New combo tackles Hard-to-Treat breast cancer

NCT ID NCT04360941

Recruiting now Disease control Sponsor: Royal Marsden NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This early-stage study tests two drugs, palbociclib and avelumab, together for people with a specific type of advanced breast cancer (AR+ triple negative). The main goals are to find the safest doses and see if the combination can shrink tumors. About 45 participants will take part.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm estrogen-receptor positive breast cancer HER2 positive breast carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERΑ+ BREAST CANCER HER2-POSITIVE BREAST CANCER LOCALLY ADVANCED BREAST CANCER METASTATIC BREAST CANCER RECURRENT BREAST CANCER TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

Addenbrooke's Hospital Cambridge University Hospitals NHS Foundation Trust
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Barts Cancer Institute
RECRUITING

London, EC1M 6BQ, United Kingdom
Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, G12 0YN, United Kingdom
Hope Clinical Trials Cancer Centre
RECRUITING

Leicester, LE1 5WW, United Kingdom
Nottingham University Hospital
ACTIVE_NOT_RECRUITING

Nottingham, NG5 1PB, United Kingdom
Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The Christie NHS Foundation Trust
RECRUITING

Manchester, Greater Manchester, M20 4BX, United Kingdom
University College London Hospitals NHS Foundation Trust
RECRUITING

London, W1T 7HA, United Kingdom
Weston Park Hospital
RECRUITING

Sheffield, S10 2SJ, United Kingdom

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