Exercise may cut breast cancer risk for women with dense tissue

NCT ID NCT06322888

Recruiting now Prevention Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a 12-week aerobic and resistance exercise program can lower breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood markers and breast tissue samples from 46 physically inactive women aged 18-59. Participants are randomly assigned to either start exercising right away or join a waitlist control group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exercise training program (aerobic and resistance exercise)
What this could lead to: If successful, this could show that regular exercise reduces breast cancer risk in women with dense breasts, pointing toward a simple, non-drug prevention strategy.
What could go wrong: This is a very small, early study (46 participants) looking at biological markers, not cancer itself. Results may not prove exercise prevents cancer, and the short 12-week program may not be enough to see lasting changes.

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Conditions

The condition(s) this trial relates to.

breast neoplasm female breast carcinoma breast cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST CANCER FEMALE

Contacts and locations

Locations

Brigham and Women's Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02115, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States

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