METASTATIC BREAST CANCER

This study is observing how well the drug inavolisib works for people with advanced breast cancer that has a specific genetic mutation and has stopped responding to hormone therapy. Researchers will follow 500 patients in China who are already receiving this treatment as part of …

This large international study is testing whether a new drug called palazestrant works better than the current standard treatment when combined with another cancer drug called ribociclib. The trial will involve about 1,000 adults with advanced breast cancer that hasn't been treat…

This study tests whether high-dose methotrexate chemotherapy given through an IV can help patients with advanced breast cancer that has spread to the membranes surrounding the brain and spinal cord. Researchers want to see if this treatment helps patients live longer than 12 week…

This study is testing whether different antibody-drug conjugate (ADC) medications can help control advanced breast cancer in patients whose cancer has progressed despite previous ADC treatment. The trial will enroll 160 adults with metastatic breast cancer who have already receiv…

This study is testing whether a new oral drug combination (lasofoxifene + abemaciclib) works better than a standard combination (fulvestrant + abemaciclib) for controlling advanced breast cancer that has a specific genetic change (ESR1 mutation) and has worsened after initial hor…

This trial is testing whether a new oral medication called OP-1250 works better than current standard hormone therapies for people with advanced breast cancer that has continued to grow despite previous hormone treatments. The study will enroll about 510 adults whose cancer is ho…

This study is testing if a more detailed type of scan (FDG-PET/CT) is better than standard CT scans for monitoring metastatic breast cancer. The goal is to see if the detailed scan can spot when the cancer is getting worse sooner, allowing doctors to change treatments earlier and…

This study is testing a new combination of two drugs, called BNT323 and BNT327, for people with advanced breast cancer that has spread or cannot be removed by surgery. The first part of the study aims to find the safest and most effective dose. The second part will compare how we…

This study is testing whether combining three existing cancer drugs works better to control advanced breast cancer that has spread. It's for people whose cancer is fueled by hormones and has either just been diagnosed as advanced or returned after more than a year. The main goal …

This study is testing whether an experimental drug called SKB264 works better than standard chemotherapy for people with advanced HR+/HER2- breast cancer that has spread or returned after at least one round of prior chemotherapy. About 376 participants will be randomly assigned t…

This large trial is testing if adding a targeted local treatment to standard drug therapy helps people with advanced breast cancer that has spread to only a few spots in the body. After 12 weeks of initial drug treatment, 340 participants will be randomly assigned to either conti…

This study is testing whether switching between two newer cancer drugs can help control advanced breast cancer that has spread and stopped responding to a similar prior treatment. It will involve about 357 people with HER2-negative metastatic breast cancer. The main goal is to se…

This early-stage study is testing a new experimental drug called BGB-43395, both alone and in combination with other cancer medications, for people with advanced hormone-positive breast cancer and other solid tumors. The main goals are to find safe dosage levels and see if the dr…

This study is testing if using highly focused radiation on a single tumor that has started growing again can help people with metastatic breast cancer stay on their current effective drug treatments longer. Participants will receive this targeted radiation while continuing their …

This study aims to understand how well a targeted drug called trastuzumab deruxtecan works for people with advanced, hard-to-treat breast cancer that has a specific marker (HER2-low). It will follow over 1,100 patients in Europe who are already receiving this drug or standard che…

This early-stage study aims to find safe and effective doses for a new breast cancer drug, palazestrant, when combined with four different existing cancer drugs. It will enroll about 190 adults with advanced or metastatic ER-positive, HER2-negative breast cancer who have had limi…

This study is for people with advanced or metastatic breast cancer that is estrogen-receptor-positive and HER2-negative, and whose cancer has grown despite prior treatments including a specific type of targeted drug (a CDK4/6 inhibitor). It aims to find out if taking the drug ela…

This study is testing a lower, daily dose of the cancer pill capecitabine for people with advanced breast cancer who are 60 or older, or who are frail at any age. The goal is to see if this gentler dose can still help control the cancer while being easier for these patients to to…

This study is testing a new combination of two cancer drugs, disitamab vedotin and tucatinib, for people with advanced or spreading breast or stomach cancer. The main goals are to find a safe and effective dose and to see if the combination can shrink tumors. It is for people who…

This study is testing a new drug, elacestrant, combined with other cancer medicines to see if they can better control advanced breast cancer that has spread. It will involve about 435 adults whose cancer has worsened despite prior hormone therapy. The first part finds safe doses,…

This study is testing whether the drug sacituzumab govitecan can help control metastatic breast cancer in people who have already received another targeted treatment called trastuzumab deruxtecan. The trial will enroll 75 adults with hormone receptor-positive, HER2-low breast can…

