Single dose of methadone may ease pain after brain surgery

NCT ID NCT06810336

Recruiting now Symptom relief Sponsor: University of Virginia Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a single dose of methadone to the standard drug remifentanil for pain control after brain surgery. About 40 adults having elective brain surgery will be randomly assigned to one of the two drugs. The goal is to see if methadone provides better pain relief and recovery quality in the first few days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methadone
What this could lead to: If it works, this could point toward a simpler, longer-lasting pain control method after brain surgery, reducing the need for other opioids.
What could go wrong: This is a very early, small trial with only 40 people, so results may not apply widely. Methadone also carries risks like respiratory depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer brain injury brain neoplasm Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN INJURY BRAIN TUMORS CRANIOTOMY SURGERY PAIN POSTOPERATIVE POSTOPERATIVE CARE

Contacts and locations

Locations

University of Virginia
RECRUITING

Charlottesville, Virginia, 22908-0710, United States

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