Dana-farber Cancer Institute

This study tests a program designed to help men with prostate cancer manage their heart health while undergoing hormone therapy (ADT). The program involves two counseling sessions with a nurse or physician assistant to educate about cardiovascular risks and how to reduce them. Re…

This phase 2 trial tests whether giving the immunotherapy drug pembrolizumab along with chemotherapy before surgery, followed by pembrolizumab alone for about a year after surgery, can improve outcomes for people with recurrent head and neck cancer. The study aims to see if this …

This phase 2 trial tests whether combining hormone therapy (letrozole) with a targeted drug (abemaciclib), and possibly adding metformin or gedatolisib, can control estrogen-receptor-positive endometrial cancer that has returned or spread. The study enrolls adults with this cance…

This early-stage trial tests a special type of immune cell (CIML NK cells) combined with a low dose of IL-2 in people whose blood cancer (like AML or MDS) came back after a stem cell transplant. The goal is to find a safe dose and see if it can put the cancer back into remission.…

This early-phase trial tests whether specially trained natural killer (NK) cells, called CIML NK cells, along with interleukin-2 (IL-2), can safely prevent leukemia from coming back after a stem cell transplant. The study enrolls 15 adults with high-risk acute myeloid leukemia, m…

This early-phase study tests a new drug called SL-401 combined with two other drugs (azacitidine and venetoclax) in people with certain blood cancers—acute myeloid leukemia, myelodysplastic syndrome, and blastic plasmacytoid dendritic cell neoplasm. The main goal is to find the s…

This early-phase trial tests a new type of immune cell therapy called CIML NK cells in 18 people with recurrent ovarian cancer that no longer responds to standard chemotherapy. The cells are taken from the patient, trained in a lab to better attack cancer, and then infused into t…

This phase 2 trial tests whether the drug belumosudil can help people who develop bronchiolitis obliterans syndrome (BOS), a type of lung scarring, after a stem cell transplant. The study will enroll 45 participants with new or early-stage BOS. Participants will take belumosudil …

This early-phase study tests a personalized neoantigen vaccine (NeoVax) in 15 people with untreated chronic lymphocytic leukemia (CLL) who have a specific genetic marker (IGHV unmutated). The vaccine is designed to train the immune system to attack each person's unique cancer cel…

This phase 2 study tests the drug pemigatinib in 24 people with advanced SDH-deficient GIST, a rare stomach tumor that has spread and cannot be removed by surgery. The goal is to see if the drug can shrink tumors and how well patients tolerate it. Participants take a daily pill, …

This phase 2 trial is testing elacestrant, a pill that breaks down estrogen receptors, in 30 people with advanced uterine sarcomas that are fueled by estrogen. The goal is to see if the drug can shrink tumors or slow their growth. Participants must have tumors that strongly expre…

This study tests whether injecting gadolinium-based nanoparticles (AGuIX) before precise MR-guided radiation can improve tumor control for people with centrally located lung tumors or locally advanced pancreatic cancer. About 100 participants will receive the nanoparticle injecti…

This study tests whether combining two drugs, sacituzumab govitecan and atezolizumab, can clear leftover cancer cells in the breast or lymph nodes of people with triple negative breast cancer. About 40 participants who still have cancer after standard chemotherapy will receive th…

This study tests a drug called abemaciclib in people with advanced solid tumors that have specific changes in cyclin or CDK genes. The drug works by blocking proteins that help cancer cells grow. Researchers want to see if it can stop or slow the cancer for at least 4 months. Abo…

This study tests whether adding pembrolizumab to sacituzumab govitecan helps control metastatic triple-negative breast cancer that is PD-L1-negative. About 110 adults with advanced TNBC will be randomly assigned to receive either the combination or sacituzumab alone. The goal is …

This phase 2 trial is testing two different drug combinations for people with stage I HER2-positive breast cancer after surgery. One group gets trastuzumab emtansine (T-DM1) followed by trastuzumab injections, while the other gets paclitaxel plus trastuzumab. The goal is to see w…

This study tests a program called CHEF that helps childhood cancer survivors and their families cook and eat healthy foods. The goal is to support heart health after cancer treatment. About 17 children who finished chemotherapy or radiation will take part. Researchers will measur…

This study tests whether adding the targeted drug T-DM1 to standard chemoradiation can prevent HER2-positive salivary gland cancer from returning after surgery. About 37 adults with advanced but removable tumors will receive the drug alongside standard care. Researchers will trac…

