University Of Virginia

This trial tested a new treatment called EGFR BATs for people with advanced pancreatic cancer. The treatment uses a patient's own immune cells, armed with a special antibody, to target cancer cells. The study included 22 participants who had already received chemotherapy. The goa…

This study tested how a pill called 2-deoxy-D-glucose (2DG) is absorbed and processed in 9 adults with epilepsy. 2DG is similar to sugar but can't be used for energy, so it may 'clog' the brain's fuel supply during a seizure and stop it. Researchers measured drug levels in the bl…

This small study tested a new tool called InsuLearn that helps people with type 1 diabetes calculate their insulin doses without needing to count carbohydrates. Seven adults on multiple daily injections used the tool for a day and were compared to their usual care. The goal was t…

This pilot study tested whether using an automated insulin delivery (AID) system for just 10 days can help people with type 2 diabetes safely adjust their long-acting insulin doses. 23 adults who already used insulin injections took part. The goal was to see if the device was saf…

This study compared two treatments for bleeding after heart surgery in children aged 2 years or younger. One group received a purified fibrinogen concentrate, the other received cryoprecipitate (a blood product). The goal was to see if the concentrate works as well as cryoprecipi…

This pilot study tested a new computer algorithm that uses continuous glucose monitor (CGM) readings to automatically suggest the right dose of long-acting insulin for people with type 2 diabetes. Thirty adults already using basal insulin were followed for 18 weeks to see if the …

This study looked at how well an artificial pancreas system (the Tandem t:slim pump with Control-IQ Technology) works for teenagers with Type 1 Diabetes during puberty. It followed 42 adolescents aged 11-13 for two years, comparing the device to usual care. The goal was to see if…

This study tested whether topiramate, a seizure medication, can help people who are dependent on both alcohol and nicotine. 236 adults received either a low or high dose of topiramate or a placebo, plus behavioral therapy. The goal was to see if the drug could reduce heavy drinki…

This study tested a continuous glucose monitor (CGM)-based advisory system to help adults with type 1 diabetes better manage their blood sugar. The system gives personalized advice based on glucose readings and the person's behavior and mindset. The goal was to improve glucose co…

This study tested a program called iSIPsmarter, which uses online lessons, text reminders, and a bathroom scale to help rural Appalachian adults cut back on sugary drinks like soda and sweet tea. About 249 adults who drank at least 200 calories of sugary beverages daily took part…

This pilot study tested whether a smartphone app can accurately measure gaze stability and the vestibulo-ocular reflex (VOR) in adults with and without balance disorders. 35 participants performed standard balance tests using both a smartphone app and a commercial computer system…

This study is developing and testing a smartphone app designed for Native American women to help them avoid pregnancy affected by alcohol. Researchers will gather feedback and pilot test new features with 407 women who are at risk. The goal is to reduce risky drinking and improve…

This study tested a 45-minute classroom program called UP2UTobacco for 9th graders. The goal was to help students quit or avoid tobacco and nicotine products, including e-cigarettes. Nearly 600 students took part, and researchers checked if the program led to more teens being tob…

This study tested whether low-intensity focused ultrasound (LIFU) can safely reduce cravings in people with cocaine use disorder. 25 adults received either real or fake (sham) ultrasound while their brain activity was measured with MRI. The goal was to see if LIFU lowers craving …

This study tested a telephone helpline designed to support people with opioid dependence. The helpline offered education, coping strategies, and referrals to medication-assisted treatment. Researchers enrolled 31 participants and measured satisfaction with the service. The goal w…

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and improve well-being in breast cancer survivors. 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild-to-moderate anxiety or depressio…

This small study tested whether donepezil (Aricept), a drug that boosts the brain chemical acetylcholine, could improve walking and balance in 6 people with Parkinson's disease. Researchers also looked at how brain shrinkage in a key area relates to gait problems. The goal is to …

This study tested whether a mobile app called IntelliCare can reduce depression and anxiety in breast cancer survivors. 313 women who had been diagnosed within the past 5 years and had elevated symptoms used the app or received standard educational materials. The study also looke…

This study looked at whether short-term use of metformin, a common diabetes drug, changes how well healthy young adults can exercise. Fourteen participants took metformin or a placebo and did bike tests to measure endurance and blood lactate levels. The goal was to see if metform…

This study uses a special MRI technique with inhaled helium-3 gas to measure how fast air moves through the windpipe and lungs. Researchers will compare airflow in healthy volunteers and people with COPD or constrictive bronchitis. The goal is to gather real-world data to improve…

This completed study from the University of Virginia looked at whether having a hiatal hernia (a stomach issue) is linked to early, undetected lung scarring. Researchers collected blood and lung fluid samples from 14 adults before surgery to measure signs of lung injury. The goal…

This pilot study tested whether computer models could predict sepsis and necrotizing enterocolitis (NEC) in very low birth weight infants (under 1500 grams). Researchers used existing NICU data to build and test these models. The goal was to see if this approach is feasible, not …

This study tested a new way to measure muscle stiffness by taking pictures of the skin on the back. Five adults, either healthy or with mild neck pain, had their skin gently pulled and stretched while cameras recorded the movement. The goal was to see if this simple imaging metho…

This study tested a group-based program to help endometrial cancer survivors adopt healthier habits. The goal was to lower their risk of other health problems like heart disease and diabetes. Twenty-three survivors who had finished cancer treatment took part in online learning an…

This study looked at how different exercise intensities affect ghrelin, a hormone that controls hunger, in 40 adults with obesity or prediabetes. Participants cycled on a stationary bike while researchers measured ghrelin levels, appetite, and blood vessel function. The goal was …