Can a drug cocktail cure metastatic breast cancer? a trial aims to find out
NCT ID NCT06439693
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This phase II trial tests whether a planned sequence of targeted therapies can eliminate HER2+ metastatic breast cancer and allow patients to stop treatment. The study enrolls people with stage IV HER2+ breast cancer at diagnosis. Participants receive a series of drug combinations over time, with the goal of achieving long-term remission without ongoing therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A sequence of drugs: a taxane (paclitaxel, docetaxel, or nab-paclitaxel) plus trastuzumab and pertuzumab, followed by trastuzumab deruxtecan, then tucatinib plus ado-trastuzumab emtansine (T-DM1), and finally trastuzumab plus pertuzumab plus tucatinib.
- What this could lead to
- If successful, this approach could point toward a cure for HER2+ metastatic breast cancer, allowing patients to stop treatment and remain cancer-free.
- What could go wrong
- This is an early-phase trial with a small number of participants, so the sequence may not work as hoped. The drugs can cause serious side effects, and the treatment is intense and lengthy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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