University Of Virginia

Coal miners in Central Appalachia use tobacco at very high rates and face serious lung diseases like cancer and black lung. This study tests a new approach: lawyers handling black-lung compensation cases identify miners who use tobacco and connect them to community pharmacists. T…

This study tests four different approaches to help adults who smoke but are not ready to quit in the next 30 days. Participants receive nicotine patches and may also get a nicotine lozenge, a pharmacist-led coaching program, or text message support. The goal is to find the best c…

This phase 3 trial tests whether adding a steroid (hydrocortisone) and a stronger mix of antibiotics to standard care can improve survival in HIV patients with sepsis in sub-Saharan Africa. The study will enroll 344 adults and measure how many are alive after 28 days. It aims to …

This study looks at whether adding exercise to the weight-loss medication tirzepatide helps people lose more weight and improve health markers like blood sugar and cholesterol. Researchers will enroll 24 adults aged 30–65 with overweight or obesity. Participants will take tirzepa…

This trial tests whether a special ultrasound technique can detect heart muscle ischemia (reduced blood flow) in people with suspected acute coronary syndrome. The approach uses microbubbles that stick to activated immune cells and blood vessel linings, potentially revealing infl…

This early-phase study tests whether a special ultrasound with a targeted contrast agent (Sonazoid) can quickly diagnose heart inflammation caused by immune checkpoint inhibitor cancer drugs. About 30 adults who recently received these drugs and show signs of heart inflammation w…

This study will test a new portable device called the Cobra Ankle Arthrometer to see if it can accurately measure ankle joint looseness. Researchers will compare it to ultrasound imaging in 62 young adults, including those with chronic ankle instability, previous sprains, or no a…

This trial tests whether self-guided digital programs can reduce both insomnia and depression in breast cancer survivors. Participants use an online insomnia program or a mental health program, either alone or in sequence, to see which approach works best. The goal is to find a s…

This study tests a smartphone app that offers short mental health exercises for breast cancer survivors. The exercises target negative thinking, coping skills, and relaxation. The goal is to see if using the app for 8 weeks reduces anxiety and depression symptoms. The study will …

This study tests a paper-based decision aid designed to help people with intermediate-risk melanoma decide whether to have a sentinel lymph node biopsy. The tool provides clear information about the procedure, its risks and benefits, and helps patients think about their personal …

This study looks at whether giving unnecessary antibiotics to malnourished infants with diarrhea harms their immune system's ability to fight future infections. Researchers will compare two groups of 150 Bangladeshi infants: one group receives only supportive care, while the othe…

This study looks at 10 adults over 50 with hearing loss and one weak balance ear. It compares implanting the device in the weak-balance ear versus the good-balance ear. The goal is to see if choosing the weaker side helps reduce dizziness after surgery.