New triple therapy aims to control advanced breast cancer with fewer side effects
NCT ID NCT05455619
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug, evexomostat, added to two standard treatments for a common type of advanced breast cancer (HR+, HER2-). The goal is to see if the triple combination is safe and can reduce high blood sugar side effects often caused by the standard drugs. About 52 adults with specific genetic changes in their cancer will take part in this early-phase trial.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Doctors Hospital of Laredo
RECRUITINGLaredo, Texas, 78045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hoag Memorial Hospital Presbyterian
RECRUITINGNewport, California, 92663, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hope and Healing Cancer Services
RECRUITINGHinsdale, Illinois, 60521, United States
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Loma Linda University Cancer Center
RECRUITINGLoma Linda, California, 92354, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Miami Cancer Institute at Baptist Health
RECRUITINGMiami, Florida, 33176, United States
Contact
Contact Email: •••••@•••••
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Penn State Milton S Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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SHARP Healthcare
RECRUITINGSan Diego, California, 92123, United States
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Trinity Health
RECRUITINGYpsilanti, Michigan, 48197, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••