This phase 2 trial tests whether giving two drugs—ficerafusp alfa and pembrolizumab (Keytruda)—before surgery can shrink tumors in people with advanced head and neck cancer. About 32 participants with resectable, PD-L1-positive squamous cell carcinoma will receive the combination…

This phase 2 trial is testing whether the drug casdatifan, alone or with zimberelimab, can safely shrink kidney tumors before surgery in people with clear cell renal cell carcinoma. About 32 adults with advanced or high-risk kidney cancer will receive the drugs before their plann…

This early-phase study tests whether giving specially trained immune cells (CIML NK cells) along with a targeted drug (venetoclax) can safely help prevent acute myeloid leukemia (AML) from coming back. Ten adults with AML who have already received standard treatment will receive …

This study tests whether a 16-week supervised exercise program (circuit training with resistance, functional, and aerobic exercises) can improve frailty and muscle loss in 80 men with metastatic prostate cancer who are on hormone therapy. Participants must be pre-frail or frail. …

This study is for people with HPV-related throat cancer who have had surgery. It tests whether a lower, personalized dose of radiation (and sometimes chemo) can control the cancer while causing fewer side effects and improving quality of life. About 111 adults whose cancer was re…

This study is testing a combination of three drugs—pembrolizumab, ibrutinib, and rituximab—in people whose primary central nervous system lymphoma has returned or not responded to treatment. The goal is to see if the combination can stop the cancer from growing for at least 6 mon…

This pilot study tests whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy can safely treat newly diagnosed primary central nervous system lymphoma. The trial will enroll 15 adults and primarily look for serious side effects, while also checkin…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from getting worse. About 32 people with a specific type of estrogen-sensitive cancer will take these pills daily after initial treatment. The goal is to see if t…

This study tests whether a 16-week, culturally tailored exercise program (aerobic and resistance training) can lower heart disease risk in Black men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). The study will enroll 62 participants, who w…

This phase 2 trial is testing whether combining zanubrutinib and venetoclax can clear even trace amounts of cancer in people with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study enrolls 45 adults whose disease has returned afte…

This master trial is testing a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. The goal is to deliver high doses precisely to tumors while protecting nearby organs. The study enrolls adults with various cancers (pancreas, lung…

This study tests a drug called belzutifan in people with a rare, hard-to-treat type of gynecologic cancer called clear cell carcinoma. The goal is to see if the drug can shrink tumors or stop them from growing. About 32 participants will receive the drug, and researchers will mon…

This study is for people with metastatic urothelial cancer (a type of bladder cancer that has spread). It tests two or three drugs together: sacituzumab govitecan, enfortumab vedotin, and pembrolizumab. The goal is to find the safest doses and see how well the combination shrinks…

This early-phase study tests a new stem cell transplant method for people with aggressive or hard-to-treat acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The approach uses specially engineered donor cells to reduce the risk of graft-versus-host disease, potentia…

This study tests whether giving focused radiation (SBRT) early to people with adenoid cystic carcinoma that has spread to a few spots can slow the cancer's growth. About 32 participants will either receive SBRT or standard care. Researchers will track how long the cancer stays un…

This study aims to see if adding simple blood tests and symptom reviews to standard screening can catch pancreatic cancer earlier in people with a high genetic risk. Researchers will enroll 5,000 participants who have certain gene mutations linked to pancreatic cancer. The goal i…

This study is testing a blood test called Galleri that looks for signs of many different cancers early. It involves 1,500 veterans who served on active duty for at least four years and are 45 or older. Researchers want to see how well the test finds cancer compared to standard sc…

This study is testing a blood test called GRAIL Galleri that looks for signs of many different cancers at once. It is being offered to 1000 people who have a high risk of cancer due to inherited genetic conditions. The goal is to see if the test can find cancers early, when they …

This study is testing a new blood test that looks for pieces of tumor DNA (EGFR mutations) to screen for lung cancer in healthy people aged 50-80 who are of East Asian, Southeast Asian, or Hispanic/Latinx background and do not currently smoke. The goal is to find lung cancer earl…

This study tests a daily light therapy device placed inside the mouth to prevent severe mouth sores in people receiving a stem cell transplant. Twenty adults will use the device for about 2-3 minutes each day from the start of their conditioning chemotherapy through day 20 after …

This study looks at whether a 12-week aerobic and resistance exercise program can lower breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood markers and breast tissue samples from 46 physically inactive women aged 18-59. Participants are…

This study tests a program called BOLSTER, which offers six telehealth sessions with a nurse to help patients with advanced gynecologic or gastrointestinal cancers and their care partners build skills, manage symptoms, and cope with challenges. Participants also get access to a w…

