tests a device called Walkasins, worn like an ankle strap and insole, that gives gentle vibrations to help people with peripheral neuropathy feel their feet better. The goal is to see if it improves walking, balance, and daily physical activity. Eighteen adults aged 60…

This study tests a device called Walkasins, worn on the lower legs, that vibrates to give sensory feedback about foot pressure. The goal is to see if using it daily for six months improves balance and walking in 200 adults aged 55+ with peripheral neuropathy. Participants will do…

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a fl…

This study tests whether a single ultrasound-guided injection of medicine around compressed leg nerves can relieve numbness, pain, and weakness in people with diabetes. 266 participants will be randomly assigned to get the real injection or a sham (fake) injection, and neither th…

This study tests whether a spinal cord stimulator can reduce pain and improve nerve function in people with diabetic peripheral neuropathy. Sixty adults with pain that hasn't responded to standard treatments will be randomly assigned to receive the implant or standard care. Resea…

This study tests whether shortwave therapy can relieve symptoms of diabetic peripheral neuropathy, a common complication causing pain and numbness. About 202 adults with diabetes will receive either real shortwave treatment or a sham device for 20 minutes daily over five days. Re…

This study tests a new medicine called suzetrigine for people with nerve pain from diabetes. About 1,100 adults with diabetic peripheral neuropathy will receive either suzetrigine, a placebo, or an active comparator to see if it safely reduces pain over 12 weeks. The goal is to f…

This Phase 2 trial tests an experimental oral drug called VX-993 for pain caused by diabetic peripheral neuropathy, a common complication of diabetes. About 300 adults with type 1 or type 2 diabetes and nerve pain in both legs for at least a year will receive VX-993, pregabalin (…

This phase 3 trial tests suzetrigine, an experimental oral drug, for pain caused by diabetic peripheral neuropathy. About 734 adults with diabetes and nerve pain in their legs for at least a year will receive either the drug or a placebo. The main goal is to see if suzetrigine re…

This study tests two types of foot and ankle exercises to see which one better helps balance, walking, and fall risk in people with diabetic peripheral neuropathy (nerve damage in the feet). Researchers will compare exercises for the small muscles in the foot with 3D ankle-foot e…

This study tests whether low-dose naltrexone (LDN) can safely reduce pain from diabetic neuropathy, a common complication of diabetes. Thirty-five adults who have not found relief from standard treatments will receive LDN and a placebo in random order. The goal is to see if LDN o…

This study tests whether a whole-food, plant-based diet (no added oils) can reduce painful diabetic neuropathy better than standard medication. Forty adults with type 2 diabetes and nerve pain will be randomly assigned to either the diet or medication optimization. The main goal …

This pilot study is testing whether CBD oil can help reduce pain and nerve damage in people with diabetic peripheral neuropathy (DPN). About 20 adults with mild to moderate DPN will receive either CBD or a placebo for 6 weeks. The goal is to see if CBD is safe and effective, and …

This early-stage trial tests whether a cream made from a modified form of capsaicin (the stuff that makes chili peppers hot) can reduce foot pain in people with diabetic neuropathy. About 80 participants will apply the cream or a placebo to their feet twice a day for two weeks an…

This study tests a new drug called HRS-2129 in 168 Chinese adults with diabetic peripheral neuropathic pain (nerve pain from diabetes). Participants will receive either HRS-2129, a placebo, or the standard drug pregabalin to see if HRS-2129 reduces pain better than placebo. The t…

This study tests whether adding peripheral magnetic stimulation to balance exercises can lower fall risk in older adults with diabetic polyneuropathy. Forty participants will receive either real or sham magnetic pulses to their feet while doing balance training. The goal is to se…

This study tests whether a new drug called LY4065967 can safely reduce nerve pain in people with diabetes. About 150 adults with diabetic nerve pain in their legs for at least 6 months will receive either the study drug or a placebo. The main goal is to see if the drug lowers ave…

This study tests whether mirogabalin can reduce nerve pain in people with diabetes. 78 adults will take either mirogabalin or the standard drug pregabalin daily for 8 weeks. Researchers will measure pain levels, side effects, and quality of life to see if mirogabalin is a better …