This study is testing whether starting older patients (age 65+) with advanced breast cancer on lower doses of two common oral cancer drugs helps them stay on treatment longer. Participants will be randomly assigned to either take the standard full dose or start with a lower dose …

This is the first study in people to test a new drug called RLY-2608, which is designed to target a specific genetic mutation (PIK3CA) found in many advanced solid tumors and breast cancers. The main goals are to find the safest and most effective dose, check for side effects, an…

This study is for people with a specific type of breast cancer (HER2-positive) that has spread to only a few other places in the body. Researchers want to know if adding surgery or targeted radiation to the standard drug treatment helps keep the cancer under control for longer co…

This early-stage study aims to find the safest and most effective dose of the drug abemaciclib when given at the same time as targeted radiation therapy. It is for people with advanced, hormone-sensitive breast cancer that has spread to the bones. The goal is to see if this combi…

This study is testing a new oral medication called PMD-026 for people with advanced breast cancer that has spread or can't be surgically removed. The research aims to determine if the drug is safe and tolerable, both alone and when combined with another cancer medication called f…

This study is testing a new strategy for treating advanced breast cancer that has spread. Researchers want to see if giving a specific sequence of already-approved drugs is practical and might work better than current approaches. The study will involve 15 women with a specific ty…

This study is testing several combination treatments involving the experimental drug FWD1802 for people with advanced ER-positive/HER2-negative breast cancer that has spread or cannot be removed by surgery. The research aims to find safe doses and see if these combinations can he…

This study is testing whether adding a new drug called inavolisib to standard maintenance therapy helps people with a specific type of advanced breast cancer live longer without their cancer getting worse. It will involve about 230 people whose cancer has spread and has two speci…

This study is testing whether a new drug called HRS-8080 works better than treatments doctors normally choose for women with advanced breast cancer that has stopped responding to hormone therapy. It will involve 240 women whose cancer has spread or is locally advanced. The main g…

This is a small, early-stage study to find a safe dose of two drugs—olaparib and estradiol—when used together for advanced breast cancer that is hormone-sensitive but has stopped responding to standard hormone treatments. It will involve about 6 post-menopausal women. The main go…

This study is testing a new oral drug called FWD1802 for women with a specific type of advanced breast cancer (ER+/HER2-) that has spread or cannot be surgically removed. The first part of the trial aims to find a safe and effective dose. The second part will see how well the dru…

This study is testing a new combination of three existing drugs—lenvatinib, pembrolizumab, and fulvestrant—to see if it is safe and effective for people with a specific type of advanced breast cancer that has spread. The main goal is to find the safest dose of this three-drug com…

This is the first human study testing a new drug called IPH5301 for people with advanced cancers that have spread. The trial has two parts: first finding the safest dose of IPH5301 alone, then testing it combined with standard chemotherapy in breast cancer patients. It's for adul…

This early-stage study is testing whether new drug combinations are safe for people with advanced hormone-positive breast cancer that has spread. Researchers will give 120 participants either two or three drugs together to see how well they're tolerated and if they help shrink tu…

This is the first time a new radioactive drug called [177Lu]Lu-ABY-271 is being tested in people. The study aims to see if it is safe and how it moves to tumors and organs in patients with advanced HER2-positive breast cancer that has spread. It will involve up to 21 participants…

This study is testing if a genetic test can help doctors choose the best second treatment for advanced breast cancer that has spread. It will compare whether starting chemotherapy or sticking with hormone-based drugs works better for patients whose cancer has a specific genetic p…

This is the first human study testing a new experimental drug called BBO-10203 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goal is to find safe doses and see how the body processes the drug, both alone and when combined with oth…

This study is testing whether a new immunotherapy combination can help people with advanced metastatic breast cancer live longer when standard treatments have stopped working. The trial will compare the experimental treatment against whatever therapy a doctor would normally choos…

This is the first study in people testing a new oral drug called OP-3136 for advanced or metastatic cancers, including certain types of breast, prostate, and lung cancer. The main goals are to find a safe dose, see how the body processes the drug, and check for early signs that i…

This study is testing whether giving estradiol (a form of estrogen) can help control advanced breast cancer that has stopped responding to standard hormone treatments. The trial will enroll 36 post-menopausal women with metastatic breast cancer who have tried at least one prior h…

This study is testing a new three-drug combination for people with a rare and aggressive type of breast cancer called metaplastic breast cancer (MpBC), which has stopped responding to standard treatments. The goal is to see if adding two new drugs (alpelisib and L-NMMA) to a stan…

This study is testing a new oral drug called zongertinib for adults with advanced HER2-positive cancers that have spread and stopped responding to prior treatments. The main goals are to find the safest and most effective dose of zongertinib when given alone or combined with othe…

