Massive pain trial aims to find new relief options

NCT ID NCT05986292

Recruiting now Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a flexible 'master protocol' so new drugs can be added over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LY3016859, LY3556050, LY3526318, LY3857210 (experimental drugs)
What this could lead to: If any of these drugs work, it could point toward new treatment options for chronic pain conditions like knee arthritis, diabetic nerve pain, or back pain.
What could go wrong: This is an early Phase 2 trial testing multiple drugs at once, so many may fail to show benefit. The study is large but still exploratory, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LOW-BACK PAIN DIABETIC NEUROPATHIC PAIN OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

Accel Research Sites - DeLand Clinical Research Unit
RECRUITING

DeLand, Florida, 32720, United States
ActivMed Practices and Research
COMPLETED

Methuen, Massachusetts, 01844, United States
Alliance for Multispecialty Research, LLC
COMPLETED

Tempe, Arizona, 85281, United States
Altoona Center For Clinical Research
RECRUITING

Duncansville, Pennsylvania, 16635, United States
Arizona Research Center
RECRUITING

Phoenix, Arizona, 85053, United States
Artemis Institute for Clinical Research
RECRUITING

Riverside, California, 92503, United States
Artemis Institute for Clinical Research
RECRUITING

San Diego, California, 92123, United States
Aventiv Research Inc
COMPLETED

Columbus, Ohio, 43213, United States
Boston Clinical Trials
NOT_YET_RECRUITING

Boston, Massachusetts, 02131, United States
Bradenton Research Center, Inc.
RECRUITING

Bradenton, Florida, 34205, United States
CMR of Greater New Haven
RECRUITING

Hamden, Connecticut, 06517, United States
Cedar Health Research
COMPLETED

Dallas, Texas, 75251, United States
Central Research Associates
RECRUITING

Birmingham, Alabama, 35205, United States
Charter Research - Lady Lake
RECRUITING

The Villages, Florida, 32162, United States
Clinical Research Center of Reading,LLC
COMPLETED

Wyomissing, Pennsylvania, 19610, United States
Clinical Research of South Florida
NOT_YET_RECRUITING

Coral Gables, Florida, 33134, United States
Clinvest Research LLC
RECRUITING

Springfield, Missouri, 65807, United States
Coastal Carolina Research Center
COMPLETED

North Charleston, South Carolina, 29405, United States
Conquest Research
RECRUITING

Winter Park, Florida, 32789, United States
Cotton O'Neil Clinical Research Center - Central Office
COMPLETED

Topeka, Kansas, 66606, United States
DelRicht Research
RECRUITING

New Orleans, Louisiana, 70115, United States
DelRicht Research
RECRUITING

Tulsa, Oklahoma, 74133, United States
Desert Oasis Healthcare Medical Group
RECRUITING

Palm Springs, California, 92262, United States
Flourish Research - Miami, LLC
RECRUITING

Miami, Florida, 33135, United States
FutureSearch Trials of Neurology
RECRUITING

Austin, Texas, 78731, United States
Great Lakes Research Group, Inc.
RECRUITING

Bay City, Michigan, 48706, United States
Irvine Clinical Research
COMPLETED

Irvine, California, 92614, United States
K2 MEDICAL Research THE VILLAGES
RECRUITING

Lady Lake, Florida, 32159, United States
K2 Medical Research ORLANDO
RECRUITING

Maitland, Florida, 32751, United States
Latin Clinical Trial Center
COMPLETED

San Juan, 00909, Puerto Rico
Lillestol Research
RECRUITING

Fargo, North Dakota, 58104, United States
Lucida Clinical Trials
RECRUITING

New Bedford, Massachusetts, 02740, United States
META Medical Research Institute
RECRUITING

Dayton, Ohio, 45432, United States
Martin E. Hale M.D., P.A.
COMPLETED

Plantation, Florida, 33317, United States
MedVadis Research Corporation
RECRUITING

Waltham, Massachusetts, 02451, United States
Merritt Island Medical Research, LLC
RECRUITING

Merritt Island, Florida, 32952, United States
New Horizon Research Center
RECRUITING

Miami, Florida, 33165, United States
North Georgia Clinical Research
RECRUITING

Woodstock, Georgia, 30189, United States
Northwest Clinical Research Center
RECRUITING

Bellevue, Washington, 98007, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
PharmQuest
COMPLETED

Greensboro, North Carolina, 27408, United States
Ponce Medical School Foundation Inc.
RECRUITING

Ponce, 00716, Puerto Rico
Precision Clinical Research
RECRUITING

Sunrise, Florida, 33351, United States
Rainier Clinical Research Center
RECRUITING

Renton, Washington, 98057, United States
Re:Cognition Health - Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
Renstar Medical Research
RECRUITING

Ocala, Florida, 34470, United States
Rochester Clinical Research, LLC
RECRUITING

Rochester, New York, 14609, United States
Rocky Mountain Clinical Research
NOT_YET_RECRUITING

Idaho Falls, Idaho, 83404, United States
SYNEXUS
COMPLETED

Murray, Utah, 84123, United States
Simon Williamson Clinic
COMPLETED

Birmingham, Alabama, 35211, United States
StudyMetrix Research
RECRUITING

City of Saint Peters, Missouri, 63303, United States
Suncoast Clinical Research, Inc.
RECRUITING

New Port Richey, Florida, 34652, United States
Synexus
COMPLETED

Dallas, Texas, 75234, United States
Synexus - Cincinnati
COMPLETED

Cincinnati, Ohio, 45236, United States
Synexus Clinical Research
COMPLETED

Chicago, Illinois, 60602, United States
Synexus Clinical Research - Glendale
COMPLETED

Glendale, Arizona, 85306, United States
Synexus Clinical Research - St. Petersburg
COMPLETED

Pinellas Park, Florida, 33781, United States
Synexus Clinical Research US, Inc.
RECRUITING

Phoenix, Arizona, 85020, United States
Synexus Clinical Research US, Inc.
NOT_YET_RECRUITING

Orlando, Florida, 32806, United States
Synexus Clinical Research US, Inc.
COMPLETED

The Villages, Florida, 32162, United States
Synexus Clinical Research US, Inc.
COMPLETED

Omaha, Nebraska, 68144, United States
Synexus Clinical Research US, Inc.
COMPLETED

San Antonio, Texas, 78229, United States
University of Miami Don Suffer Clinical Research Building
NOT_YET_RECRUITING

Miami, Florida, 33136, United States
VIN-Julie Schwartzbard
COMPLETED

Aventura, Florida, 33180, United States

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