Diabetes patients often suffer from dry mouth, which affects eating, speaking, and quality of life. This study tests whether endocrinologists can deliver simple oral care—like screening, counseling, and saliva substitutes—during routine diabetes visits. Researchers will follow 80…

This study tests if a non-invasive device that stimulates the vagus nerve can reduce pain, numbness, and tingling in people with diabetic nerve damage. Researchers will measure pain levels, nerve signals, and walking ability in 40 adults aged 45-60. The goal is to find a drug-fre…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. Researchers will enroll 25 adults with painful diabetic neuropathy and …

This study tests whether special balance exercises or sensory retraining better improve walking and stability in people with diabetic nerve damage. 80 adults aged 40-75 with diabetes and nerve problems will be randomly assigned to one of two training programs. Both groups also re…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study tests whether combining a hands-on nerve treatment (intraneural facilitation) with a balance exercise program can reduce pain, improve balance, and enhance quality of life in people with diabetic peripheral neuropathy. About 65 adults aged 50-75 with type 2 diabetes an…

This study tests whether injecting a botulinum toxin (similar to Botox) around nerves in the lower legs can safely reduce pain from diabetic neuropathy. About 80 adults with diabetes and chronic foot pain will receive either the active drug or a placebo injection every 12 weeks f…

This study tests whether combining foot-ankle exercises with mindful walking can reduce pain, improve foot and ankle function, and boost quality of life in people with diabetic polyneuropathy. Thirty-eight adults aged 40-75 with confirmed diabetic nerve damage and moderate to sev…

This study compares two non-invasive treatments—Intraneural Facilitation Therapy and standard physical therapy—for people with type 2 diabetes who have nerve pain, numbness, or tingling. Forty participants will be randomly assigned to one of the two treatments over six weeks. The…

This study tests whether high-frequency spinal cord stimulation can reduce leg pain and improve quality of life in people with both peripheral arterial disease (PAD) and painful diabetic neuropathy. Fifteen adults who already have a spinal cord stimulator implanted will receive t…

This study tests whether adding nerve gliding exercises (neural mobilization) to standard balance training can reduce pain, improve balance, and boost quality of life in people with diabetic neuropathy. Thirty-two adults aged 50-75 with type 2 diabetes and nerve pain will be spli…

This study will give 100 adults with diabetes a thermal camera that attaches to their smartphone to take daily pictures of their feet. The goal is to collect temperature data and see if hot spots can predict where foot ulcers might form. Participants will use the device at home f…

This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for…

This study tests whether real-time visual and audio cues can help people with diabetic peripheral neuropathy walk better. Researchers will measure foot pressure and push-off force as 25 participants walk on a treadmill. The goal is to understand how biofeedback changes walking pa…

This study looks at how type 1 diabetes affects the nerves that control the heart in children. Researchers will measure heart rate variability in 100 children with diabetes and compare them to healthy kids of the same age and sex. The goal is to find early signs of cardiac dysaut…

This study is collecting information from 4,000 adults with peripheral neuropathy (nerve damage) to better understand the condition. Researchers will combine standard tests with nerve ultrasound to see if it helps diagnose and track the disease. No new treatments are being tested…

This study looks at whether environmental factors like heavy metals from gold mining, past viral infections, or traditional plant remedies are linked to peripheral neuropathy (nerve damage) in French Guiana. Researchers will compare 78 people with and without nerve damage to see …

This study is looking at how nerve pain (neuropathic pain) affects the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain levels and quality of life in 128 adults with type 2 diabetes. The goal is to better unders…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …

This study is translating and testing an Arabic version of a survey that measures quality of life in people with type 2 diabetes who have nerve damage or foot ulcers. Researchers will enroll 290 Arabic-speaking adults to ensure the translated survey is accurate, reliable, and cul…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study uses ultrasound to measure the size and appearance of leg nerves in people with type 2 diabetes who have nerve damage (diabetic polyneuropathy). Researchers will then test how these nerve measurements relate to balance, walking, and daily life. The goal is to better un…