This study is testing whether a simple blood test taken early in treatment can help doctors make better decisions for patients with advanced breast cancer. Patients will receive standard first-line treatment, then have their blood tested after two weeks. If the test shows the tre…

This study is testing if adding the drug capivasertib to standard hormone therapy can help people with a specific type of advanced breast cancer stay on their treatment longer and maintain their quality of life. It is for adults whose cancer has continued to grow despite prior ho…

This study is testing several different combinations of cancer drugs to see which ones work best for people with advanced breast cancer that has spread. It will include nearly 800 participants who have different types of breast cancer and have received different amounts of prior …

This study is testing a flexible approach to chemotherapy for advanced breast cancer that has spread. Researchers want to see if adjusting the dose of the drug capecitabine based on how the tumor responds—using scans and blood tests—can help control the cancer longer while possib…

This study is testing a personalized method to help choose the next chemotherapy for patients with advanced breast cancer. Doctors take a small sample of a patient's tumor and grow it in the lab to create a 'tumor avatar.' They test different chemotherapy drugs on this avatar to …

This study is testing a new drug called patritumab deruxtecan (U3-1402) for people with advanced breast cancer that is hormone-receptor positive and has stopped responding to standard hormone-blocking therapies and a specific type of targeted drug (CDK4/6 inhibitors). Participant…

This study is testing if combining two drugs, capecitabine and elacestrant, works better than just capecitabine alone for people with advanced, hormone-sensitive breast cancer. It's for patients whose cancer has stopped responding to a common class of prior medications. The main …

This study is testing whether adding the drug belzutifan to standard hormone therapy (fulvestrant) works better than current standard treatments for people with a specific type of advanced breast cancer. It will involve about 120 adults whose cancer has continued to grow despite …

This is the first human study of an experimental drug called ERX-315 for people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to find a safe dose and understand how the body processes the drug. Researchers will also look for earl…

This study is testing a new drug called EP0062, both alone and combined with standard treatments, for women with a specific type of advanced breast cancer that has come back after prior therapy. The main goals are to find the safest and most effective dose and to see how well the…

This pilot study is testing whether the time of day people take their hormone-based cancer drugs makes a difference. It will enroll 50 people with metastatic breast or prostate cancer and randomly assign them to take their medication either in the morning or the evening. The main…

This study is testing whether a new drug called SKB264 works better than standard chemotherapy for people with advanced breast cancer that has stopped responding to hormone therapy. It will involve about 430 participants with HR+/HER2- breast cancer that has spread or returned. T…

This study is testing if the drug enzalutamide, alone or combined with mifepristone, can help control a specific type of advanced breast cancer that has spread. It will compare these treatments to standard chemotherapy options to see which is better at delaying cancer growth. The…

This is the first study in people testing a new oral drug called BBI-940 for advanced or metastatic breast cancer. The main goal is to find a safe and tolerable dose, either alone or combined with another cancer drug. Researchers will enroll about 96 adults whose cancer has progr…

This global Phase 3 trial is testing which of two drug combinations works better to control advanced breast cancer that has a specific genetic change (PIK3CA mutation) and has worsened after standard hormone therapy. It will enroll about 540 adults whose cancer has returned or sp…

This study is testing whether adding an experimental drug called alisertib to standard hormone therapy can better control advanced breast cancer that has stopped responding to previous hormone treatments. It will enroll about 150 adults whose cancer has returned or spread and aim…

This study is testing whether using a highly focused, high-dose radiation treatment on all visible tumor sites can help people with a limited number of cancer metastases live longer without their disease getting worse. It is for adults with breast cancer or non-small cell lung ca…

This study is for people with metastatic breast cancer whose current medication is working well but who have a few new spots of cancer growth. Researchers want to see if using very precise, high-dose radiation on just those few spots can control them, allowing patients to safely …

This study is testing whether adding immunotherapy drugs (pembrolizumab with or without olaparib) to standard radiation therapy is safe and more effective at controlling metastatic breast cancer than radiation alone. It is for adults with specific types of breast cancer (triple-n…

This study is testing if adding the drug tocilizumab to standard chemotherapy works better than chemotherapy alone for controlling metastatic triple-negative or estrogen-receptor-low breast cancer. It will enroll 168 Black and non-Black patients to see if the combination improves…

This early-stage study is testing the safety and effectiveness of combining two drugs, palbociclib and avelumab, for patients with advanced breast cancer. It focuses on a specific, hard-to-treat type called AR-positive triple-negative breast cancer. The goal is to see if this new…

This study aims to compare two types of imaging scans to see which is better at finding and tracking metastatic lobular breast cancer. Researchers will test a new scan (FES PET/CT) against the standard scan (FDG PET/CT) in 30 adults with this specific cancer type. The goal is to …

