Hyperglycemia

This study tests a new medicine called LY3938577 against a standard insulin (degludec) in 100 adults with type 2 diabetes who already use basal insulin. The goal is to see if the new drug helps keep blood sugar in a healthy range more safely and effectively over about 26 weeks. P…

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study is testing a community-based program that uses exercise training and lifestyle changes to help people with high blood pressure, high blood sugar, or high cholesterol. The goal is to improve heart and lung function and overall disease control. The program will enroll 10…

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study tests a computer program that alerts doctors and nurses when hospital patients have dangerously high or low blood sugar. The tool suggests care steps to improve glucose control. Researchers will track over 15,000 adults across multiple hospitals to see if the tool redu…

This study tests whether breathing a special mix of low and high oxygen air (called intermittent hypoxic-hyperoxic training) can help lower blood sugar in people with type 2 diabetes. About 250 adults aged 50-74 will be split into groups receiving either a 3-day or 10-day course …

This study tests whether taking a daily 30 mg zinc supplement for one year can lower blood sugar and HbA1c levels in people with prediabetes. Two hundred Amish adults aged 18–80 with prediabetes will be randomly assigned to receive either zinc or a placebo pill. Researchers will …

This study compares standard gastric bypass surgery to bypass plus a nerve-cutting procedure (truncal vagotomy) in 40 adults with obesity and type 2 diabetes. The goal is to see if the added nerve cut helps more people achieve diabetes remission without medication for at least a …

This study tests a new drug, evexomostat, added to two standard treatments for a common type of advanced breast cancer (HR+, HER2-). The goal is to see if the triple combination is safe and can reduce high blood sugar side effects often caused by the standard drugs. About 52 adul…

This study tests whether a 15-minute brisk walk, taken right after a missed insulin dose, can prevent high blood sugar in people with type 1 diabetes. Researchers will compare blood sugar levels in 30 adults aged 18-24 who either take insulin before a meal, after a meal, or after…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can lower inflammation and pain after major spine surgery. About 50 adults having long-segment spinal fusion will be randomly assigned to receive the stimulation or standard care. Researchers…

This study tests whether a single infusion of arginine hydrochloride, a natural amino acid, can help people with type 2 diabetes recover faster from diabetic ketoacidosis (DKA), a serious complication. Sixty adults arriving at emergency rooms with DKA will receive either arginine…

This study is testing a mini-program (like a smartphone app) that gives personalized exercise advice to people with high blood pressure, high blood sugar, high cholesterol, and high uric acid. Over six months, 100 participants will use the app to increase their daily steps and ph…

This study tests a 24-week church-based program called FELLAship for Black men at risk of heart disease, diabetes, and obesity. Participants attend weekly sessions with exercise and health education, get coaching, and use a smartwatch to track progress. The goal is to see if the …

This study tests whether oral semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside standard care. The goal is to see if it works as well …

This pilot study looks at whether closely monitoring and managing blood sugar levels can help people with pancreatic cancer. About 50 participants will wear a continuous glucose monitor during chemotherapy. Half will get intensive glucose management from an endocrinologist, while…

This study tests whether wearing a continuous glucose monitor that shows real-time blood sugar levels on a smartphone app, plus joining a group chat with other pregnant women, helps keep glucose levels healthy during pregnancy. About 70 pregnant women at risk for gestational diab…

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while checking blood sugar with a finger prick. The goal is to see if breath chemicals can repl…

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This study tests if mulberry leaf extract capsules are safe for healthy people with slightly high blood sugar. 48 volunteers will take either the extract or a placebo three times a day for 8 weeks. Researchers will check blood counts, liver and kidney function, and blood sugar le…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study looks at whether using a continuous glucose monitor (CGM) after hospital discharge helps people with diabetes feel more in control and satisfied with their care. About 60 adults with type 1 or type 2 diabetes who need insulin will use a CGM at home and answer questionn…

This early-phase trial tests a new drug called TQF3250 in 66 healthy adults with high blood sugar. The drug is designed to activate only certain parts of the GLP-1 receptor, aiming for better blood sugar control with fewer side effects. The main goal is to check safety and how th…

