Precision radiation combo aims to tame High-Risk prostate cancer
NCT ID NCT04465500
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests a combination of hormone therapy, external beam radiation, and MRI-guided internal radiation implants for men with unfavorable-intermediate to very high-risk prostate cancer. The goal is to see if this precise approach causes fewer urinary side effects than standard treatments. Sixty participants will be followed for outcomes like cancer control, quality of life, and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Combination of external beam radiation therapy (EBRT), MRI-guided high dose-rate (HDR) brachytherapy, and androgen deprivation therapy (ADT)
- What this could lead to
- If successful, this approach could offer a more precise radiation treatment for high-risk prostate cancer with fewer severe side effects.
- What could go wrong
- This is a small, single-center phase 2 trial with only 60 participants, so results may not apply broadly. The combination therapy also carries risks of urinary, bowel, and sexual side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Virginia
Charlottesville, Virginia, 22908, United States
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