This study tests whether a special cooling cap can reduce hair loss in people with metastatic breast cancer who are receiving certain chemotherapy drugs. About 120 participants will either use the Paxman Scalp Cooling System or not, and researchers will compare hair loss rates an…

This study tests a tool called CASI that helps ovarian cancer patients, their caregivers, and doctors set a shared plan for each visit. The goal is to see if using this tool is practical and helpful. About 112 people with advanced ovarian cancer and their caregivers will take par…

This study is testing an online educational program called On-Trac to help adult cancer survivors cope with anxiety. The program teaches practical strategies based on well-known therapies like CBT and ACT. Researchers will measure changes in anxiety levels and emotional well-bein…

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer receive all their planned chemotherapy at the right dose. Participants will either do resistance exercises and take protein or receive health educati…

This study tests a device that cools and squeezes the arms and legs during chemotherapy to prevent nerve damage, which can cause numbness, tingling, and pain. Fifty adults with breast or gynecologic cancer receiving taxane chemo will wear the device during infusions. Researchers …

This study looks at whether 12 weeks of different exercise programs can help people with advanced lung cancer who are already receiving immunotherapy. The goal is to see if exercise is safe and doable, and if it can improve immune markers. About 30 adults with non-small cell lung…

This study tests a telehealth program called REVITALIZE to see if it can reduce how much fatigue interferes with daily life for adults with advanced ovarian cancer who are taking PARP inhibitors. About 240 participants will either receive the REVITALIZE program or educational mat…

This study tests whether a 12-week program of short exercise breaks (walking, cycling, resistance bands) can improve heart health and reduce chemotherapy side effects in 24 newly diagnosed lymphoma patients. Participants will use activity trackers and get coaching to interrupt lo…

This study looks at whether a 12-week virtual dance program can improve quality of life and reduce pain, fatigue, and body image issues in breast cancer survivors who have ongoing pain after surgery. Thirty participants who had a lumpectomy or mastectomy and still have moderate t…

This study tests a program designed specifically for Chinese and Korean American smokers who are at high risk for lung cancer. The program includes counseling sessions, family coaching, nicotine replacement therapy (like patches or gum), and information about lung cancer screenin…

This study looks at whether a home-based aerobic and resistance exercise program is feasible for adults with graft-versus-host disease (GVHD) after a stem cell transplant. Participants will either do aerobic and resistance exercises or simple stretching. The goal is to see if exe…

This study looks at whether a 6-month home exercise and nutrition program can improve thinking and physical abilities in cancer survivors aged 65 and older, along with their support person. About 1,500 participants will be assigned to either a virtually supervised or unsupervised…

This study tests whether a 16-week virtual high-intensity interval training (HIIT) program, done on a stationary bike at home, can improve physical fitness, thinking skills, and emotional well-being in young adults (ages 18-45) who survived a pediatric brain tumor. Thirty partici…

This study tests a program called UPLYFT designed to help lymphoma survivors who have finished treatment cope with the fear that their cancer might return. The program provides information and tools to improve quality of life and reduce worry. Researchers will first gather feedba…

This study looks at whether a home-based resistance exercise program combined with protein supplements can help people with pancreatic cancer maintain muscle mass while on chemotherapy. About 45 participants will be assigned to one of three groups: exercise plus protein, exercise…

This study tests whether a 16-week, virtually supervised exercise program can help patients with ovarian or endometrial cancer maintain leg function and reduce chemotherapy-induced nerve damage. Thirty patients who have had surgery and are starting first-line chemo will be assign…

This study looks at whether adding a special support program (called RISE) to usual care can reduce financial and material hardships for low-income families of children with high-risk neuroblastoma. About 84 children and their parents will take part, with half getting the extra s…

This study tests whether a 12-week virtual tai chi program is practical and acceptable for cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN), which causes pain, numbness, and balance problems. Researchers plan to enroll 21 participants who have completed che…

This study tests whether a 16-week high-intensity interval training (HIIT) program on a stationary bike can improve thinking, memory, and heart health in women undergoing chemotherapy for breast cancer. Thirty participants will be randomly assigned to either HIIT or a stretching …

This study tests whether an 8-week home-based exercise program, done before a stem cell transplant, can improve muscle strength and physical fitness in people with multiple myeloma. Thirty participants will either exercise via Zoom or continue normal activities. The goal is to se…

