Could a 3-Month pill course spare older breast cancer patients from radiation?
NCT ID NCT06507618
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This Phase III trial is for women aged 65 and older with early-stage, hormone-sensitive breast cancer. Half will take hormone-blocking pills for three months before surgery, while the other half will proceed directly to surgery as usual. The goal is to see if the pre-surgery pills help women feel more confident about skipping radiation therapy afterward. The study will track how well women tolerate the pills and whether they stick with the treatment plan.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
endocrine therapy (tamoxifen, letrozole, anastrozole, or exemestane)
What this could lead to
If successful, this approach could help older women with early breast cancer avoid unnecessary radiation therapy by using a short course of hormone-blocking pills before surgery.
What could go wrong
This is a Phase III trial, but it focuses on decision-making and adherence, not on curing cancer. The results may not apply to younger women or those with more aggressive tumors. Side effects from endocrine therapy can include hot flashes, joint pain, and fatigue.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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INOVA Schar Cancer
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-••••
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Riverside Health System
RECRUITINGNewport News, Virginia, 23601, United States
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University of Virginia
RECRUITINGCharlottesville, Virginia, 22903, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Virginia Community Health
RECRUITINGCulpeper, Virginia, 22701, United States
Contact Email: •••••@•••••
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23298, United States
Contact Email: •••••@•••••
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Yale University
RECRUITINGNew Haven, Connecticut, 06511, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••