This study looks at children with suspected or confirmed genetic and metabolic disorders to find new disease-causing gene mutations. Researchers will analyze blood samples for DNA and metabolites, and in some cases take a small skin sample. The goal is to better understand these …

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study looks at whether personality traits are linked to routine lab test results in 1,000 adults getting a health check-up. Participants fill out a personality questionnaire and provide blood samples. The goal is to see if certain personality types are more likely to have ab…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study looks at how lean pork loin and plant-based protein affect muscle building and blood sugar control in adults with prediabetes. Twenty participants aged 40-65 will eat prepared meals for three days. Researchers will measure muscle protein synthesis and glucose levels to…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …

This study is testing whether a continuous glucose monitor (CGM) designed for diabetes can work in intensive care patients with septic shock. Currently, nurses must prick patients' fingers every 2 hours to check blood sugar, which is painful and disruptive. The CGM uses a small s…

This study uses three wearable devices—a continuous glucose monitor, a heart monitor, and an activity tracker—to see if high blood sugar is linked to heart problems in people with Duchenne muscular dystrophy. Researchers will compare 80 participants with and without DMD. The goal…

This study watches how a standard dose of dexamethasone, a drug often given during surgery, changes blood sugar levels in 100 adults having non-cardiac operations. Participants wear a continuous glucose monitor for 10 days to track sugar levels more closely than finger-prick test…

This study looks at whether the standard A1C blood sugar test works correctly in people with a Left Ventricular Assist Device (LVAD), a type of heart pump. Researchers will compare A1C results with continuous glucose monitor (CGM) readings over 3 months in 20 adults with type 2 d…

This study looks at whether reducing ultra-processed foods (like chips and sugary drinks) can improve blood sugar levels in healthy Korean adults aged 20-39. Participants will wear a continuous glucose monitor and report their diet for 10 days before and after receiving dietary c…

This study is looking at 160 people who had a ruptured brain aneurysm and need a temporary drain. Researchers will measure glucose in their spinal fluid and blood daily for up to 14 days. The goal is to see if higher glucose levels are linked to needing a permanent shunt later. P…

This pilot study is testing a new smartphone app called Healthmine that pairs data from a continuous glucose monitor and a Fitbit. Thirty young adults aged 16-24 who were diagnosed with type 2 diabetes before age 18 will use the app for 30 days. The goal is to see if the app is e…

This study uses MRI scans to look for brain differences in people with metabolic diseases compared to healthy volunteers. Researchers will track changes over time and link them to body fat and other health measures. About 126 adults will take part at Ulm University Hospital. No d…

This study looks at whether a continuous glucose monitor (CGM) — a small sensor worn under the skin — is an acceptable and useful tool for checking diabetes risk in women who recently had gestational diabetes. Twenty women will wear the CGM for 10 days at 6-8 weeks after giving b…

This study is for people with diabetic macular edema, a condition that causes vision loss. Researchers want to see if certain substances in the blood and patterns on eye scans can predict how well a patient will respond to two common treatments: anti-VEGF injections or a dexameth…

This study follows 40 liver transplant patients after they leave the hospital, using a continuous glucose monitor to track their blood sugar levels. The goal is to see how blood sugar control relates to complications like wound healing or other transplant outcomes. Participants m…

This study will test if wearable devices like continuous glucose monitors and heart rate monitors can help detect early signs of heart problems in people with Duchenne muscular dystrophy (DMD). Ten participants will wear these devices at home over two years and have periodic hear…

The SMILE study is tracking 10,000 adults aged 18 and older to see how sarcopenia (age-related muscle loss) and metabolic diseases like diabetes influence overall health and lifespan. Researchers will collect data from medical records, tests, and surveys over time. This is an obs…

This study follows 100 children under 18 who are already on a ketogenic diet for conditions like drug-resistant epilepsy, autism, chronic migraine, or brain tumors. Researchers want to see if the diet supports healthy growth, improves symptoms, and boosts quality of life. The die…