Jules Bordet Institute

This study is for women with ER+/HER2- breast cancer that has spread and is starting to grow again in 1 to 3 spots while on hormone therapy. Doctors will use precise radiation on those growing spots while continuing the same pills. The goal is to see if this approach can delay th…

This study is for people with advanced HER2-positive breast cancer whose disease has worsened after a drug called T-DXd. Researchers will use a special PET scan to see if the cancer still has HER2 on its surface. If the scan is positive, participants get a different drug called T…

This study compares two standard treatment approaches for older adults (age 70 and up) with locally advanced rectal cancer. The goal is to see which approach helps people live longer and with fewer side effects. About 230 participants will be randomly assigned to one of the two t…

This study compares a targeted radiation treatment (SBRT) to standard care for men whose prostate cancer returns after surgery. About 284 participants will receive either SBRT or usual treatments to see which better controls the cancer and reduces side effects. The goal is to man…

This study tests whether giving testosterone injections every 15 days can improve quality of life in men with low testosterone who are receiving best supportive care and have no further treatment options. The study will enroll 20 men and track changes in daily living activities a…

This study is for men with advanced prostate cancer that has spread. It tests whether a special scan (dosimetry) after the first treatment cycle can predict if the therapy will work. The goal is to personalize treatment early, avoiding ineffective cycles. About 110 participants w…

This study is for people with solid tumors that have spread to the brain. Researchers want to collect data and samples (like blood and spinal fluid) from 600 participants to understand why and how brain metastases happen. The goal is to find better ways to treat or prevent them i…

This study reviews medical records of 500 adults who had extensive abdominal surgery for advanced cancers to find out how often incisional hernias develop. Researchers will identify patient and surgical factors that raise hernia risk and describe how these hernias were managed. T…