University Of Virginia

This Phase III trial is for women aged 65 and older with early-stage, hormone-sensitive breast cancer. Half will take hormone-blocking pills for three months before surgery, while the other half will proceed directly to surgery as usual. The goal is to see if the pre-surgery pill…

This study tests a new treatment called EGFR FPBMC for people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The treatment uses a patient's own immune cells, which are modified in the lab to better attack cancer cells, then given back through an …

This study tests a new treatment for people with metastatic breast or prostate cancer that has stopped responding to standard therapies. Participants receive infusions of their own immune cells that have been armed with a special antibody to help them find and attack cancer cells…

This study is testing whether the BCG vaccine, originally developed for tuberculosis, can safely treat Mycobacterium avium complex (MAC) lung disease. Researchers will give 48 adults either a single BCG injection or a placebo and monitor them for side effects, immune responses, a…

This phase 3 trial tests whether adding ketamine to the standard drug levetiracetam stops prolonged seizures (status epilepticus) more effectively than levetiracetam alone. About 770 people aged 1 and older who are still seizing after initial treatment will receive either the com…

This early-phase trial tests a new cell therapy for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who still have small amounts of cancer cells after standard treatment. The therapy uses the patient's own blood cells, armed with a special antibody to t…

This study tests whether giving two common heart medications (a beta blocker and an ACE inhibitor) before and during intensive chemotherapy can prevent heart damage in people newly diagnosed with acute myeloid leukemia (AML). About 70 adults will be randomly assigned to receive t…

This study looks at whether exercise training, the drug liraglutide, or both together can improve blood flow to the heart and muscles and help the body use insulin better in adults with metabolic syndrome. About 80 participants will be randomly assigned to one of four groups: con…

This early-stage trial tests a new treatment for a fast-growing brain cancer called glioblastoma. It combines special immune cells (EGFR BATs) with low-intensity focused ultrasound to temporarily open the blood-brain barrier, allowing more treatment to reach the tumor. The study …

This study tests three different antibiotics in 60 malnourished Bangladeshi children with small intestine bacterial overgrowth (SIBO). The goal is to find which antibiotic best clears the overgrowth, which may help prevent stunted growth. Children receive one of the antibiotics f…

This study tests a program called QuitAid, where pharmacists coach rural smokers on quitting. About 768 participants from Appalachia will get nicotine patches, and some will also get lozenges, text support, or phone counseling. The goal is to see which combination works best and …

This study looks at whether natural estrogen given through a skin patch improves bone strength more than natural estrogen pills or a synthetic birth control patch in women aged 14–30 with functional hypothalamic amenorrhea (missed periods due to stress, low weight, or exercise). …

This study tests whether an artificial pancreas system can improve blood sugar control and, in turn, reduce heart disease risk in people with type 1 diabetes. The system combines an insulin pump with a continuous glucose monitor to mimic a healthy pancreas. Researchers will measu…

This study tests whether a new drug called CIR-0602K can help people with type 1 diabetes keep their blood sugar in a healthy range and reduce their insulin needs. The trial involves 40 adults aged 18-45 who already use an automated insulin pump. Half will get the drug and half a…

This early-stage trial tests a single dose of a lab-made clotting protein (recombinant von Willebrand factor) in 12 adult patients on ECMO who have major bleeding. The goal is to see if the drug is safe and how it behaves in the body. If successful, it may lead to a new way to co…

This study is testing whether a lower dose of radiation, guided by a blood test that detects HPV DNA from tumors, can safely treat head and neck cancer. About 90 adults with squamous cell carcinoma of the oropharynx will receive reduced radiation to the neck. The goal is to see i…

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can improve treatment outcomes. Researchers will enroll 200 adults and children with active, drug-sensitive tuberculosis in Tanzania. The goal is to see if personalized dosing helps m…

This study tests if a combination of two drugs (romidepsin and oral azacytidine) works better than standard single drugs for people with peripheral T-cell lymphoma (PTCL) that has returned or not responded to prior therapy. About 50 adults will be randomly assigned to either the …

This study tests a digital program called weSIPsmarter to help preschool children and their parents in rural areas cut back on sugary drinks. About 744 families from 12 Head Start programs will take part, with half using the program and half receiving a reading-focused website in…

This study tests an experimental treatment for adults with advanced melanoma who are already getting immunotherapy and planning surgery. The treatment combines focused ultrasound (using sound waves to heat and destroy tumor tissue) with an injection of a drug called polyICLC that…

This study tests whether a drug called Brezavvy (an SGLT2 inhibitor) can improve blood flow in the tiny vessels of the heart and reduce chest pain in women who have angina but no blocked major arteries. 150 women will take either the drug or a placebo for 12 weeks and undergo hea…

This study tests whether a special MRI using inhaled xenon gas can detect early signs of rejection in lung transplant patients. Researchers will compare MRI images with lung tissue samples and breathing tests in 60 participants. The goal is to find a safer, non-invasive way to di…

This study is testing a new blood test called the Enlighten Device to see if it can predict which pregnant women will develop postpartum depression (PPD). Researchers will collect blood from 500 pregnant women in their third trimester and then follow them for 6 months after birth…

This study is testing a new test called the Enlighten Device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and follow them for three months after delivery…

This study tests different combinations of an online program called CARRII, designed to help Native American women reduce their risk of alcohol-exposed pregnancy. Over 500 participants will be randomly assigned to one of eight versions of the program for three months. The goal is…

