Dana-farber Cancer Institute

This study is testing whether the oral drug belzutifan can help control recurrent clear cell cancers of the ovary, uterus, cervix, and other gynecologic sites. It will enroll 32 adults who have already received platinum-based chemotherapy. Researchers will measure how well the dr…

This early-stage study is testing a new, personalized cancer vaccine for people newly diagnosed with glioblastoma, a fast-growing brain tumor. The vaccine is custom-made for each patient using proteins from their own tumor, with the goal of training their immune system to attack …

This study is testing whether adding high-intensity exercise and a high-fiber diet to standard immunotherapy can improve health outcomes for people with advanced melanoma. Researchers want to see if these lifestyle changes are doable during treatment and if they can improve gut h…

This study is testing whether two drugs, abemaciclib and letrozole, can help control advanced or recurrent endometrial cancer after initial chemotherapy. The drugs are taken daily as maintenance therapy for up to two years to try to delay cancer progression. The trial will enroll…

This study is testing whether adding the drug T-DM1 to standard radiation and chemotherapy after surgery can help prevent cancer from coming back in people with HER2-positive salivary gland cancer. The drug specifically targets cancer cells that have the HER2 protein. About 55 pa…

This study is testing whether a combination of two targeted drugs (pertuzumab and trastuzumab) plus hormone therapy, given after surgery, can help prevent cancer from returning in people with early-stage, hormone-positive, HER2-positive breast cancer. About 375 participants will …

This early-stage study is testing a new type of stem cell transplant for adults with aggressive or hard-to-treat forms of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The goal is to see if adding special donor immune cells can help the transplant fight the can…

This early-stage study is testing a new therapy that uses specially trained immune cells from a donor to try to prevent blood cancers from coming back after a stem cell transplant. The goal is to see if these 'memory-like' natural killer (NK) cells, given with a supporting drug, …

This study is testing whether giving two drugs—ficerafusp alfa (an experimental drug) and pembrolizumab (an approved immunotherapy)—before surgery can help shrink tumors and improve outcomes for people with high-risk, operable head and neck cancer. The goal is to see if this pre-…

This study is testing a new talk therapy program designed to help cancer patients who are taking opioid pain medication. The goal is to see if the therapy is practical and acceptable for patients, and if it can help reduce risky opioid use and improve mental health. About 40 adul…

This study is testing whether a newer targeted drug combination (T-DM1 followed by Herceptin Hylecta) causes fewer side effects than the standard treatment (paclitaxel with Herceptin Hylecta) for people with early-stage HER2-positive breast cancer after surgery. About 500 partici…

This study is testing a new treatment for adults and teens whose blood cancers like leukemia have come back after a stem cell transplant. The treatment involves giving patients special immune cells, called CIML NK cells, from their original transplant donor, along with a drug cal…

This early-stage study is testing whether adding pembrolizumab, an immunotherapy drug, to standard chemotherapy helps treat primary central nervous system lymphoma, a rare cancer that starts in the brain or spinal cord. The study will enroll about 15 adults with newly diagnosed d…

This is a first-in-human study to test the safety of a new type of immune cell therapy for adults with acute myeloid leukemia (AML). Researchers will give patients specially trained 'memory-like' natural killer (NK) cells along with a standard drug called venetoclax, aiming to be…

This study is testing a new radiation therapy approach that uses MRI scans during treatment to adjust radiation beams in real time. Researchers want to see if this method can better target tumors while sparing healthy tissue in patients with various cancers including pancreatic, …

This early-stage study is testing the safety of a new drug, SL-401, when combined with standard medications for certain aggressive blood cancers. It aims to find the highest safe dose for patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or blastic plasm…

This early-stage study is testing a new type of treatment for ovarian cancer that has come back and stopped responding to standard platinum-based chemotherapy. Researchers are collecting a patient's own immune cells, boosting them in a lab to create 'memory-like' natural killer (…

This study is testing new combinations of cancer drugs for people with advanced bladder cancer that has spread. The first part aims to find the safest doses of two drugs. The second part will test how well these two drugs work together, and also test a three-drug combination, to …

This study is testing whether adding an immunotherapy drug (pembrolizumab) to a targeted chemotherapy drug (sacituzumab govitecan) works better than the chemotherapy drug alone. It is for people with a specific, hard-to-treat type of advanced breast cancer (triple-negative and PD…

This study is testing the drug osimertinib as a first treatment for people with advanced non-small cell lung cancer that has a specific genetic change called an EGFR mutation. The main goal is to understand how the cancer eventually becomes resistant to the drug. Participants wil…

This study is testing a drug called belumosudil in adults who have developed early or new lung scarring (Bronchiolitis Obliterans Syndrome) after a stem cell transplant. The goal is to see if the drug can improve lung function and stop the scarring from getting worse. About 45 pa…

This study is testing whether using a highly focused type of radiation (SBRT) early on can help control cancer that has spread to a few sites. It will compare this approach to standard care in about 32 patients with adenoid cystic carcinoma. The main goals are to see if it delays…

