Could a quick insulin shot stop Steroid-Induced blood sugar spikes?
NCT ID NCT07757464
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
Steroid injections for knee arthritis can temporarily raise blood sugar in people with type 2 diabetes. This trial tests whether giving a short course of NPH insulin right after the injection can prevent those high blood sugar episodes. Adults with type 2 diabetes and knee osteoarthritis will be randomly assigned to receive either the pre-emptive insulin or their usual diabetes care. Both groups will wear continuous glucose monitors to track blood sugar levels for 72 hours after the injection, and the study will also check for low blood sugar and other side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NPH insulin (a type of intermediate-acting insulin) given as a short course of injections after a knee steroid injection
- What this could lead to
- If it works, this could offer a simple way to prevent steroid-related blood sugar spikes in people with type 2 diabetes, making joint pain relief safer and more comfortable.
- What could go wrong
- This is an early-phase trial with a modest number of participants, so results may not apply to everyone. NPH insulin can cause low blood sugar, and the added injections may be burdensome.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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