This study tests whether well-timed text messages can help young Air Force trainees avoid binge drinking and its consequences. About 7,000 trainees will either get the standard alcohol intervention or that plus automated texts sent just before, during, and after they first get ac…

This study tests whether semaglutide (a drug used for diabetes and weight loss) can prevent weight gain and fatty liver disease in people who have recently had a liver transplant. About 50 adults who had a transplant 2 to 6 months ago will receive either semaglutide or a placebo.…

This early-phase trial at the University of Virginia is testing whether psilocybin (the active ingredient in magic mushrooms) can help people with prolonged grief disorder. Twelve adults aged 18-65 with complicated grief will receive a single 25 mg dose of psilocybin along with t…

This study tests whether a simple wooden block stretching routine can replace standard physical therapy for people recovering from ankle or pilon fracture surgery. About 30 adults aged 18-65 who had surgery for these fractures will be randomly assigned to either the wooden block …

This study looks at whether short-term beetroot juice (a source of nitrate) can improve blood vessel function, insulin sensitivity, and exercise ability in adults with prediabetes. Researchers will compare people who take metformin with those who do not. The goal is to find simpl…

This study compares a single dose of methadone to the standard drug remifentanil for pain control after brain surgery. About 40 adults having elective brain surgery will be randomly assigned to one of the two drugs. The goal is to see if methadone provides better pain relief and …

This study tests whether taking melatonin can improve sleep quality and duration for medical residents working night float shifts. Fifty residents will be randomly assigned to receive either melatonin or a placebo, and their sleep will be measured with a portable brain-wave monit…

This study tests two ways of giving feedback to people in a weight loss program: one that only praises progress, and another that mixes praise with tips for improvement. Researchers want to see which style helps people lose more weight. About 127 adults with overweight or obesity…

This early-stage study tests a non-invasive procedure that uses focused ultrasound to create a tiny lesion in the brain's pain center. It is for 20 adults with head, neck, or brachial cancer whose pain is not controlled by opioids. The goal is to see if it is safe and can reduce …

This study tests whether an online insomnia treatment, followed by either a meditation program or pain education, can reduce pain in adults with chronic low back pain and insomnia. About 300 participants will first complete a 9-week internet-based cognitive behavioral therapy for…

This study is testing a smartphone app called MindTrails-Movement to see if it can help reduce anxiety in people with Huntington's or Parkinson's disease. The app uses a technique called cognitive bias modification for interpretation (CBM-I) to train users to think less negativel…

This study looks at whether starting physical therapy 2 weeks after reverse total shoulder replacement (for a broken upper arm bone) is better than waiting 6 weeks. Ten adults aged 50-85 will be randomly assigned to one of the two rehab schedules. The goal is to see which timing …

This study looks at whether men with prostate cancer who have hot flashes from hormone therapy will consistently wear a smartwatch to track their symptoms. For 4 weeks, 18 participants will wear the watch, log hot flashes by pressing a button, and complete daily surveys. The goal…

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study uses advanced MRI to measure the fat around the heart in people with a type of heart failure called HFpEF. Researchers want to see if the fat's composition, not just its amount, is linked to disease severity. They will also test if a diabetes drug called semaglutide ch…

This study tests whether offering a small cash payment to households can encourage more people to get screened for tuberculosis (TB) in rural Tanzania. Researchers will enroll 360 people recently diagnosed with TB and their families. Half will receive the usual care, and half wil…

This study looks at why people with cystic fibrosis often develop kidney disease. Researchers will test blood and urine samples for early signs of kidney damage, comparing CF patients with and without frequent hospital stays, as well as people without CF. The goal is to find bett…

This study is testing a new imaging method called 4D-MRI that creates 3D movies of the lungs and liver as a person breathes. The goal is to help doctors better track tumor movement during radiation therapy, making treatment more precise. Researchers will test this in healthy volu…

This study tests a fast genetic test done in the hospital to see if it helps doctors pick the best blood thinner for stroke patients. Some people have a gene variation that makes the common drug clopidogrel less effective. The test checks for 11 known gene variants and alerts the…

This study tracks bone health in 120 teens aged 12–21 with obesity who are either starting a GLP-1 drug (like semaglutide) or following lifestyle changes. Over 24 months, researchers measure bone density and strength using scans and lab tests. The goal is to see if these popular …

This study tests whether private Facebook groups can help pregnant women and new parents follow safe sleep guidelines and breastfeed longer. About 3,000 participants from WIC or with low income will join either a support group or a control group. The goal is to reduce the higher …

This observational study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity in 70 adults with heart failure, peripheral artery disease, or overweight…

This study looks at how the meaning we find in music can change the way we feel pain. Researchers will ask 50 healthy adults to listen to music and report their pain sensations. They will also interview some participants to learn which parts of music are most meaningful and how t…

This study checks if having a vaginal infection before vulvar surgery raises the risk of wound infections or breakdown. About 91 adults with non-cancerous vulvar conditions will be tested with a swab on surgery day. Researchers will follow up by phone at 1 week and a clinic visit…

This study compares two ways to provide pre-test genetic counseling to people at high risk for hereditary cancers: a chatbot (Genetic Information Assistant) versus a live telegenetics session with a genetic counselor. About 96 participants will be randomly assigned to one method,…

This study looks at why people with angina but no blocked arteries (ANOCA) often have poor fitness. Researchers will test whether a 4-week, remotely supervised high-intensity interval training (HIIT) program can safely improve heart function, exercise capacity, and quality of lif…