Could a common painkiller sabotage your knee treatment?
NCT ID NCT07766330
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This study tests whether taking ibuprofen after a platelet-rich plasma (PRP) injection changes pain relief and knee function in adults with knee osteoarthritis. Participants receive one ultrasound-guided PRP injection and then take either ibuprofen or acetaminophen for five days. Researchers will compare pain scores, knee function, and the need for extra pain medicine over six months to see if the anti-inflammatory drug interferes with the treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Leukocyte-rich platelet-rich plasma (PRP) injection, followed by either ibuprofen or acetaminophen
- What this could lead to
- If it works, this could help clarify whether avoiding anti-inflammatory drugs after PRP injections improves long-term knee pain relief and function in osteoarthritis.
- What could go wrong
- This is a relatively small trial, and results may not apply to everyone. Taking ibuprofen after PRP could also reduce the treatment's effectiveness, or cause stomach or kidney side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Disciplina de Medicina Esportiva da UNIFESP
São Paulo, São Paulo, 04022-002, Brazil
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