Can mapping tumor DNA unlock personalized breast cancer care?

NCT ID NCT02102165

Recruiting now Knowledge-focused Sponsor: Jules Bordet Institute Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

The AURORA study is collecting tumor and blood samples from 1,300 people with metastatic breast cancer across Europe. By analyzing genetic changes in both the original and metastatic tumors, researchers hope to understand why some patients respond well to therapy while others do not. The goal is to identify the right treatment for each individual and ultimately improve outcomes for all patients with this advanced disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: metastatic lesion biopsy
What this could lead to: If successful, this could lead to more personalized treatments for metastatic breast cancer, improving outcomes for patients.
What could go wrong: This is an observational study, so it won't directly test a treatment. The findings may not immediately translate into new therapies, and the genetic complexity of the disease may limit generalizable conclusions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm invasive lobular breast carcinoma Neoplasm Metastasis triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER

Contacts and locations

Locations

Beatson West of Scotland Cancer Centre
ACTIVE_NOT_RECRUITING

Glasgow, G12 0YN, United Kingdom
CHU de Liège
ACTIVE_NOT_RECRUITING

Liège, 4000, Belgium
Centre Hospitalier
ACTIVE_NOT_RECRUITING

Luxembourg, 1210, Luxembourg
Centro Integral Oncológico Clara Campa
ACTIVE_NOT_RECRUITING

Madrid, 28050, Spain
Champalimaud Foundation
RECRUITING

Lisbon, 1400-038, Portugal
Christie NHS Foundation Trust
ACTIVE_NOT_RECRUITING

Manchester, United Kingdom
Clinique et Maternité Sainte-Elisabeth (CMSE - Namur)
RECRUITING

Namur, 5000, Belgium
Cliniques Universitaires St-Luc
RECRUITING

Brussels, 1200, Belgium
Complexo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, 15006, Spain
Consorcio Hospitalario Provincial de Castellón
COMPLETED

Castellon, 12002, Spain
Dr Rosell Oncology Institute, Quirón Dexeus University Hospital
ACTIVE_NOT_RECRUITING

Barcelona, 08028, Spain
Edinburgh Cancer Centre - Western General Hospital
ACTIVE_NOT_RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Fondazione Salvatore Maugeri
COMPLETED

Pavia, Italy
Frauenkliniken Maistrasse-Innenstadt und Großhadern
ACTIVE_NOT_RECRUITING

München, 80336, Germany
Grand Hopital Charleroi
RECRUITING

Charleroi, 6000, Belgium
Hospital Clinico Universitario de Valencia
ACTIVE_NOT_RECRUITING

Valencia, 46010, Spain
Hospital Clínico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital General Universitario de Valencia
COMPLETED

Valencia, 46014, Spain
Hospital San Pedro de Alcantara
ACTIVE_NOT_RECRUITING

Cáceres, 10003, Spain
Hospital Universitari Arnau de Vilanova
ACTIVE_NOT_RECRUITING

Lleida, 25198, Spain
Hospital Universitario 12 de Octubre
ACTIVE_NOT_RECRUITING

Madrid, 28041, Spain
Hospital Universitario Virgen del Rocio
COMPLETED

Seville, 41013, Spain
Hospital Vall d'Hebron
ACTIVE_NOT_RECRUITING

Barcelona, 08035, Spain
Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
IRCCS AOU San Martino-IST
ACTIVE_NOT_RECRUITING

Genova, 16132, Italy
IRCCS Az Ospedaliera S.Maria Nuova
ACTIVE_NOT_RECRUITING

Reggio Emilia, Italy
Inselspital Bern
COMPLETED

Bern, Switzerland
Institut Jules Bordet
RECRUITING

Brussels, 1000, Belgium
Instituto Valenciano de Oncología
RECRUITING

Valencia, 46009, Spain
Istituto Europeo di Oncologia
ACTIVE_NOT_RECRUITING

Milan, 20141, Italy
Kantonsspital Baden
COMPLETED

Baden, Switzerland
Kantonsspital Graubuenden
COMPLETED

Chur, Switzerland
Kliniken Essen-Mitte, Klinik für Senologie/ Brustzentrum
COMPLETED

Essen, 45136, Germany
Landspitali
ACTIVE_NOT_RECRUITING

Reykjavik, 101, Iceland
Luzerner Kantonsspital, Division of Medical Oncology
COMPLETED

Lucerne, 6003, Switzerland
MD Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Madrid, 28033, Spain
NHS Tayside, Ninewells Hospital
ACTIVE_NOT_RECRUITING

Dundee, DD1 9SY, United Kingdom
Nottingham University Hospital NHS Trust
ACTIVE_NOT_RECRUITING

Nottingham, United Kingdom
Ospedale Ramazzini di Carpi
ACTIVE_NOT_RECRUITING

Carpi, Italy
Ospedale degli Infermi - S.O.C.Oncologia
COMPLETED

Biella, Italy
Ospedale di Bolzano - Oncologia Medica
ACTIVE_NOT_RECRUITING

Bolzano, 39100, Italy
Queen Elizabeth Hospital - University Hospitals Birmingham NHS Foundation Trust
ACTIVE_NOT_RECRUITING

Birmingham, B15 2TH, United Kingdom
Royal Cornwall Hospital - Royal Cornwall Hospitals NHS Trust
ACTIVE_NOT_RECRUITING

Truro, TR1 3LJ, United Kingdom
Ryhov County Hospital
ACTIVE_NOT_RECRUITING

Jönköping, 55185, Sweden
Sahlgrenska University Hospital
ACTIVE_NOT_RECRUITING

Gothenburg, Sweden
Singleton Hospital - ABM University Health Board
ACTIVE_NOT_RECRUITING

Swansea, SA2 8QA, United Kingdom
ULSS 21 Legnago
ACTIVE_NOT_RECRUITING

Legnago, 37045, Italy
UOC Oncologia Medica - AOU Parma
ACTIVE_NOT_RECRUITING

Parma, 43126, Italy
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
University Hospitals Bristol NHS Foundation Trust
ACTIVE_NOT_RECRUITING

Bristol, BS2 8HW, United Kingdom
Velindre NHS Trust
ACTIVE_NOT_RECRUITING

Cardiff, CF15 7QZ, United Kingdom
Yeovil District Hospital NHS Foundation Trust
ACTIVE_NOT_RECRUITING

Yeovil, BA21 4AT, United Kingdom

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