This study is testing whether combining two targeted drugs, zanubrutinib and venetoclax, can effectively treat adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has returned after prior therapy. The goal is to see if this combination can achi…

This study is testing a combination of three drugs (pembrolizumab, ibrutinib, and rituximab) for adults with primary central nervous system lymphoma (PCNSL) that has returned or not responded to prior treatment. The goal is to see if this combination can control the cancer and st…

This study is testing whether a 16-week home exercise program can improve heart health in Black men with prostate cancer who are receiving hormone therapy. Researchers will compare a group doing supervised virtual workouts with a group maintaining their usual activity. The goal i…

This study is testing whether the drug abemaciclib can slow or stop the growth of advanced solid tumors that have specific genetic abnormalities. It is for adults with cancers that have mutations in certain genes (CCND1, CCND2, CCND3, CDK4, or CDK6) and for whom standard treatmen…

This study is testing whether doctors can safely use less radiation and chemotherapy after surgery for throat cancers linked to HPV. The goal is to maintain good cancer control while reducing side effects and improving patients' quality of life. The trial will enroll 111 adults w…

This study aims to find the best treatment approach for older adults with advanced bladder cancer who cannot tolerate standard chemotherapy. Researchers will compare two different treatment combinations to see which provides better quality of life with fewer side effects. The stu…

This is a very early, small study to see if a new type of immune cell therapy is safe and possible to give to people. It will test a treatment made from a patient's own 'natural killer' immune cells, which are collected and specially prepared in a lab to potentially fight cancer.…

This study is testing whether a special exercise and nutrition program before surgery helps people with rectal cancer. About 40 participants will be randomly assigned to either follow this 'prehabilitation' program or receive usual care. The main goal is to see if the program is …

This study is testing a new blood test designed to find early signs of a specific type of lung cancer in people who are at risk but cannot get regular CT scans. It aims to enroll 1000 healthy adults of East Asian or Latinx descent who do not currently use tobacco. The test looks …

This study is testing a blood test called Galleri that is designed to find many types of cancer early. It will enroll 1,500 military veterans to see how well the test works compared to standard care. The goal is to see if this test can help find cancers sooner in this high-risk g…

This study is testing a blood test called Galleri that aims to detect many types of cancer early. It will enroll 1,000 adults who are at higher-than-average risk due to a genetic condition or strong family history of cancer. Researchers will follow participants for up to 3 years …

This study is testing a counseling and education program designed specifically for Chinese and Korean American smokers who are at high risk for lung cancer. About 50 participants will be randomly assigned to receive either this new culturally tailored program or standard care. Th…

This study is testing if a special LED light device, used inside the mouth, can prevent painful mouth sores in patients undergoing a stem cell transplant. About 20 adult patients will use the 'LED Lollipop' device daily during their transplant treatment. The goal is to see if thi…

This study aims to see if a home-based program of exercise and healthy eating can improve thinking skills and physical ability in older cancer survivors and the person who supports them. Researchers will compare a program with virtual coaching to one without coaching over 6 month…

This study is testing whether adding a special support program to usual care helps low-income families whose children have high-risk neuroblastoma. About 84 families will be randomly assigned to receive either the usual care or the usual care plus the new support program for 6 mo…

This study is testing if an 8-week, home-based exercise program done before a stem cell transplant can help multiple myeloma patients. Researchers want to see if this 'prehabilitation' improves patients' muscle strength, physical fitness, and quality of life compared to patients …

This study is testing whether a simple 12-week program of short activity breaks is helpful for people newly diagnosed with lymphoma who are receiving chemotherapy. Researchers want to see if interrupting long periods of sitting can improve heart health and reduce some side effect…

This study is testing a new therapy program called UPLYFT, designed to help people who have finished lymphoma treatment but are still worried about their cancer coming back. The program provides information and coping tools through weekly sessions. Researchers want to see if this…

This study is testing whether a 16-week, home-based, high-intensity interval training (HIIT) program delivered over video calls can improve the health and well-being of young adults who survived brain tumors as children. Researchers want to see if this virtual exercise plan is pr…

This study is testing a new hospice care program that provides blood transfusions at home for patients with advanced blood cancers. The goal is to see if this program improves patients' quality of life and mood, and helps more people choose hospice care, compared to the usual sta…

This study is testing whether a 12-week virtual Tai Chi program is a practical and acceptable way to help cancer survivors manage nerve pain and balance problems caused by chemotherapy. About 21 participants with these symptoms will be randomly assigned to either start the Tai Ch…

This study is testing whether a 16-week home exercise program, done over video calls, can help women with ovarian or endometrial cancer who are receiving chemotherapy after surgery. Researchers want to see if the exercise helps patients keep their leg strength and mobility, and r…

This study is testing a new telehealth support program called BOLSTER for people with advanced gastrointestinal or gynecologic cancers who have complex care needs, like feeding tubes or drains. The program aims to improve patients' quality of life, ease symptoms, and reduce the b…

This study is testing a new communication tool called CASI to help ovarian cancer patients, their caregivers, and doctors have better conversations during clinic visits. Researchers want to see if this tool makes it easier to discuss treatment plans and if it improves patients' q…