This study is testing whether regular MRI brain scans can help find breast cancer that has spread to the brain earlier than usual. It involves patients with certain aggressive or metastatic breast cancer types where brain screening is not currently standard. The goal is to see if…

This pilot study is testing whether a community navigator can help Black and Latina women with metastatic breast cancer better access supportive care services. Participants will work with a trained navigator who helps connect them to resources and provides education. The study ai…

This study is testing whether a 12-week home exercise program can help reduce the severe fatigue that often comes with metastatic breast cancer treatment. Researchers will enroll 80 patients who are receiving Enhertu medication and experiencing fatigue. Participants will follow a…

This study is testing whether a 5-session palliative care program can help people with metastatic breast cancer and their caregivers communicate better with doctors, manage symptoms, and improve quality of life. 400 patients and their caregivers will be randomly assigned to recei…

This study is testing whether a free, 16-week exercise program can help people with metastatic breast cancer feel better and be more active. Researchers want to see if participating in the 'Get Real and Heel' program improves quality of life, reduces fatigue, and decreases feelin…

This study is testing whether a scalp cooling device can help prevent hair loss in people receiving chemotherapy for metastatic breast cancer. About 120 participants will be assigned to either use the cooling cap during their treatment or not, and researchers will compare hair lo…

This study aims to understand how metastatic breast cancer evolves and becomes resistant to treatments. Researchers will follow 2000 patients over time, collecting detailed information about their tumors and treatments. The goal is to identify patterns and markers that can help p…

This study aims to understand if a patient's emotional distress at the start of treatment affects how well their first-line therapy works for metastatic breast cancer. It will observe 1,000 patients receiving standard treatments to see if their emotional state is linked to how lo…

This study is testing a blood test called DiviTum®TKa to see if it can predict early whether standard hormone-based treatments for advanced breast cancer will stop working. Researchers will measure a specific marker in the blood of 100 patients with hormone-positive, HER2-negativ…

This study asks cancer doctors for their feedback on a new calculator designed to estimate how long patients with advanced breast cancer might live. Researchers will interview about 15 doctors, nurses, and nurse navigators to understand what would make this tool useful and easy t…

This study aims to better understand the experience of patients with advanced breast cancer who are receiving care at home through hospice. Researchers will use regular telehealth check-ins to connect patients and their caregivers with their cancer care team. The goal is to learn…

This study is testing a new type of imaging scan to see if it can better detect and track a very aggressive form of breast cancer called triple-negative. It will involve about 12 patients who already have metastatic triple-negative breast cancer. The goal is to see if this new sc…

This study aims to understand how the genetic makeup of advanced breast cancer changes as patients receive treatment. Researchers will compare blood tests from 70 patients before and after therapy to see if new mutations emerge. The goal is to gather knowledge that may help guide…

This study aims to understand how breast cancer changes and becomes resistant to treatment by taking multiple tissue samples from different tumor sites over time. Researchers will collect biopsy samples from 200 people with metastatic breast cancer at diagnosis and when their can…

This study aims to find markers in the blood that might predict which patients with advanced breast cancer are more likely to experience serious side effects from the drug T-DXd. Researchers will observe 84 patients receiving this standard treatment and collect their blood sample…

This study is creating a patient registry to better understand metastatic lobular breast cancer, a specific type that can be harder to track. Researchers will follow about 12 patients over time, collecting information on their treatments, survival, and how the disease progresses.…

This study aims to create a detailed database for metastatic breast cancer by collecting tumor and blood samples from 5,000 patients. The goal is to analyze the genetic makeup of the cancer to find specific biomarkers. These biomarkers will help match patients to future clinical …

This study aims to create a detailed atlas of proteins and cell structures within different types of breast cancer. Researchers will analyze tumor samples from 1,050 patients with early-stage or newly diagnosed metastatic breast cancer. The goal is to understand how fat storage a…

This study aims to collect real-world information about how well FDA-approved antibody-drug conjugate (ADC) treatments work for people with advanced HER2-negative breast cancer. Researchers will follow 100 patients receiving these treatments as part of their regular care to under…

This study aims to find out if certain substances in the blood can predict if and where breast cancer might spread. Researchers will compare blood samples from 160 women: some with metastatic breast cancer, some with early-stage cancer, and some who are healthy. The goal is to de…

This study is testing whether a special imaging scan, originally developed for prostate cancer, can detect a specific marker (PSMA) in certain types of advanced breast cancer. Researchers want to see if this marker can help predict which patients might not respond well to a commo…

This study is testing a new questionnaire designed to help women with metastatic breast cancer and their caregivers talk about their personal values and goals with their doctors. The goal is to see if using this tool helps patients feel less conflicted about decisions and improve…