University Of Virginia

This study is testing whether a lower dose of radiation to the neck can be as effective as standard treatment for HPV-positive throat cancer, but with fewer side effects. About 90 adults with this type of cancer will receive the lower-dose radiation, and their response will be mo…

This study is testing a new program where community pharmacists help people in rural Appalachia quit smoking. It will compare different combinations of support, like text messages, phone coaching, and nicotine replacement therapy (patches and lozenges), to see what works best. Th…

This early-stage study is testing the safety of a lab-made clotting factor (recombinant von Willebrand Factor) in adults on ECMO life support who have severe, hard-to-control bleeding. The treatment aims to help the blood clot properly and reduce dangerous bleeding. Researchers w…

This early-stage study is testing a new cell therapy for adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who still have detectable cancer cells after initial treatment. Doctors collect a patient's own immune cells, modify them in a lab to better target …

This large, Phase 3 trial is testing whether adding the drug ketamine to the standard seizure medication levetiracetam can stop a dangerous condition called status epilepticus more effectively. Status epilepticus is a prolonged, life-threatening seizure that doesn't stop on its o…

This study aims to improve tuberculosis treatment by personalizing drug doses. Researchers will use a simple urine test to check if patients are getting enough of a key TB drug (rifampin) and adjust their dose if needed. The trial involves 200 adults and children in Tanzania who …

This study is testing whether taking hormone therapy pills for 3 months before breast cancer surgery helps women aged 65+ with early-stage, hormone-sensitive breast cancer make better decisions about radiation treatment. Participants are randomly assigned to either take the pills…

This study is testing whether a new oral drug, CIR-0602K, can help adults with type 1 diabetes who use automated insulin pumps. Researchers want to see if the drug helps people spend more time in a healthy blood sugar range and reduces the total amount of insulin they need each d…

This study is testing whether using an artificial pancreas system for 12 weeks can improve heart and blood vessel health in adults with type 1 diabetes. The artificial pancreas combines an insulin pump and continuous glucose monitor to automatically manage blood sugar. Researcher…

This study is testing a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery. Doctors take a patient's own immune cells, arm them in the lab to better recognize and attack cancer, and then infuse them back into the patient. The main goals are…

This study is testing if a drug called Brezavvy, currently used for diabetes, can improve blood flow in the tiny heart vessels and reduce chest pain in women. Researchers will compare the drug to a placebo in 150 women who have chest pain but no major blockages in their large hea…

This early study is testing whether combining two experimental treatments can help control advanced melanoma. Eleven patients receiving immunotherapy before surgery will get focused ultrasound to heat and destroy tumor tissue, followed by an injection of an immune-stimulating dru…

This study is testing whether a combination of two oral drugs (azacytidine and romidepsin) works better than standard single-drug treatments for a rare and aggressive type of blood cancer called Peripheral T-Cell Lymphoma (PTCL) that has come back or hasn't responded to prior the…

This study aims to find the best way to give estrogen to young women with a condition called Functional Hypothalamic Amenorrhea (FHA) to improve their bone strength and prevent fractures. Researchers will compare a natural estrogen skin patch, a natural estrogen pill, and a synth…

This early-stage study is testing a new two-part treatment for a hard-to-treat brain cancer called glioblastoma. Doctors take a patient's own immune cells, arm them to target the cancer, and then use gentle sound waves to temporarily open the blood-brain barrier. The main goals a…

This study is testing a special type of MRI scan to see if it can detect early signs of rejection in people who have received a lung transplant. The goal is to spot problems earlier than current tests can, which might help doctors treat rejection sooner and help patients keep the…

This study is testing a new device called 'Enlighten' that aims to predict a woman's risk of developing postpartum depression (PPD) before she gives birth. Researchers will enroll 1,000 pregnant women to see if analyzing biomarkers in blood or saliva samples collected at home can…

This study aims to validate a new blood test designed to predict a woman's risk of developing postpartum depression. Up to 500 pregnant women will have a blood draw in their third trimester and then be followed for six months after giving birth to see if they develop depression. …

This study is testing a digital health program called 'weSIPsmarter' designed to help families in rural areas reduce sugary drink consumption. It involves parents and their preschool-aged children (2-5 years old) enrolled in Head Start programs. The main goal is to see if this in…

This study is developing and testing a mobile app specifically for Native American women to help them avoid pregnancies affected by alcohol. The app aims to reduce risky drinking and improve contraception use to prevent Fetal Alcohol Spectrum Disorders. Researchers are working wi…

This study is testing if private Facebook groups can help pregnant people and new parents learn and follow safe infant care practices. It aims to increase safe sleep habits and breastfeeding rates, specifically to reduce racial disparities in these areas. The program provides edu…

This study is testing whether adding meditation or pain education to a proven sleep therapy program can better reduce pain for adults who have both chronic low back pain and long-term insomnia. Researchers will compare three approaches: the standard sleep therapy alone, sleep the…

This study is testing short, easy-to-use digital activities delivered via a smartphone app to help breast cancer survivors manage distress and improve their wellbeing. It will involve 120 women who are within five years of their diagnosis and are experiencing elevated anxiety or …

This study is for people who have chest pain or shortness of breath but no major blockages in their heart arteries. Researchers want to understand why these patients often have poor fitness and see if a 4-week, remotely monitored high-intensity exercise program can safely improve…

This study is testing a phone app designed to help reduce anxiety in people with Huntington's or Parkinson's disease. The app uses daily exercises to help participants change unhelpful, negative thought patterns. Researchers will compare the app's effects on anxiety and quality o…

This small, early-stage study is exploring whether a single dose of psilocybin (the active compound in 'magic mushrooms'), given with supportive therapy, can help ease the intense and lasting symptoms of prolonged grief disorder. Researchers will enroll 12 adults to see if the tr…

This study is testing a new, non-surgical procedure to relieve severe pain in people with head, neck, or shoulder cancer. The procedure uses focused sound waves, guided by an MRI, to target a tiny area in the brain involved in pain signaling. Researchers want to see if this is sa…

This study is testing a new way to provide education about genetic cancer risk. Researchers want to see if using an AI chatbot for pre-test counseling is as effective as a video call with a human genetic counselor at getting people to complete genetic testing. They are enrolling …

This study aims to understand the relationship between the bacteria in a person's mouth, how well blood flows to their muscles, and their overall fitness level. Researchers want to see if these factors are connected, especially in people with heart conditions or who are overweigh…

This study aims to find out if taking metformin, a common diabetes medication, changes how well healthy young adults can exercise. Researchers will give 20 participants either metformin or a placebo and measure their endurance on a stationary bike and their blood lactate levels. …

This study aims to understand if having a vaginal infection at the time of surgery increases the risk of wound complications. Researchers will test 91 patients for common infections right before their vulvar surgery and then check their healing at follow-up visits. The goal is to…

This study aims to understand if a popular weight-loss medication (semaglutide) affects bone strength in teens and young adults with obesity. Researchers will follow 120 participants for two years, comparing those taking the medication to those managing weight through lifestyle c…

This study aims to understand how the personal meaning we find in music can change how we feel pain. Researchers will enroll 50 healthy volunteers to listen to music while experiencing mild pain, then rate their pain levels and complete surveys about their emotions and sense of m…