This study is testing the best way to deliver a mobile app program called PRISM, which teaches skills to manage stress and build resilience. It aims to help adolescents and young adults (ages 12-25) cope with anxiety and depression after finishing their main cancer treatment. Res…

This study is testing whether a program of supervised strength training exercises, with or without protein shakes, is practical and helpful for people with pancreatic cancer who are starting chemotherapy. The main goal is to see if this approach can help patients maintain or buil…

This study is testing whether a 16-week supervised exercise program can help reduce frailty and muscle loss in men with metastatic prostate cancer who are on hormone therapy. About 80 participants who are already experiencing weakness or frailty will be randomly assigned to eithe…

This study is testing if wearing special cooling and pressure sleeves on the arms and legs during chemotherapy can help reduce nerve damage. Nerve damage is a common side effect of certain chemo drugs, causing numbness, tingling, and pain. About 50 adults with breast or gynecolog…

This study is testing whether different types of home exercise can help people with advanced lung cancer who are receiving immunotherapy. Researchers want to see if high-intensity or moderate-intensity workouts improve fitness, reduce treatment side effects, and enhance quality o…

This study is testing if a home-based exercise program can help patients who develop Graft-Versus-Host Disease (GVHD) after a stem cell transplant. The goal is to see if exercise can improve blood sugar control, body composition, fitness, and quality of life while patients are on…

This study is testing a telehealth program called REVITALIZE to see if it can help reduce the severe fatigue that often interferes with daily life for people with advanced ovarian cancer who are taking PARP inhibitor medications. About 240 participants will be randomly assigned t…

This study is testing whether a financial support program called PediRISE can be successfully offered to families of children with cancer who are facing financial hardship. It will enroll 40 low-income families, who will be randomly assigned to either receive the PediRISE program…

This study is testing whether a 16-week high-intensity interval training (HIIT) exercise program can help improve memory, focus, and thinking skills in women undergoing chemotherapy for breast cancer. Researchers will compare the exercise group to a control group doing gentle str…

This study is testing whether a 12-week virtual dance program can help breast cancer survivors who have persistent pain after surgery. Researchers want to see if dancing improves pain, fatigue, body image, and overall quality of life. About 30 participants will take part in the o…

This study is testing whether a scalp cooling device can help prevent hair loss in people receiving chemotherapy for metastatic breast cancer. About 120 participants will be assigned to either use the cooling cap during their treatment or not, and researchers will compare hair lo…

This study aims to understand how exercise might help lower breast cancer risk in women with dense breast tissue. Researchers will compare 46 inactive women who either participate in a 16-week exercise program or wait without exercise. They'll measure changes in blood and breast …

This study is testing whether a blood test can predict if two types of bone cancer (Ewing sarcoma and osteosarcoma) will come back after treatment. Researchers will collect blood samples from about 340 patients aged 1 to 50 years old to look for tiny pieces of tumor DNA. The goal…

This study is testing a decision-making toolkit designed to help women aged 80 and older who have survived breast cancer decide whether to continue getting regular mammograms. Researchers will compare the toolkit against usual care to see if it improves decision quality and chang…

This study is testing a new online platform called Nest, designed to help young adults (ages 18-39) who have had genetic testing for cancer risk. The platform provides patients and their doctors with updated information about their genetic results and recommended care plans. Rese…

This study aims to understand why some people with early, symptom-free blood cell changes develop the cancer multiple myeloma, while others do not. It will follow 30,000 people who are at higher risk due to family history or race. The goal is to find markers that can predict who …

This study is testing whether a short educational video can be a good alternative to standard genetic counseling for patients with certain cancers. Researchers want to see if the video helps people understand their risk for hereditary cancers and makes genetic testing information…

This study aims to better understand the experience of patients with advanced breast cancer who are receiving care at home through hospice. Researchers will use regular telehealth check-ins to connect patients and their caregivers with their cancer care team. The goal is to learn…

This early-phase study is testing if injecting a standard flu vaccine directly into a type of skin cancer tumor can change the immune cells inside it. Researchers will study the tumor tissue from 25 participants after this injection and their standard surgery to see if the vaccin…

This study aims to understand why some early, non-symptomatic blood conditions turn into cancer. Researchers will observe 10,000 adults who have these early conditions or a history of cancer. They will analyze genetic material from routine blood and tissue samples to identify cha…

This study aims to understand why some people develop lung cancer at age 45 or younger, which is unusual. Researchers will collect blood, saliva, and tumor samples from 500 participants to look for genetic patterns and risk factors. The goal is to gather knowledge that could lead…

This study is testing a new method to better predict how mesothelioma will progress and respond to treatment. Researchers will analyze tissue samples from 240 patients collected during routine diagnostic biopsies. The goal is to develop a more accurate way to determine cancer sta…

This study is testing if doctors can accurately find and test the first lymph nodes that drain from an inflammatory breast cancer tumor using a special imaging scan and dye. Researchers want to see if this less invasive procedure works for this aggressive cancer type, as it could…