BREAST CANCER FEMALE

This study looks at the safety of a new type of skin substitute (called acellular dermal matrix) used in breast reconstruction surgery after mastectomy for breast cancer. About 120 women will be observed to see if this new material causes fewer short-term complications compared t…

This study tests a high-precision radiation treatment called SABR for women aged 65 and older with a common type of early breast cancer. Participants receive five focused radiation sessions instead of surgery. The goal is to control the cancer while keeping side effects low and p…

This study is testing whether using MRI scans before surgery can identify women with early breast cancer who have a very low risk of the cancer returning, allowing them to skip post-operative radiotherapy. About 1,400 women aged 50 and older with certain types of breast cancer wi…

This study tests whether combining two drugs—elacestrant and trastuzumab deruxtecan—can shrink tumors in people with a specific type of advanced breast cancer (HR+/HER2-low) that no longer responds to standard hormone therapy or CDK4/6 inhibitors. About 65 participants will recei…

This study tests whether exercise and diet can reduce heart disease risk in breast cancer survivors. 45 postmenopausal women will be assigned to exercise, exercise plus diet counseling, or stretching for 6 months. Researchers will measure insulin resistance, metabolic health, and…

This study is testing whether high-intensity focused ultrasound (HIFU) can destroy small breast tumors before a patient's scheduled surgery. The goal is to see if this non-invasive, radiation-free technique can completely eliminate the cancer cells in the treated area. Fifteen pa…

This study is gathering images from 800 women who have suspicious breast findings (BI-RADS 4 or 5) to test a new 3D automated ultrasound system called ATUSA. The goal is to see if this radiation-free, operator-independent device can accurately detect breast cancer compared to sta…

This study is testing a new blood test called Oncoliq to see if it can find breast cancer early. The test looks for tiny molecules called miRNAs that tumors release into the blood. Researchers will compare blood samples from 300 women with and without breast cancer to build a com…

This study looks at whether adding a special type of mammogram (contrast-enhanced mammography, or CEM) every two years to the standard yearly 3D mammogram can find breast cancer earlier in women who have already had breast cancer. About 1,500 women aged 30-79 who are at least one…

This study trains Nigerian radiologists to use a tablet-based ultrasound system to perform breast biopsies. The goal is to make breast cancer diagnosis more accessible and reliable in Nigeria. About 900 women with suspicious breast lumps will take part.

This study looks at how exercise might reduce breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood and breast tissue in 46 women who are inactive. Half will start an exercise program, and the other half will wait. The goal is to see if e…

This study is testing a device called the GammaPod that delivers a single, precise radiation boost to the tumor site after breast cancer surgery. The goal is to shorten the overall radiation treatment by a few days and see if this improves patients' quality of life. About 160 wom…

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer complete their full chemotherapy schedule. Participants will either do resistance exercises at home or receive health education. The goal is to see i…

This pilot study is testing a 12-week exercise program designed for Black women who have finished treatment for early-stage breast cancer. The goal is to see if the program is practical and enjoyable, and whether it helps improve physical and emotional well-being. About 75 women …

This study looks at two different exercise programs to see which one helps women gain muscle mass after finishing breast cancer treatment. Researchers will track changes in muscle and fat, as well as how well participants stick with the program. The goal is to find the best way t…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. The goal is to see if this non-invasive brain stimulation can reduce pain scores. About 19 women with persiste…

This study tests a training program that teaches breast cancer survivors with memory and concentration problems (brain fog) how to use thinking strategies to improve daily activities and quality of life. About 50 women who finished cancer treatment 6 months to 3 years ago will ta…

This study looks at whether eating only during an 8-hour window each day (time-restricted eating) can help women with breast cancer have fewer side effects and better quality of life during chemotherapy. Some participants will also follow a Mediterranean diet. The study involves …

This study looks at whether taking creatine supplements can help breast cancer survivors build strength and endurance faster through exercise. Researchers will compare results from 60 women who recently finished chemotherapy with healthy women of the same age. The goal is to impr…

This study tests whether a guided digital self-hypnosis program can reduce hot flashes in women being treated for breast cancer with hormone therapy. About 76 participants will use the app daily for three weeks. The goal is to ease this common side effect, improve quality of life…

This study looks at whether exercise therapy and cognitive behavioral therapy (a type of talk therapy) can help reduce fatigue in women with breast cancer. About 100 female patients in Singapore will take part. The goal is to see if these treatments are acceptable, culturally sen…

This large study tests whether giving lidocaine (a common numbing medicine) through an IV during breast cancer surgery can prevent moderate to severe pain that lasts for a year or more. About 4,300 women having mastectomy or lumpectomy will be randomly assigned to receive lidocai…

This study looks at whether a blood test that measures circulating tumor DNA (ctDNA) can help predict how well breast cancer responds to chemotherapy before surgery. Researchers will take blood samples from 125 women with stage II or III breast cancer before, during, and after tr…

This study is looking at how antibiotics change the bacteria in the gut and breast after a mastectomy with implant reconstruction. Researchers want to see if certain bacteria make infections more likely. About 200 women with breast cancer or a high genetic risk will provide sampl…

This study takes tumor samples from women with aggressive breast cancer (triple negative or luminal B) and implants them into mice to create living models. The goal is to learn how tumors change and resist treatment over time. About 85 participants will provide samples, but the s…

This study looks at what happens to breast cancer tumors when they get less oxygen during surgery. Researchers will take small tumor samples at different times during the operation to see which genes and proteins change. The goal is to learn more about how the cancer responds, no…

This study is for women aged 65 and older with early-stage, hormone-sensitive breast cancer. It tests whether taking hormone pills for 3 months before surgery helps patients feel more confident about skipping radiation after surgery. Half the participants will receive this pre-su…

This study collects mammogram images and survey answers from 20,000 adults to train artificial intelligence (AI) models. The goal is to help doctors read mammograms more accurately for different groups and types of breast cancer. Participants donate their images and get to view t…

This study aims to understand why some breast cancer patients experience memory and concentration problems after chemotherapy. Researchers will compare 150 women—those about to start chemo and healthy volunteers—using cognitive tests and blood samples over five months. An optiona…

This study follows 310 women who had breast cancer surgery to see how access to extra supportive services (like counseling or nutrition advice) affects their quality of life. Participants will fill out questionnaires about their physical, emotional, and social well-being over tim…