This study tests a mobile app program called PRISM to help teens and young adults (ages 12-25) who have finished cancer treatment manage stress and build resilience. Participants will use the app to learn skills to cope with difficult situations. The goal is to see which version …

This study explores whether regular video or phone check-ins between hospice patients with advanced breast cancer and their oncology team can improve the hospice experience. About 200 participants, along with their caregivers and nurses, will take part. The goal is to see if this…

This study tests a new program that gives blood cancer patients access to blood transfusions at home while they receive hospice care. The goal is to see if this improves their quality of life, mood, and reduces hospital visits near the end of life. The trial will include 700 adul…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study aims to uncover genetic factors that increase the risk of thyroid cancer, especially in children and families with a strong history of the disease. Researchers will collect medical history and blood or saliva samples from 250 participants to look for inherited gene cha…

This study aims to make clinical trials more inclusive by training 40 adults who are in remission from blood cancer to review and give feedback on trial plans. The goal is to see if this community-based review process is practical and acceptable. The study does not test a new tre…

This study is testing whether an 8-minute educational video can effectively prepare cancer patients for genetic testing, compared to standard genetic counseling. Over 1,000 adults with various cancers will participate. The goal is to see if the video is acceptable and improves un…

This study is testing a web-based tool called TRIAL that provides information and resources about acute leukemia and clinical trials. Researchers want to see if the tool is easy to use and if people will complete the surveys. About 75 English-speaking adults with suspected acute …

This early-phase trial is looking at how vitamin D affects colon cancer at the genetic level. About 80 people with stage I-III colon cancer or resectable liver metastases will take either high-dose vitamin D or a placebo for 14-28 days before their scheduled surgery. Researchers …

This study looks at genetic changes in people with early-stage blood cancers or conditions that may lead to cancer. Researchers will analyze blood, bone marrow, or cheek cell samples from up to 10,000 participants to find DNA errors linked to cancer risk and progression. The goal…

The PROMISE study is enrolling 30,000 people at high risk for multiple myeloma, including African Americans and those with a family history of blood cancers. Participants provide blood samples so researchers can track changes over time and identify who progresses to myeloma. The …

This research study is collecting tissue samples from 240 adults with malignant pleural mesothelioma to test a new method that combines molecular, radiological, and blood tests. The goal is to create a score that helps doctors predict how the disease will progress. Participants m…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives both patients and their doctors access to updated information about genetic findings. Researchers want to see if the tool is easy t…

This study collects tumor samples and medical information from people with lymphoma or related blood cancers who have a family history of these diseases. Researchers want to find genetic changes that may increase the risk of developing lymphoma. Participants provide blood or tiss…

This study aims to collect tissue samples and medical information from up to 2,750 people with chronic lymphocytic leukemia (CLL) or related conditions. Researchers hope to learn more about what causes CLL and how it behaves. Participants will not receive any new treatment; the g…

This study tests a decision-making toolkit for women aged 80 and older who have had breast cancer. The toolkit provides clear information to help them and their doctors decide whether to continue yearly mammograms. Researchers will track how many mammograms participants get over …

This study is collecting information and samples from 1,500 people with TP53 gene changes (linked to Li-Fraumeni Syndrome, a condition that raises cancer risk) and their relatives. Researchers want to better understand how these gene variants affect cancer risk and how accurate f…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study looks at whether a short survey called the Geriatric-8 can help doctors choose the best treatment for older patients with advanced bladder cancer who cannot take the strong chemotherapy drug cisplatin. Researchers will compare quality of life and side effects between t…

This study looks at whether families of children with cancer are willing to join a program that provides financial support. About 40 families will be randomly assigned to either receive the PediRISE support program or standard care. The goal is to see if the program is feasible a…

This study looks at whether special imaging and dye can help doctors find the first lymph nodes that cancer might spread to in people with inflammatory breast cancer. About 50 women with this rare and aggressive cancer will take part. The goal is to see if these methods work well…

This study looks at whether a pre-surgery program of exercise and nutrition advice is practical for people with stage II or III rectal cancer. About 40 participants will either join the program or receive usual care. The main goal is to see if enough people sign up and stick with…

This study aims to learn more about lung cancer in adults diagnosed at age 45 or younger. Researchers will collect blood samples and medical information from 500 participants to study the biology of these cancers and look for genetic changes that could lead to better treatments. …

This early-phase trial is testing whether injecting the seasonal flu vaccine directly into skin cancer tumors can boost the immune system's attack on the cancer. About 25 people with cutaneous squamous cell carcinoma will receive one injection into their tumor before standard sur…