University Of Virginia

This study tests a treatment plan that adjusts chemotherapy based on a patient's fitness level for adults aged 60 and older with untreated classical Hodgkin lymphoma. All participants receive the immunotherapy drug pembrolizumab plus another targeted drug, then a PET scan and fit…

This phase 2 trial tests a combination of hormone therapy, external beam radiation, and MRI-guided internal radiation implants for men with unfavorable-intermediate to very high-risk prostate cancer. The goal is to see if this precise approach causes fewer urinary side effects th…

This phase 2 trial tests whether dulaglutide, a drug used for type 2 diabetes, can improve small blood vessel function in adults with type 1 diabetes. The study involves 47 participants aged 18-40 with long-standing type 1 diabetes. Researchers measure blood flow and insulin sens…

This early-phase trial tests whether combining the immunotherapy pembrolizumab (Keytruda) with chemotherapy drugs pralatrexate and decitabine is safe and can shrink tumors in people with relapsed peripheral or cutaneous T-cell lymphoma. About 37 adults whose cancer has returned o…

This study tests a new treatment for women with metastatic breast cancer that has spread. It combines specially trained immune cells (HER2 BATs) that attack cancer cells with a drug called pembrolizumab that helps the immune system work better. The goal is to find a safe dose and…

This study looks at whether memantine, a drug already used for Alzheimer's symptoms, might help prevent the disease in people at high risk. Researchers are testing it in 32 adults aged 50 to 65 who have a family history of dementia and carry the ApoE4 gene. The main goal is to se…

This study tests whether adding special lessons to an existing social-skills program (Second Step) helps prevent violence and improve classroom relationships. About 145 teachers and their students in elementary and middle schools will take part. The program teaches four key skill…

This study compares two types of nerve blocks (PENG and FICB) to see which provides better pain relief for people with hip fractures in the emergency department. About 50 adults with a broken hip will receive one of the two blocks, and researchers will measure their pain scores a…

This study tests a smartphone app called Tremor Retrainer for people with functional tremor, a movement disorder not caused by other diseases. About 20 participants aged 10 and older will use the app and be monitored via video. The goal is to see if the app is easy to use and if …

This study looks at whether starting palliative care early can help adults with aggressive leukemias or myelodysplastic syndrome (MDS) have a better end-of-life experience. Researchers will compare where patients die (home, hospice, or hospital) and how often they need hospital c…

This study aimed to see if metformin or birth control pills were more satisfying for treating PCOS in women aged 40-49. It planned to use a quality-of-life questionnaire to measure patient satisfaction. However, the study was withdrawn before any participants were enrolled, so no…

This study tests whether a pharmacist-led program can help low-income smokers use nicotine patches or lozenges to quit or reduce smoking. About 100 adults from community health centers will receive counseling sessions and text support. The goal is to see if this approach is pract…

This study looks at whether adults aged 65 and older with memory concerns can collect a small blood sample at home to check for Alzheimer's disease risk. Participants will use a simple device to draw blood, mail it to a lab, and get results from a doctor over video. The goal is t…

This study looks at 109 people in Virginia with nontuberculous mycobacterial (NTM) lung disease. Researchers use genetic sequencing to tell if a repeat infection is a relapse or a new infection from the environment. The goal is to better understand how the disease comes back and …

This study looks at whether obesity makes multiple sclerosis (MS) worse in children. Researchers will compare brain scans and blood markers between normal-weight and overweight/obese kids recently diagnosed with MS. The goal is to understand how obesity might drive inflammation a…

This study looks at whether a new type of heart medication, called a cardiac myosin inhibitor, can improve blood flow in the small blood vessels of the heart in people with hypertrophic cardiomyopathy (HCM). Researchers will use special ultrasound imaging to measure blood flow be…

This study looks at how certain blood components and heart imaging patterns might help predict the worsening of aortic stenosis, a common heart valve condition in older adults. Researchers will study 65 people with mild or moderate aortic stenosis and compare them to healthy cont…

This study aims to understand how the body's response to insulin changes during pregnancy in people with type 1 diabetes. Researchers will analyze data from continuous glucose monitors and insulin pumps used by 100 participants from before pregnancy to six months after birth. The…

This study tests whether a remote monitoring system—including a smartphone app, a Fitbit, and a smart pill cap—can effectively track symptoms and side effects in 30 lung cancer patients taking oral targeted therapy. Participants will use the system for up to 24 weeks, and the goa…